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301. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - Could the authors please add more language to the methods section on the use of meta analysis. … Decisions on what to pool in a meta-analysis can often be subjective. … We considered conducting a meta-analysis of length of stay in hospital. … Meta-analysis of median values is generally not acceptable and we determined that transformation of … It’s unclear why only three of the RCTs were included in the meta-analysis.

302. Supplemental Project To Assess the Transparency of Reporting Requirements: Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
     June 01, 2017 - Analysis Registry searches were categorized as follows (1) included in the original review but not … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34. … Detecting and adjusting for small-study effects in meta-analysis. … Meta-analysis, funnel plots and sensitivity analysis. … A sensitivity analysis for publication bias in systematic reviews.

303. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
     September 30, 2014 - , deletion/duplication analysis, and uniparental disomy study. … Practice guidelines for the molecular analysis of Prader-Willi and Angelman syndromes. … chromosome rearrangement and a meta- analysis. … A rapid microarray based whole genome analysis for detection of uniparental disomy. … in 117 patients referred for cytogenetic analysis and impact on clinical practice.

304. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
     September 01, 2016 - any) Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … of pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary out- … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted

305. Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/psoriasis-chronic/research-protocol
     September 27, 2011 - In 2008, Schmitt and colleagues published a meta-analysis analyzing the efficacy and tolerability of … Based on the results of their meta-analysis, the authors concluded that the efficacy of systemic agents … One of the main research gaps identified in this meta-analysis was the lack of comparative effectiveness … We will conduct sensitivity analysis limiting the analysis to only trials rated as good quality. … Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. PMID: 3802833.

306. SAS.doc (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-effects-estimates-tool_research.pdf
     April 18, 2007 - Correct specification of the regression m odel is one of the most fundamental assumptions in statistical analysis … Correct specification of the regression model is one of the most fundamental assumptions in statistical analysis … data=SAS-data-set is the standard SAS® method for indicating which dataset should be used for the analysis … common_support=number where number is between 0 and 1 (inclusive), will limit the region of analysis … EXAMPLE 2 The next example represents an analysis of simulated data where the exposure of interested

307. Evaluation and Treatment of Tinnitus: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/tinnitus/research-protocol
     February 22, 2012 - If clinical groups are too heterogeneous to permit meta-analysis, a separate qualitative analysis will … Were the statistical analysis methods described and appropriate? … Analysis The statistical analysis is appropriate for the design of the study. … Statistical analysis Were potential confounders measured and adequately addressed in the analysis? … Was the statistical analysis described? Were missing data reported?

308. Methods Research Report - Meta-Analytical Statistical Inferences for Continuous Measure Outcomes as a Function of Effect Size Metric and Other Assumptions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/statistical-inference_research.pdf
     April 01, 2013 - The number of studies in a meta-analysis, k = 10, 20, 50, and 100. 2. … Publication bias in meta-analysis: prevention, assessment and adjustments. … Statistical methods for meta-analysis. Orlando: Academic Press; 1985. 9. … Meta-analysis of experiments with matched groups or repeated measures designs. … Statistical power analysis for the behavioral sciences. 2nd ed.

309. Ace-Inhibitor-Arb-Update-Surveillance-160328 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
     March 28, 2016 - $$ Blood$Pressure$Control$$ SRC(Literature(Analysis:( •$ ACEIs(vs. … .$$ $ Four$studies$(one$RCT,$one$pooled$analysis$of$10$studies,$a$pooled$analysis$of$two$ RCTs,$and … $$ Cough$$ SRC(Literature(Analysis:( •$ DRI(vs. … $$ SRC(Literature(Analysis:( •$ No$studies$were$identified( ! … &ACEIs&or&ARBs& $ A$meta"analysis$of$10$trials$of$DRI$aliskiren$ •$ vs.

310. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - In 2008, Schmitt and colleagues published a meta-analysis analyzing the efficacy and tolerability of … Based on the results of their meta-analysis, the authors concluded that the efficacy of systemic agents … One unique analysis, which was represented by two citations, was finally included. … Only one subgroup analysis from a RCT met our inclusion criteria. … Presently, the literature base is too scarce to conduct such an analysis.

311. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - The report focuses its analysis on the hospital cases as the unit of analysis. … Such analysis is beyond the scope of the Report. … The analysis of this topic is beyond the scope of this report. … A similar analysis can be done for other indications. … Determinants of intracerebral hemorrhage growth: an exploratory analysis.

312. Correcting for Publication Bias in the Presence of Covariates | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/publication-bias/research
     September 16, 2011 - The "trim and fill" method was developed to adjust for censored (i.e., missing) studies in a meta-analysis … The new algorithm should be seen as a sensitivity analysis to the influence of covariates on funnel plot

313. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - We also repeated our main analysis excluding preprint studies. … Was appropriate statistical analysis used? 23 Table B-3. … Methods to estimate the between-study variance and its uncertainty in meta-analysis. … Introduction to meta-analysis. Chichester, U.K.: John Wiley & Sons; 2009. 22. … A general parametric approach to the meta‐analysis of randomized clinical trials.

314. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/ptsd-repository-update/protocol
     September 21, 2021 - Methodological differences, such as data coding approaches and combining treatment categories for analysis … Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta-analysis … type of primary PTSD outcome measure (ITT, completer) Statistical analysis method for primary PTSD … 2.6) Was an appropriate analysis used to estimate the effect of assignment to intervention? … that was finalized before unblinded outcome data were available for analysis?

315. Migraine-Emergency Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - The mixed-treatment analysis showed that the most effective treatments were combination therapy ( … Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. … The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis. … Borrowing strength from external trials in a meta-analysis. Stat Med. 1996;15(24):2733-49. … Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.

316. Using Deliberative Methods to Engage the Public: How to Design and Implement an Effective Deliberative Session (Video Presentation) | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/deliberative-methods/presentation-2012
     April 19, 2012 - , Associate Member, Department of Political Science Member, Centre for Health Economics and Policy Analysis … include the design and evaluation of public engagement to inform health system decision making; the analysis … of the role of public values in health policy; and the analysis of the determinants of health policy … Yegian received a PhD in Health Services and Policy Analysis from the University of California at Berkeley

317. S108 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s108.pdf
     October 01, 2007 - simulation output was analyzed by Cox proportional hazards regression and by a weighted regression analysis … The magnitude of bias was calculated for each method of analysis. … IPW We performed a weighted regression analysis based on IPW. … The phenomenon of uncontrolled heterogeneity is called the frailty effect in survival analysis. … Incorporation of individual random effects into a survival analysis potentially allows estimation of

318. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/exposure-definition-and-measurement_chapter-4.pptx
     January 01, 2013 - The unit of analysis must also be justified. … Unit of Analysis When creating a definition for an exposure measurement, it is necessary to consider … The nature of the intervention largely dictates the appropriate unit of analysis. … The unit of analysis must also be justified. … The unit of analysis must also be justified.

319. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research-protocol
     October 14, 2011 - : adjustment for potential confounders and intention-to-treat analysis Quality will be assessed on … Using standard statistical methods, the data might be pooled (random effects meta-analysis), with the … This software supports meta-analysis of both matched and unmatched data. … testing could be compared to a meta-analysis of studies that investigated the diagnostic accuracy of … DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer.

320. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - meta-analysis where there are no events in both arms. … meta-analysis where there are no events in both arms. … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed