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221. Osteoporosis-Bone-Fracture Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
     March 01, 2012 - Studies that reported fracture only as an adverse event were excluded from effectiveness analysis; … , and overall fracture risk in another pooled analysis … High Our pooled analysis of eight trials found an increased risk with raloxifene of hot flashes. … Moderate A pooled analysis of three trials of teriparatide found an increased risk of headaches. … High A pooled analysis of four trials of denosumab found an increased risk for infection.

222. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - Matched Analysis Presentation of Results ............................................................ … Study design options include restriction and matching, while analysis options include stratification … Figure 5 is a presentation of the results of matched analysis. … This type of study poses several challenges for statistical analysis. … Otherwise, it is used in the regression analysis.

223. Systematic Review of Calcineurin Inhibitors for Kidney Transplant | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/calcineurin-inhibitor/research-protocol
     October 14, 2014 - 15.3 years for living donor transplants in 2009-2010. 2 Survival rates continue to improve; a recent analysis … using the Hartung-Knapp method. 31,32 Meta-regression and subgroup analysis will be used to explore … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Validity of statistical analysis and reporting adequacy: Was the statistical analysis performed appropriately

224. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - The flow, key questions, review of the literature and analysis are well structured and thoughtfully … The pooled analysis was presented by Dr. … (Supportive Literature: Salazar, Pooled Analysis, ASCO 2012 Tabernero, Pooled Analysis, ASCO GI 2012 … (Supportive Literature: Tabernero, Pooled Analysis, ASCO GI 2012; Salazar, Pooled Analysis, ASCO 2012 … (Supportive Literature: Tabernero, Pooled Analysis, ASCOGI 2012).

225. Comparative Effectiveness of Pharmacologic Therapies for the Management of Crohn’s Disease | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/crohns-disease/research-protocol
     September 01, 2010 - Because of the recent high quality meta-analysis focused on treatment options after surgical resection … A sensitivity analysis will include study populations with all levels of disease severity. … A sensitivity analysis will include study populations with all levels of disease severity. … The TEP does not do analysis of any kind nor contribute to the writing of the report. … Sensitivity analysis for KQ3 will include inflammatory bowel disease not specified.

226. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
     December 11, 2015 - We will also examine potential sources of heterogeneity using sensitivity analysis or analysis of subgroups … Using qualitative comparative analysis to study causal complexity. … In addition to the planned analysis, we will use quantitative comparative analysis (QCA) using the … Identify cases for use in analysis. … A study with three arms provides 2 cases for analysis. 3.

227. Disposition of Comments Report for Comparative Effectiveness Review #68 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
     July 01, 2012 - In my opinion, this is not a valid analysis. … The statistical methods are appropriate for this analysis. Thank you. … I would report the clinical populations separately in the primary analysis. … This section has been revised to reflect that change in analysis approach. … Important analysis regarding the benefits in ACPE are offered. Thank you.

228. Attention Deficit Hyperactivity Disorder Medications and Risk of Serious Cardiovascular Disease in Children and Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-heart-disease-adults_research.pdf
     November 01, 2011 - Analysis in Which Former Users Served as the Reference Appendix J. … The findings of this analysis were not materially different from our primary analysis. … Analysis in Which Former Users Served as the Reference. … Alternative Analyses Alternative Analysis Addressing Exposure Group Definitions In this analysis, … In this analysis, the analysis was restricted to new users and focused on the individual endpoints,

229. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb_surveillance.pdf
     July 06, 2015 - A. and Renin Angiotension System Modulator Meta-Analysis, I. (2012). … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •!

230. Surveillance Report: CER 30: Comparative Effectiveness of Pain Management for Hip Fracture (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain_surveillance.pdf
     July 08, 2015 - Local anesthetic systemic toxicity after combined psoas compartment-sciatic nerve block: analysis of … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: ! … All conclusions were up to date SRC Literature Analysis: •! … All conclusions were up to date SRC Literature Analysis: •!

231. DST_Draft_Protocol_Nov_4_2013_clean (2) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
     November 12, 2013 - The determination on the appropriateness of meta-analysis will be made before any data analysis; we … will not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … A systematic review and meta-analysis. … Network meta-analysis for indirect treatment comparisons. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

232. Decision Support Tools for Screening and Treatment Decisions in Early Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/cancer-decision-support-tools/research-protocol
     November 12, 2013 - The determination on the appropriateness of meta-analysis will be made before any data analysis; we will … not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … A systematic review and meta-analysis. … Network meta-analysis for indirect treatment comparisons. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

233. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/alcohol-pharma-final-protocol.pdf
     January 01, 2023 - (i.e., meta-analysis) of the data from those studies. … The analysis will include both head-to-head and placebo-controlled trials. F. … A meta-analysis of alcohol consumption and the risk of 15 diseases. … Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. … Quantifying heterogeneity in a meta-analysis.

234. Management of Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_policymaker.pdf
     June 01, 2016 - N Finding SOE BETA-BLOCKERS Propranolol vs. observation or placebo Improvement in IH Network meta-analysis … propranolol arm (fewer than 15% of children) ��� Propranolol vs. steroids Improvement in IH Network meta-analysis … Equivalent response ��� Topical timolol vs. placebo or observation Improvement in IH Network meta-analysis … more effective ��� STEROIDS Oral steroids vs. observation or placebo Improvement in IH Network meta-analysis … observation or placebo Improvement in IH Network meta-analysis N/A Intralesional steroids more effective

235. Systematic Review on Treatments for Acute Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/main-apps-surv-report-2-acute-pain.pdf
     May 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta-analysis … ); consistency in findings between the new studies and the original meta-analysis (meta-analysis performed … and a trial sequential analysis. … Effect of preemptive acetaminophen on opioid consumption: a meta-analysis. … Meta-Analysis Results Figure G-1.

236. Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/diagnostic-tests-reviews/research
     March 27, 2012 - one of four related projects designed to document the current standards and methods used in the meta-analysis … Methods We identified systematic reviews including quantitative synthesis (meta-analysis) of test accuracy … there have been substantial improvements in the literature review, quality assessment and statistical analysis

237. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-technical-brief-protocol.pdf
     August 23, 2023 - Life cycle analysis (LCA) provides a pathway to evaluate products, processes, and procedures within … A limitation in the analysis may be unknown associated impacts at various points from cradle to grave … What data sources, measures/indicators, and methods were used in the analysis? iii. … The technical brief will provide a trend analysis showing the interest in LCAs over time. … LCA data quality: sensitivity and uncertainty analysis.

238. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - Life cycle analysis (LCA) provides a pathway to evaluate products, processes, and procedures within … A limitation in the analysis may be unknown associated impacts at various points from cradle to grave … What data sources, measures/indicators, and methods were used in the analysis? iii. … The technical brief will provide a trend analysis showing the interest in LCAs over time. … LCA data quality: sensitivity and uncertainty analysis.

239. Management of Infantile Hemangioma | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/infantile-hemangioma/clinician
     June 21, 2016 - In a network meta-analysis, the largest mean estimate of expected clearance was for oral propranolol … The efficacy of steroids may be higher than reflected in this analysis. … Beta-blockers Propranolol vs. observation or placebo Improvement in IH Network meta-analysis; 4 … of children) NA [evidence medium] Propranolol vs. steroids Improvement in IH Network meta-analysis … For these reasons, efficacy may be higher than that reflected in this analysis.

240. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
     December 01, 2015 - Long-term clinical outcomes SRC Literature Analysis: •! … Short-term mortality SRC Literature Analysis: •! … Short-term quality of life SRC Literature Analysis: •! … Other SRC Literature Analysis: •! … Short-term quality of life SRC Literature Analysis: •!