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effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
February 01, 2012 - Cost–Benefit Analysis
A quality-adjusted cost–benefit analysis is recommended, comparing the incremental … trials to allow meta-
analysis, but patient-level meta-analysis would be required to evaluate the differential … Patient-Level Meta-analysis
Standard meta-analysis of existing studies is not feasible due to the large … analysis and performing a unitary analysis. … into
a regression analysis and performing a unitary analysis.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_disposition-comments.pdf
September 28, 2015 - General This report describes the process and findings of an
extensive systematic review and meta-analysis … For example, in the results section for the ethnicity
subgroup analysis in the Executive summary we … We have added the findings for inconsistency for the
network meta-analysis to the results section, “ … A
consistency analysis was performed for the HbA1c
analysis and it was found that only two quadratic … We did run a sensitivity analysis where we thinned
the MCMC to every 10th iteration.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_policymaker.pdf
June 01, 2016 - N Finding SOE
BETA-BLOCKERS
Propranolol vs. observation or placebo Improvement in IH Network meta-analysis … propranolol arm
(fewer than 15% of children)
���
Propranolol vs. steroids Improvement in IH Network meta-analysis … Equivalent response ���
Topical timolol vs. placebo or observation Improvement in IH Network meta-analysis … more effective ���
STEROIDS
Oral steroids vs. observation or placebo Improvement in IH Network meta-analysis … observation or placebo
Improvement in IH Network meta-analysis N/A Intralesional steroids more effective
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
January 01, 2011 - Exclusion rate from the analysis 6±2 4. Exclusion rate from the analysis 6±3
5. … Sampling bias is addressed in
the analysis
5±3 5. … Statistical analysis 5±1
Assessment of temporality*** 5±2
10. … A
meta-analysis of three methods of treatment. … Meta-analysis of anterior veneer restorations
in clinical studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
March 14, 2024 - A recent meta-
analysis of 30 randomized controlled trials of psychosocial interventions compared with … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the
same … If a meta-analysis is
deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Hartung-Knapp-Sidik-Jonkman approach and its modification
for random-effects meta-analysis with few … Technical Experts do not do
analysis of any kind; neither do they contribute to the writing of the report
-
effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
February 24, 2016 - Can be part of a separate key
question or just part of this analysis. … For this
reason, CV and metabolic endpoints should be considered in the
analysis. … Page 106: Meta Analysis for Radical vs. … Heterogeneity in study design and reported
outcomes prevent meta-analysis. … Results
should also be labeled as to what analysis they were derived from.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - Meta<analysis! … Meta<analysis! … versus usual care)
through standard meta-analysis, a network meta-analysis allows for simultaneous … Analysis!of!Subgroups!! … to network meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
May 01, 2017 - A network meta-analysis of the mean duration of middle ear effusion is presented in the full report. … After excluding 4 studies, 7 studies were included in the
network meta-analysis. … Key Question 5
Seven RCTs were included in a network meta-analysis of
the comparative effectiveness … Grommets in otitis
media with effusion: an individual patient data meta-analysis. … Meta analysis of tympanostomy
tube sequelae. Otolaryngol Head Neck Surg. 2001 Apr;124(4):374-
80.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
January 01, 2009 - A sub-analysis of the KIMS database. Growth Horm IGF Res
2005;15:349-359. … Sensitivity Analyses: A ‘what if’ analysis that helps determine the robustness of a study. … Statistical Heterogeneity: Variability in the observed effects among studies in a meta-analysis. … Analysis of cystic fibrosis referrals for lung
transplantation. … Longitudinal analysis of pulmonary function
decline in patients with cystic fibrosis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
May 01, 2022 - (meta-analysis performed if new evidence
was large relative to the studies in the original meta-analysis … ); consistency in findings between
the new studies and the original meta-analysis (meta-analysis performed … and a trial sequential analysis. … Acupuncture
for acute low back pain: a systematic review
and meta-analysis. … Effect of
preemptive acetaminophen on opioid
consumption: a meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
April 01, 2022 - (meta-analysis performed if new
evidence was large relative to the studies in the original meta-analysis … ); consistency in findings
between the new studies and the original meta-analysis (meta-analysis performed … performed if the strength of evidence based on the original meta-
analysis was low or insufficient and … Opioids for chronic low back pain
management: a Bayesian network meta-
analysis. … A Systematic Review and
Meta-Analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c-prepub-final.xlsx
January 01, 2025 - screening (analysis 2). … Only data from analysis 1 was used in this review. … Patients with inflammatory conditions not included in our analysis. … 4.4 Were all patients included in the analysis? … Another 1,498 that were enrolled had samples reserved for future analysis and were not used in the analysis
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-final-app-c.xlsx
January 01, 2025 - screening (analysis 2). … Only data from analysis 1 was used in this review. … Patients with inflammatory conditions not included in our analysis. … 4.4 Were all patients included in the analysis? … Another 1,498 that were enrolled had samples reserved for future analysis and were not used in the analysis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
September 01, 2010 - Because of the recent high quality meta-analysis focused on treatment options
after surgical resection … A sensitivity analysis
will include study populations with all levels of disease severity. … A sensitivity analysis will
include study populations with all levels of disease severity. … The TEP does not do analysis of any kind nor contribute to the writing of the
report.
X. … Sensitivity
analysis for KQ3 will include inflammatory bowel disease not specified.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
November 24, 2014 - (i.e., meta-analysis) of the data from those studies. … We will also examine potential sources of heterogeneity using sensitivity analysis
or analysis of subgroups … Antidepressant drug effects and
depression severity: a patient-level meta-analysis. … Psychotherapy for depression in
adults: a meta-analysis of comparative outcome studies. … Brief psychotherapy for depression: a
systematic review and meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
May 08, 2023 - Last year of data used in analysis 2015
or later for original research
6
Study
Parameter … We will
not conduct a meta-analysis. … Making health care safer: a critical
analysis of patient safety practices. … Making Healthcare Safer III: A Critical
Analysis of Existing and Emerging Patient Safety Practices. … We will not conduct a meta-analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
June 01, 2016 - In a network meta-analysis,
the largest mean estimate of expected clearance was for
oral propranolol … The efficacy of steroids may be higher
than reflected in this analysis. … placebo or observation
Improvement
in IH
Network
meta-analysis
3 additional studies
(188 subjects … observation or placebo
Improvement
in IH
Network
meta-analysis
Oral steroids more
effective … For these reasons, efficacy may be
higher than that reflected in this analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
February 01, 2015 - Random-effects meta-analysis of
inconsistent effects: a time for change. … Random-effects
model for meta-analysis of clinical trials: an
update. … How do you use existing risk of bias in a modified or new analysis? … studies to adding the
new studies and rerunning the existing analysis. … Scenario 3 Use review with new or modified analysis
Will do a new analysis if the existing analysis
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
March 26, 2013 - An analysis of claims from one large insurer
demonstrated that the most common indication for colorectal … We argue that the retracted study should not be included at all in a meta-analysis. … The determination on the appropriateness of meta-analysis will be made before any data
analysis; we … will not base the decision to perform meta-analysis on statistical criteria for
heterogeneity. … Network meta-analysis for indirect treatment comparisons. Stat Med 2002 Aug
30;21:2313-24.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
March 24, 2017 - , without
attempting to incorporate the new studies into the
meta-analysis. … When analyzing newer studies to
add to the analysis of Griebeler et al, it appears that
these newer … studies were not added to the meta-
analysis, but instead taken individually and directly
compared … We had made this decision to be consistent with
Griebeler et al. meta-analysis that we were
using … We have conducted a new meta-
analysis in this section, including unpublished
trials.