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341. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
     February 22, 2012 - : adjustment for potential confounders and intention-to-treat analysis • Intervention studies will … In addition, intention-to-treat analysis is used for RCTs. Fair. … Intention-to-treat analysis has been done for RCTs. … Schwarzer G. meta: Meta-Analysis with R (version 1.6-1). 2011. http://CRAN.R-project.org/. … Fixed- and random-effects models in meta-analysis. Psychol Meth. 1998;3(4):486-504.

342. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - Eligibility criteria included English language studies evaluating SNP analysis of human populations, … The SNP analysis had to be across more than one gene, commercially available (or close to this), and … There would be value in applying decision analysis methods. … Screening for prostate cancer: Systematic review and meta-analysis of randomised controlled trials. … Receiver operating characteristic analysis: a primer. Acad Radiol. 2005;12(7):909-16.

343. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
     July 01, 2011 - If the original report includes a meta-analysis, a quantitative signal is considered. … A survival analysis. Ann Intern Med 2007;147(4):224-233. 20. … Cumulative meta-analysis of therapeutic trials for myocardial infarction. … Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. … Cumulative meta-analysis: a consideration of indicators of sufficiency and stability.

344. Disposition of Comments for CER 158 Diagnosis of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-diagnosis-disposition-160727.pdf
     February 24, 2016 - of the performance of tests or clinical features ‘compared to synovial fluid analysis’. … However, at various times throughout the analysis, data are included that use clinical criteria as … Unfortunately, and partly due to the difficulties with crystal analysis, study participants do not … of having neither so many or so few features of gout that SF analysis was unnecessary. … These findings tend to support not undertaking MSU analysis in the primary care setting .

345. Treatments for Schizophrenia in Adults: A Systematic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
     January 01, 2017 - A published network meta-analysis of 212 trials found that clozapine was superior to other oral SGAs … This analysis found that all of the drugs included were superior to placebo. … Analysis of age subgroups did not find differences for comparisons of olanzapine with risperidone. … Cognitive remediation for negative symptoms of schizophrenia: A network meta- analysis. … A meta-analysis of controlled research on social skills training for schizophrenia.

346. Benefits of Postpartum Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/postpartum-inforgraphic.pdf
     October 08, 2025 - Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-Analysis.

347. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
     August 19, 2024 - inherently involve change and measurement changes over time will require careful consideration in analysis … , with interpretation of results) and quantitatively (meta-analysis) when appropriate. … If sufficient numbers of RCTs (≥10) are available, quantitative funnel plot analysis may be done. … The Volume of Breast Milk Intake in Infants and Young Children: A Systematic Review and Meta-Analysis … Advanced Dietary Analysis and Modeling: A Deep Dive into the National Cancer Institute Method.

348. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis—An Update of the 2006 Report. (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
     October 01, 2011 - The sentence in question in the Executive Summary is referring to the finding in meta-analysis that … We revised to clarify (page 20, starting line 26): “A meta-analysis of 41 randomized trials found no … Patrick du Souich Results In page 52, based on the meta-analysis of Wandel et al.(1)it is stated … We did not identify a meta-analysis restricted to low- dose aspirin. … Each category of analgesics provided a detailed analysis.

349. Clinical-Care-Rapid-Review-Appendix-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/clinical-care-rapid-review-appendix-c.xlsx
     January 01, 2018 - Information collected from the time of the report through the event analysis, full explanation, apology … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results, n (%) Within Arm Comparison Between Arm Comparison Adjusted Factors Disclosure … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Kachalia, 2010

350. Smoking-Pregnancy-Infants Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/smoking-pregnancy-infants_research-protocol.pdf
     March 11, 2013 - The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … Multivariate analysis of factors associated with smoking cessation in women. … The validity of self-reported smoking: a review and meta-analysis. … the analysis, reporting, and claim of subgroup effects in randomized trials.

351. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
     October 01, 2010 - The most commonly reported of these were selected for meta-analysis, while the remaining outcomes were … Trials that enrolled patients with a range of pubertal status were excluded from subgroup analysis. … In one controlled trial, mean Tanner stage improved regardless of gender, and in an analysis of three … In one multivariate analysis, higher percent predicted FEV1 was associated with improvements in “ways … data merged and in a subgroup analysis.

352. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - o Data analysis was based on the intention-to-treat-principle. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Assessing the amount of heterogeneity in random-effects meta-analysis. … STATA® Data Analysis and Statistical Software. MP Parallel ed. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

353. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

354. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

355. Ptsd-Adult-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_executive.pdf
     April 01, 2013 - For each meta-analysis, we conducted sensitivity analyses by removing each study from the analysis … The analysis included both head-to-head and placebo-controlled trials. … Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: L. … Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: L. … Quantifying heterogeneity in a meta- analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

356. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - We will deposit data used in a meta-analysis into the Systematic Review Data Repository (SRDR). … We anticipate performing a meta-analysis to describe the effects of treatment decisions on outcomes … The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report

357. Prostate-Cancer-Test Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
     April 01, 2013 - • Regression analysis using regression coefficients and associated relative odds ratios. … This bias cannot be avoided by statistical analysis, but was addressed by stratifying analyses and … Using the most commonly reported comparator and analysis (tPSA and AUC), we performed a regression … A meta-analysis of the performance characteristics of the free prostate-specific antigen test. … A systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2006 9(4):374-8.

358. Major-Depressive-Disorder Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder_executive.pdf
     December 01, 2015 - We examined potential sources of heterogeneity using sensitivity analysis or analysis of subgroups. … Network meta-analysis indicated response rates that did not differ statistically for patients on SGAs … In contrast, a second secondary analysis involving 727 patients, which was government funded, found … Statistical approaches for conducting network meta-analysis in drug development. … Antidepressant drug effects and depression severity: a patient-level meta-analysis.

359. Anxiety in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/anxiety-children_research-protocol.pdf
     September 12, 2016 - If meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random effect method … to combine direct comparisons between treatments if the number of studies included in the analysis … We will evaluate the feasibility of conducting network meta-analysis to combine direct and indirect … Consistency of network meta- analysis will be evaluated using side-splitting models. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

360. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - Furthermore, a large proportion of the effectiveness analysis focused on gabapentin and vigabatrin, … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 5. … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … analysis, the results were less likely to show significance.