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401. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - We refer the investigators to the following citation: A survey of current problems in meta-analysis. … This is not reflected in the current analysis. 4-mm studies did not meet our inclusion criteria. … Although we are aware of those data, we did not include them in our analysis on rhythm control because … Since this analysis was conducted, an additional study has been released that would be relevant to … Jais 2008 has been added to the analysis.

402. Disposition of Comments for Treatment Strategies for Patients With Peripheral Artery Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
     May 29, 2013 - The authors should include their analysis of the ability to conduct randomized surgical trials. … Methods Meet generally accepted practice of scientific analysis. Thank you. … J Vasc Surg 2009; 49:1217-1225) The study was performed using Markov analysis and concluded that … However the only RCT, the BASIL trial, is not fully represented by the authors of this analysis. … , but this subgroup analysis does not provide the level of evidence to make a key point and should

403. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - Peer Reviewer #2 General Comment A future cost benefit analysis would also be helpful. … needed for future cost benefit analysis. … The detailed analysis of the papers is handicapped by excessive simplification. … The expert panel had no role in article selection or in the analysis. … Peer Reviewer #2 Discussion/ Conclusion Additionally a cost benefit analysis should be conducted

404. Data Points #11: Newly Medicare-eligible disabled: comparison of duals and nonduals | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/medicare-eligible-disabled/research
     December 01, 2019 - Conclusion Our analysis underscores the need for policy and research to focus beyond disabled Medicare … Our analysis does not distinguish beneficiaries who are institutionalized from those who are community … This analysis serves as a reminder that broad groupings of disabled persons obscure important distinctions … Healthcare Quality and Disparities Report (NHQDR) Research Report Nov 09, 2022 Analysis

405. Menopause-Protocol-130612 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
     June 12, 2013 - Revisiting the duration of vasomotor symptoms of menopause: a meta-analysis. … Network meta-analysis also formally allows quantitative indirect comparisons. … Subset: Systematic Review OR Publication Type: Meta-analysis OR (“meta-analysis” OR metaanalysis OR … Intention to treat analysis is performed. … Intention to treat analysis is lacking.

406. Labor Dystocia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/labor-dystocia/research-protocol
     August 01, 2020 - analysis, or simulation model). … For a meta-analysis, feasibility depends on the volume of relevant literature, conceptual homogeneity … For a decision analysis or simulation model, feasibility will be based on a judgment about the degree … Technical experts do not do analysis of any kind nor do they contribute to the writing of the report. … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses

407. VU EPC DBD Protocol_AHRQ comments_revised_clean (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
     January 30, 2014 - We will examine the appropriateness of each study for inclusion in a meta-analysis. … The specific meta-analysis or meta- regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … I: A meta- analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. … the analysis, reporting, and claim of subgroup effects in randomized trials.

408. Disposition of Comments Report for Acute Migraine Treatment in Emergency Settings (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
     November 27, 2012 - The statistical methods are standard for this type of analysis. … We used the data from the placebo controlled trials in our network meta-analysis. … We conducted a mixed treatment analysis for akathisia (KQ4). … One can also use the mixed treatment analysis presented in Figure 31. … One can also use the mixed treatment analysis presented in Figure 31.

409. antibiotics-respiratory-infection-protocol-140922 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
     September 22, 2014 - In consultation with our statistician, we will consider a network analysis to make comparisons across … When meta-analysis cannot be performed, the data will be summarized qualitatively, grouping studies … In: Shojania KG MK, Wachter RM, Owens DK, ed Closing the Quality Gap: A Critical Analysis of Quality … Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539--58. 20. … Methods for Meta-Analysis in Medical Research: John Wiley & Sons, Inc.; 2000. 21.

410. Peripheral-Artery-Disease-Treatment Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
     January 31, 2013 - Meta-analysis from the Antithrombotic Trialists’ Collaboration has demonstrated the benefit of at least … showing no difference in amputation-free survival or mortality at 2 years, the as-treated analysis … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses … "[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses

411. Changing Patterns of Medication Use in Patients With Rheumatoid Arthritis in a Medicaid Population | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine-1/research
     January 01, 2020 - A secondary analysis which identified RA patients based on diagnosis codes alone, showed similar patterns … Statistical Analysis We estimated the proportion of RA patients who were using study medications on … with RA patients prescribed DMARDs who likely had more severe disease, we performed a secondary analysis … Sensitivity Analysis The application of less specific selection criteria increased our number of total … Compared with our primary analysis, there were no material differences in the distribution of demographic

412. Gout Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gout_executive.pdf
     March 01, 2016 - the following strategy for data synthesis/analysis: 1. … in prior SRs Included in analysis (N=15) KQ4 (N=26) Included in analysis (N=26) KQ 5 (N=3 … Moxibustion for rheumatic conditions: A systematic review and meta-analysis. … Increased risk of skin reactions with gout medications: An analysis of va databases. … Serum urate levels and gout flares: analysis from managed care data.

413. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
     May 05, 2017 - Text of ES edited to clarify that RCTs only included in meta-analysis. … A forest plot is shown as we have done meta- analysis of the NRCS. … We preferred not to combine RCTs and NRCS in the meta-analysis. … Text edited to reflect that this was an intention to treat analysis. … "Two studies were excluded from our meta-analysis.

414. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/tympanostomy-tubes-disposition.pdf
     May 05, 2017 - Text of ES edited to clarify that RCTs only included in meta-analysis. … A forest plot is shown as we have done meta- analysis of the NRCS. … We preferred not to combine RCTs and NRCS in the meta-analysis. … Text edited to reflect that this was an intention to treat analysis. … "Two studies were excluded from our meta-analysis.

415. Liver-Cancer-Therapy Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
     May 01, 2013 - that adjusts for potential confounders and intention-to-treat analysis. … In addition, for RCTs, intention-to-treat analysis is used. … Intention-to-treat analysis is done for RCTs. … For RCTs, intention-to-treat analysis is lacking. … TACE combined with PEI versus TACE alone in the treatment of HCC: a meta-analysis.

416. Acs-Pci-Adjunctive-Devices Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
     July 01, 2010 - They have serious errors in design, analysis, or reporting; large amounts of missing information; or … For example, when a meta-analysis is performed, we will evaluate the confidence interval around the … Meta-Analysis in clinical trials. Controlled Clin Trials. 1986 ;7 :177-188. 10. … Bias in Meta-Analysis Detected by a Simple, Graphical Test. BMJ 1997;315:629-34. 11. … The TEP does not do analysis of any kind nor contribute to the writing of the report. X.

417. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-mortality-elderly_research.pdf
     March 01, 2009 - in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis … In the FDA’s analysis, heart-related events (heart failure and sudden death) and infections (mostly … Based on suggested pharmacologic effects of conventional APMs 5-8,12 and the FDA analysis, 1 we … An instrumental variable analysis was also used to provide estimates that would remain unbiased even … Analysis using instrumental variables. JAMA 1994 Sep 21;272(11):859- 866. 20.

418. final Fibromyalgia CER protocol_3-31-14 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/fibromyalgia_research-protocol.pdf
     April 03, 2014 - Data fields to be extracted will be determined based upon the proposed summary analysis. … The risk of bias of the individual RCTs that comprise each pooled analysis will be assessed per the … Because of the high probability of placebo effects in fibromyalgia treatments, if subgroup analysis … We will conduct a brief qualitative sensitivity analysis of the excluded observational literature for … Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol.

419. Anxiety in Children | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/anxiety-children/research-protocol
     June 01, 2021 - We will determine whether meta-analysis is appropriate (i.e., more than 2 trials address the same PICOTS … If meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random effect method … to combine direct comparisons between treatments if the number of studies included in the analysis is … Consistency of network meta-analysis will be evaluated using side-splitting models. … Meta-analysis in clinical trials. Controlled clinical trials. 1986 Sep;7(3):177-88.

420. Dietary Proteins | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/dietary-proteins?page=2
     September 19, 2012 - Products Systematic Review Archived September 19, 2012 Serum Free Light Chain Analysis … breast cancer Systematic Review Archived August 23, 2012 Serum Free Light Chain Analysis … Prostate Cancer Risk Assessment Methods Guide – Chapter June 1, 2012 Chapter 8: Meta-Analysis