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461. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

462. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - For Key Question 4, on subgroups, conclusions are up to date, with the exception that one new meta-analysis … (Insufficient) A new meta-analysis concluded that no oral DMARDs were associated with increased … A new meta-analysis of 6 RCTs of tocilzumab + MTX vs. placebo7 showed increased risk of infection, … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 4. … Dixon, 2011b12 GCs Meta- analysis NA GCs Studies published before January 2010 21 RCTs and 42

463. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - o Data analysis was based on the intention-to-treat-principle. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Assessing the amount of heterogeneity in random-effects meta-analysis. … STATA® Data Analysis and Statistical Software. MP Parallel ed. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

464. Anxiety in Children (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/anxiety-children_research-protocol.pdf
     September 12, 2016 - If meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random effect method … to combine direct comparisons between treatments if the number of studies included in the analysis … We will evaluate the feasibility of conducting network meta-analysis to combine direct and indirect … Consistency of network meta- analysis will be evaluated using side-splitting models. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

465. Major-Depressive-Disorder Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/major-depressive-disorder_executive.pdf
     December 01, 2015 - We examined potential sources of heterogeneity using sensitivity analysis or analysis of subgroups. … Network meta-analysis indicated response rates that did not differ statistically for patients on SGAs … In contrast, a second secondary analysis involving 727 patients, which was government funded, found … Statistical approaches for conducting network meta-analysis in drug development. … Antidepressant drug effects and depression severity: a patient-level meta-analysis.

466. Prostate-Cancer-Test Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
     April 01, 2013 - • Regression analysis using regression coefficients and associated relative odds ratios. … This bias cannot be avoided by statistical analysis, but was addressed by stratifying analyses and … Using the most commonly reported comparator and analysis (tPSA and AUC), we performed a regression … A meta-analysis of the performance characteristics of the free prostate-specific antigen test. … A systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2006 9(4):374-8.

467. Ptsd-Adult-Treatment Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_executive.pdf
     April 01, 2013 - For each meta-analysis, we conducted sensitivity analyses by removing each study from the analysis … The analysis included both head-to-head and placebo-controlled trials. … Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: L. … Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ: L. … Quantifying heterogeneity in a meta- analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

468. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
     October 01, 2010 - The most commonly reported of these were selected for meta-analysis, while the remaining outcomes were … Trials that enrolled patients with a range of pubertal status were excluded from subgroup analysis. … In one controlled trial, mean Tanner stage improved regardless of gender, and in an analysis of three … In one multivariate analysis, higher percent predicted FEV1 was associated with improvements in “ways … data merged and in a subgroup analysis.

469. Smoking-Pregnancy-Infants Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/smoking-pregnancy-infants_research-protocol.pdf
     March 11, 2013 - The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … Multivariate analysis of factors associated with smoking cessation in women. … The validity of self-reported smoking: a review and meta-analysis. … the analysis, reporting, and claim of subgroup effects in randomized trials.

470. Clinical-Care-Rapid-Review-Appendix-C (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/clinical-care-rapid-review-appendix-c.xlsx
     January 01, 2018 - Information collected from the time of the report through the event analysis, full explanation, apology … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Helmchen, 2016 … N at Analysis Results, n (%) Within Arm Comparison Between Arm Comparison Adjusted Factors Disclosure … N at Analysis Results Within Arm Comparison Between Arm Comparison Adjusted Factors CRP Kachalia, 2010

471. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - Furthermore, a large proportion of the effectiveness analysis focused on gabapentin and vigabatrin, … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 5. … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … analysis, the results were less likely to show significance.

472. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - Furthermore, a large proportion of the effectiveness analysis focused on gabapentin and vigabatrin, … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID 17638714. 5. … , are characteristically similar to that of their meta-analysis (OR 1.1 [0.9 to 1.2]). … analysis, the results were less likely to show significance.

473. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/presentation.ppt
     August 01, 2009 - Various types of heterogeneity may preclude a quantitative synthesis (e.g., meta-analysis). … Why Not Meta-analysis? Even studies meeting the same inclusion criteria can vary. … Why Not Meta-analysis? … In theory, one can perform a meta-analysis when there are many filled cells across a row/SNP in a super … A forest plot is often used in presenting meta-analysis data, but it can also be useful when we are not

474. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - (i.e., meta-analysis) of the data from those studies. … The analysis will include both head-to-head and placebo-controlled trials. F. … A meta-analysis of alcohol consumption and the risk of 15 diseases. … Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539-58.

475. Coronary-Artery-Stenting Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
     February 01, 2013 - We considered evidence to be sparse if only one study of a small sample size addressed the analysis … aSeven studies provided eight data points for analysis. … bFour studies provided five data points for analysis. … cFive studies provided six data points for analysis. … dThree studies provided four data points for analysis.

476. Noninvasive, Nonpharmacological Treatment for Chronic Pain (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
     September 20, 2017 - For chronic headache, biofeedback will provide a common comparator for analysis. … of results) and quantitatively (meta-analysis) when appropriate. … of a small number of studies.23 To determine whether meta-analysis could be meaningfully performed, … Random-effects meta-analysis of inconsistent effects: a time for change. … A likelihood approach to meta-analysis with random effects.

477. Colon-Cancer-Gene-Profiling Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
     March 13, 2012 - Was a reclassification analysis performed with risk stratification using GEP when compared with that … (It is suggested that samples from at least two-thirds of the patients must be available for analysis … o Type(s) of tissue used (e.g., fresh tissue) o Time for analysis (turnaround time) • Inclusion and … • Was MSI (MMR) status considered in the overall analysis? o If so, how? … • Was the GEP performed (analysis, calculation, interpretation) as described in initial studies for

478. S16 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/s16.pdf
     October 01, 2007 - Individual patient meta-analysis is more powerful for this purpose, and has been used with success in … An analysis of 7 primary prevention trials suggests that the TABLE 4. … Subgroup analysis of trials indicates that the benefits are much greater in asymptomatic men than in … NIH Program on Clinical Research Policy and Analysis and Coordination. … Subgroup analysis in randomized controlled trials: im- portance, indications, and interpretation.

479. Untitled (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
     October 12, 2015 - They had serious errors in design, analysis, or reporting; large amounts of missing information; or … We will then determine the feasibility of completing a quantitative synthesis (i.e., meta- analysis, … decision analysis, or simulation model). … to which such an analysis will provide additional insight into the key questions based 21! … Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis.

480. Antipsychotics-Children-Surveillance-150120 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children-surveillance-150120.pdf
     October 01, 2014 - Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. … SRC Literature Analysis: • The original CER concluded that SGAs were favored over FGAs for symptom … We performed meta-analysis for primary and secondary outcomes, when possible. … RESULTS: Planned interim analysis for the primary end-point in the RCT resulted in early termination … Per-protocol analysis was significant (p=0.02).