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241. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - Thank you for pointing us to the meta-analysis by Holmes et al. … The individual patient data meta-analysis by Brar et al. … We realize that this analysis also assumes a dominant genetic model. … In addition, although no meta-analysis is done, it looks to the naked eye as if a meta-analysis would … An analysis to determine the robustness of cutoff selection was performed in a meta‐ analysis of patient‐level

242. Meditation Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
     October 17, 2012 - • Was intent-to-treat analysis used? … Mindfulness-based stress reduction and cancer: a meta-analysis. Psychooncology. … Use and avoidance of continuity corrections in meta-analysis of sparse data. … This is not a statistical analysis, but rather a way to visually display the data. … We will also conduct a sensitivity analysis of this analysis by reversing the prioritization order

243. Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cancer-ovarian-contraceptives/research
     December 01, 2019 - with persistent human papillomavirus infection who used OCs, but heterogeneity prevented a formal meta-analysis … Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis … Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis … contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis

244. Methods Guide for Medical Test Reviews Chapter 12 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
     July 01, 2012 - A meta-analysis could provide more precise estimates of outcome probabilities. … A meta-analysis of randomized control trials. Circulation 1990;82(4):1106-16. 24. … Anemia and mortality in heart failure patients: a systematic review and meta-analysis. … Decision curve analysis: a novel method for evaluating prediction models. … Meta- analysis of summary survival curve data.

245. Disposition of Comments: Comparative Effectiveness Review No. 239: Acute Treatments for Episodic Migraine (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-239-episodic-migraine-comments.pdf
     December 29, 2020 - A meta-analysis that included 6 trials revealed that IN lidocaine reduced pain intensity at 5 minutes … “Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials.” … A relevant meta-analysis found that IV Mg reduces acute migraine attacks within 15 - 45 minutes, 120 … Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled

246. | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/research-methods/tools-and-software
     April 02, 2019 - SRDR+) Abstract February 11, 2014 mmeta: Exact Bayesian Inference for Multivariate Meta-analysis … Screening Abstract February 23, 2012 OpenMetaAnalyst: Powerful Open-Source Software for Meta-Analysis

247. The Effectiveness of Indoor Allergen Reduction and the Role of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
     October 04, 2016 - Decisions about whether meta-analysis is appropriate will depend on the judged clinical homogeneity … using the Hartung-Knapp method.18,19 Meta-regression and subgroup analysis will be used to explore … A refined method for the meta-analysis of controlled clinical trials with binary outcome. … Random-effects meta-analysis of inconsistent effects: a time for change. … Technical Experts do not do analysis of any kind nor do they contribute to writing the report.

248. Quantitative Synthesis—An Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-quantitative-synthesis-update/methods
     December 01, 2019 - We focus on interventional studies and do not address diagnostic studies, individual patient level analysis … , or observational studies, which are addressed elsewhere. 4 Quantitative synthesis, or meta-analysis … The guide is not meant to be a textbook on meta-analysis nor is it a comprehensive review of methods, … In addition, several steps in meta-analysis require subjective judgment, such as when combining studies … describes an indirect evidence technique that has not been included in previous guidance—network meta-analysis

249. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - Life cycle analysis (LCA) provides a pathway to evaluate products, processes, and procedures within … A limitation in the analysis may be unknown associated impacts at various points from cradle to grave … What data sources, measures/indicators, and methods were used in the analysis? iii. … The technical brief will provide a trend analysis showing the interest in LCAs over time. … LCA data quality: sensitivity and uncertainty analysis.

250. The Effect of Protein Intake on Health | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/effect-protein-intake/protocol
     December 01, 2023 - . 36 When meta-analysis is not possible, we will provide a qualitative synthesis. … ) 37 random effects model in Comprehensive Meta-Analysis version 3 (Biostat, Englewood, New Jersey) … If meta-analysis is not possible, we will present results in a narrative Summary of Findings table. … Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis. … Meta-Analysis with R. 2015. Higgins JP, Thompson SG, Deeks JJ, Altman DG.

251. Evaluation and Treatment of Tinnitus: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/tinnitus/research-protocol
     December 01, 2019 - If clinical groups are too heterogeneous to permit meta-analysis, a separate qualitative analysis will … Were the statistical analysis methods described and appropriate? … Analysis The statistical analysis is appropriate for the design of the study. … Statistical analysis Were potential confounders measured and adequately addressed in the analysis … Was the statistical analysis described?

252. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol-amendment.pdf
     September 19, 2023 - We will not conduct a meta- analysis. … Analysis of Subgroups or Subsets We will perform a sub-group analysis for pediatric patients and adults … Effects of rapid response systems on clinical outcomes: systematic review and meta-analysis. … Rapid Response Teams: A Systematic Review and Meta-analysis. … Rapid response systems: a systematic review and meta-analysis.

253. Management of Suicidal Thoughts and Behaviors in Youth | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/suicidal-thoughts-youth/protocol
     February 01, 2025 - A recent meta-analysis of 30 randomized controlled trials of psychosocial interventions compared with … reviews, editorials, letters, or erratum), Cross-sectional (i.e., nonlongitudinal) studies Subgroup analysis … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the same … If a meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Technical Experts do not do analysis of any kind; neither do they contribute to the writing of the report

254. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
     February 05, 2025 - A recent meta- analysis of 30 randomized controlled trials of psychosocial interventions compared with … We will determine whether meta-analysis is appropriate (i.e., more than two studies address the same … If a meta-analysis is deemed appropriate, we plan to use the DerSimonian and Laird random-effects method … Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few … Technical Experts do not do analysis of any kind; neither do they contribute to the writing of the report

255. Smoking Cessation Interventions in Pregnancy and Postpartum Care | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/smoking-pregnancy-infants/research
     December 01, 2019 - A meta-analysis of effectiveness data assessed relative impact of components in smoking cessation interventions … In the meta-analysis, incentives demonstrated the strongest effect; other components with a greater than … Jun 02, 2023 Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-analysis

256. Treatment of Depression During Pregnancy and the Postpartum Period | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-pregnancy-postpartum/research-protocol
     December 01, 2019 - To determine the appropriateness of meta-analysis, the quality of the studies and the heterogeneity among … Appropriate measures will be chosen based on the type of data for meta-analysis. … Quantifying heterogeneity in a meta-analysis. … Methods for Meta-Analysis in Medical Research. … Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have

257. Interventions to Decrease Hospital Length of Stay | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hospital-length-of-stay/protocol
     August 01, 2020 - In addition to published literature, what unpublished resources could help inform our analysis? … Key Informants do not do analysis of any kind nor contribute to the writing of the report and will not … '/de OR (systematic* NEAR/2 review*) OR metaanalysis OR 'meta analysis' OR Cochrane) 15 Limit … '/de OR (systematic* NEAR/2 review*) OR metaanalysis OR 'meta analysis' OR Cochrane) 19 Limit … '/de OR (systematic* NEAR/2 review*) OR metaanalysis OR 'meta analysis' OR Cochrane) 27 Remove

258. Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/psoriasis-chronic/research-protocol
     December 01, 2019 - In 2008, Schmitt and colleagues published a meta-analysis analyzing the efficacy and tolerability of … Based on the results of their meta-analysis, the authors concluded that the efficacy of systemic agents … The biases may arise from serious errors in conduct, analysis or reporting, large amounts of missing … We will conduct sensitivity analysis limiting the analysis to only trials rated as good quality. … Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. PMID: 3802833.

259. Disposition of Comments for Evidence Report 221 Behavioral Programs for Diabetes Mellitus (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_disposition-comments.pdf
     September 28, 2015 - General This report describes the process and findings of an extensive systematic review and meta-analysis … For example, in the results section for the ethnicity subgroup analysis in the Executive summary we … We have added the findings for inconsistency for the network meta-analysis to the results section, “ … A consistency analysis was performed for the HbA1c analysis and it was found that only two quadratic … We did run a sensitivity analysis where we thinned the MCMC to every 10th iteration.

260. Multiple Myeloma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/multiple-myeloma
     September 19, 2012 - Products Systematic Review Archived September 19, 2012 Serum Free Light Chain Analysis … Research Needs Systematic Review Archived August 23, 2012 Serum Free Light Chain Analysis … Plasma Cell Dyscrasias Research Protocol Archived May 2, 2011 Serum-Free Light Chain Analysis