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281. - (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
     January 01, 2009 - A sub-analysis of the KIMS database. Growth Horm IGF Res 2005;15:349-359. … Sensitivity Analyses: A ‘what if’ analysis that helps determine the robustness of a study. … Statistical Heterogeneity: Variability in the observed effects among studies in a meta-analysis. … Analysis of cystic fibrosis referrals for lung transplantation. … Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis.

282. Making Healthcare Safer IV Rapid Review: Prevention in Adults of Infection With Transmission of Multidrug-Resistant Organisms (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-infection-prevention-mdro-rapid-research.pdf
     April 01, 2024 - We did not conduct a meta-analysis. … reduction in HAI incidence, but this benefit was not seen when the analysis was restricted to only … • A meta-analysis found more anxiety and depression in patients who were in infectious isolation … : A systematic review and meta- analysis. … Making health care safer: a critical analysis of patient safety practices.

283. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - An analysis of claims from one large insurer demonstrated that the most common indication for colorectal … We argue that the retracted study should not be included at all in a meta-analysis. … The determination on the appropriateness of meta-analysis will be made before any data analysis; we … will not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … Network meta-analysis for indirect treatment comparisons. Stat Med 2002 Aug 30;21:2313-24.

284. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
     April 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta-analysis … ); consistency in findings between the new studies and the original meta-analysis (meta-analysis performed … performed if the strength of evidence based on the original meta-analysis was low or insufficient and … Opioids for chronic low back pain management: a Bayesian network meta- analysis. … A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2020 Jun 25;25:25.

285. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/saturated-fat-replacement/protocol
     November 01, 2024 - confounders Analyses of dietary fat as a continuous variable (e.g., RR per g/day intake) without an analysis … be considered to be at moderate risk of bias If there are no major concerns about study design or analysis … and control for potential confounders was conducted with propensity score analysis (or equivalent), … Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report.

286. Making Healthcare Safer IV: Failure to Rescue—Rapid Response Systems | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mhs4-failure-rescue/protocol
     September 01, 2023 - We will not conduct a meta-analysis. … Analysis of Subgroups or Subsets We will perform a sub-group analysis for pediatric … Effects of rapid response systems on clinical outcomes: systematic review and meta-analysis. … Rapid Response Teams: A Systematic Review and Meta-analysis. … Rapid response systems: a systematic review and meta-analysis.

287. Registries for Evaluating Patient Outcomes: A User's Guide: 2nd Edition | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/registries-guide-2nd-edition/research
     October 01, 2019 - Medicaid Services, commissioned a guide to provide practical, scientific advice on the design, operation, analysis … were added on emerging challenges and controversies in registry planning, design, ethics, management, analysis … "Registry Design" (Chapter 3) and "Analysis and Interpretation" (Chapter 13) were reorganized to be more … Health Records (EHRs) Chapter 12: Adverse Event Detection, Processing, and Reporting Chapter 13: Analysis

288. Acs-Pci-Adjunctive-Devices Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
     April 01, 2013 - adverse cardiovascular events (MACE) and coronary dissection were significantly lower in the overall analysis … One new meta-analysis reported better outcomes in patients treated with aspiration thrombectomy than … One new meta-analysis reported no difference in outcomes in patients treated with mechanical thrombectomy … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID: 17638714. 4. … Evidence Table Author, year Study design Comparison Sample size Results Kumbhani, 20136 Meta-analysis

289. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - Their analysis seems to be biased. … , but this analysis was not prespecified. … The result in the ITT analysis was not statistically significant, and while the per-protocol analysis … We further considered the responder analysis, which favored BT, but note that this analysis was not … Analysis of results for the intention-to-treat population found no improvement, but analysis of results

290. Appendicitis Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
     December 09, 2013 - The determination on the appropriateness of meta-analysis will be made before any data analysis. … Meta-analysis of the clinical and laboratory diagnosis of appendicitis. … A meta-analysis. Saudi Med J.2007 Feb;28(2):173-80. [PMID: 17268692] 12. … A Meta-Analysis. Radiology. 2006 Oct;241(1):83- 94. … MR imaging in cases of antenatal suspected appendicitis--a meta-analysis.

291. Topic 0494 Tacrolimus Monitoring and Treatment Renal Transplantation NSD FINAL (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
     March 13, 2013 - Mass Spectrometry versus Immunoassay: In renal transplants, does mass from Nominator: spectrometric analysis … and therapeutic monitoring of tacrolimus as compared with immunoassay analysis and therapeutic monitoring … monitoring of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus, how does mass spectrometric analysis … compare with immunoassay analysis for: 1) organ survival, 2) acute and long-term rejections, 3) nephrotoxicity

292. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorder | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/disruptive-behavior-disorder/research-protocol
     December 01, 2019 - We will examine the appropriateness of each study for inclusion in a meta-analysis. … The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … I: A meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. … the analysis, reporting, and claim of subgroup effects in randomized trials.

293. Diabetes-Behavior-Programs Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_research-protocol.pdf
     June 05, 2014 - Meta-analysis: chronic disease self-management programs for older adults. … Behavioural interventions for type 2 diabetes: an evidence- based analysis. … Diabetes patient education: a meta-analysis and meta- regression. … Random effects meta-analysis of inconsistent effects: a time for change. … Quantifying heterogeneity in a meta-analysis. Stats Med. 2002;21(11):1539-58.

294. Executive Summary_Systematic Review: Association of Digestible Carbohydrate Intake With Cardiovascular Disease, Type 2 Diabetes, Obesity, and Body Composition (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-executive-summary.pdf
     March 01, 2025 - The linear dose-response meta-analysis showed a significant association between the risk of incident … Subgroup Analysis Based on Sex and Geographic Location We found no significant linear dose-response … • Dose-response meta- analysis also showed nonsignificant associations. … Subgroup Analysis Based on Sex and Geographic Location We found similar U-shaped nonlinear dose-response … is important to acknowledge the limitations of study-level meta-regression and dose-response meta- analysis

295. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/transparency-neuropathy/research-protocol
     June 01, 2021 - Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted results

296. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
     March 01, 2012 - These two studies provided a small amount of events to the overall analysis as well. … For example,“KQ3 (analysis of covariates) Although we agree this would help to remind the reader … Was meta-analysis of subgroup data, estimates of association, or meta-regression not possible? … Additionally, the design and results of each review/analysis were reviewed to make comparisons with … Peer Reviewer #3 Results This sensitivity analysis on good trials, instead, should have been graded

297. Calcineurin_Inhibitors_Protocol_FINAL_10-07-2014 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
     October 08, 2014 - 15.3 years for living donor transplants in 2009-2010.2 Survival rates continue to improve; a recent analysis … Decisions about whether meta-analysis is appropriate will depend on the judged clinical homogeneity … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Validity of statistical analysis and reporting adequacy: Was the statistical analysis performed appropriately

298. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - Whether to use it in an analysis as rigorous as the current study is questionable. … This meta-analysis should be shown. … This analysis has real validity issues and should be either redone or removed. … We also changed the analysis to use the adjusted or propensity-scored HRs in the meta- analysis to reduce … Unfortunately, we do not have individual patient-level data available for analysis.

299. Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients Wtih Kidney Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
     August 11, 2014 - We decided to keep the meta- analysis figures sorted by cutpoints but mentioned the lack of temporal … The data analysis and synthesis are appropriate for this type of meta-analysis. … Therefore a meta-analysis could have been conducted with the limitations cited. … The number of subjects enrolled in to each trial could also be shown in the meta-analysis. … We do not think a cumulative meta-analysis will help to address our Key Questions.

300. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
     September 01, 2016 - any) Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … of pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary out- … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted