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21. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
    August 23, 2012 - Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and … Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias … In addition, they were all independent prognosticators in multivariate analysis. … I agree with the author’s decision on not conducting any meta-analysis. Thank you. … § SFLC analysis should be performed as part of the criteria for stringent complete response.

22. Gastric-Cancers-Supplementary-App-E (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-e.xlsx
    June 25, 2025 - meta‐analysis results. … meta‐analysis results. … meta‐analysis results. … meta‐analysis results. … meta‐analysis results.

23. Covariate Selection for Observational Comparative Effectiveness Research
    effectivehealthcare.ahrq.gov/sites/default/files/considerations-for-statistical-chapter-10.pptx
    January 01, 2013 - Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Considerations for statistical analysis. In: Velentgas P and Dreyer NA, eds. … Adjusted Analysis Adjusted Analysis Traditional Multivariable Regression Regression analysis is often … missing data, called a complete-case analysis.

24. Gastric-Cancers-Supplementary-App-D (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
    January 01, 2023 - Intention-to-treat (ITT) analysis was used, ensuring proper treatment effect estimation. … Lack of access to a pre-specified statistical analysis plan raises some uncertainty. … No protocol or statistical analysis plan is available, but selective reporting analysis selected on … Intention to treat analysis was performed for all relevant outcomes. … Intention to treat analysis was performed for all relevant outcomes.

25. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - Meta-analysis of clinical trial safety data in a drug development program: Answers to frequently asked … ► Cherry-picking studies to include in meta-analysis can introduce bias. … Heterogeneity and study size in random-effects meta-analysis. … Meta-analysis of clinical trial safety data in a drug development program: Answers to frequently asked … Heterogeneity and study size in random-effects meta-analysis. J Appl Stat 2013;40(1):2-16.

26. Ch 11-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
    January 03, 2012 - This chapter considers the forms of sensitivity analysis that can be included in the analysis of an … Also, estimators resulting from the IV analysis may differ from main analysis estimators (see Supplement … Sensitivity Analysis [propensity score] to a relative risk of 1.64 [traditional regression analysis … (http://www.drugepi.org/dope- downloads/#Sensitivity Analysis) Other tools for sensitivity analysis … The use of sensitivity analysis to examine the underlying assumptions in the analysis process will

27. Gastric-Cancers-Supplementary-App-I (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-i.xlsx
    January 01, 2019 - Analysis does not appear to adjust for multiplicity. … N/A N/A Very low credibility Evaluation of modification is a post-hoc analysis. … Analysis is specified as post-hoc. … Based on post-hoc analysis. … Analysis is specified as post-hoc.

28. Slide 1
    effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
    January 01, 2013 - Sensitivity analysis. In: Velentgas P and Dreyer NA, eds. … Sensitivity analysis. In: Velentgas P and Dreyer NA, eds. … Sensitivity analysis. In: Velentgas P and Dreyer NA, eds. … sources as a sensitivity analysis. … Instrumental variable analysis This type of analysis is based on different assumptions than conventional

29. Defining an Optimal Format for Presenting Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
    January 01, 2019 - Search Flow for Systematic Reviews with Meta-Analysis 22T ........................................... … EVPI is an analysis that places an upper bound to this opportunity cost, or equivalently, an upper … Our literature search identified 414 systematic reviews with meta-analysis. … Table 1 summarizes our findings from systematic reviews with meta-analysis. 7 Table 1. … Searches for systematic reviews with meta-analysis (("meta-analysis"[Publication Type] OR "meta-analysis

30. S89 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
    October 01, 2007 - Two forms of maxSPRT were implemented: an analysis using concurrent matched controls, and an analysis … Analysis Using Matched Controls We used 2 forms of maxSPRT in this study. … Meningococcal Vaccinations in the Analysis for This Outcome* Cumulative No. … The x-axis shows how the LLR changes each week during the analysis. … However, analysis using matched controls has important limitations.

31. Ch 10-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
    January 01, 2011 - In addition to the primary analysis, they also conducted a propensity score matched-pairs analysis … as well as an instrumental variable analysis. … missing data—called a complete-case analysis. … – Should state if there will be a “multilevel” analysis (e.g., an analysis of effects of both practice-level … Statistical Analysis with Missing Data. 2nd edition.

32. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - Subgroup analysis and meta-regression. … Sensitivity analysis should always be conducted in a meta-analysis to investigate the robustness of … be used for meta-analysis. 5. … Other interesting topics, such as meta-analysis of individual patient data, meta-analysis of diagnostic … Meta- analysis of rare events: an update and sensitivity analysis of cardiovascular events in randomized

33. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - Subgroup analysis and meta-regression. … Sensitivity analysis should always be conducted in a meta-analysis to investigate the robustness of … be used for meta-analysis. 5. … Other interesting topics, such as meta-analysis of individual patient data, meta-analysis of diagnostic … Meta- analysis of rare events: an update and sensitivity analysis of cardiovascular events in randomized

34. Rapid Evidence Product: Adverse Events Associated With COVID-19 Pharmaceutical Treatments (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/COVID-19-pharmaceutical-treatments-rapid-review.pdf
    March 01, 2024 - This is consistent with a prior network meta-analysis of antiviral agents for COVID-19 treatment which … Tocilizumab in Coronavirus Disease 2019- Related Critical Illness: A Propensity Matched Analysis. … Risk of Bias (ROB) RR = 2.96; CI: 0.12, 72.49 Risk factor analysis: NR Pub. … Risk of Bias (ROB) RR = 3.03; CI: 0.12, 74.27 Risk factor analysis: NR Pub. … Risk of Bias (ROB) RR = 3.02; CI: 0.12, 73.90 Risk factor analysis: NR Pub.

35. Fraenkel (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/fraenkel.pdf
    May 29, 2025 - . • Option has one branch  Moderate functional impairment Slide 5: Conjoint Analysis • Developed … marketing • Works in “real world” o Data not predicted by managers Slide 6: How  Does  Conjoint Analysis …  Efficacy,   Mucositis,  Cystitis,  Nausea, Zoster, Alopecia Slide 11: Types  of Conjoint Analysis … • Full profile • CBC, or choice-­‐based conjoint analysis • ACBC, adaptive choice-­‐based conjoint … analysis • ACA, or adaptive conjoint analysis Slide 12: ACA • ACA: o Interactive – can handle a lot

36. Cer-235-Pharma-Nonpharm-Ptsd-Update-Appendix-G-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-235-pharma-nonpharm-ptsd-update-appendix-g-1.xlsx
    May 29, 2025 - Selection Bias Domain: ITT Analysis? Performance Bias Domain: Care Providers Masked? … education, or PTSD severity • ≥20% differential on other demographic variables Yes: • Study stated ITT analysis … • >90% of randomized participants analyzed in allocated group No: • Per-protocol analysis with ≤90% … extreme or high • Measurement attrition (overall or differential) moderate paired with CA (completer analysis … Also, MI computation used group as the unit of analysis (means, across groups) rather than individuals

37. Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
    February 01, 2018 - Learning objectives Statistical models for meta-analysis • Meta-analysis can be performed with either … Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88. … Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88. … Statistical models for meta-analysis� Recommendations for �Chapter 3. … Statistical models for meta-analysis� Author References

38. CER 221 Disposition of Comments: Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-comments_0.pdf
    October 11, 2019 - If so, how did you handle this in the analysis? … or network meta- analysis. … We did not conduct a network meta-analysis. … : No We didn’t conduct network meta-analysis. … : No We didn’t conduct network meta-analysis.

39. Evidence Summary: Comparative Effectiveness Review No. 245_Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-evidence-summary-updated-1.pdf
    October 01, 2021 - Comparative Effectiveness Review No. 245_Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis … Effectiveness Review Number 245 Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis … Implications and Conclusions Our analysis of all surgical choices examined as KQs in this review finds … Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis.

40. White Paper_Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
    December 01, 2024 - The analysis also explored what percentage of patients with incident hip fracture were not taking bone … Among the challenges with data collection and analysis, defining and refining variables and queries … Reformatting EHR data for analysis required significant upfront time investment. … Identifying specific evidence gaps to be addressed by such analysis is challenging while the review … Unfortunately, the evidence gaps most amenable to supplementary data analysis are often not evident