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161. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/data-extraction.ppt
     January 01, 2009 - Meta-analysis: combining the results of independent experiments. … Berlin J, for the University of Pennsylvania Meta-analysis Blinding Study Group. … Does blinding of readers affect the results of meta-analysis? Lancet 1997;350:185-6. … Does blinding of readers affect the results of meta-analysis? Lancet 1997;350:185-6. … Meta-analysis: combining the results of independent experiments.

162. Methods-Balancing-Harms-Benefits Research-2012 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
     January 01, 2012 - decision analysis approach. … Benefit-Less-Risk Analysis Benefit-less-risk analysis (BLRA) combines benefit and harm into a single … Multicriteria Decision Analysis Multicriteria decision analysis allows for systematic decisionmaking … Probabilistic analysis and sensitivity analysis are two examples of quantitative approaches that reviewers … Studies included in a network meta-analysis should be, as in any conventional meta-analysis, comparable

163. Chapter 12: Systematic Review of Prognostic Tests | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-prognostic/methods
     December 01, 2019 - A meta-analysis could provide more precise estimates of outcome probabilities. … A meta-analysis of randomized control trials. Circulation 1990;82(4):1106-16. … Anemia and mortality in heart failure patients: a systematic review and meta-analysis. … Decision curve analysis: a novel method for evaluating prediction models. … Meta-analysis of summary survival curve data. Stat Med 2008;27(22):4381-96.

164. Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/liver-cancer/research
     December 01, 2019 - studies was assessed, data were extracted, and results were summarized quantitatively (through meta-analysis … Analyses were stratified by imaging type and unit of analysis (patient or HCC lesion). … settings, based on studies that directly compared imaging modalities and using HCC lesions as the unit of analysis … sensitivity included use of explanted liver as the reference standard, use of HCC lesions as the unit of analysis … Imaging techniques for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis

165. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
     June 16, 2010 - Study and Independent Patient Level Meta-Analysis Selection: Results from study- and patient-level meta-analysis … Did the analysis include an intention-to-treat analysis? … The hazards of scoring the quality of clinical trials for meta-analysis. … meta: Meta-Analysis, R package version 1.5-0. 55. R Development Core Team. 2010. … metafor: Meta-Analysis Package for R. R package version 1.1-0.

166. Gout Dx protocol_140715-draft (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
     January 01, 2014 - However, use of the gold standard synovial fluid analysis for diagnosis of gout is difficult and seldom … In fact, evidence from a 2011 survey of rheumatologists suggests that SF analysis is underused in the … Studies will also be included if they compare the accuracy of synovial fluid aspiration and analysis … Comparators will be microscopic synovial fluid analysis. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.

167. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
     November 19, 2009 - Decision analysis is a natural framework to assess such tradeoffs. … How to use a clinical decision analysis. B. … Meta- analysis of diagnostic tests with imperfect reference standards. … Regression methods for meta-analysis of diagnostic test data. … Endoscopic colorectal cancer screening: a cost-saving analysis.

168. Disposition of Comments Report for Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
     June 07, 2013 - It may be of interest to include analysis comparing those who are nullipara to those who have been … Narod study-- included in the table but excluded from meta analysis?) … This seems like a reasonable exploratory analysis potentially? … Our systematic review incorporates a meta-analysis of published data rather than a pooled analysis or … individual patient-level meta-analysis.

169. App-F-Surv-Rept-1-Acute-Pain (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-f-surv-rept-1-acute-pain.xlsx
     September 21, 2022 - Intention-to-Treat Analysis? Post-Randomization Exclusions? Outcomes Prespecified? … Yes Yes Yes Yes No/No No No Yes Fair Desjardins, 2020 Yes Yes Yes Yes Yes Yes Yes No/No Yes; full analysis

170. Decision-Analytic Modeling to Evaluate Benefits and Harms of Medical Tests – Uses and Limitations | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/benefits-harms-modeling/research
     November 01, 2017 - Decision analysis is a natural framework to assess such tradeoffs. … How to use a clinical decision analysis. B. … Meta-analysis of diagnostic tests with imperfect reference standards. … Regression methods for meta-analysis of diagnostic test data. … Endoscopic colorectal cancer screening: a cost-saving analysis.

171. Microsoft Word - ehcrr#2toCSI.doc (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
     August 01, 2007 - We restricted the analysis to just APM initiators to guard against selection bias among prevalent users … A multivariable analysis of the mortality difference estimated an increase of 3.5 per 100 (95% CI: 2.7 … Analysis using instrumental variables. … Sensitivity analysis of the observed association between conventional APM use and death. … year adjusted analysis of death within 180 days 1.11 (1.04-1.19) Multivariable adjusted analyses of

172. Topic Brief: Interventions to Decrease Hospital Length of Stay (pdf file)
     effectivehealthcare-admin.ahrq.gov/system/files/docs/topic-brief-hospital-length-of-stay.pdf
     November 01, 2019 - Enhanced Recovery after Bariatric Surgery: Systematic Review and Meta-Analysis. … and Trial Sequential Analysis of Evidence. … : A Systematic Review and Meta-analysis of Major Abdominal Surgery. … Traditional vs ERAS radical cystectomy: systematic review, meta- analysis and trial sequential analysis … No subgroup analysis is planned. • Processes. Two reviews looked at healthcare processes.

173. Comparative Effectiveness of Pharmacologic Therapies for the Management of Crohn’s Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/crohns-disease/research-protocol
     December 01, 2019 - Because of the recent high quality meta-analysis focused on treatment options after surgical resection … A sensitivity analysis will include study populations with all levels of disease severity. … A sensitivity analysis will include study populations with all levels of disease severity. … The TEP does not do analysis of any kind nor contribute to the writing of the report. … Sensitivity analysis for KQ3 will include inflammatory bowel disease not specified.

174. First and Second Generation Antipsychotics for Children and Young Adults-Comparative Effectiveness Review Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children-update/research-protocol
     April 01, 2020 - ), the type of analysis (e.g., subgroup/stratified or regression analysis), the outcomes assessed (dependent … versus usual care) through standard meta-analysis, a network meta-analysis allows for simultaneous evaluation … Chapter 9: Analyzing data and undertaking meta-analysis. … Bayesian methods in meta-analysis and evidence synthesis. … to network meta-analysis.

175. Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/major-depressive-disorder/research-protocol
     December 01, 2019 - (i.e., meta-analysis) of the data from those studies. … We will also examine potential sources of heterogeneity using sensitivity analysis or analysis of subgroups … Antidepressant drug effects and depression severity: a patient-level meta-analysis. … Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. … Brief psychotherapy for depression: a systematic review and meta-analysis.

176. RESPONSE TO REQUEST FOR WORK ASSIGNMENT (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
     December 01, 2009 - A recent meta-analysis showed an increased risk of cardiovascular mortality,17 while this meta-analysis … This resulted in 17 medication regimens included in the analysis. … Only in the analysis in which patients with baseline hospitalizations were excluded did we not find … Tiotropium for stable chronic obstructive pulmonary disease: A meta- analysis. … Pooled clinical trial analysis of tiotropium safety. Chest 2006 Dec;130(6):1695-703. 20.

177. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
     December 01, 2019 - We argue that the retracted study should not be included at all in a meta-analysis. … The determination on the appropriateness of meta-analysis will be made before any data analysis; we … will not base the decision to perform meta-analysis on statistical criteria for heterogeneity. … Network meta-analysis for indirect treatment comparisons. Stat Med 2002 Aug 30;21:2313-24. … Meta-analysis in clinical trials. Control Clin Trials 1986 Sep;7(3):177-88. PMID: 3802833.

178. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
     December 01, 2024 - Our analysis identified important discrepancies in effect sizes, with meta-analyses of both published … The third study (#29060/627) yielded mixed (equivocal) results: the intent-to-treat analysis using the … and responder analysis using CGI-I did not show significant associations. … a Statistically significant benefit shown in the LOCF analysis of CAPS-2 score but not in the observed … case analysis of CAPS score or in CGI-I responder analysis.

179. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
     July 13, 2011 - For example, in a sensitivity analysis of a meta-analysis on the risk of nausea and vomiting during … : no limit For qualitative analysis: n ≥ 40 Key Question 2a: Maintenance of remission Study … A “poor” rating indicates significant bias (e.g., stemming from serious errors in design or analysis … (meta-analysis) of data from those studies. … The TEP does not do analysis of any kind nor contribute to the writing of the report. X.

180. The Effect of Protein Intake on Health (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-protein-intake-protocol-amendment.pdf
     November 29, 2023 - .36 When meta-analysis is not possible, we will provide a qualitative synthesis. … When meta-analysis is possible, we will synthesize data using a Hartung, Knapp, Sidik, and Jonkman … If meta-analysis is not possible, we will present results in a narrative Summary of Findings table. … Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis. … Meta-Analysis with R. 2015. 39. Higgins JP, Thompson SG, Deeks JJ, Altman DG.