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461. FRN 35 - Preventive Pharmacological Treatments for Migraine in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
     April 01, 2013 - Among off-label drugs, pooled analyses demonstrated that the off-label antidepressant amitriptyline … Exploratory Bayesian network meta-analyses demonstrated that topiramate and off-label antiepileptics … • Several post hoc subgroup analyses of topiramate versus placebo provided inconsistent evidence … The analyses demonstrated few significant differences between individual drugs. … Among off-label drugs, pooled analyses demonstrated that the off-label antidepressant amitriptyline

462. Disposition of Comments for Pulmonary Arterial Hypertension: Screening, Management, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_disposition-comments.pdf
     April 25, 2013 - Regarding the modified PRISMA: we ultimately used meta-analyses as a source for primary studies and … We did not end up including any quantitative estimates from published meta-analyses in our analyses … This made it possible to include more studies in the meta-analyses. … We attempted to address these issues in the quality scoring and sensitivity analyses in KQ 1. … Class comparisons were performed in our analyses.

463. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_research-protocol.pdf
     December 06, 2010 - prospective and retrospective cohort studies, case- control studies, and cross-sectional studies • Meta-analyses … factors that influence the treatments we are analyzing, we will consider performing quantitative analyses … The TEP does not perform analyses of any kind nor does it contribute to the writing of the report.

464. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
     September 01, 2016 - conclusions • Where ClinicalTrials.gov provides additional results, and we are able to conduct meta- analyses … , we will conduct sensitivity analyses, with and without the additional data from ClinicalTrials.gov

465. Trauma-Interventions-Maltreatment-Child Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
     April 01, 2013 - Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. … Although many studies compared baseline characteristics across study conditions, subgroup analyses to … Additionally, small samples precluded subgroup analyses and examination of moderating and mediating … comparisons and limit post-hoc analyses. … In complex multifactorial interventions, planned statistical analyses should include the assessment

466. Ear-Infection Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
     May 01, 2013 - all analyses qualitatively. … Evidence used in the synthesis included the results from the earlier meta-analyses, additional data … We did not include 23 high-risk-of-bias studies in our analyses (Appendix C of the full report). … Thirty one studies and 12 meta-analyses examined signs and symptoms of OME. … Thirty studies and six meta-analyses examined hearing as an outcome.

467. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nppv-respiratory-failure_research-protocol.pdf
     April 21, 2011 - Food and Drug Administration analyses). … For comparison, we will also perform fixed-effect meta-analyses. … If there are sufficient studies, we will perform subgroup analyses and/or meta-regression analyses

468. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - This approach is recommended for analyses where neither test can be considered a reference (gold) standard … Analyses of sensitivity and specificity will also be undertaken where appropriate. … effect of an intervention on intermediate and clinical outcomes, we will consider performing meta-analyses … We will perform only random-effects model meta-analyses. F.

469. Kidney-Disease-Medicine Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
     January 01, 2012 - A recent series of meta-analyses of large prospective cohort studies demonstrated the independent associations … • Limits: All but one study were post hoc analyses in which CKD was defined by impaired eGFR or … Research Recommendations • Post hoc analyses of ongoing or completed RCTs that already have collected … • Patient-level meta-analyses of treatment RCTs to evaluate the effect of treatments relative to … Measuring inconsistency in meta-analyses. BMJ 2003 Sep 6;327(7414):557-60. PMID 12958120. 23.

470. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
     December 15, 2010 - Exploring heterogeneity, sensitivity and subgroup analyses Heterogeneity may be explored by using … subgroup analyses, sensitivity analyses, or random-effects meta-regression for study-level covariates … of heterogeneity will follow recommendations from the AHRQ Methods Guide.33 Prespecified subgroup analyses … When possible, subgroup meta-analyses will be presented separately. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. 35.

471. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - Moher et al.20 have demonstrated that exclusion of non–English-language studies from meta-analyses has … Trials must focus on, or provide separate analyses for, subjects with localized disease (T1/T2). … National Health Service Economic Evaluation Database for unique reviews, trials, economic analyses, … What contributions do languages other than English make on the results of meta-analyses? … Direction and impact of language bias in meta-analyses of controlled trials: empirical study.

472. Fatty-Acids-Cardiovascular-Disease Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_research-protocol.pdf
     April 02, 2015 - We expect to conduct random effects model meta-analyses of comparative studies, if they are sufficiently … If appropriate data are available, we may also conduct meta-regression analyses to evaluate study features … Dose-response meta-analyses that also allow for threshold effects require specialized approaches because … a threshold which is not necessarily examined in the studies, b) utilize information from adjusted analyses … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

473. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - Sensitivity analyses can aid in defining the extent to which a hypothesized unmeasured confounder could … Comparative analyses that incorporate the non-overlapping subjects in the tails would be extrapolating … This in turn may inhibit performance of important sensitivity analyses. … However, with 50 variables that measure this factor, the effect modification analyses may be cumbersome … Stratification As with propensity scores, disease risk scores can also be used for stratified analyses

474. ADHD-Update-protocol-160818 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
     August 18, 2016 - English-language only • Published January 1, 2009, to present • Relevant systematic reviews, meta-analyses … the inclusion of lower quality studies would change any of our conclusions and perform sensitivity analyses … If there are sufficient studies, we will perform subgroup analyses and/or meta-regression analyses to … Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

475. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
     April 18, 2017 - The IOM Sodium Intake in Populations report listed “analyses examining the effects of dietary sodium … Naïve “high versus low” or extreme quantile meta-analyses may produce uninterpretable pooled results … We will conduct and report on subgroup analyses to answer the subquestions on subpopulations of interest … Effect of lower sodium intake on health: systematic review and meta-analyses. … Effect of lower sodium intake on health: systematic review and meta-analyses.

476. Disposition of Comments for CER 171 Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_disposition-comments.pdf
     March 29, 2016 - Peer Reviewer 2 Methods Analyses was performed in subgroups of patients stratified by different pre-test … No pooled analyses combined patients from ED and outpatient settings. … It is unclear what additional analyses would be fruitful. … They authors have formulated the results and key messages of their analyses well and appropriately. … The authors have candidly described the limitations of their review and analyses. Thank you.

477. Pharmacologic and Nonpharmacologic Treatments of Post-Traumatic Stress Disorder (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol.pdf
     July 10, 2018 - urgent government or media inquiries; (2) serve as a data source for future systematic reviews or meta-analyses … Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta- analyses … Indicate if subgroup analyses are reported* Population Characteristics a. … Methods Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta-analyses

478. Pharmacologic and Nonpharmacologic Treatments of Post-Traumatic Stress Disorder (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-protocol.pdf
     July 10, 2018 - urgent government or media inquiries; (2) serve as a data source for future systematic reviews or meta-analyses … Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta- analyses … Indicate if subgroup analyses are reported* Population Characteristics a. … Methods Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta-analyses

479. Ch 6-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
     October 30, 2012 - They conducted analyses to demonstrate that varying definitions of 76 Developing an Observational … In health economic analyses, utilities are used to justify devoting resources to a treatment. … These and other considerations for sensitivity analyses are covered in detail in chapter 11. … – Plan sensitivity analyses relating to expected questions that arise around the study outcomes. … – Propose sensitivity analyses that address different relevant definitions of the study outcome(s

480. Mrsa-Screening-2010 Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
     January 01, 2010 - A number of analyses suggest that MRSA infections are associated with increased mortality and cost … Published Online: October 24, 2011 appropriate signage posted on the door to the room.20 Other analyses … Research and Quality in its Methods Guide about inclusion of results from previously conducted meta-analyses … Response criteria – Followup frequency and duration – Data analysis details: Statistical analyses … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment