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121. Disposition of Comments Report for Comparative Effectiveness Review 128 Oral Mechanical Bowel Preparation for Colorectal Surgery (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
     April 30, 2014 - Peer Reviewer #5 Methods The choice of odds-ratio as the unit of analysis is acceptable. … stratified analysis). … The network analysis is presented in detail but is not a valid comparison. … We have removed the recommendation for decision analysis or decision aids. … A statistical reviewer has reviewed the analysis methods.

122. Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/nephropathy-contrast-induced/clinician
     December 01, 2019 - or qualitative synthesis of studies when meta-analysis was not performed: ↓ = decreased; ↔ = no … c Twenty-three studies were included in the meta-analysis. … d Seventeen studies were included in the meta-analysis. … or qualitative synthesis of studies when meta-analysis was not performed: ↓ = decreased; ↑ = increased … f Three studies were included in the meta-analysis.

123. Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
     August 01, 2016 - c Twenty-three studies were included in the meta-analysis. … d Seventeen studies were included in the meta-analysis. … or qualitative synthesis of studies when meta-analysis was not performed: ⬇ = decreased; ⬆ = increased … e One study included in this meta-analysis compared a statin + sodium bicarbonate + IV saline versus … f Three studies were included in the meta-analysis.

124. Disposition of Comments Report for CER 207 on PTSD (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-207-ptsd-disposition-comments.pdf
     May 17, 2018 - Random-effects meta-analysis of inconsistent effects: a time for change. … But not as much as a sensitivity analysis would. … The network meta-analysis results must be interpreted with caution as indicated in the report. … ) on the validity of the network meta- analysis. … (or of diagnostics) on the validity of the network meta- analysis.

125. Outcomes Associated With Tiotropium use in Chronic Obstructive Pulmonary Disease Patients | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/copd-anticholinergic-medicines/research
     January 01, 2020 - A recent meta-analysis showed an increased risk of cardiovascular mortality, 17 while this meta-analysis … This resulted in 17 medication regimens included in the analysis. … Analysis Analyses were done separately for each outcome. … Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis. … Pooled clinical trial analysis of tiotropium safety. Chest 2006 Dec;130(6):1695-703. 20.

126. Summary Variables in Observational Research: Propensity Scores and Disease Risk Scores | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/observational-research-scores/research
     January 01, 2019 - Study design options include restriction and matching, while analysis options include stratification, … the analysis is a restriction, matching, stratification, regression adjustment, or weighting. … Figure 5 is a presentation of the results of matched analysis. … This type of study poses several challenges for statistical analysis. … Otherwise, it is used in the regression analysis.

127. An Ethical Framework for N-of-1 Trials: Clinical Care, Quality Improvement, or Human Subjects Research? (Chapter 2) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/n-1-trials/research-2014-3
     August 01, 2019 - If a researcher later includes this case in a secondary aggregate analysis, it exemplifies Model C . … Study Delivery System + Secondary Analysis (Model D) The more challenging case to be made to an IRB … or meta-analysis with expedited review. … Model C: Clinical care with secondary analysis – expedited IRB approval sought for secondary analysis … Prospective consent for secondary data analysis is preferred whenever possible.  

128. Quantitative Synthesis: Chapter 2. Presenting Different Effects for Different Data Types (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
     February 01, 2018 - • Recognize common measures of association for meta-analysis (e.g., risk difference, odds ratio … Learning Objective Outcomes and effect measures • Methods for meta-analysis depend on the outcome … to calculate binary effect sizes will be published and the data can be analyzed using statistical analysis … • The data needed for analysis can be presented in this way: Binary outcomes • Every effort should … • The selection of the preferred relative effect measure depends on the specific meta-analysis.

129. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
     March 10, 2010 - Methods Adding NNT or NNH to the analysis may make it better to understand the effect. … While the authors should be applauded for their meticulous and exhaustive data collection analysis, … Maybe sensitivity analysis could help here. Thank you for this comment. … Results In this analysis, ACEI or ARB did not reduce the incidence of Afib. … The prior mentioned meta-analysis differs from our report in several notable ways.

130. Systematic Review on Treatments for Acute Pain: Surveillance Report 3 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-3-acute-pain.pdf
     June 01, 2022 - (meta-analysis performed if new evidence was large relative to the studies in the original meta- analysis … ); consistency in findings between the new studies and the original meta-analysis (meta- analysis performed … and a trial sequential analysis. … Effect of preemptive acetaminophen on opioid consumption: a meta-analysis. … Meta-analysis Results Figure G-1.

131. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
     June 22, 2017 - REML is one of the preferred methods for meta-analysis. … Direct factor Xa inhibitors (FXaI) were not available at the time of the pooled analysis. … Peer Reviewer #4 Results Page 37, subgroup analysis: p < 0.03? P <0.20? … If this is mislabeled, then the analysis of Mechanical vs. … The network meta-analysis is especially useful.

132. Omega-3 Fatty Acids and Maternal and Child Health: An Update (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
     October 01, 2016 - Forest plots were provided for random effects meta-analysis. … An alternative method for meta-analysis. Biometrical Journal. 1999;41(8):901-16. … Robust variance estimation for random effects meta-analysis. … Computational Statistics & Data Analysis. 2006;50(12):3681-701. 14. … Confidence intervals for the overall effect size in random-effects meta-analysis.

133. Comparative Effectiveness of Second Generation Antidepressants in the Pharmacologic Treatment of Adult Depression – An Update to a 2007 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antidepressants-update/research-protocol
     December 01, 2019 - For example, in a sensitivity analysis of a meta-analysis on the risk of nausea and vomiting during treatment … : no limit For qualitative analysis: n ≥ 40 Key Question 2a : Maintenance of … A “poor” rating indicates significant bias (e.g., stemming from serious errors in design or analysis) … (meta-analysis) of data from those studies. … The TEP does not do analysis of any kind nor contribute to the writing of the report.

134. Peripheral Nerve Blocks for Postoperative Pain Management in Cardiothoracic Surgery (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/peripheral-nerve-block-protocol.pdf
     November 18, 2023 - Transversus Abdominis Plane Block for Post Hysterectomy Pain: A Systematic Review and Meta-Analysis. … with trial sequential analysis. … BOPv1U Review and Meta-Analysis. AANA J. 2023;91(6):455-463. 49. … and trial sequential analysis. … Technical Experts do not conduct analysis or contribute to the writing of the report.

135. Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Report 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
     June 01, 2022 - Placebo, subgroup analysis by age No study in the original report evaluated this subgroup. … Real- world data analysis of REN treatment in migraine patients. … Acute treatments for episodic migraine in adults: a systematic review and meta-analysis. … Subgroup Analysis Table H-1. … Subgroup Analysis Appendix I. Appendix References

136. Clopidogrel after Drug-Eluting Stent Implantation: Is current practice sufficient (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
     March 01, 2009 - Landmark Analyses Based on Clopidogrel Use Landmark analysis is a form of survival analysis that classifies … For the 12-month landmark analysis, patients with PCI procedures occurring after July 31, 2004 were … Limitations There are two important caveats to this analysis. … Statistical analysis: Eisenstein, Anstrom, Shaw, Tuttle. … Analysis of survival by tumor response. Journal of Clinical Oncology 1983;1:710-719. 13.

137. Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prevent-hai-draft-report.pdf
     January 16, 2025 - For the analysis, authors used SimaPro 9.5.0.1. … in this analysis is complete and well-documented. … Methods for this analysis were documented well. … A systematic review and cost effectiveness analysis of reusable vs. … Reusable versus disposable surgical drapes: A cost-benefit analysis.

138. Instrumental Variable Methods in Comparative Safety and Effectiveness Research | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/instrumental-variable-methods/research
     January 01, 2019 - Such an analysis can help to identify the ‘marginal patients.’ … Here, one might consider using the IV in a secondary or sensitivity analysis. … Analysis using instrumental variables. JAMA 1994;272:859-866. 26. … IV as a Secondary Analysis. … may be useful as a confirmatory or secondary analysis.

139. Behavioral Programs for Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/diabetes-behavior-programs/research-protocol
     December 01, 2019 - Meta-analysis: chronic disease self-management programs for older adults. … Behavioural interventions for type 2 diabetes: an evidence-based analysis. … Diabetes patient education: a meta-analysis and meta-regression. … A simple confidence interval for meta-analysis. Stats Med. 2002;21:3153-59. … Random effects meta-analysis of inconsistent effects: a time for change.

140. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - Results The literature search revealed 29 RCTs for summary and analysis and 10 observational studies … When the analysis was stratified by route of administration, the pooled risk ratio was 0.80 (95% CI … However, a recent meta-analysis of RCTs comparing IOCM and LOCM that included such studies found no … As mentioned above, one study was a network meta- analysis that pooled all outcomes without focusing … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. PMID: 3802833. 9.