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321. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - The report focuses its analysis on the hospital cases as the unit of analysis. … Such analysis is beyond the scope of the Report. … The analysis of this topic is beyond the scope of this report. … A similar analysis can be done for other indications. … Determinants of intracerebral hemorrhage growth: an exploratory analysis.

322. Medical Therapies for Locally Advanced Gastric Adenocarcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gastric-cancers/protocol
     February 01, 2025 - Data Synthesis: We will summarize the evidence qualitatively and quantitatively (e.g., meta-analysis … , network meta-analysis) when possible. … To assess whether pairwise meta-analysis will be appropriate, we will consider population factors such … In considering network meta-analysis, we will evaluate how these factors are distributed across direct … Estimating interactions and subgroup‐specific treatment effects in meta‐analysis without aggregation

323. Migraine-Emergency Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - The mixed-treatment analysis showed that the most effective treatments were combination therapy ( … Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. … The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis. … Borrowing strength from external trials in a meta-analysis. Stat Med. 1996;15(24):2733-49. … Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.

324. Making Healthcare Safer IV: Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug Events | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mhs4-computerized-cds/protocol
     September 01, 2023 - Last year of data used in analysis 2015 or later for original research Setting Inpatient and … We will not conduct a meta-analysis. … Making health care safer: a critical analysis of patient safety practices. … Making health care safer II: an updated critical analysis of the evidence for patient safety practices … Making Healthcare Safer III: A Critical Analysis of Existing and Emerging Patient Safety Practices.

325. Comparative Effectiveness of Screening for Methicillin-Resistant Staphylococcus aureus (MRSA) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mrsa-screening-2010/research-protocol
     December 01, 2019 - A meta-analysis by Cosgrove and colleagues identified a 2-fold increased risk of death associated with … Analysis: adjustment for potential confounders and intention-to-treat analysis. … In addition, for randomized controlled trials, intention-to-treat analysis is used. Fair. … An intention-to-treat analysis is done for randomized controlled trials. Poor. … For randomized controlled trials, intention-to-treat analysis is lacking.

326. S108 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/s108.pdf
     October 01, 2007 - simulation output was analyzed by Cox proportional hazards regression and by a weighted regression analysis … The magnitude of bias was calculated for each method of analysis. … IPW We performed a weighted regression analysis based on IPW. … The phenomenon of uncontrolled heterogeneity is called the frailty effect in survival analysis. … Incorporation of individual random effects into a survival analysis potentially allows estimation of

327. Appendix A: Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-appendix-a.pdf
     September 26, 2023 - clomipramine or Clozapine or "Cognitive behavioral therap*" or "Cognitive therap*" or "Cognitive-Behavioral Analysis … young women" or youth or youths).ti,ab,kf,hw. 40 38 and 39 41 exp "Systematic Review"/ 42 exp Meta-Analysis … Studies as Topic/ or Follow-Up Studies/ or Historically Controlled Study/ or Interrupted Time Series Analysis … clomipramine OR Clozapine OR "Cognitive behavioral therap*" OR "Cognitive therap*" OR "Cognitive-Behavioral Analysis

328. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - A recent meta- analysis of 30 randomized controlled trials of psychosocial interventions compared with … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the same … If a meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few … Technical Experts do not do analysis of any kind; neither do they contribute to the writing of the report

329. Mindfulness-Based Interventions for Wellbeing and Mental Health in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amended.pdf
     September 25, 2024 - , network meta- analysis). … Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis … Mindfulness-based interventions for youth with anxiety: a systematic review and meta-analysis. … An updated meta- analysis of randomised controlled trials. … Network meta-analysis of multicomponent interventions.

330. Mindfulness-Based Interventions for Wellbeing and Mental Health in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amendment.pdf
     February 05, 2025 - , network meta- analysis). … Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis … Mindfulness-based interventions for youth with anxiety: a systematic review and meta-analysis. … An updated meta- analysis of randomised controlled trials. … Network meta-analysis of multicomponent interventions.

331. Interventions to Improve Care of Bereaved Persons | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bereaved-persons/protocol
     December 01, 2023 - We will use meta-analysis as a data-aggregation technique with appropriate meta-analysis models 39 which … Widowhood and mortality: a meta-analysis and meta-regression. … The prevention and treatment of complicated grief: a meta-analysis. … Risk of bias: a simulation study of power to detect study-level moderator effects in meta-analysis. … Bias in meta-analysis detected by a simple, graphical test.

332. Effects of Dietary Sodium and Potassium Intake on Chronic Disease Outcomes and Related Risk Factors | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/sodium-potassium/research-protocol
     January 01, 2019 - Meta-analysis will be used to synthesize results across studies in random effect models. … Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis. … Multivariate Dose-Response Meta-Analysis: The dosresmeta R Package. … Computational Statistics & Data Analysis. 2009;53(12):4157-67. … Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies.

333. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - meta-analysis where there are no events in both arms. … meta-analysis where there are no events in both arms. … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed … In the event where quantitative analysis is not possible for a KQ, qualitative analysis was completed

334. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
     May 13, 2014 - I wonder about the dropouts and how they handled missing data in thier outcome analysis. … The authors use “risk of bias” as a reason to exclude studies from their meta-analysis. … outcome for the data analysis. … If survival analysis was too complicated an outcome to be used in the data analysis it is a simple matter … This is based on only 4 studies, only two of which were included in the “meta-analysis”.

335. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
     May 08, 2023 - Last year of data used in analysis 2015 or later for original research 6 Study Parameter … We will not conduct a meta-analysis. … Making health care safer: a critical analysis of patient safety practices. … Making Healthcare Safer III: A Critical Analysis of Existing and Emerging Patient Safety Practices. … We will not conduct a meta-analysis.

336. Attention Deficit Hyperactivity Disorder: Effectiveness of Treatment in At-risk Preschoolers; Long-term Effectiveness in All Ages; and Variability in Prevalence, Diagnosis, and Treatment | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/adhd/research-protocol
     December 01, 2019 - A recent meta-analysis estimates prevalence for childhood ADHD world-wide to be 5.29% ( 95% CI 5.01 – … A recent meta-analysis produced a pooled prevalence world wide of 2.5 % (95% CI 2.1-3.1). 5 Over the … The worldwide prevalence of ADHD: a systematic review and metaregression analysis. … Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. … The TEP does not do analysis of any kind nor contribute to the writing of the report.

337. Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/kidney-stones/protocol
     December 01, 2024 - (when available), serum chemistries, and urine analysis for first-time stone formers, with 24-hour urine … If outcomes are quantitatively synthesized, we will conduct a sensitivity analysis excluding studies … Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies … Comparison of four heterogeneity measures for meta-analysis. … Bias in meta-analysis detected by a simple, graphical test.

338. breast-biopsy-update-130920 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
     September 20, 2013 - For KQ 3, we will not perform a meta-analysis but will depict results graphically or in tabular form … The appropriateness of a meta-analysis will be determined before any data analysis; we will not base … We will perform additional sensitivity analyses including leave-one-out meta-analysis, all-subsets meta … Good  research  practices  for  cost-­‐effectiveness  analysis   alongside  clinical   … Chapter  8:  meta-­‐analysis  of  test  performance  when   there  is  a  "gold

339. Nephropathy-Contrast-Induced Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
     October 01, 2013 - The higher risk-of-bias studies could be considered in a sensitivity analysis. 37 . E. … cumulative meta-analysis. … Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. … Meta-analysis: serum creatinine changes following contrast enhanced CT imaging. … Efficacy of short-term high-dose statin in preventing contrast-induced nephropathy: a meta-analysis

340. Disposition of Comments for Progestogens for Prevention of Preterm Birth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
     September 07, 2012 - The review now includes a meta-analysis by indication. … The report includes a full and varied analysis of the use of progestogen, including separate analysis … It would be useful to include these in the overall analysis. … The report includes a full and varied analysis of the use of progestogen, including separate analysis … The review now includes a meta-analysis by formulation.