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201. Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
     May 01, 2017 - A network meta-analysis of the mean duration of middle ear effusion is presented in the full report. … After excluding 4 studies, 7 studies were included in the network meta-analysis. … Key Question 5 Seven RCTs were included in a network meta-analysis of the comparative effectiveness … Grommets in otitis media with effusion: an individual patient data meta-analysis. … Meta analysis of tympanostomy tube sequelae. Otolaryngol Head Neck Surg. 2001 Apr;124(4):374- 80.

202. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
     September 01, 2010 - Because of the recent high quality meta-analysis focused on treatment options after surgical resection … A sensitivity analysis will include study populations with all levels of disease severity. … A sensitivity analysis will include study populations with all levels of disease severity. … The TEP does not do analysis of any kind nor contribute to the writing of the report. X. … Sensitivity analysis for KQ3 will include inflammatory bowel disease not specified.

203. - (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
     January 01, 2009 - A sub-analysis of the KIMS database. Growth Horm IGF Res 2005;15:349-359. … Sensitivity Analyses: A ‘what if’ analysis that helps determine the robustness of a study. … Statistical Heterogeneity: Variability in the observed effects among studies in a meta-analysis. … Analysis of cystic fibrosis referrals for lung transplantation. … Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis.

204. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
     May 02, 2025 - Data Synthesis: We will summarize the evidence qualitatively and quantitatively (e.g., meta- analysis … , network meta-analysis) when possible. … To assess whether pairwise meta-analysis will be appropriate, we will consider population factors such … In considering network meta-analysis, we will evaluate how these factors are distributed across direct … Estimating interactions and subgroup‐ specific treatment effects in meta‐analysis without aggregation

205. Major-Depressive-Disorder Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
     November 24, 2014 - (i.e., meta-analysis) of the data from those studies. … We will also examine potential sources of heterogeneity using sensitivity analysis or analysis of subgroups … Antidepressant drug effects and depression severity: a patient-level meta-analysis. … Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. … Brief psychotherapy for depression: a systematic review and meta-analysis.

206. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-6-protocol.pdf
     December 07, 2024 - Analysis Type 5. Method for Handling Missing Data 6. Statistical Analysis Method 7. … Adjusted Variables in Statistical Analysis 8. Cluster Randomized Trial 9. … Analysis Type 6. Statistical Analysis Method 7. Adjusted Variables in Statistical Analysis 8. … Analysis Type 2. Assessment Point Category 3. Assessment Point 4. Outcome Measure 5. … plan that was finalized before unblinded outcome data were available for analysis?

207. Mindfulness-Based Interventions for Wellbeing and Mental Health in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amendment.pdf
     February 05, 2025 - , network meta- analysis). … Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis … Mindfulness-based interventions for youth with anxiety: a systematic review and meta-analysis. … An updated meta- analysis of randomised controlled trials. … Network meta-analysis of multicomponent interventions.

208. Mindfulness-Based Interventions for Wellbeing and Mental Health in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amended.pdf
     September 25, 2024 - , network meta- analysis). … Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis … Mindfulness-based interventions for youth with anxiety: a systematic review and meta-analysis. … An updated meta- analysis of randomised controlled trials. … Network meta-analysis of multicomponent interventions.

209. Suicidal-Thoughts-Young-People-Amendement-May-2025 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
     January 01, 2025 - A recent meta- analysis of 30 randomized controlled trials of psychosocial interventions compared with … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the same … If a meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few … Technical Experts do not do analysis of any kind; neither do they contribute to the writing of the report

210. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - A recent meta- analysis of 30 randomized controlled trials of psychosocial interventions compared with … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the same … If a meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few … Technical Experts do not do analysis of any kind; neither do they contribute to the writing of the report

211. Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
     February 01, 2015 - Random-effects meta-analysis of inconsistent effects: a time for change. … Random-effects model for meta-analysis of clinical trials: an update. … How do you use existing risk of bias in a modified or new analysis? … studies to adding the new studies and rerunning the existing analysis. … Scenario 3 Use review with new or modified analysis Will do a new analysis if the existing analysis

212. Chronic-urinary-retention-protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research-protocol.pdf
     November 19, 2012 - We will therefore use clinicaltrials.gov to identify studies that specify CUR subgroup analysis in their … Data fields to be abstracted will be determined based upon proposed summary analysis. … Investigator assessment of these items will compare reported results to planned analysis described in … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have … as Topic/ (12608) 54 meta analy$.tw. (43811) 55 metaanaly$.tw. (1130) 56 Meta-­‐Analysis/ (37918)

213. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - , without attempting to incorporate the new studies into the meta-analysis. … When analyzing newer studies to add to the analysis of Griebeler et al, it appears that these newer … studies were not added to the meta- analysis, but instead taken individually and directly compared … We had made this decision to be consistent with Griebeler et al. meta-analysis that we were using … We have conducted a new meta- analysis in this section, including unpublished trials.

214. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - , without attempting to incorporate the new studies into the meta-analysis. … When analyzing newer studies to add to the analysis of Griebeler et al, it appears that these newer … studies were not added to the meta- analysis, but instead taken individually and directly compared … We had made this decision to be consistent with Griebeler et al. meta-analysis that we were using … We have conducted a new meta- analysis in this section, including unpublished trials.

215. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - We also repeated our main analysis excluding preprint studies. … Was appropriate statistical analysis used? 23 Table B-3. … Methods to estimate the between-study variance and its uncertainty in meta-analysis. … Introduction to meta-analysis. Chichester, U.K.: John Wiley & Sons; 2009. 22. … A general parametric approach to the meta‐analysis of randomized clinical trials.

216. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - An analysis of claims from one large insurer demonstrated that the most common indication for colorectal … We argue that the retracted study should not be included at all in a meta-analysis. … The determination on the appropriateness of meta-analysis will be made before any data analysis; we … will not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … Network meta-analysis for indirect treatment comparisons. Stat Med 2002 Aug 30;21:2313-24.

217. Ced -Appendix-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
     May 29, 2025 - We are concerned about the approach to analysis and recommendations through a literature search involving … not included and we believe transparency into this decision would provide important context to this analysis … CED should not substitute CMS analysis of clinical evidence and conclusions for decisions delegated to … Flexibility in determining the most appropriate study design, data, outcomes, and analysis methods is … not included and we believe transparency into this decision would provide important context to this analysis

218. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - Their analysis seems to be biased. … , but this analysis was not prespecified. … The result in the ITT analysis was not statistically significant, and while the per-protocol analysis … We further considered the responder analysis, which favored BT, but note that this analysis was not … Analysis of results for the intention-to-treat population found no improvement, but analysis of results

219. Acs-Pci-Adjunctive-Devices Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
     April 01, 2013 - adverse cardiovascular events (MACE) and coronary dissection were significantly lower in the overall analysis … One new meta-analysis reported better outcomes in patients treated with aspiration thrombectomy than … One new meta-analysis reported no difference in outcomes in patients treated with mechanical thrombectomy … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID: 17638714. 4. … Evidence Table Author, year Study design Comparison Sample size Results Kumbhani, 20136 Meta-analysis

220. Appendix A: Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-appendix-a.pdf
     September 26, 2023 - clomipramine or Clozapine or "Cognitive behavioral therap*" or "Cognitive therap*" or "Cognitive-Behavioral Analysis … young women" or youth or youths).ti,ab,kf,hw. 40 38 and 39 41 exp "Systematic Review"/ 42 exp Meta-Analysis … Studies as Topic/ or Follow-Up Studies/ or Historically Controlled Study/ or Interrupted Time Series Analysis … clomipramine OR Clozapine OR "Cognitive behavioral therap*" OR "Cognitive therap*" OR "Cognitive-Behavioral Analysis