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181. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - Thank you for pointing us to the meta-analysis by Holmes et al. … The individual patient data meta-analysis by Brar et al. … We realize that this analysis also assumes a dominant genetic model. … In addition, although no meta-analysis is done, it looks to the naked eye as if a meta-analysis would … An analysis to determine the robustness of cutoff selection was performed in a meta‐ analysis of patient‐level

182. Infantile-Hemangioma Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_executive.pdf
     January 01, 2016 - Excluded studies had no further analysis. … included 18 studies in a network meta-analysis. … The network meta- analysis provided additional data. … Observation or Placebo Network meta-analysis Improvement in IH Moderate In network meta-analysis oral … Observation or Placebo Network meta-analysis Improvement in IH Low In network meta-analysis intralesional

183. An analytical framework for quantifying components of variability in prescriber decisions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
     April 01, 2010 - Also, we have suggested some approaches for reporting the results of such an analysis. … Here, one might consider using the IV in a secondary or sensitivity analysis. … Analysis using instrumental variables. JAMA 1994;272:859-866. 26. … IV as a Secondary Analysis. … may be useful as a confirmatory or secondary analysis.

184. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - Life cycle analysis (LCA) provides a pathway to evaluate products, processes, and procedures within … A limitation in the analysis may be unknown associated impacts at various points from cradle to grave … What data sources, measures/indicators, and methods were used in the analysis? iii. … The technical brief will provide a trend analysis showing the interest in LCAs over time. … LCA data quality: sensitivity and uncertainty analysis.

185. Executive Summary_Systematic Review: Association of Digestible Carbohydrate Intake With Cardiovascular Disease, Type 2 Diabetes, Obesity, and Body Composition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-executive-summary.pdf
     March 01, 2025 - The linear dose-response meta-analysis showed a significant association between the risk of incident … Subgroup Analysis Based on Sex and Geographic Location We found no significant linear dose-response … • Dose-response meta- analysis also showed nonsignificant associations. … Subgroup Analysis Based on Sex and Geographic Location We found similar U-shaped nonlinear dose-response … is important to acknowledge the limitations of study-level meta-regression and dose-response meta- analysis

186. Meditation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
     October 17, 2012 - • Was intent-to-treat analysis used? … Mindfulness-based stress reduction and cancer: a meta-analysis. Psychooncology. … Use and avoidance of continuity corrections in meta-analysis of sparse data. … This is not a statistical analysis, but rather a way to visually display the data. … We will also conduct a sensitivity analysis of this analysis by reversing the prioritization order

187. Methods Guide for Medical Test Reviews Chapter 12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
     July 01, 2012 - A meta-analysis could provide more precise estimates of outcome probabilities. … A meta-analysis of randomized control trials. Circulation 1990;82(4):1106-16. 24. … Anemia and mortality in heart failure patients: a systematic review and meta-analysis. … Decision curve analysis: a novel method for evaluating prediction models. … Meta- analysis of summary survival curve data.

188. EHC Protocol: Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
     September 24, 2024 - (when available), serum chemistries, and urine analysis for first-time stone formers, with 24-hour … have a preference for this workup.3 Some authorities claim that optimal treatment includes metabolic analysis … If outcomes are quantitatively synthesized, we will conduct a sensitivity analysis excluding studies … Comparison of four heterogeneity measures for meta-analysis. … Bias in meta-analysis detected by a simple, graphical test.

189. The Effectiveness of Indoor Allergen Reduction and the Role of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
     October 04, 2016 - Decisions about whether meta-analysis is appropriate will depend on the judged clinical homogeneity … using the Hartung-Knapp method.18,19 Meta-regression and subgroup analysis will be used to explore … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Technical Experts do not do analysis of any kind nor do they contribute to writing the report.

190. Disposition of Comments for Evidence Report 221 Behavioral Programs for Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_disposition-comments.pdf
     September 28, 2015 - General This report describes the process and findings of an extensive systematic review and meta-analysis … For example, in the results section for the ethnicity subgroup analysis in the Executive summary we … We have added the findings for inconsistency for the network meta-analysis to the results section, “ … A consistency analysis was performed for the HbA1c analysis and it was found that only two quadratic … We did run a sensitivity analysis where we thinned the MCMC to every 10th iteration.

191. Future Research Needs for Treatment of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
     February 01, 2012 - Cost–Benefit Analysis A quality-adjusted cost–benefit analysis is recommended, comparing the incremental … trials to allow meta- analysis, but patient-level meta-analysis would be required to evaluate the differential … Patient-Level Meta-analysis Standard meta-analysis of existing studies is not feasible due to the large … analysis and performing a unitary analysis. … into a regression analysis and performing a unitary analysis.

192. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol-amendment.pdf
     September 19, 2023 - We will not conduct a meta- analysis. … Analysis of Subgroups or Subsets We will perform a sub-group analysis for pediatric patients and adults … Effects of rapid response systems on clinical outcomes: systematic review and meta-analysis. … Rapid Response Teams: A Systematic Review and Meta-analysis. … Rapid response systems: a systematic review and meta-analysis.

193. Making Healthcare Safer IV: Interventions to Prevent Nonventilator Hospital-acquired Pneumonia (NV-HAP) for Inpatients (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-iv-nv-hap-protocol.pdf
     August 05, 2024 - are at risk for NV-HAP.7 An analysis of over six million hospitalizations in the U.S. … We will not conduct a meta-analysis. … Analysis of Subgroups or Subsets We will report if the effectiveness of the PSP differs across patient … care and postoperative pneumonia in non- cardiac surgical patients: A systematic review and meta-analysis … Effect of Dysphagia Screening on Pneumonia in Acute Stroke Patients: A Systematic Review and Meta-Analysis

194. Asthma-Immunotherapy-2011 Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
     January 01, 2011 - Exclusion rate from the analysis 6±2 4. Exclusion rate from the analysis 6±3 5. … Sampling bias is addressed in the analysis 5±3 5. … Statistical analysis 5±1 Assessment of temporality*** 5±2 10. … A meta-analysis of three methods of treatment. … Meta-analysis of anterior veneer restorations in clinical studies.

195. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0002_03-04-2008.pdf
     January 01, 2008 - Therefore, the topic is being considered for refinement as a meta-analysis that includes individual … systematic review on the topic is not warranted at this time, but an individual patient-level data (IPD) analysis … An IPD analysis has the potential to impact this topic in several ways, including 1) to elucidate why

196. Management of Infantile Hemangioma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
     June 01, 2016 - In a network meta-analysis, the largest mean estimate of expected clearance was for oral propranolol … The efficacy of steroids may be higher than reflected in this analysis. … placebo or observation Improvement in IH Network meta-analysis 3 additional studies (188 subjects … observation or placebo Improvement in IH Network meta-analysis Oral steroids more effective … For these reasons, efficacy may be higher than that reflected in this analysis.

197. Disposition of Comments for CER 167 Renal Masses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
     February 24, 2016 - Can be part of a separate key question or just part of this analysis. … For this reason, CV and metabolic endpoints should be considered in the analysis. … Page 106: Meta Analysis for Radical vs. … Heterogeneity in study design and reported outcomes prevent meta-analysis. … Results should also be labeled as to what analysis they were derived from.

198. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - Could the authors please add more language to the methods section on the use of meta analysis. … Decisions on what to pool in a meta-analysis can often be subjective. … We considered conducting a meta-analysis of length of stay in hospital. … Meta-analysis of median values is generally not acceptable and we determined that transformation of … It’s unclear why only three of the RCTs were included in the meta-analysis.

199. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
     December 04, 2015 - Meta<analysis! … Meta<analysis! … versus usual care) through standard meta-analysis, a network meta-analysis allows for simultaneous … Analysis!of!Subgroups!! … to network meta-analysis.

200. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
     February 07, 2025 - Data Synthesis: We will summarize the evidence qualitatively and quantitatively (e.g., meta- analysis … , network meta-analysis) when possible. … To assess whether pairwise meta-analysis will be appropriate, we will consider population factors such … In considering network meta-analysis, we will evaluate how these factors are distributed across direct … Estimating interactions and subgroup‐ specific treatment effects in meta‐analysis without aggregation