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421. Topic 0505 Genetic Testing for Developmental Diseases NSD FINAL_SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0594-131115.pdf
     March 13, 2013 - advanced genetic testing Summary: (comparative genomic hybridization [CGH], chromosomal microarray analysis … intellectual (DD/ID) disabilities and autism spectrum disorder (ASD) Intervention(s): Chromosomal microarray analysis

422. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/copd/protocol
     October 10, 2018 - If meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random effect method … Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. … Clinical outcomes and cost analysis of exacerbations in chronic obstructive pulmonary disease. … Economic analysis of the Confronting COPD survey: an overview of results. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

423. Methods Research Report - Progression-Free Survival: What Does It Mean for Psychological Well-Being or Quality of Life? (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/survival-quality_research.pdf
     April 01, 2013 - Data Synthesis The analysis of study data is qualitative only. … PD) adjusted for baseline scores (treatment arms pooled for this analysis) ANCOVA = analysis of covariance … Future studies using patient level data and analysis would also be useful. … Meta-analysis for the evaluation of surrogate endpoints in cancer clinical trials. … Managing the delivery of bad news: An in-depth analysis of doctors' delivery style.

424. Antipsychotics-Adults Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_surveillance.pdf
     August 30, 2014 - SRC Literature Analysis: • No new research was found. Reviewer Questions: 1. … SRC Literature Analysis: • No new research was found. Reviewer Questions: 1. … SRC Literature Analysis: • No new research was found. Reviewer Questions: 1. … SRC Literature Analysis: • No new research was found. Reviewer Questions: 1. … Analysis was done by intention to treat.

425. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain-surveillance-151130.pdf
     July 10, 2015 - All conclusions were up-to-date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •! No new literature was found. … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •! No new literature was found.

426. GRADING THE STRENGTH OF A BODY OF EVIDENCE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
     November 01, 2013 - , they can evaluate precision based on the CI from the meta-analysis. … meta-analysis: precision vs. heterogeneity? Contemp Clin Trials. 2007 May;28(3):324- 8. … Quinine for nocturnal leg cramps: a meta-analysis including unpublished data. … Comparison of two methods to detect publication bias in meta-analysis. … Meta-analysis, funnel plots and sensitivity analysis. Biostatistics. 2000 Sep;1(3):247-62.

427. Identification and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/acs-depression/research-protocol
     August 31, 2016 - We will then determine the feasibility of completing a quantitative synthesis (i.e., meta-analysis). … A descriptive analysis of minor depression. … Screening and case-finding instruments for depression: a meta-analysis. … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses

428. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
     August 10, 2010 - A recent meta-analysis estimates prevalence for childhood ADHD world-wide to be 5.29% ( 95% CI 5.01 … A recent meta-analysis produced a pooled prevalence world wide of 2.5 % (95% CI 2.1-3.1).5 Over … The worldwide prevalence of ADHD: a systematic review and metaregression analysis. … Prevalence and correlates of adult attention- deficit hyperactivity disorder: meta-analysis. … The TEP does not do analysis of any kind nor contribute to the writing of the report. X.

429. Effects of Dietary Sodium and Potassium Intake on Chronic Disease Outcomes and Related Risk Factors | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
     March 01, 2017 - Meta-analysis will be used to synthesize results across studies in random effect models. … Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis. … Multivariate Dose-Response Meta-Analysis: The dosresmeta R Package. … Computational Statistics & Data Analysis. 2009;53(12):4157-67. … Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies.

430. Treatment Strategies for Women With Coronary Artery Disease: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment-future_research.pdf
     February 01, 2013 - Meta-Analysis or Individual Patient Data Analysis Across RCTs? … Analysis of Existing Data? Model? … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses … Meta-Analysis of RCTs If a new RCT is not feasible, then a meta-analysis of existing RCTs may provide … Meta-Analysis of Observational Studies If a meta-analysis of RCTs is not feasible, the next most valid

431. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
     April 18, 2017 - Meta-analysis will be used to synthesize results across studies in random effect models. … Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis. … Multivariate Dose-Response Meta-Analysis: The dosresmeta R Package. … Computational Statistics & Data Analysis. 2009;53(12):4157-67. 23. … Salt intake, stroke, and cardiovascular disease: meta- analysis of prospective studies.

432. Treatments for Fibromyalgia in Adult Subgroups | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/fibromyalgia/research
     January 26, 2015 - Adverse effects were reported for the MDD subgroup in one duloxetine pooled analysis; these were similar … Future studies should be designed to support subgroup analysis to improve clinical applicability.

433. Migraine-Adults-Executive-130408 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
     April 01, 2013 - We explored heterogeneity with meta-regression and sensitivity analysis, reporting only the results … rather than network meta-analysis … We synthesized evidence from drug classes in network 6 meta-analysis when individual drugs from … Pooled analysis was possible only for four paired drug comparisons (Table B). … According to network meta-analysis, 14 Ta b le C .

434. Data Points 13: Use of Preoperative Breast MRI among older women with ductal carcinoma in situ and locally invasive breast cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
     August 01, 2012 - Women who were diagnosed in Louisiana in 2005 were also excluded from this analysis because of the … MRI used in diag- nostic evaluation is excluded from this analysis. … Rates of MRI increased dramatically from 2002 to 2007; therefore, we limited the analysis of covariates … Use of Preoperative Breast MRI • # 13 • Data Points Surgery type: We used the Medicare Provider Analysis … Thus, our analysis underesti- mates the use of preoperative breast MRI and should not be used to assess

435. Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/prostate-cancer-therapies-update/research-protocol
     March 29, 2013 - Data analysis was based on the intention-to-treat-principle. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. PMID: 3802833. … Assessing the amount of heterogeneity in random-effects meta-analysis. … STATA® Data Analysis and Statistical Software. MP Parallel ed. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

436. C-Diff-Infections-Surveillance-140925 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
     January 01, 2014 - , but not with strict intention-to-treat analysis. … A survival analysis. Ann Intern Med. 2007;147(4):224- 33.17638714 4. … (15.4% vs. 25.3%, P=0.005) and the per-protocol analysis (13.3% vs. 24.0%, P=0.004). … Weiss et 2012 Safety analysis A total of 728 adults 116 healthy N/A; tolerability, In this safety analysis … , but not with strict intention-to-treat analysis.

437. Colorectal-Surgery-Preparation Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
     April 01, 2014 - We used both pairwise and network meta-analysis. … OMBP Versus No OMBP Eighteen RCTs and seven NRCSs contributed information to the main analysis. … These findings, in conjunction with the wide CrIs observed in the overall meta-analysis, support the … Using network meta-analysis we compared “OMBP with or without enema,” “enema,” and “no preparation” … We did not attempt a meta-analysis because of the substantial diversity in outcome definitions, and

438. S131 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
     October 01, 2007 - Data Source of Empirical Analysis The study cohort was drawn from a population of seniors age 65 years … Cohort 5—Subgroup Analysis of Typical Trial-Eligible Subjects We restricted our final analysis to subjects … In the most restricted analysis (cohort 5), the unadjusted RR was 0.72. … An analysis of the exclusion criteria used in observational pharmacoepidemiological studies. … Subgroup analysis in randomized controlled trials: im- portance, indications, and interpretation.

439. Identification and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
     February 15, 2017 - They had serious errors in design, analysis, or reporting; large amounts of missing information; or … A descriptive analysis of minor depression. … Screening and case-finding instruments for depression: a meta-analysis. … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses

440. FRN 41 - Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis-future_research_1.pdf
     February 01, 2013 - Meta-Analysis or Individual Patient Data Analysis Across RCTs? … Meta-Analysis or Individual Patient Data Analysis Across RCTs? … Multivariable analysis. … : Observational Meta-analysis of Observational Studies Yes META-ANALYSIS: OBSERVATIONAL STUDIES … Meta-Analysis of RCTs If a new RCT is not feasible, then a meta-analysis of existing RCTs may provide