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81. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
    September 01, 2011 - A clinical rationale for these decisions should be provided or separate analyses should be presented … We have revised our depression analyses, conducting separate analyses for augmention studies of tx … Patient heterogenity is an issue in most of our analyses. … Yet the computation of the overall effects in several of the meta-analyses, which may be one of the … Actually, we refrained from doing pooled analyses across, drugs in response to reviewers comments

82. Assessing the Risk of Bias in Systematic Reviews of Health Care Interventions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
    December 01, 2017 - Previous Reviews • When using an existing systematic review in a new systematic review or subgroup analyses … Previous Reviews If you are using an existing systematic review in a new systematic review or subgroup analyses … Use Risk of Bias Assessments in Synthesizing Evidence (I) At stage 4, you conduct preplanned analyses … Consider and conduct, as appropriate, additional quantitative or qualitative sensitivity analyses or … When summarizing evidence, consider conducting sensitivity analyses to evaluate whether including studies

83. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
    September 25, 2013 - As such, we have refrained from these analyses. … It had already been included in our analyses. … – e.g. modified ROC analyses – are generally rarely reported). … We used fixed effects analyses as sensitivity analyses. … In such cases we actually performed meta-analyses.

84. Disposition of Comments Report for CER 207 on PTSD (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-207-ptsd-disposition-comments.pdf
    May 17, 2018 - We did not include any high risk of bias studies in our meta analyses or SOE gradings. … Peer Reviewer 1 Methods Why did this SR not include sensitivity analyses like the 2013 SR? … We have now indicated that STATA was used for all meta analyses. … This study did not report findings from such an analyses. … Peer Reviewer 1 General 3) not doing quantitative sensitivity analyses.

85. Methods Guide for Medical Test Reviews Chapter 9 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
    July 01, 2012 - Summarizing results from major axis regressions or Bland-Altman analyses is probably informative. … Again, it is advisable to seek expert statistical help when considering such quantitative analyses, … An important piece of information gained from such analyses is the range of 9-11 values defined … The difference versus average analyses from each study are represented by three horizontal lines: a … Applying the right statistics: analyses of measurement studies.

86. Blood-Clots-Hip-Knee-Surgery Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
    March 01, 2012 - as to compare results of our meta- analyses with previously published similar analyses. … Our results are similar to that of previous pooled analyses of patients with total hip and total knee … The results of previous meta- analyses are in general agreement with the findings of our comparative … In base case analyses, prolonged prophylaxis increases the occurrence of minor bleeding and surgical … Sensitivity Analyses: A “what if” analysis that helps determine the robustness of a study.

87. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
    March 01, 2012 - The quality of these meta-analyses could vary greatly. … Also what is the real value to include all these prior-meta-analyses while some earlier meta-analyses … We performed all the meta- analyses that we judged were appropriate based on the analyses conducted … additional trials not included in the prior analyses. … It did not do de novo meta-analyses when meta-analyses already existed.

88. Menopause Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
    March 01, 2015 - 1 that reported subgroup analyses were included. … For vasomotor symptoms and quality-of-life outcomes, network meta-analyses formed the primary analyses … Finally, interpreting network and pairwise meta-analyses deserves comment. … In the pairwise meta-analyses, only direct randomized comparisons are included; the network analyses … Data extraction errors in meta-analyses that use standardized mean differences.

89. Since their introduction in 20xx, DES have been shown in clinical trials to decrease TLR (… (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
    January 01, 2010 - The resulting analyses will better inform national practice patterns overall and in important patient … We refer to these latter analyses as 6 and 12 month landmark analyses. … S ens itivity Analys es We conducted two sensitivity analyses. … P res pec ified Outc omes Death Prior analyses comparing survival in DES and BMS treated patients … Unadjusted and adjusted results from time-to-event analyses for prespecified endpoints.

90. Microsoft Word - ehcrr#2toCSI.doc (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
    August 01, 2007 - Results were confirmed in propensity score analyses and instrumental variables estimation adjusting for … yielded no substantive changes relative to traditional multivariable Cox regression analyses. … In instrumental variable analyses, conventional APMs continued to be associated with greater risks of … Sensitivity analyses revealed that very large relative risks of 5 or greater would be needed linking … This is evidence that our analyses did not differentially adjust important confounding variables with

91. Prostate-Cancer-Test Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - Systematic Reviews and Meta-Analyses The quality of included systematic reviews/meta-analyses will … (e.g., sensitivity or subgroup analyses); and assessment of bias across studies? … (e.g., sensitivity or subgroup analyses); and assessment of bias across studies? … Assuming that two unmatched analyses can be performed for PCA3 testing and a comparator, further analyses … What contributions do languages other than English make on the results of meta-analyses?

92. Cancer-Ovarian-Contraceptives Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
    June 01, 2013 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … No comparative effectiveness analyses have been conducted to inform decisions about the use of OCs … We stratified analyses by study type (i.e., case-control, cohort, pooled analyses). … Of these, 39 were case- control studies, 10 were cohort studies, and 6 were pooled analyses. … None of the pooled analyses met criteria for inclusion in the meta-analyses examining OC use and ovarian

93. Disposition of Comments for PCA3 Testing for the Diagnosis and Management of Prostate Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_disposition-comments.pdf
    April 01, 2013 - a couple additional analyses may be helpful. … Abstracts often represent early analyses of data that may contain errors and/or analyses may change … Abstracts often represent early analyses of data that may contain errors and/or analyses may change … biopsies, and these separate analyses have been performed. … , and their analyses were informative.

94. Ptsd-Adult-Treatment Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_executive.pdf
    April 01, 2013 - For analyses of the efficacy of psychological interventions, we stratified our meta-analyses by comparison … Heterogeneity was also explored through sensitivity analyses. … Quantitative pairwise meta-analyses were conducted using Stata® version 11.1. … Analyses were generally not powered to detect anything but large differences. … These sensitivity analyses did not produce significantly different results for our pairwise meta-analyses

95. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - In this systematic review, some of the data will allow for meta- analyses to pool the data. … Subgroup and sensitivity analyses. … In this systematic review, some of the data will allow for meta-analyses to pool the data. … Subgroup and sensitivity analyses. … Subgroup analyses will be conducted to assess the effect age, gender, and baseline clinic...

96. ADHD Medications and Risk of Serious Coronary Heart Disease in Yough and Middle-Aged Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-heart-disease-children_research.pdf
    January 01, 2023 - All analyses were done with SAS version 9.1. All p-values were two sided. … In addition to analyses on the full cohort of users and non-users, we conducted several analyses within … Age Results of subgroup analyses are presented in Tables 5a-c. … Sensitivity Analyses—Adjustment Method In sensitivity analyses to examine the effect of allowing the … (including remote user comparison and new user analyses) and the results of our sensitivity analyses

97. Ced-Appendix-3 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
    June 24, 2022 - to be pursued; if identified data are used, analyses are conducted within secure network areas from … : There is established knowledge on how to conduct such studies, but the question of when such analyses … If not, can sensitivity analyses be designed to examine their potential influence? … If not, can sensitivity analyses be designed to examine their potential influence? … FDA Design_sensivity analyses Prespecify the essential sensivity analyses and other statistical diagnositics

98. Untitled (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
    October 05, 2015 - Systematic reviews, with or without meta-analyses •! … (PRISMA) checklist.63 All methods and analyses are determined a priori. … analyses. 15! … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses including high risk-of-bias studies

99. Methods-Guidance-Reporting-Bias Methods (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-reporting-bias_methods.pdf
    November 01, 2013 - Analysis reporting bias The selective reporting, in published studies, of one or more analyses as a … only for the whole study population when analyses were also done for subpopulations. … Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses. … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … What contributions do languages other than English make on the results of meta-analyses?

100. Disposition of Comments: Comparative Effectiveness Review No. 273_Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-disposition-comments.pdf
     August 20, 2024 - • Some reviewers felt that the long-term update (post hoc, secondary analyses) of the RTOG 9811 … The secondary analyses of the RTOG 9811 trial was not preplanned, was assessed at higher risk of bias … outcomes using data from the parent trial report as opposed to the report with post hoc, secondary analyses