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    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
    January 01, 2009 - A sub-analysis of the KIMS database. Growth Horm IGF Res 2005;15:349-359. … Sensitivity Analyses: A ‘what if’ analysis that helps determine the robustness of a study. … Statistical Heterogeneity: Variability in the observed effects among studies in a meta-analysis. … Analysis of cystic fibrosis referrals for lung transplantation. … Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-infection-prevention-mdro-rapid-research.pdf
    April 01, 2024 - We did not conduct a meta-analysis. … reduction in HAI incidence, but this benefit was not seen when the analysis was restricted to only … • A meta-analysis found more anxiety and depression in patients who were in infectious isolation … : A systematic review and meta- analysis. … Making health care safer: a critical analysis of patient safety practices.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
    March 26, 2013 - An analysis of claims from one large insurer demonstrated that the most common indication for colorectal … We argue that the retracted study should not be included at all in a meta-analysis. … The determination on the appropriateness of meta-analysis will be made before any data analysis; we … will not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … Network meta-analysis for indirect treatment comparisons. Stat Med 2002 Aug 30;21:2313-24.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
    April 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta-analysis … ); consistency in findings between the new studies and the original meta-analysis (meta-analysis performed … performed if the strength of evidence based on the original meta-analysis was low or insufficient and … Opioids for chronic low back pain management: a Bayesian network meta- analysis. … A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2020 Jun 25;25:25.
  5. effectivehealthcare-admin.ahrq.gov/products/saturated-fat-replacement/protocol
    November 01, 2024 - confounders Analyses of dietary fat as a continuous variable (e.g., RR per g/day intake) without an analysis … be considered to be at moderate risk of bias If there are no major concerns about study design or analysis … and control for potential confounders was conducted with propensity score analysis (or equivalent), … Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort … Technical Experts do not do analysis of any kind nor do they contribute to the writing of the report.
  6. effectivehealthcare-admin.ahrq.gov/products/mhs4-failure-rescue/protocol
    September 01, 2023 - We will not conduct a meta-analysis. … Analysis of Subgroups or Subsets We will perform a sub-group analysis for pediatric … Effects of rapid response systems on clinical outcomes: systematic review and meta-analysis. … Rapid Response Teams: A Systematic Review and Meta-analysis. … Rapid response systems: a systematic review and meta-analysis.
  7. effectivehealthcare-admin.ahrq.gov/products/registries-guide-2nd-edition/research
    October 01, 2019 - Medicaid Services, commissioned a guide to provide practical, scientific advice on the design, operation, analysis … were added on emerging challenges and controversies in registry planning, design, ethics, management, analysis … "Registry Design" (Chapter 3) and "Analysis and Interpretation" (Chapter 13) were reorganized to be more … Health Records (EHRs) Chapter 12: Adverse Event Detection, Processing, and Reporting Chapter 13: Analysis
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
    April 01, 2013 - adverse cardiovascular events (MACE) and coronary dissection were significantly lower in the overall analysis … One new meta-analysis reported better outcomes in patients treated with aspiration thrombectomy than … One new meta-analysis reported no difference in outcomes in patients treated with mechanical thrombectomy … A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. PMID: 17638714. 4. … Evidence Table Author, year Study design Comparison Sample size Results Kumbhani, 20136 Meta-analysis
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
    December 14, 2017 - Their analysis seems to be biased. … , but this analysis was not prespecified. … The result in the ITT analysis was not statistically significant, and while the per-protocol analysis … We further considered the responder analysis, which favored BT, but note that this analysis was not … Analysis of results for the intention-to-treat population found no improvement, but analysis of results
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
    December 09, 2013 - The determination on the appropriateness of meta-analysis will be made before any data analysis. … Meta-analysis of the clinical and laboratory diagnosis of appendicitis. … A meta-analysis. Saudi Med J.2007 Feb;28(2):173-80. [PMID: 17268692] 12. … A Meta-Analysis. Radiology. 2006 Oct;241(1):83- 94. … MR imaging in cases of antenatal suspected appendicitis--a meta-analysis.
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
    March 13, 2013 - Mass Spectrometry versus Immunoassay: In renal transplants, does mass from Nominator: spectrometric analysis … and therapeutic monitoring of tacrolimus as compared with immunoassay analysis and therapeutic monitoring … monitoring of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus, how does mass spectrometric analysis … compare with immunoassay analysis for: 1) organ survival, 2) acute and long-term rejections, 3) nephrotoxicity
  12. effectivehealthcare-admin.ahrq.gov/products/disruptive-behavior-disorder/research-protocol
    December 01, 2019 - We will examine the appropriateness of each study for inclusion in a meta-analysis. … The specific meta-analysis or meta-regression will depend on the data available. … for variables where it makes sense to do so, or subgroup analysis (with random effects meta-analysis … I: A meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. … the analysis, reporting, and claim of subgroup effects in randomized trials.
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_research-protocol.pdf
    June 05, 2014 - Meta-analysis: chronic disease self-management programs for older adults. … Behavioural interventions for type 2 diabetes: an evidence- based analysis. … Diabetes patient education: a meta-analysis and meta- regression. … Random effects meta-analysis of inconsistent effects: a time for change. … Quantifying heterogeneity in a meta-analysis. Stats Med. 2002;21(11):1539-58.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-executive-summary.pdf
    March 01, 2025 - The linear dose-response meta-analysis showed a significant association between the risk of incident … Subgroup Analysis Based on Sex and Geographic Location We found no significant linear dose-response … • Dose-response meta- analysis also showed nonsignificant associations. … Subgroup Analysis Based on Sex and Geographic Location We found similar U-shaped nonlinear dose-response … is important to acknowledge the limitations of study-level meta-regression and dose-response meta- analysis
  15. effectivehealthcare-admin.ahrq.gov/products/transparency-neuropathy/research-protocol
    June 01, 2021 - Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted results
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
    March 01, 2012 - These two studies provided a small amount of events to the overall analysis as well. … For example,“KQ3 (analysis of covariates) Although we agree this would help to remind the reader … Was meta-analysis of subgroup data, estimates of association, or meta-regression not possible? … Additionally, the design and results of each review/analysis were reviewed to make comparisons with … Peer Reviewer #3 Results This sensitivity analysis on good trials, instead, should have been graded
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
    October 08, 2014 - 15.3 years for living donor transplants in 2009-2010.2 Survival rates continue to improve; a recent analysis … Decisions about whether meta-analysis is appropriate will depend on the judged clinical homogeneity … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Validity of statistical analysis and reporting adequacy: Was the statistical analysis performed appropriately
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
    January 01, 2014 - Whether to use it in an analysis as rigorous as the current study is questionable. … This meta-analysis should be shown. … This analysis has real validity issues and should be either redone or removed. … We also changed the analysis to use the adjusted or propensity-scored HRs in the meta- analysis to reduce … Unfortunately, we do not have individual patient-level data available for analysis.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
    August 11, 2014 - We decided to keep the meta- analysis figures sorted by cutpoints but mentioned the lack of temporal … The data analysis and synthesis are appropriate for this type of meta-analysis. … Therefore a meta-analysis could have been conducted with the limitations cited. … The number of subjects enrolled in to each trial could also be shown in the meta-analysis. … We do not think a cumulative meta-analysis will help to address our Key Questions.
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - any) Population Total enrollment, sample size in each arm, drop-outs Participants included in analysis … of pre-specified primary outcomes, number of primary outcomes Description of secondary outcome Analysis … Description of the pre-specified statistical analysis plan Results of primary and secondary out- … If a meta-analysis is possible, sensitivity analysis, running analysis with and without the information … Notably, according to an analysis by Zarin and colleagues, out of 2178 clinical trials with posted

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