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441. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
     January 01, 2013 - Limitations Because only cases with discrepant exposure history contribute information to the analysis … The new-user design offers a further advantage in anchoring the time scale for analysis at time since … A meta-analysis of the association between adherence to drug therapy and mortality. … Biases introduced by suboptimal study design cannot usually be removed by statistical analysis. … Biases introduced by suboptimal study design cannot usually be removed during the statistical analysis

442. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
     October 22, 2012 - They had serious errors in design, analysis, or reporting; large amounts of missing information; or … We will then determine the feasibility of completing a quantitative synthesis (i.e., meta- analysis). … treatment meta-analysis due to insufficient data from head-to-head trials to draw conclusions. … to the standard random- effects models used in the meta-analysis of effect sizes. … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses

443. Disposition of Comments Report for Evaluation and Treatment of Cryptorchidism (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_disposition-comments.pdf
     December 11, 2012 - Epidemiologic studies and review articles were not included in our analysis per our a priori inclusion … It refers to a meta-analysis published in the Journal of Clinical Endocrinology and Metabolism in 1995 … Because this study was a meta- analysis it would not have been included in our literature review. … Furthermore, the authors of the 2005 review article note that the meta-analysis was limited by the … Finally, there is debate about how to define a normal semen analysis.

444. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
     September 01, 2011 - Or is this a mistake given that numerous studies prior to 1996 are cited and used for analysis? … Unfortunately, the sample size precluded this analysis. … This had very little impact on the analysis. … However, a description of meta-analysis goes beyond this report. … This had only a small effect on the analysis.

445. Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_policymaker.pdf
     August 01, 2016 - among patients treated with AUD medication when compared with patients treated without it.2 A meta-analysis … column only includes studies rated as having a low or medium risk of bias that were included in the main analysis … Extended-release naltrexone for alcohol and opioid dependence: a meta-analysis of healthcare utilization

446. Antidepressant Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
     July 01, 2014 - Interpersonal psychotherapy for depression: a meta-analysis. … Brief psychotherapy for depression: a systematic review and meta- analysis. … Methods for Meta- Analysis in Medical Research. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58. … A systematic review and meta-analysis of the best evidence.

447. Future Research Needs for Childhood Obesity Prevention Programs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/child-obesity-future_research.pdf
     March 31, 2010 - Questions from “Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-analysis … Questions from “Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis … Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis. … Furthermore, further research might be conducted with stratified analysis on sub-groups, such as by … Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis.

448. Project Name: (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_disposition-comments.pdf
     October 25, 2011 - Statistical analysis appears sound although this is not my area of expertise. … Since additional analysis is minimal, the results are clear and easy to follow. … We have also added a meta-analysis. … I was surprised to see that only 5 studies were included in this analysis. … or meta- analysis.

449. Tx-For-Localized-Prostate-Cancer Surveillanceassesment 20120614 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
     May 01, 2012 - However, a subgroup analysis suggested that men with high-risk features (PSA > 10, and intermediate … Sub-group analysis did not vary by age, race, Charleson score, or performance status. … Only one RCT provided subgroup analysis according to age. … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID: 17638714. 4. … Only one RCT provided subgroup analysis according to age.

450. ADHD-Update-protocol-160818 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
     August 18, 2016 - "[pt] OR "meta-analysis as topic"[MeSH] OR "meta-analysis"[tiab] OR "meta- analyses"[tiab]) NOT (Editorial … "[pt] OR "meta-analysis as topic"[MeSH] OR "meta-analysis"[tiab] OR "meta-analyses"[tiab]) NOT (Editorial … "[pt] OR "meta-analysis as topic"[MeSH] OR "meta-analysis"[tiab] OR "meta-analyses"[tiab]) NOT (Editorial … They had serious errors in design, analysis, or reporting; large amounts of missing information; or … We will then determine the feasibility of completing a quantitative synthesis (i.e., meta- analysis).

451. Tx-For-Localized-Prostate-Cancer Surveillanceassesment 20120614 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
     May 01, 2012 - However, a subgroup analysis suggested that men with high-risk features (PSA > 10, and intermediate … Sub-group analysis did not vary by age, race, Charleson score, or performance status. … Only one RCT provided subgroup analysis according to age. … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID: 17638714. 4. … Only one RCT provided subgroup analysis according to age.

452. Surveillance & Identification of Triggers for Updating Systematic Reviews for the EHC Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
     August 01, 2012 - CERs with no meta-analysis were examined for qualitative signals only, as was the case for this CER. … For any CER that contains meta-analysis (es) we first assess for, the qualitative signal(s), and if … Cycle 1 (November 2011) No new evidence No Signal NA (no meta- analysis in CER) None All 3 … A survival analysis. Ann Intern Med 2007 Aug 21;147(4):224-33. [PMID: PM:17638714] 5. … (in relation to a meta-analysis in the original CER) or non-pivotal trial – A7

453. Disposition of Comments for CER 161 Major Depressive Disorder (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder-disposition-160504.pdf
     December 08, 2015 - Why here, as opposed to reporting the results of the network meta-analysis separately? … Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. … Brief psychotherapy for depression: A systematic review and meta-analysis. … , if it were otherwise eligible it would be included in the network meta-analysis … We addressed the SSRI dosing using sensitivity analysis.

454. Cystic-Fibrosis-Hgh Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
     August 01, 2012 - However, with multivariate analysis, IGF-1 levels were not elevated.17 Same study (subsequent … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … In multivariate analysis, the latter was independently associated with increased mortality when … For the DM analysis, only Type 1 was considered. were CNS-related). … merged and in a subgroup analysis.

455. Disposition of Comments for Evidence Report 224 Omega-3 Fatty Acids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
     October 12, 2016 - Unfortunately, few studies took maternal weight gain into account in a multivariate analysis, and the … Peer Reviewer #2 Methods (2) meta-regression or subgroup analysis based on omega-3 dosing. … But i would view publication bias analysis as essential here. … Decisions regarding criteria for study inclusion and analysis were made by the research team based … Moreover, adding to existing meta-analysis was not done consistently.

456. Disposition of Comments Report for Treatment of Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_disposition-comments.pdf
     June 28, 2013 - of CARE-HF and the analysis of MADIT-CRT. … We have clarified that the calcium channel blockers included in our analysis are non-dihydropyridine … Including a statistical analysis section could have used to address these issues. … Both studies meet our inclusion criteria, and in our opinion, should be kept in the analysis. … Because this analysis was not an RCT the study did not meet our inclusion criteria.

457. Topic Disposition: Evaluation and Management of Headaches in Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/system/files/docs/headaches-pregnancy-topic-brief.pdf
     January 01, 2019 - Pregnancy outcome following prenatal exposure to triptan medications: a meta-analysis. … puncture headache among women undergoing Cesarean section surgery under spinal anesthesia: A meta- analysis … Risk factors for post-dural puncture headache following injury of the dural membrane: a root-cause analysis … Pregnancy outcome following prenatal exposure to triptan medications: a meta-analysis. … Prevention of post-dural puncture headache in parturients: a systematic review and meta-analysis.

458. Cad-Women-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-treatment_executive.pdf
     August 01, 2012 - Data Synthesis and Analysis We synthesized the primary literature by continuous data (e.g., age, event … We determined the feasibility of completing a quantitative synthesis (i.e., meta-analysis). … The feasibility of a meta- analysis depended on the volume of relevant literature (two or more studies … When a meta-analysis was appropriate, we used random-effects models to quantitatively synthesize the … Patient-Level Meta-Analysis Given the small representation of women in these RCTs, the heterogeneity

459. CER 173 Executive Summary: Diabetes Medications for Adults With Type 2 Diabetes: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
     January 01, 2015 - If we conducted a meta- analysis for a body of evidence, we relied on the results of the meta-analysis … Random-effects meta- analysis of inconsistent effects: a time for change. … Cardiovascular safety of sulfonylureas: a meta-analysis of randomized clinical trials. … Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. … Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies.

460. Disposition of Comments Report for Stroke Prevention in Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_disposition-comments.pdf
     August 23, 2013 - and included individual studies from that analysis which met our inclusion criteria. … - to-treat analysis. … TEP #2 Methods Should describe which Random Effects model was used in meta-analysis. … When appropriate, meta analysis techniques have been applied to the available literature. … There is no overall c-index, and no formal meta-analysis (or head to head comparisons) cited.