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321. Evidence Summary: Breast Cancer: Medication Use to Reduce Risk | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-cancer-medications-for-risk-reduction
     September 03, 2019 - by using a profile likelihood random-effects model to account for variation among studies. 15 All analyses … For outcomes of major adverse events, analyses were stratified by active vs posttreatment periods, although … Estimates used combined RRs from the meta-analyses and combined event rates from placebo groups of included … invasive breast cancer risk (RR, 0.83 [95% CI, 0.42-1.62]; n = 1884) and was not included in the meta-analyses … Consequently, they were not included in the meta-analyses of raloxifene trials.

322. Screening for Chronic Obstructive Pulmonary Disease: Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/BhnZRA--TRpXdg9_tYmZ_M
     April 05, 2016 - Given the clinical heterogeneity of studies, meta-analyses were not conducted for any of the questions … (Table 6).44-46,50,51,53-55 ICS One trial of patients with mild to moderate COPD, 2 post hoc sub- analyses … tiotropium in patients naive to mainte- nance treatment with moderate COPD (n = 457)55 and 4 subgroup analyses … Furthermore, there were a number of limitations in the in- cluded subgroup analyses for all classes of … However, the treatment literature was largely limited to subgroup analyses, al- most exclusively among

323. Archived: Evidence Summary: Human Immunodeficiency Virus (HIV) Infection: Screening, 2005 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/human-immunodeficiency-virus-hiv-infection-screening-2005
     July 05, 2005 - Agency staff and USPSTF members participated in the initial design of the study and reviewed interim analyses … Cost-effectiveness analyses Good Two good-quality cost-effectiveness analyses found that the cost-effectiveness … In addition, intention-to-treat analyses of clinical outcomes incorporate the effects of intolerable … We also included cost-effectiveness analyses of HIV screening in outpatient settings in the HAART era … Are appropriate sensitivity analyses performed?

324. Xt2Uhv4Qyluz8O2Hb A4Yq (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/xt2Uhv4qyLUZ8o2HB_a4YQ
     July 01, 2013 - For policy context, however, the USPSTF reviewed some cost- effectiveness analyses published since its … These analyses, which include downstream costs, support the cost-effectiveness of HIV screening in settings … Subsequent analyses from the DAD study (36–38) and other cohort studies (39, 40) also report cardiovascular … recommen- dation statement now includes a brief summary of its con- textual review of cost-effectiveness analyses

325. Archived: Carotid Artery Stenosis: Screening, 1996 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/carotid-artery-stenosis-screening-1996
     January 01, 1996 - Subgroup analyses suggest that endarterectomy may be less effective in women than in men (17% vs. 66% … Revised cost-effectiveness analyses of various screening and treatment strategies for asymptomatic carotid

326. Current Processes of the U.S. Preventive Services Task Force: Refining Evidence-Based Recommendation Development (pdf file)
     www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/currprocess.pdf
     July 01, 2007 - For the literature search on bene- fits, the search is limited to meta-analyses, systematic reviews, … and RCTs; for harms, the search includes meta- analyses, systematic reviews, RCTs, cohort and case– control

327. Screening for HIV: A Review of the Evidence for the U.S. Preventive Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/3qpQqeeozW8nV3a4_BWntp
     June 20, 2019 - Agency staff and USPSTF members participated in the initial design of the study and reviewed interim analyses … Cost-effectiveness analyses Good Two good-quality cost-effectiveness analyses found that the cost-effectiveness … We also included cost-effectiveness analyses of HIV screen- ing in outpatient settings in the HAART era … Cost-Effectiveness Analyses: Criteria Framing 1. … Are appropriate sensitivity analyses performed?

328. Comparative Effectiveness of Antiviral Treatment for Hepatitis C Virus Infection in Adults: A Systematic Review (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/o6pGCffkVCx24mNebJGCXg
     January 01, 2013 - We performed meta-analyses of trials that evaluated similar populations, interventions, comparisons, … Statistical heterogeneity was explored through sensitivity and subgroup analyses based on study quality … Analyses were per- formed with Stata software, version 11.0 (StataCorp, Col- lege Station, Texas). … We did not perform formal analyses for publication bias because of the small numbers of trials, but analyses … Meta-analyses were per- formed by using the DerSimonian–Laird random-effects model, which results in

329. Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/boPWHmzrtxnkkPQAoCNENS
     September 18, 2018 - Random-effects meta-analyses were conducted for weight loss outcomes in behavior-based interventions. … Full method- ologicaldetails(includingstudyselection,excludedstudies,anddescrip- tion of data analyses … The reference lists of previously published reviews, meta-analyses, and primary studies were also examined … For weight outcomes in behavior-based interventions, random- effects meta-analyses were conducted using … Quantitative analyses were conducted using Stata version 13.1 (Stata Corp LP).

330. Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/aHpXYasjc3n6zhaTtoWMwK
     August 01, 2016 - To determine whether meta-analyses were appropriate, the clinical and methodological heterogeneity of … were developed for each type of serologic test, and separate analyses were conducted for HerpeSelect … The metandi program in Stata version 1412 was used to conduct all quantitative analyses. … and specificity based on hierarchical summary receiver operating characteristic curve and bivariate analyses … NA NA Key question 2: Accuracy of serologic screening tests 11 Total: 7129; pooled analyses: 6537 (

331. Screening for Prediabetes and Type 2 Diabetes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/h8qcZeQ68AQPS9DemArgXX
     July 13, 2021 - review of abstracts, full-text articles, and study quality; qualitative synthesis of findings; meta-analyses … To determine whether meta-analyses were appropriate, the clinical and methodological heterogeneity of … Quantitative analyses were conducted using Comprehensive Meta- Analysis version 3.3 (Biostat Inc) and … High strength of evidence from meta-analyses found that life- style interventions for obese or overweight … Measuring inconsistency in meta-analyses.

332. Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Reaffirmation Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/mggnaKHr496c8QCgHe9-tm
     May 01, 2021 - tality, or health-related quality of life.13,16 The USPSTF reviewed 3 trials with newly published analyses … bronchodilators and ICS in the treat- ment of COPD, such as heart failure and pneumonia, as described in meta-analyses

333. Final Research Plan: Unhealthy Alcohol Use in Adolescents and Adults: Screening and Behavioral Counseling Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/unhealthy-alcohol-use-in-adolescents-and-adults-screening-and-behavioral-counseling-interventions
     October 20, 2016 - Suggestions for implementation of the review (e.g., stratifying analyses based on alcohol use severity

334. Screening for Latent Tuberculosis Infection in Adults: U.S. Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/Wx_w92ukxeDvNShoRQXbhP
     September 06, 2016 - Based on pooled analyses of studies reviewed by the USPSTF, when using a positive threshold of 10 mm, … has sensitivity of 79% (11 studies; n = 988) and specificity of 97% (9 studies; n = 9651).2 Pooled analyses … Pooled analyses of the QuantiFERON-TB Gold In-Tube test (another type of IGRA) indicate sensitivity of

335. Archived: Hepatitis B Virus Infection: Screening, 2014 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/hepatitis-b-virus-infection-screening-nonpregnant-adolescents-adults-may-2014
     June 18, 2014 - Results remained consistent when stratified by individual drug and in sensitivity and subgroup analyses … Analyses were limited by small numbers of trials. … Pooled analyses from 3 fair- to good-quality trials showed that vaccination was also associated with

336. Archived: Evidence Summary: Suicide Risk in Adolescents, Adults and Older Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary20/suicide-risk-in-adolescents-adults-and-older-adults-screening
     April 15, 2013 - For key questions 4 and 5 only, we conducted random-effects meta-analyses to estimate the effect size … We used Stata, version 11.2 (StataCorp, College Station, Texas), for all statistical analyses. … to older adults NA NA NA NA NA No trials were limited to older adults, and no subgroup analyses … adults No data NA NA NA NA NA No trials were limited to older adults, and no subgroup analyses … XX Significant group differences for at least 1 but fewer than one half of reported follow-ups or analyses

337. Procedure Manual Section 2. Topic Selection, Prioritization, and Updating | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-2-topic-selection-prioritization-and-updating
     June 22, 2025 - the belief that a gap exists between evidence and practice) New evidence (e.g., new studies or new analyses

338. Recommendation: Depression and Suicide Risk in Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-depression-suicide-risk-adults
     June 20, 2023 - screening questions, CES-D, and EPDS. 1 , 58 One study conducted a series of individual patient data meta-analyses … In the individual patient data meta-analyses, the PHQ-9 identified 85% of participants with major depression … evidence available suggested benefits of psychological treatment in these populations. 1 , 58 Pooled analyses … statistically significant (OR, 0.94 [95% CI, 0.73-1.22]; 12 RCTs [n = 14,573]; I 2 = 11.2%). 1 , 58 Pooled analyses

339. Archived: Evidence Summary: Folic Acid for the Prevention of Neural Tube Defects: Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/folic-acid-for-the-prevention-of-neural-tube-defects-preventive-medication-january-2017
     January 10, 2017 - To determine whether meta-analyses were appropriate, the clinical and methodological heterogeneity (in … A third meta-analysis, 35 consisting of a subset of the primary studies in other meta-analyses, also … high or unclear risk of bias. 32 articles representing 24 studies were included in the quantitative analyses … 40 b A third meta-analysis, 35 consisting of a subset of the primary studies in the other 2 meta-analyses

340. Archived: Tuberculosis Infection, Including Bacille Calmette-Guérin Immunization: Screening, 1996 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/tuberculosis-infection-screening-immunization-1996
     February 11, 2014 - cirrhosis-related deaths was increased in one of the communities participating in the study. 29 More recent analyses … The results of these analyses have been inconsistent.