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81. Methods Guide for Comparative Effectiveness Reviews - Expanded Guidance on Selected Quantitative Synthesis Topics (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - Thus the meta-analysis of three “mega-trials” will be more reliable than the meta-analysis of three … • Only widely accepted composite outcomes should be used in meta-analysis. … Distinguish between prespecified and post hoc analysis. … Bayesian methods in meta-analysis and evidence synthesis. … Statistical power analysis for the behavioral sciences, 2nd ed.

82. Procalcitonin for Diagnosis and Management of Sepsis | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/procalcitonin/research-protocol
    December 01, 2019 - Analysis: adjustment for potential confounders and intention-to-treat analysis. … Intention-to-treat analysis has been done for RCTs. Poor. … For RCTs, intention-to-treat analysis is lacking. … analysis ↓ Single-arm study, post-hoc multivariate analysis Less informative Single-arm … For RCTs, intention-to-treat analysis is lacking.

83. Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
    October 01, 2016 - , extreme value analysis, dimensional analysis).166 In addition, software production techniques, such … Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis … Sensitivity analysis in the context of uncertainty analysis for computationally intensive models. … Sensitivity analysis versus uncertainty analysis: When to use what? … Bias analysis via missing-data methods.

84. Cer-235-Pharma-Nonpharm-Ptsd-Update-Appendix-G-1 (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-235-pharma-nonpharm-ptsd-update-appendix-g-1.xlsx
    November 12, 2020 - Selection Bias Domain: ITT Analysis? Performance Bias Domain: Care Providers Masked? … education, or PTSD severity • ≥20% differential on other demographic variables Yes: • Study stated ITT analysis … • >90% of randomized participants analyzed in allocated group No: • Per-protocol analysis with ≤90% … extreme or high • Measurement attrition (overall or differential) moderate paired with CA (completer analysis … Also, MI computation used group as the unit of analysis (means, across groups) rather than individuals

85. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
    February 01, 2018 - example, sex) can produce unbiased results in analysis … removed in analysis (see below sections for analytic strategies). … Complete Case Analysis The complete case analysis strategy restricts the analysis to patients with … Using causal diagrams to guide analysis in missing data problems. … Using causal diagrams to guide analysis in missing data problems.

86. Liver-Cancer Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
    October 01, 2014 - MRI and CT performed similarly when patients with HCC were the unit of analysis, but sensitivity was … higher for MRI than for CT when HCC lesions were the unit of analysis (pooled difference 0.09; 95% … Surveillance settings Unit of analysis: patients with HCC CT Sensitivity: Low Specificity: Low … Surveillance settings Unit of analysis: patients with HCC MRI or PET Insufficient No evidence … Nonsurveillance settings Unit of analysis: HCC lesions CT Sensitivity: Moderate Specificity:

87. Clopidogrel After Drug-Eluting Stent Implantation: Is Current Practice Sufficient? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/stent-clopidogrel-practice/research
    January 01, 2020 - Landmark Analyses Based on Clopidogrel Use Landmark analysis is a form of survival analysis that classifies … Limitations There are two important caveats to this analysis. … Statistical analysis: Eisenstein, Anstrom, Shaw, Tuttle. … Diagram of 6-month landmark analysis   Figure 1B. … Diagram of 12-month landmark analysis   Figure 2A.

88. PowerPoint Presentation (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - The systematic reviewers first attempted to use analysis option 3, then moved on to analysis option 2 … Systematic Review Example: Analysis Option 3 — Naïve Estimates The reviewers decided on the third analysis … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis Dashed line = line of perfect agreement … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis Here is an example of the analysis … Analysis options 1, 2, and 3 are recommended. Analysis option 4 requires expert statistical help.

89. PowerPoint Presentation (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - The systematic reviewers first attempted to use analysis option 3, then moved on to analysis option 2 … Systematic Review Example: Analysis Option 3 — Naïve Estimates The reviewers decided on the third analysis … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis Dashed line = line of perfect agreement … Systematic Review Example: Analysis Option 2 — Pooled Data Analysis Here is an example of the analysis … Analysis options 1, 2, and 3 are recommended. Analysis option 4 requires expert statistical help.

90. S166 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/s166.pdf
    October 01, 2007 - meta-analysis. … Systematic Reviews in Health Care: Meta-Analysis in Context. … Bayesian methods in meta analysis. In: Methods for Meta-Analysis n Medical Research. … Bayesian approaches to ran- dom-effects meta-analysis: a comparative study. … The random effects procedure is then followed as a normal meta-analysis of 2 studies.

91. Safety of Vaccines Used for Routine Immunization in the United States | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/safety-vaccines/protocol
    January 01, 2021 - Rubella Immunity in Pregnant Iranian Women: A Systematic Review and Meta-Analysis. … A systematic review and meta-analysis. … : A Systematic Review and Meta-Analysis. … Therapeutic vaccination for chronic hepatitis B: A systematic review and meta-analysis. … Risk analysis : an official publication of the Society for Risk Analysis. 2016;36(7):1297-314. doi: 10.1111

92. Disposition of comments_Comparative Effectiveness Review No. 242: Radiation Therapy for Brain Metastases (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
    June 09, 2021 - TEP #6 General Cost analysis – SRS can generate huge bills. Something to note. … analysis and outcome in sufficient detail. … It was clear the reason of not included meta-analysis. Noted. … Was the analysis conducted with incorrectly assigned trials? … Consider pooling these analysis (but do include the separate analysis as well)grammatical page 18

93. Research Protocol: Safety of Vaccines Used for Routine Immunization in the United States (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
    January 30, 2020 - Rubella Immunity in Pregnant Iranian Women: A Systematic Review and Meta-Analysis. … A systematic review and meta-analysis. … : A Systematic Review and Meta-Analysis. … A Systematic Review and Meta- Analysis. … Risk analysis : an official publication of the Society for Risk Analysis. 2016;36(7):1297-314. doi:

94. Version-3-Immunity-After-Covid-19-Appendix-Table-B-1 (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
    January 24, 2022 - N1 total positive cohort included in analysis N2 total negative (control) cohort included in analysis … Delta analysis, and before August 30, 2020 for long-term effectiveness analysis Delta virus analysis … effectiveness analysis: 11,186 Delta analysis: 274,830 Long-term effectiveness analysis: 141,417 Delta … analysis: 40 Long-term effectiveness analysis: 81 Delta analysis: 50,287 Long-term effectiveness analysis … : 11,105 Delta analysis: 1,494 Long-term effectiveness analysis: 7,167 Delta analysis: 273,336 Long-term

95. Peripheral Nerve Blocks for Postoperative Pain Management in Cardiothoracic Surgery | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/peripheral-nerve-blocks/protocol
    May 01, 2024 - A sensitivity analysis will be conducted to compare the results from the full set to the results with … Transversus Abdominis Plane Block for Post Hysterectomy Pain: A Systematic Review and Meta-Analysis. … with trial sequential analysis. … and trial sequential analysis. … Technical Experts do not conduct analysis or contribute to the writing of the report.

96. Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment–An Update to the 2006 Report | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/cancer-anemia-update/research-protocol
    December 01, 2019 - Study and Independent Patient Level Meta-Analysis Selection: Results from study- and patient-level meta-analysis … Did the analysis include an intention-to-treat analysis? … The hazards of scoring the quality of clinical trials for meta-analysis. … Schwarzer G. 2010. meta: Meta-Analysis, R package version 1.5-0. R Development Core Team. 2010. … The TEP does not do analysis of any kind nor contribute to the writing of the report.

97. Effective Health Care (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0320_06-17-2009.pdf
    January 01, 2009 - 10 1 Results of Topic Selection Process & Next Steps  Serum free light chain assay analysis … presents a series of questions for a review on the effectiveness of serum free light chain (FLC) assay analysis … Intervention(s): Serum FLC analysis. … Serum Free Light Chain Assay Analysis Nomination Summary Document http://effectivehealthcare.ahrq.gov … Is there improved diagnostic and/or therapeutic accuracy for FLC analysis in conjunction with serum

98. Cancer-Ovarian-Contraceptives Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
    June 01, 2013 - We included data from pooled analysis articles in our meta- analysis if (1) none of the individual studies … included in the pooled analysis had already been included for meta- analysis, (2) at least half the … under consideration in the analysis, and (3) data in the pooled analysis were presented such that inclusion … in the current meta-analysis was feasible. … A pooled meta-analysis of 11 studies (3 case-control, 1 pooled analysis, and 7 cohort, of which 4

99. Layout 1 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/registries-guide_executive.pdf
    April 01, 2007 - Analysis and Interpretation Analysis and interpretation of registry data begin with answering a series … Analysis of registry outcomes first requires an analysis of the completeness of data collection and data … plan that contains sufficient detail to explain the main focus and proposed methods of analysis … Analysis • Accepted analytic techniques are used; these may be augmented by new or novel approaches … Analysis • Loss to followup is characterized at key stages during the conduct of the study.

100. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/reporting.ppt
     September 01, 2009 - A systematic review and meta-analysis of randomized placebo-controlled trials. … Methods: Additional Analyses Additional analysis, such as a subgroup analysis or a meta-regression, should … Systematic review and meta-analysis of randomised controlled trials. BMJ 2005;331:313-21. … Meta-analysis: chondroitin for osteoarthritis of the knee or hip. … A systematic review and meta-analysis of randomized placebo-controlled trials.