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effectivehealthcare.ahrq.gov/products/safety-vaccines/protocol
April 06, 2020 - Rubella Immunity in Pregnant Iranian Women: A Systematic Review and Meta-Analysis. … A systematic review and meta-analysis. … : A Systematic Review and Meta-Analysis. … Therapeutic vaccination for chronic hepatitis B: A systematic review and meta-analysis. … Risk analysis : an official publication of the Society for Risk Analysis. 2016;36(7):1297-314. doi: 10.1111
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effectivehealthcare.ahrq.gov/products/quantitative-synthesis-expanded-methods/methods
March 13, 2013 - Thus the meta-analysis of three “mega-trials” will be more reliable than the meta-analysis of three small … Only widely accepted composite outcomes should be used in meta-analysis. … Distinguish between prespecified and post hoc analysis. … Investigating underlying risk as a source of heterogeneity in meta-analysis. … Statistical power analysis for the behavioral sciences, 2nd ed.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methodological-recommendations-framework-communications_research.pdf
September 01, 2013 - So how does one choose the underlying true model in a meta-analysis? … Meta-analysis Of Observational Studies in
Epidemiology (MOOSE) group. … Meta-analysis of
multiple outcomes by regression with
random effects. … Meta-
analysis of rare events: an update and
sensitivity analysis of cardiovascular events
in randomized … of a full
Bayesian analysis.
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effectivehealthcare.ahrq.gov/sites/default/files/introductory-slides-ahrq-cf-webinar.pdf
August 27, 2012 - Stakeholder Preferences in
Comparative Effectiveness Research:
Potential Uses of Multi-Criteria
Decision Analysis … approaches to
eliciting and quantifying stakeholder preferences
Compare and contrast Conjoint Analysis … reviews of existing research
Decision modeling, with or without cost information
Retrospective analysis … Chair of the ISPOR Conjoint Analysis (CA) Experimental
Design Task Force.
Dr. … Forum Team)
10:30-10:40 AM
An introduction to the use of Analytical Hierarchy
Process and Conjoint Analysis
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/rt-bone-metatases-qa-tables-appendix-F.xlsx
January 01, 2019 - Differential loss to followup acceptable Intent-to-treat analysis? Outcomes
prespecified? … index publication) Unclear Unclear Yes Unclear No No Yes No Yes Unclear Yes Poor
Howell, 2013
Subgroup analysis … 2005 (above) Unclear Unclear No Unclear No No Yes No No Unclear Unclear Poor
Konski, 2006
Subgroup analysis … , 2006
(index publication) Yes Yes Yes No No No No Unclear Yes Unclear Yes Fair
Sande, 2009
(sub analysis … Unclear No No Yes No Yes No Yes Fair
Sprave, 2018 Quality of Life and Radiation-induced
Secondary analysis
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-app-f.xlsx
January 01, 2019 - Differential Loss to Followup Acceptable Intent-To-Treat Analysis? Outcomes
Prespecified? … index publication) Unclear Unclear Yes Unclear No No Yes No Yes Unclear Yes Poor
Howell, 2013
Subgroup analysis … 2005 (above) Unclear Unclear No Unclear No No Yes No No Unclear Unclear Poor
Konski, 2006
Subgroup analysis … , 2006
(index publication) Yes Yes Yes No No No No Unclear Yes Unclear Yes Fair
Sande, 2009
(sub analysis … Unclear No No Yes No Yes No Yes Fair
Sprave, 2018 Quality of Life and Radiation-induced
Secondary analysis
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effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - Integrating stakeholder preferences in
comparative effectiveness research
using multi-criteria decision analysis … (MCDA) and Conjoint Analysis (CA)
Maarten J. … L3.2 = 0.5
L2,1 = 0.25
L2,2 = 0.25
L3,1 = 0.25
L3,1 = 0.25
4
Multi-criteria decision analysis … and Conjoint Analysis
Multi-criteria Decision analysis (MCDA) is a subdiscipline of
operations … Conjoint analysis methods
Helps to improve judgment
Decomposed
Hierarchical
Low cognitive
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - Thus the meta-analysis of
three “mega-trials” will be more reliable than the meta-analysis of three … • Only widely accepted composite outcomes should be used in meta-analysis. … Distinguish between prespecified and post hoc analysis. … Bayesian methods
in meta-analysis and evidence synthesis. … Statistical power analysis for the
behavioral sciences, 2nd ed.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
October 01, 2016 - , extreme value analysis,
dimensional analysis).166 In addition, software production techniques, such … Meta-analysis, decision analysis,
and cost-effectiveness analysis: methods for
quantitative synthesis … Sensitivity analysis in the context
of uncertainty analysis for computationally
intensive models. … Sensitivity analysis versus
uncertainty analysis: When to use what? … Bias analysis
via missing-data methods.
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effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
January 01, 2013 - To estimate treatment effects in clinically relevant subgroups (subgroup analysis)
2. … This type of analysis evaluates the treatment effect for a number of subgroups, one variable at a time … Subgroup Analysis
Subgroup analysis is the most popular analytic approach for examining heterogeneity … The study intent, design, and analysis are all focused on the subgroup hypotheses to be tested. … Descriptive subgroup analysis
The main goal of descriptive subgroup analysis is to describe the subgroup
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effectivehealthcare.ahrq.gov/sites/default/files/cer-235-pharma-nonpharm-ptsd-update-appendix-g-1.xlsx
November 12, 2020 - Selection Bias Domain: ITT Analysis? Performance Bias Domain: Care Providers Masked? … education, or PTSD severity
• ≥20% differential on other demographic variables Yes:
• Study stated ITT analysis … • >90% of randomized participants analyzed in allocated group
No:
• Per-protocol analysis with ≤90% … extreme or high
• Measurement attrition (overall or differential) moderate paired with CA (completer analysis … Also, MI computation used group as the unit of analysis (means, across groups) rather than individuals
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-235-pharma-nonpharm-ptsd-update-appendix-g-1.xlsx
November 12, 2020 - Selection Bias Domain: ITT Analysis? Performance Bias Domain: Care Providers Masked? … education, or PTSD severity
• ≥20% differential on other demographic variables Yes:
• Study stated ITT analysis … • >90% of randomized participants analyzed in allocated group
No:
• Per-protocol analysis with ≤90% … extreme or high
• Measurement attrition (overall or differential) moderate paired with CA (completer analysis … Also, MI computation used group as the unit of analysis (means, across groups) rather than individuals
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - example, sex) can
produce unbiased results in analysis … removed in analysis (see below sections for analytic strategies). … Complete Case Analysis
The complete case analysis strategy restricts the analysis to patients with … Using causal
diagrams to guide analysis in missing data
problems. … Using causal
diagrams to guide analysis in missing data
problems.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - example, sex) can
produce unbiased results in analysis … removed in analysis (see below sections for analytic strategies). … Complete Case Analysis
The complete case analysis strategy restricts the analysis to patients with … Using causal
diagrams to guide analysis in missing data
problems. … Using causal
diagrams to guide analysis in missing data
problems.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
October 01, 2014 - MRI and CT performed similarly when patients
with HCC were the unit of analysis, but sensitivity was … higher for MRI than for CT when HCC lesions were the
unit of analysis (pooled difference 0.09; 95% … Surveillance
settings
Unit of analysis:
patients with
HCC
CT Sensitivity: Low
Specificity: Low … Surveillance
settings
Unit of analysis:
patients with
HCC
MRI or PET Insufficient No evidence … Nonsurveillance
settings
Unit of analysis:
HCC lesions
CT Sensitivity:
Moderate
Specificity:
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - The systematic reviewers first attempted to use analysis option 3, then moved on to analysis option 2 … Systematic Review Example: Analysis Option 3 — Naïve Estimates
The reviewers decided on the third analysis … Systematic Review Example:
Analysis Option 2 — Pooled Data Analysis
Dashed line = line of perfect agreement … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis
Here is an example of the analysis … Analysis options 1, 2, and 3 are recommended.
Analysis option 4 requires expert statistical help.
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - The systematic reviewers first attempted to use analysis option 3, then moved on to analysis option 2 … Systematic Review Example: Analysis Option 3 — Naïve Estimates
The reviewers decided on the third analysis … Systematic Review Example:
Analysis Option 2 — Pooled Data Analysis
Dashed line = line of perfect agreement … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis
Here is an example of the analysis … Analysis options 1, 2, and 3 are recommended.
Analysis option 4 requires expert statistical help.
-
effectivehealthcare.ahrq.gov/sites/default/files/s166.pdf
October 01, 2007 - meta-analysis. … Systematic Reviews
in Health Care: Meta-Analysis in Context. … Bayesian methods in meta
analysis. In: Methods for Meta-Analysis n Medical Research. … Bayesian approaches to ran-
dom-effects meta-analysis: a comparative study. … The random effects procedure
is then followed as a normal meta-analysis of 2 studies.
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effectivehealthcare.ahrq.gov/products/telehealth-acute-chronic/research-protocol
February 16, 2017 - or/1-4
limit 5 to (meta analysis or systematic reviews)
meta-analysis.pt. … meta-analysis/ or systematic review/ or meta-analysis as topic/ or "meta analysis (topic)"/ or "systematic … (meta-analysis or systematic review).ti,ab. … meta-analysis/ or systematic review/ or meta-analysis as topic/ or "meta analysis (topic)"/ or "systematic … (meta-analysis or systematic review).ti,ab.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
January 30, 2020 - Rubella Immunity in Pregnant Iranian
Women: A Systematic Review and Meta-Analysis. … A systematic review and meta-analysis. … : A Systematic
Review and Meta-Analysis. … A Systematic Review and Meta-
Analysis. … Risk analysis : an official publication of
the Society for Risk Analysis. 2016;36(7):1297-314. doi: