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221. Appendicitis Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
     December 09, 2013 - The determination on the appropriateness of meta-analysis will be made before any data analysis. … Meta-analysis of the clinical and laboratory diagnosis of appendicitis. … A meta-analysis. Saudi Med J.2007 Feb;28(2):173-80. [PMID: 17268692] 12. … A Meta-Analysis. Radiology. 2006 Oct;241(1):83- 94. … MR imaging in cases of antenatal suspected appendicitis--a meta-analysis.

222. Diabetes-Behavior-Programs Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_research-protocol.pdf
     June 05, 2014 - Meta-analysis: chronic disease self-management programs for older adults. … Behavioural interventions for type 2 diabetes: an evidence- based analysis. … Diabetes patient education: a meta-analysis and meta- regression. … Random effects meta-analysis of inconsistent effects: a time for change. … Quantifying heterogeneity in a meta-analysis. Stats Med. 2002;21(11):1539-58.

223. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - Whether to use it in an analysis as rigorous as the current study is questionable. … This meta-analysis should be shown. … This analysis has real validity issues and should be either redone or removed. … We also changed the analysis to use the adjusted or propensity-scored HRs in the meta- analysis to reduce … Unfortunately, we do not have individual patient-level data available for analysis.

224. Calcineurin_Inhibitors_Protocol_FINAL_10-07-2014 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
     October 08, 2014 - 15.3 years for living donor transplants in 2009-2010.2 Survival rates continue to improve; a recent analysis … Decisions about whether meta-analysis is appropriate will depend on the judged clinical homogeneity … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Validity of statistical analysis and reporting adequacy: Was the statistical analysis performed appropriately

225. Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients Wtih Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
     August 11, 2014 - We decided to keep the meta- analysis figures sorted by cutpoints but mentioned the lack of temporal … The data analysis and synthesis are appropriate for this type of meta-analysis. … Therefore a meta-analysis could have been conducted with the limitations cited. … The number of subjects enrolled in to each trial could also be shown in the meta-analysis. … We do not think a cumulative meta-analysis will help to address our Key Questions.

226. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
     September 30, 2014 - , deletion/duplication analysis, and uniparental disomy study. … Practice guidelines for the molecular analysis of Prader-Willi and Angelman syndromes. … chromosome rearrangement and a meta- analysis. … A rapid microarray based whole genome analysis for detection of uniparental disomy. … in 117 patients referred for cytogenetic analysis and impact on clinical practice.

227. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
     March 01, 2012 - These two studies provided a small amount of events to the overall analysis as well. … For example,“KQ3 (analysis of covariates) Although we agree this would help to remind the reader … Was meta-analysis of subgroup data, estimates of association, or meta-regression not possible? … Additionally, the design and results of each review/analysis were reviewed to make comparisons with … Peer Reviewer #3 Results This sensitivity analysis on good trials, instead, should have been graded

228. Supplemental Project To Assess the Transparency of Reporting Requirements: Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
     June 01, 2017 - Analysis Registry searches were categorized as follows (1) included in the original review but not … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34. … Detecting and adjusting for small-study effects in meta-analysis. … Meta-analysis, funnel plots and sensitivity analysis. … A sensitivity analysis for publication bias in systematic reviews.

229. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
     May 08, 2023 - Last year of data used in analysis 2015 or later for original research 6 Study Parameter … We will not conduct a meta-analysis. … Making health care safer: a critical analysis of patient safety practices. … Making Healthcare Safer III: A Critical Analysis of Existing and Emerging Patient Safety Practices. … We will not conduct a meta-analysis.

230. Disposition of Comments for CER 211: Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-211-rheumatoid-arthritis-disposition-comments.pdf
     December 20, 2018 - Bayesian methods in meta- analysis and evidence synthesis. … For other timepoints a sensitivity analysis could have been performed. … Please present the data which have been included in each analysis. … This is an updated analysis and most findings that support previous reviews. … Rationale: Not clear which studies are included in each network analysis.

231. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
     April 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta-analysis … ); consistency in findings between the new studies and the original meta-analysis (meta-analysis performed … performed if the strength of evidence based on the original meta- analysis was low or insufficient and … Opioids for chronic low back pain management: a Bayesian network meta- analysis. … A Systematic Review and Meta-Analysis.

232. Systematic Review on Treatments for Acute Pain: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
     May 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta-analysis … ); consistency in findings between the new studies and the original meta-analysis (meta-analysis performed … and a trial sequential analysis. … Acupuncture for acute low back pain: a systematic review and meta-analysis. … Effect of preemptive acetaminophen on opioid consumption: a meta-analysis.

233. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
     September 01, 2016 - any) Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary out- … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted

234. Topic 0494 Tacrolimus Monitoring and Treatment Renal Transplantation NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
     March 13, 2013 - Mass Spectrometry versus Immunoassay: In renal transplants, does mass from Nominator: spectrometric analysis … and therapeutic monitoring of tacrolimus as compared with immunoassay analysis and therapeutic monitoring … monitoring of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus, how does mass spectrometric analysis … compare with immunoassay analysis for: 1) organ survival, 2) acute and long-term rejections, 3) nephrotoxicity

235. Migraine-Emergency Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - The mixed-treatment analysis showed that the most effective treatments were combination therapy ( … Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. … The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis. … Borrowing strength from external trials in a meta-analysis. Stat Med. 1996;15(24):2733-49. … Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.

236. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - The report focuses its analysis on the hospital cases as the unit of analysis. … Such analysis is beyond the scope of the Report. … The analysis of this topic is beyond the scope of this report. … A similar analysis can be done for other indications. … Determinants of intracerebral hemorrhage growth: an exploratory analysis.

237. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - In 2008, Schmitt and colleagues published a meta-analysis analyzing the efficacy and tolerability of … Based on the results of their meta-analysis, the authors concluded that the efficacy of systemic agents … One unique analysis, which was represented by two citations, was finally included. … Only one subgroup analysis from a RCT met our inclusion criteria. … Presently, the literature base is too scarce to conduct such an analysis.

238. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - We will abstract the treatment approach in detail together with the study design, analysis, and any … We will use meta-analysis as a data-aggregation technique with appropriate meta-analysis models39 which … Widowhood and mortality: a meta-analysis and meta-regression. … The prevention and treatment of complicated grief: a meta-analysis. … Bias in meta-analysis detected by a simple, graphical test.

239. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
     January 01, 2021 - Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta- analysis … Analysis type of primary PTSD outcome measure (ITT, completer) d. … Statistical analysis method for primary PTSD outcome e. … 2.6) Was an appropriate analysis used to estimate the effect of assignment to intervention? … that was finalized before unblinded outcome data were available for analysis?

240. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
     October 01, 2022 - Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta- analysis … Analysis type of primary PTSD outcome measure (ITT, completer) d. … Statistical analysis method for primary PTSD outcome e. … 2.6) Was an appropriate analysis used to estimate the effect of assignment to intervention? … that was finalized before unblinded outcome data were available for analysis?