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341. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - Please consider revising the analysis accordingly. ES2: Simva vs. … ES6: We agree and have revised this section and the analysis accordingly: rosuvastatin is evaluated … This is also the finding of a meta- analysis by Costanzo et al. (J. Am. Coll. … We suggest that the authors consider revising the analysis accordingly. … For instance, where possible paired analysis would be chosen.

342. hemangioma-protocol-141223 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_research-protocol.pdf
     December 23, 2014 - The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta- analysis … the analysis, reporting, and claim of subgroup effects in randomized trials. … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report … Propranolol is an effective treatment for airway haemangiomas: a critical analysis and meta-analysis

343. Mental-Illness-Heart Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
     April 01, 2013 - We then determined the feasibility of completing a quantitative synthesis (i.e., meta-analysis). … A systematic review and pooled analysis. J Psychopharmacol. 2010;24(4 Suppl):69-80. … An analysis of the definitions of mental illness used in state parity laws. … Quantifying heterogeneity in a meta- analysis. Statistics in Medicine. 2002;21(11):1539-58. … Value-of-Information Analysis for Patient-Centered Outcomes Research Prioritization.

344. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - However, in 2013, a re- analysis of the pivotal trial substantially reduced the FDA’s concern leading … , or state that the individuals included in the analysis were similar to those lost to follow up or … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. 31. … Random- Effects Meta-analysis of Inconsistent Effects: A Time for Change. … Bias in meta-analysis detected by a simple, graphical test.

345. Colorectal-Cancer-Staging Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
     September 01, 2014 - We performed meta- analysis wherever appropriate and possible. … We explored possible causes of heterogeneity with subgroup analysis. … We pooled the results from both studies in a random-effects meta-analysis. … A unification of models for meta-analysis of diagnostic accuracy studies. … Diagnostic precision of CT in local staging of colon cancers: a meta-analysis.

346. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
     February 22, 2012 - : adjustment for potential confounders and intention-to-treat analysis • Intervention studies will … In addition, intention-to-treat analysis is used for RCTs. Fair. … Intention-to-treat analysis has been done for RCTs. … Schwarzer G. meta: Meta-Analysis with R (version 1.6-1). 2011. http://CRAN.R-project.org/. … Fixed- and random-effects models in meta-analysis. Psychol Meth. 1998;3(4):486-504.

347. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - Eligibility criteria included English language studies evaluating SNP analysis of human populations, … The SNP analysis had to be across more than one gene, commercially available (or close to this), and … There would be value in applying decision analysis methods. … Screening for prostate cancer: Systematic review and meta-analysis of randomised controlled trials. … Receiver operating characteristic analysis: a primer. Acad Radiol. 2005;12(7):909-16.

348. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
     July 01, 2011 - If the original report includes a meta-analysis, a quantitative signal is considered. … A survival analysis. Ann Intern Med 2007;147(4):224-233. 20. … Cumulative meta-analysis of therapeutic trials for myocardial infarction. … Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. … Cumulative meta-analysis: a consideration of indicators of sufficiency and stability.

349. Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-202-bronchial-thermoplasty-asthma.pdf
     December 01, 2017 - Analysis of results for the intention-to-treat population did not find improvement, but analysis of … A responder analysis (proportion of patients who achieved the minimum important difference) favored … Compared with sham treatment, the intention-to-treat analysis in a single RCT suggests that BT had no

350. Disposition of Comments_Comparative Effectiveness Review No. 276: Diagnosis and Managment of Obsessive Compulsive Disorders in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/obsessive-compulsive-disorder-disposition-comments.pdf
     December 06, 2024 - • Multiple peer reviewers raised concerns about our choice to conduct a network meta-analysis (NMA … • One reviewer asked whether we would perform a sensitivity analysis of the effect of RoB. …  A simple sensitivity analysis of RoB is likely to have low power.

351. Disposition of Comments for CER 158 Diagnosis of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-diagnosis-disposition-160727.pdf
     February 24, 2016 - of the performance of tests or clinical features ‘compared to synovial fluid analysis’. … However, at various times throughout the analysis, data are included that use clinical criteria as … Unfortunately, and partly due to the difficulties with crystal analysis, study participants do not … of having neither so many or so few features of gout that SF analysis was unnecessary. … These findings tend to support not undertaking MSU analysis in the primary care setting .

352. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
     August 19, 2024 - inherently involve change and measurement changes over time will require careful consideration in analysis … , with interpretation of results) and quantitatively (meta-analysis) when appropriate. … If sufficient numbers of RCTs (≥10) are available, quantitative funnel plot analysis may be done. … The Volume of Breast Milk Intake in Infants and Young Children: A Systematic Review and Meta-Analysis … Advanced Dietary Analysis and Modeling: A Deep Dive into the National Cancer Institute Method.

353. Treatments for Schizophrenia in Adults: A Systematic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
     January 01, 2017 - A published network meta-analysis of 212 trials found that clozapine was superior to other oral SGAs … This analysis found that all of the drugs included were superior to placebo. … Analysis of age subgroups did not find differences for comparisons of olanzapine with risperidone. … Cognitive remediation for negative symptoms of schizophrenia: A network meta- analysis. … A meta-analysis of controlled research on social skills training for schizophrenia.

354. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - We will deposit data used in a meta-analysis into the Systematic Review Data Repository (SRDR). … We anticipate performing a meta-analysis to describe the effects of treatment decisions on outcomes … The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report

355. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis—An Update of the 2006 Report. (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
     October 01, 2011 - The sentence in question in the Executive Summary is referring to the finding in meta-analysis that … We revised to clarify (page 20, starting line 26): “A meta-analysis of 41 randomized trials found no … Patrick du Souich Results In page 52, based on the meta-analysis of Wandel et al.(1)it is stated … We did not identify a meta-analysis restricted to low- dose aspirin. … Each category of analgesics provided a detailed analysis.

356. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - o Data analysis was based on the intention-to-treat-principle. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Assessing the amount of heterogeneity in random-effects meta-analysis. … STATA® Data Analysis and Statistical Software. MP Parallel ed. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

357. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

358. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

359. Clinical-Care-Rapid-Review-Appendix-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/clinical-care-rapid-review-appendix-c.xlsx
     January 01, 2018 - Information collected from the time of the report through the event analysis, full explanation, apology … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results, n (%) Within Arm Comparison Between Arm Comparison Adjusted Factors Disclosure … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Kachalia, 2010

360. Smoking-Pregnancy-Infants Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/smoking-pregnancy-infants_research-protocol.pdf
     March 11, 2013 - The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … Multivariate analysis of factors associated with smoking cessation in women. … The validity of self-reported smoking: a review and meta-analysis. … the analysis, reporting, and claim of subgroup effects in randomized trials.