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301. Screening for Obesity and Intervention for Weight Management in Children and Adolescents: Evidence Report and Systematic Review (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/Jz4WcZ2Wy3-nV6jNUrwUzX
     June 20, 2017 - For metformin, separatemeta­ analyses were conducted for BMI, BMI z score, and cardiometa­ bolic outcomes … There were not sufficient data to perform these analyses for other outcomes or for metformin trials. … Analyses were conducted in Stata version 13.1 (StataCorp). … In pooled analyses, metformin was associated with a lower BMI z score (−0.10 [95% CI, −0.17 to −0.03 … Pooled analyses showed a between-group difference in fasting glucose levels of −3.7 mg/dL with wide

302. Effectiveness of Weight Management Interventions in Children: A Targeted Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/b5LjDb3-UoPV8LEWavJWB8
     February 01, 2010 - For the behavioral inter- ventions, we conducted meta-analyses of short-term and maintenance out- comes … As a sensitivity analysis, we also ran meta-analyses to examine only those that reported BMI change. … All meta-analyses were con- ducted by using RevMan 4.2 (Copenha- gen: The Nordic Cochrane Center, The … Quantitative Synthesis For the behavioral interventions, we conducted meta-analyses of short- term and … All meta- analyses were conducted by using Rev- Man 4.2.

303. Archived: Evidence Summary: Diabetes Mellitus (Type 2) in Adults: Screening, 2003 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/diabetes-mellitus-type-2-in-adults-screening-2003
     February 03, 2003 - Further analyses, however, showed that these benefits were out of proportion to the achieved glycemic … Ten RCTs and three meta-analyses have compared clinical outcomes among diabetic persons treated with … Second, the meta-analyses grouped specific drugs within a class together. … Nonetheless, the meta-analyses compared results across trials. … diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels: subgroup analyses

304. Archived: Human Immunodeficiency Virus (HIV) Infection: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/human-immunodeficiency-virus-hiv-infection-screening-2013
     April 15, 2013 - For policy context, however, the USPSTF reviewed some cost-effectiveness analyses published since its … These analyses, which include downstream costs, support the cost-effectiveness of HIV screening in settings … Subsequent analyses from the DAD study 36-38 and other cohort studies 39 , 40 also report cardiovascular … recommendation statement now includes a brief summary of its contextual review of cost-effectiveness analyses

305. Archived: Final Evidence Summary: Folic Acid to Prevent Neural Tube Defects: Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary25/folic-acid-to-prevent-neural-tube-defects-preventive-medication-2009
     May 15, 2009 - English-language randomized, controlled trials; cohort studies; case–control studies; systematic reviews; and meta-analyses … We evaluated systematic reviews and meta-analyses on comprehensiveness of sources considered, search … Subgroup analyses: women who had subfertility problems or received antiepileptic drugs. … Subset analyses: women not reporting unwanted childlessness, unlike-sex twin pairs.

306. Screening for Hepatitis B Virus Infection in Nonpregnant Adolescents and Adults: Updated Evidence Report and Systematic Review for the US Preventive Service Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/TkWNoq6KQb3SoZ54gscLCQ
     July 25, 2016 - statistical tests for small sample effects were not conducted because of fewer than 10 trials for most analyses … clinical heterogeneity (due to differences in the drugs evaluated and populations [eg, HBeAg status]) in analyses … Subgroup analyses found no statisti- cally significant interactions between HBeAg status or duration … Oth- erwise, subgroup analyses were not performed because of small num- bers of trials. … Results were gen- erally consistent when analyses were stratified by individual drug, although some estimates

307. Archived: Diabetes Mellitus (Type 2) in Adults: Screening, 2003 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/diabetes-mellitus-type-2-in-adults-screening-2003
     February 04, 2003 - treatments for patients with lipid abnormalities had enough patients with diabetes to permit subgroup analyses … trial of lipid therapy has included sufficient numbers of patients with diabetes to perform reliable analyses … simvastatin‐treated patients with coronary heart disease and diabetes or impaired fasting glucose levels:subgroup analyses

308. Folic Acid Supplementation for the Prevention of Neural Tube Defects: An Update of the Evidence (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/y6xRBv7uSZY5bGCx7y48x7
     May 01, 2009 - randomized, controlled trials; co- hort studies; case–control studies; systematic reviews; and meta- analyses … We evaluated systematic re- views and meta-analyses on comprehensiveness of sources considered, search … Subgroup analyses: women who had subfertility problems or received antiepileptic drugs. … Subset analyses: women not reporting unwanted childlessness, unlike-sex twin pairs.

309. Archived: Osteoporosis to Prevent Fractures: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/osteoporosis-screening-june-2018
     June 26, 2018 - Overall, based on pooled analyses, studies on bisphosphonates showed no increased risk of discontinuation … Pooled analyses showed no increased risk of discontinuation due to adverse events (RR, 1.12 [95% CI, … 6438) or increased risk of leg cramps (RR, 1.41 [95% CI, 0.92-2.14]; 3 studies; n = 6000). 4 However, analyses … Pooled analyses showed no significant increase in discontinuation (RR, 1.14 [95% CI, 0.85-1.52]) or serious

310. Final Research Plan: Prostate Cancer: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prostate-cancer-screening
     April 28, 2016 - designs KQ 1: Randomized, controlled trials; systematic reviews (of included study designs); meta analyses

311. Interventions for Weight Management in Children and Adolescents: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/e9f8a_uGMXxSbBUxpRPkrc
     June 18, 2024 - review, including individual study results for all out- comes at all time points, eligible subgroup analyses … reported between-group effects were used in the meta-analysis if they were reported, with adjusted analyses … Although some individual trial findings were statistically significant, most evidence and the meta-analyses … found any statistically significant improvements in quality of life at any time point; however, pooled analyses … between risk factors in the prediction of onset of eating disorders: exploratory hypothesis-generating analyses

312. Final Research Plan: Weight Loss to Prevent Obesity-Related Morbidity and Mortality in Adults: Behavioral Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/obesity-in-adults-interventions
     March 31, 2016 - clinical trials, including cluster randomized trials KQ 3: Systematic reviews, including meta-analyses

313. Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: US Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/uM5P-6XpsqVfEC2axGnZaD
     November 16, 2020 - Although not definitive, some subgroup analyses suggest that more intensive physician counseling (>20 … Another systematic review,67 which pooled analyses of 65 stud- ies (n = 23 331), found that cessation … Pooled analyses from 97 studies (n = 26 637) found that use of any psychosocial intervention was associated … The major- ity of studies used counseling interventions, and analyses of only counseling interventions … evidence on harms of behavioral counseling interventions.68 Based on analyses of 13 trials (n = 5831)

314. Screening for Lung Cancer With Low-Dose Computed Tomography: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/ghbfx9e3A6jQEqVW26y8Jv
     March 09, 2021 - To determine whether meta-analyses were appropriate, the clinical and methodological heterogeneity of … the studies was assessed according to established guidance.11 Meta-analyses were not conducted because … Quantitative analyses were conducted using Stata version 14 (StataCorp). … Seven publications using DLCST, LUSI, NELSON, or NLST data described subgroup analyses for age, sex, … by age group among the men in the trial (not including the women in those analyses) but did not report

315. Recommendation: Chronic Obstructive Pulmonary Disease: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/chronic-obstructive-pulmonary-disease-screening
     May 10, 2022 - mortality, or health-related quality of life. 13 , 16 The USPSTF reviewed 3 trials with newly published analyses … bronchodilators and ICS in the treatment of COPD, such as heart failure and pneumonia, as described in meta-analyses

316. Screening for Cognitive Impairment in Older Adults: A Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/s9Hht_QpMB4gQg26rTpcaN
     November 01, 2013 - We conducted quantitative analyses on important pa- tient outcomes reported in most trials. … We used Stata 11.2 for all statistical analyses. … Meta-analyses of effects of AChEIs and memantine on withdrawals due to adverse events. … Meta-analyses of effects of psychoeducational caregiver interventions on caregiver burden. … Meta-analyses of effects of psychoeducational caregiver interventions on caregiver depression.

317. Recommendation: Iron Deficiency Anemia in Young Children: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/iron-deficiency-anemia-in-young-children-screening
     September 07, 2015 - Some comments also requested separate analyses of certain high-risk populations. … USPSTF sought this information, limitations in the evidence prevented it from performing separate analyses

318. Szn5Hhs8W5Sar6Bbpabsab (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/sZN5HHS8w5Sar6bBPabsaB
     June 01, 2008 - Limitations: Most of the data on diabetes treatment were not from primary trial data but from subgroup analyses … Agency staff and USPSTF mem- bers participated in the initial scope of this work and reviewed interim analyses … Results from our meta-analyses showed that the inci- dence of type 2 diabetes was decreased with lifestyle … nondiabetes (subgroup analyses); RCTs with duration of T2DM �1 y (50–52, 55, 57–61) Several studies … Fourth, most of the data on dia- betes treatment were from prespecified subgroup analyses of large trials

319. Archived: Final Evidence Summary: Diabetes Mellitus (Type 2) in Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary23/diabetes-mellitus-type-2-in-adults-screening-2008
     June 15, 2008 - Limitations: Most of the data on diabetes treatment were not from primary trial data but from subgroup analyses … Agency staff and USPSTF members participated in the initial scope of this work and reviewed interim analyses … Results from our meta-analyses showed that the incidence of type 2 diabetes was decreased with lifestyle … Fourth, most of the data on diabetes treatment were from prespecified subgroup analyses of large trials … RCTs with diabetes vs. nondiabetes (subgroup analyses); RCTs with duration of T2DM ≤1 y. 50-52 , 55

320. Evidence Summary: Tobacco Smoking Cessation in Adults, Including Pregnant Persons: Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions
     January 19, 2021 - Independent critical appraisal and data abstraction; qualitative synthesis and random-effects meta-analyses … Methods for the meta-analyses of data from trials of pharmacotherapy among pregnant women are described … abstinence in late pregnancy, up to and including the period of hospitalization for birth. 54 Pooled analyses … secondary analyses of a randomised controlled trial. … Moderate to high evidence of benefit f Relapse prevention 1 review (77 RCTs, n = 67,285) Analyses