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441. AHRQ Slide Template-Widescreen
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
     May 22, 2025 - We did not detect differential treatment effects associated with ADHD presentation, but analyses were … Department of Health and Human Services. 28 Context Systematic review with meta-analyses Purpose: … , other factors – for prioritized outcomes Synthesize evidence narratively and quantitatively (meta-analyses … cohorts) with multivariable analysis of potential effect modifiers/subgroups of interest 2 secondary analyses … Multiphase Optimization Strategy analyses can be used to ascertain which components are essential to

442. Disposition of Comments Report for Evaluation and Treatment of Tinnitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_disposition-comments.pdf
     August 23, 2013 - They then used this estimate to assist in the computation of all of their meta-analyses. … Given that no sub-analyses were conducted on different delivery formats or different forms of CBT, … Discussion/ Conclusion: Three independent systematic reviews and meta-analyses (Hesser et al., 2011 … of analyses to combine the SE from different areas perhaps but I think this is catered for by the … regarding the feasibility of meta-analyses).

443. Crohns-Disease Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_executive.pdf
     February 01, 2014 - We abstracted information on subgroup analyses to understand how disease characteristics could modify … We conducted meta- analyses when there were sufficient data (at least three studies) and when studies … We conducted all meta-analyses using Intercooled STATA 9.2 (College Station, TX). … Subgroup Analyses Six trials reported a statistical interaction test on disease characteristics that … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. PMID: 12958120. 17.

444. Arthritis-Psoriatric Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
     April 01, 2012 - shortcoming that leads to a very high risk of bias) in one or more categories and excluded them from our analyses … controlled trials, 0 head- to-head nonrandomized controlled trials, 10 placebo- controlled trials, 3 meta-analyses … The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT): results of radiographic analyses

445. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol-amendment.pdf
     February 05, 2025 - Reviews.18 Our reporting will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … For all meta-analyses, we will use random effects models to estimate pooled effects. … To determine whether quantitative analyses are appropriate, we will assess the contextual, clinical, … heterogeneity of the studies under consideration following established guidance.26 If we conduct meta-analyses

446. Research Protocol: Safety of Vaccines Used for Routine Immunization in the United States (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
     January 30, 2020 - , main analysis, or subgroup analyses. … We refer to these as multivariate risk factor analyses. … Where possible, we will combine study results in meta-analyses, aggregating data across studies. … The analyses will explore whether patient or vaccine characteristics are systematically associated … Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions.

447. Protocol Amendment - Safety of Vaccines 030413 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
     September 18, 2012 - Partners Inc., Ottawa, Ontario, Canada),21 which is designed specifically for systematic reviews and meta-analyses … Analyses will be conducted with Stat Xact® Procs for SAS.23 Unless statistical power is adequate, … subgroup analyses will be narrative in order to be able to make comparisons between study designs and … assessed for quality, and analyzed) as one study to ensure that the same participants do not enter the analyses … control/comparison group such as population surveillance, retrospective and prospective cohorts, and analyses

448. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - This approach is recommended for analyses in which neither test can be considered a reference (gold) … Analyses of sensitivity and specificity can be inappropriate. … the effect of an intervention on intermediate and clinical outcomes—we will consider performing meta-analyses … We will perform only random effects model meta-analyses. … If data are available, we will consider sub-group meta-analyses based on the findings of these studies

449. Evidence Summary for CER 239: Acute Treatments for Episodic Migraine (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
     December 01, 2020 - Reviews.7 The reporting complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

450. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - Study Design KQ1-2: Screening and diagnosis impact analyses and diagnostic accuracy studies KQ3- … For screening and diagnostic studies, we will include screening and diagnostic analyses that assess … conference abstracts) will be excluded because these will provide insufficient detail for detailed analyses … primary research studies, but relevant scoping reviews, systematic reviews, evidence maps, and meta-analyses … We will explore potential sources of heterogeneity through subgroup analyses while recognizing that

451. Diagnosis and Management of Obsessive Compulsive Disorders in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ocd-protocol.pdf
     August 15, 2023 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … In extraction and summary of RCTs and NRCSs, we will preferentially include adjusted over crude analyses … Where appropriate and feasible, we will conduct random-effects meta-analyses of comparative studies … For KQ 2, we will explore the possibility of conducting network meta-analyses of a widely reported

452. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
     September 13, 2011 - followup times will be included, with attention paid to validity issues when pooling or conducting other analyses … comparable groups, reliable and valid measurements, clear definition of interventions, and appropriate analyses … Quantitative Analyses Key Questions 1, 3, and 4 We will assess whether the included studies are … We will undertake meta-analyses of studies where appropriate for the outcomes listed below. … We will undertake subgroup analyses to explore heterogeneity among studies irrespective of the magnitude

453. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - Moher et al.20 have demonstrated that exclusion of non–English language studies from meta-analyses has … inconsistent will be examined for possible causes of the inconsistency; if any are found, subgroup analyses … What contributions do languages other than English make on the results of meta-analyses? … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

454. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
     February 25, 2016 - We will not exclude studies rated high risk of bias a priori, but will perform sensitivity analyses … based on similarities in the populations, interventions, comparisons, and settings evaluated.35 Meta-analyses … on clinical outcomes using the DerSimonian-Laird model; if statistical heterogeneity is present in analyses … of clinical outcomes we will also perform analyses using the Profile Likelihood method. … Stratified and sensitivity analyses will be performed on the potential modifiers of effects described

455. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
     October 05, 2012 - When meta- analysis could be performed, subgroup and sensitivity analyses would be based on assessment … flaws are listed, but in this report, the most common fatal flaw was a lack of intention-to-treat analyses … Meta-analyses have been added for antibiotic duration, antibiotic prescription rate, short-term mortality … We have added meta-analyses on antibiotic duration for both critically ill/ventilator-associated pneumonia … PR #1 General Comments Authors should note that older studies, and thus meta- analyses, are limited

456. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - Discussions with the TEP also informed pre-planned subgroup analyses described in the data synthesis … resource countries or conflict zones Study Design KQ1: Diagnostic accuracy and diagnostic impact analyses … abstracts) Note: KQ key question, TEP technical expert panel Relevant systematic reviews and meta-analyses … termination of studies, inadequate reporting of intervention details, and lack of intention-to-treat analyses … tethered cord syndrome) versus confirmed tethered spinal cord syndrome We will perform meta-regression analyses

457. Finding Evidence for Comparing Medical Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-finding-evidence_methods.pdf
     January 01, 2011 - Grey literature in meta-analyses. Nurs Res [Review] 2003 Jul-Aug;52(4):256-261. 11. … Grey literature in meta-analyses of randomized trials of health care interventions. … What should be included in meta-analyses? … An exploration of methodological issues using the ISPOT meta-analyses. … English-language restriction when conducting systematic review-based meta- analyses: systematic review

458. Disposition of comments_Comparative Effectiveness Review No. 244: Safety of Vaccines Used for Routine Immunization in the United States: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-of-vaccines.pdf
     May 25, 2021 - We believe that our approach is more suitable to the 400+ meta-analyses undertaken for this report. … We considered including forest plots, however because of the number of analyses (400+) and the length … There is an important discussion of the limitations of self-controlled case series analyses (Page 132 … Does the fact that results from self- controlled case series analyses cannot be combined with results … The content and analyses of multiple studies are provided in an organized and easy-to- follow manner

459. Prevention, Diagnosis, and Management of Opioids, Opioid Misuse and Opioid Use Disorder in Older Adults: Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioids-oa-protocol.pdf
     June 29, 2019 - The primary definition of older adult is ≥65 years of age, but we will include studies and subgroup analyses … or retrospective studies o cross-sectional or longitudinal studies o surveys or qualitative research analyses … years of age are more traditional age thresholds for identifying older adults, we will allow subgroup analyses … For the evidence map, all analyses will be qualitative and descriptive.

460. Future Research Needs for Attention Deficit Hyperactivity Disorder: Effectiveness of Treatment in At-Risk Preschoolers, Long-Term Effectiveness in All Ages, and Variability in Prevalence, Diagnosis, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
     May 01, 2012 - Subset analyses to examine the sensitivity of prevalence methods across demographic subpopulations will … • Ethical, legal, and social issues o While secondary data analyses generally do not incur major … Analyses would involve consideration of moderators and mediators. … Secondary analyses of trials, which generally have higher quality and more standard data collection, … Secondary analyses of existing cohort studies, in which patient characteristics are more reflective