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381. Treatments for Fibromyalgia in Adult Subgroups | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/fibromyalgia/research-protocol
     April 03, 2014 - Data fields to be extracted will be determined based upon the proposed summary analysis. … tool as described above. 53,54 The additional risk of bias in how the pooled analysis was conducted … We will conduct a brief qualitative sensitivity analysis of the excluded observational literature for … Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol. … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have

382. Systematic Review of Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
     January 01, 2020 - , we will assess whether to update the analysis by considering how the results of recently published … If meta-analysis seems appropriate in these circumstances, we will perform only random- effects model … Breastfeeding and maternal health outcomes: a systematic review and meta-analysis. … Association between breastfeeding and breast cancer risk: evidence from a meta-analysis. … Random-effects meta-analysis of inconsistent effects: a time for change.

383. Treatment of Depression During Pregnancy and the Postpartum Period | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/depression-pregnancy-postpartum/research-protocol
     March 29, 2013 - To determine the appropriateness of meta-analysis, the quality of the studies and the heterogeneity among … Appropriate measures will be chosen based on the type of data for meta-analysis. … Quantifying heterogeneity in a meta-analysis. … Methods for Meta-Analysis in Medical Research. … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have

384. Methods Guide for Medical Test Reviews Chapter 10 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
     July 01, 2012 - Meta-analysis of test performance when there is a "gold standard." … How to use a clinical decision analysis. B. … How to use a clinical decision analysis. A. Are the results of the study valid? … Endoscopic colorectal cancer screening: a cost-saving analysis. … Meta-analysis of test performance when there is a “gold standard.”

385. depression-pregnancy-postpartum-protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
     March 29, 2013 - To determine the appropriateness of meta-analysis, the quality of the studies and the heterogeneity … Appropriate measures will be chosen based on the type of data for meta-analysis. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58. … Methods for Meta-Analysis in Medical Research. … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have

386. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - In the analysis of N-acetylcysteine plus intravenous saline compared with intravenous saline alone, … Our primary analysis showed that intravenous sodium bicarbonate did not produce a clinically important … However, in a sensitivity analysis, we found low SOE for a clinically important benefit in decreasing … Unfortunately, we had a limited ability to stratify the analysis according to baseline risk because … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. PMID: 3802833. 7.

387. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
     December 01, 2009 - In our analysis of biopsy accuracy, we focused on measures that evaluate the extent of false-negative … Underestimation rates were combined using a random-effects meta-analysis. … , and for summary estimates calculated after assuming our analysis had overestimated the sensitivity … percent, but we present the results of this sensitivity analysis as a “worst case” scenario. … having cancer after a negative core-needle biopsy result1 Analysis Analysis Analysis overestimated

388. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - We refer the investigators to the following citation: A survey of current problems in meta-analysis. … This is not reflected in the current analysis. 4-mm studies did not meet our inclusion criteria. … Although we are aware of those data, we did not include them in our analysis on rhythm control because … Since this analysis was conducted, an additional study has been released that would be relevant to … Jais 2008 has been added to the analysis.

389. Disposition of Comments for Treatment Strategies for Patients With Peripheral Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
     May 29, 2013 - The authors should include their analysis of the ability to conduct randomized surgical trials. … Methods Meet generally accepted practice of scientific analysis. Thank you. … J Vasc Surg 2009; 49:1217-1225) The study was performed using Markov analysis and concluded that … However the only RCT, the BASIL trial, is not fully represented by the authors of this analysis. … , but this subgroup analysis does not provide the level of evidence to make a key point and should

390. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - Peer Reviewer #2 General Comment A future cost benefit analysis would also be helpful. … needed for future cost benefit analysis. … The detailed analysis of the papers is handicapped by excessive simplification. … The expert panel had no role in article selection or in the analysis. … Peer Reviewer #2 Discussion/ Conclusion Additionally a cost benefit analysis should be conducted

391. Changing Patterns of Medication Use in Patients With Rheumatoid Arthritis in a Medicaid Population | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/rheumatoid-arthritis-medicine-1/research
     March 30, 2009 - A secondary analysis which identified RA patients based on diagnosis codes alone, showed similar patterns … Statistical Analysis We estimated the proportion of RA patients who were using study medications on … Sensitivity Analysis Since the application of a specific RA definition in our study enriched our cohorts … with RA patients prescribed DMARDs who likely had more severe disease, we performed a secondary analysis … Sensitivity Analysis The application of less specific selection criteria increased our number of total

392. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
     January 01, 2013 - Study Design and Analysis (1 of 2) Study Design and Analysis (1 of 2) Avoidance of Bias in Study … Sensitivity analysis This type of analysis determines how varying definitions of study outcome will affect … Study Design and Analysis (2 of 2) Study Design and Analysis (2 of 2) Study Period and Length of … Use appropriate analytic methods suitable to the outcome measure and sensitivity analysis to address … Analysis The proposed analytical methods should correspond to the nature of the outcome measure (e.g.

393. Empirical Evidence of Associations Between Trial Quality and Effect Size | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/trial-quality-effect-evidence/research
     June 21, 2011 - assessor blinding, care provider blinding, patient blinding, acceptable dropout rate, intention-to-treat analysis … A factor analysis-based model suggested three distinct quality domains.

394. Systematic Review on Noninvasive Nonpharmacological Treatment for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/surveillance-report-2-noninvasive-nonpharma.pdf
     April 01, 2022 - (meta- analysis performed if new evidence was large relative to the studies in the original meta- analysis … ); consistency in findings between the new studies and the original meta-analysis (meta- analysis performed … / or systematic review/ or meta-analysis as topic/ or "meta analysis (topic)"/ or "systematic review … A Secondary Analysis of a Randomized Controlled Trial. … A systematic review and meta-analysis.

395. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/study-size-planning-chapter-9.pptx
     January 01, 2013 - Consider potential reductions in the number of recruited patients available for analysis. … Potential reductions in the number of recruited patients available for analysis (e.g., due to loss to … less overlap in propensity score distributions across cohorts), many patients will drop out of the analysis … Examples include Stata, Confidence Interval Analysis, and Power Analysis and Sample Size (PASS). … include: The investigators anticipate strong confounding that will eliminate many patients from the analysis

396. Menopause-Protocol-130612 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
     June 12, 2013 - Revisiting the duration of vasomotor symptoms of menopause: a meta-analysis. … Network meta-analysis also formally allows quantitative indirect comparisons. … Subset: Systematic Review OR Publication Type: Meta-analysis OR (“meta-analysis” OR metaanalysis OR … Intention to treat analysis is performed. … Intention to treat analysis is lacking.

397. Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/signals/research
     June 15, 2011 - Using a modification of the Ottawa method, new trial data were meta-analyzed with the original meta-analysis … A sensitivity analysis that reclassified these situations as agreement between the two methods yielded

398. VU EPC DBD Protocol_AHRQ comments_revised_clean (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
     January 30, 2014 - We will examine the appropriateness of each study for inclusion in a meta-analysis. … The specific meta-analysis or meta- regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … I: A meta- analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. … the analysis, reporting, and claim of subgroup effects in randomized trials.

399. antibiotics-respiratory-infection-protocol-140922 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
     September 22, 2014 - In consultation with our statistician, we will consider a network analysis to make comparisons across … When meta-analysis cannot be performed, the data will be summarized qualitatively, grouping studies … In: Shojania KG MK, Wachter RM, Owens DK, ed Closing the Quality Gap: A Critical Analysis of Quality … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539--58. 20. … Methods for Meta-Analysis in Medical Research: John Wiley & Sons, Inc.; 2000. 21.

400. Disposition of Comments Report for Acute Migraine Treatment in Emergency Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
     November 27, 2012 - The statistical methods are standard for this type of analysis. … We used the data from the placebo controlled trials in our network meta-analysis. … We conducted a mixed treatment analysis for akathisia (KQ4). … One can also use the mixed treatment analysis presented in Figure 31. … One can also use the mixed treatment analysis presented in Figure 31.