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2201. Alcohol-misuse-drug-therapy-140326 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
      January 27, 2012 - (i.e., meta-analysis) of the data from those studies. … The analysis will include both head-to-head and placebo-controlled trials. F. … A meta-analysis of alcohol consumption and the risk of 15 diseases. … Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

2202. Noninvasive, Nonpharmacological Treatment for Chronic Pain (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
      September 20, 2017 - For chronic headache, biofeedback will provide a common comparator for analysis. … of results) and quantitatively (meta-analysis) when appropriate. … of a small number of studies.23 To determine whether meta-analysis could be meaningfully performed, … Random-effects meta-analysis of inconsistent effects: a time for change. … A likelihood approach to meta-analysis with random effects.

2203. Coronary-Artery-Stenting Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
      February 01, 2013 - We considered evidence to be sparse if only one study of a small sample size addressed the analysis … aSeven studies provided eight data points for analysis. … bFour studies provided five data points for analysis. … cFive studies provided six data points for analysis. … dThree studies provided four data points for analysis.

2204. Recurrent Nephrolithiasis in Adults: A Comparative Effectiveness Review of Preventive Medical Strategies | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/kidney-stone-prevention/research-protocol
      June 15, 2011 - Testing may include an analysis of stone composition and biochemical evaluations of blood (e.g., calcium … Where data allow, the proposed systematic review and meta-analysis will comprehensively address all these … The ratings may be used to conduct sensitivity analysis of results, such as by including and excluding … Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis. … TEP members will not perform analysis of any kind, or contribute to the writing of the report.

2205. S16 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
      October 01, 2007 - Individual patient meta-analysis is more powerful for this purpose, and has been used with success in … An analysis of 7 primary prevention trials suggests that the TABLE 4. … Subgroup analysis of trials indicates that the benefits are much greater in asymptomatic men than in … NIH Program on Clinical Research Policy and Analysis and Coordination. … Subgroup analysis in randomized controlled trials: im- portance, indications, and interpretation.

2206. Colon-Cancer-Gene-Profiling Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
      March 13, 2012 - Was a reclassification analysis performed with risk stratification using GEP when compared with that … (It is suggested that samples from at least two-thirds of the patients must be available for analysis … o Type(s) of tissue used (e.g., fresh tissue) o Time for analysis (turnaround time) • Inclusion and … • Was MSI (MMR) status considered in the overall analysis? o If so, how? … • Was the GEP performed (analysis, calculation, interpretation) as described in initial studies for

2207. Untitled (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
      October 12, 2015 - They had serious errors in design, analysis, or reporting; large amounts of missing information; or … We will then determine the feasibility of completing a quantitative synthesis (i.e., meta- analysis, … decision analysis, or simulation model). … to which such an analysis will provide additional insight into the key questions based 21! … Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis.

2208. Antipsychotics-Children-Surveillance-150120 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-surveillance-150120.pdf
      October 01, 2014 - Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. … SRC Literature Analysis: • The original CER concluded that SGAs were favored over FGAs for symptom … We performed meta-analysis for primary and secondary outcomes, when possible. … RESULTS: Planned interim analysis for the primary end-point in the RCT resulted in early termination … Per-protocol analysis was significant (p=0.02).

2209. A Bayesian Missing Data Framework for Multiple Continuous Outcome Mixed Treatment Comparisons (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research-2013.pdf
      January 01, 2013 - Our data analysis also has some limitations. … Bayesian approaches to random-effects meta-analysis: a comparative study. … Accounting for correlation in network meta- analysis with multi-arm trials. … Bayesian Analysis 1. 2006;1:651-706. 25. Salanti G, Ades AE, Ioannidis JP. … Meta- analysis of mixed treatment comparisons at multiple follow-up times.

2210. Evidence-based Practice Center Systematic Review Protocol: Depression in Children: Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-childhood-protocol.pdf
      August 06, 2018 - A systemic review and meta-analysis of the effectiveness of interpersonal psychotherapy for adolescents … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report … ”[pt] OR “meta- analysis”[ti] OR “systematic literature review”[ti] OR “this systematic review”[tw] … ”[pt] OR “meta- analysis”[ti] OR “systematic literature review”[ti] OR “this systematic review”[tw] … 2 #34 Search (#31 NOT (#19 or #21)) Sort by: Author Filters: Meta-Analysis; Systematic Reviews 9

2211. Meditation Programs for Psychological Stress and Well-Being | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/meditation/research
      January 06, 2014 - We conducted meta-analysis using standardized mean differences to obtain aggregate estimates of effects … Meditation Programs for Psychological Stress and Well-being: A Systematic Review and Meta-analysis.

2212. Calcineurin Inhibitors for Kidney Transplant | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/calcineurin-inhibitor/research
      March 15, 2016 - Key Question 1 compares immunoassay analysis with liquid chromatographic or mass spectrometric analytical … These studies were heterogeneous and were not combined for meta-analysis.

2213. Progestogens-Preterm-Birth Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
      September 01, 2012 - Meta-Analysis We conducted a Bayesian meta-analysis to provide aggregate estimates of the effectiveness … Interpretation of Meta-Analysis In the Results section of the full report, we report the findings from … meta-analysis as odds ratios (OR) from Bayesian models. … The relationship between number of injections and outcome was examined in a single database analysis … We calculated meta-analysis estimates by using RCTs grouped by progestogen formulation (17OHP, oral,

2214. Reliability Testing of the AHRQ EPC Approach to Grading the Strength of Evidence in Comparative Effectiveness Reviews | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/reliability-testing-grading-evidence/research
      May 22, 2012 - We used logistic regression analysis to describe the relationship between domain scores and the final … greatly, particularly when they are faced with bodies of evidence that do not lend themselves to meta-analysis

2215. Case Study Comparing Bayesian and Frequentist Approaches for Multiple Treatment Comparisons (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
      March 01, 2013 - Among 83 RCTs, 65 studies are included for our analysis. … For Bayesian analysis, we report the posterior median values. … However, there are some limitations in the frequentist analysis. … analysis (in the UI data analysis, σ for continence and discontinuation outcomes are close to zero) … Bayesian Methods for Data Analysis, 3rd edition.

2216. Radiotherapy Treatments for Head and Neck Cancer: Update | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/head-neck-cancer-update/research-protocol
      February 04, 2014 - If an EPC performed a meta-analysis, then it may also consider whether the CI crossed a threshold for … If meta-analysis is infeasible or inappropriate, the EPC may consider the narrowness of the range of … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have … In addition, intention-to-treat analysis is used for RCTs. … Intention-to-treat analysis has been done for RCTs.

2217. Methods Guide for Comparative Effectiveness Reviews - Avoiding Bias in Selecting Studies (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
      February 01, 2013 - One meta-analysis published in 2002 included 10 trials, while another published in 2004 included only … Our analysis of this example showed that included study designs varied among reviews. … A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women. … Meta-analysis of alendronate for the treatment of postmenopausal women. … University of Pennsylvania Meta-analysis Blinding Study Group.

2218. Chronic-Cough Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-cough_executive.pdf
      March 01, 2014 - We supplemented the meta-analysis of direct comparisons with a mixed treatment meta-analysis that incorporated … standard random-effects models used in the meta-analysis of effect sizes. … This analysis included 11 studies and 700 patients. … We performed a similar meta-analysis for cough frequency, including 7 studies and 396 patients. … bTotal number of studies/patients from mixed treatment meta-analysis. 13 agents.

2219. Nppv-Respiratory-Failure Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_executive.pdf
      July 01, 2012 - We then determined the feasibility of completing a quantitative synthesis (i.e., meta-analysis). … quantitatively using the Comprehensive Meta-Analysis software (Version 2; Biostat, Englewood, NJ). … Mortality is a dichotomous outcome and was fitted using multiple logistic regression analysis. … Meta-analysis: noninvasive ventilation in acute cardiogenic pulmonary edema. … Meta-analysis of multitreatment studies. Med Decis Making. 1998;18(1):37-43. PMID: 9456207. 53.

2220. Layout 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
      May 01, 2010 - Framework for analyzing outcomes for rFVIIa use Premier Database Analysis to Assess In-Hospital Use … Data Measures and Unit of Analysis We classified hospitalizations where rFVIIa use was reported into … The unit of analysis was any hospital “case” of rFVIIa use—defined as any application during a patient … Statistical Analysis The goals of our statistical analysis of the Premier database were: (1) to provide … of the research available on the spectrum of rFVIIa off-label use (Key Question 1), (b) analysis of