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441. Disposition of Comments Report for Evaluation and Treatment of Tinnitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_disposition-comments.pdf
     August 23, 2013 - They then used this estimate to assist in the computation of all of their meta-analyses. … Given that no sub-analyses were conducted on different delivery formats or different forms of CBT, … Discussion/ Conclusion: Three independent systematic reviews and meta-analyses (Hesser et al., 2011 … of analyses to combine the SE from different areas perhaps but I think this is catered for by the … regarding the feasibility of meta-analyses).

442. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - We reviewed primary studies, as defined by our inclusion criteria, and we performed de novo meta-analyses … Our results are similar to results of three published meta-analyses, which reported no statistically … LOCM.42-44 Even though our review included six RCTs that have been published since those three meta-analyses … important limitations and included different sets of studies than our review.45-49 In one of these meta-analyses

443. Crohns-Disease Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_executive.pdf
     February 01, 2014 - We abstracted information on subgroup analyses to understand how disease characteristics could modify … We conducted meta- analyses when there were sufficient data (at least three studies) and when studies … We conducted all meta-analyses using Intercooled STATA 9.2 (College Station, TX). … Subgroup Analyses Six trials reported a statistical interaction test on disease characteristics that … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. PMID: 12958120. 17.

444. Implementation of Recommended Screening and Counseling Interventions to Prevent Mental Health Disorders in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol.pdf
     October 01, 2023 - Reviews.18 Our reporting will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … For all meta-analyses, we will use random effects models to estimate pooled effects. … To determine whether quantitative analyses are appropriate, we will assess the contextual, clinical, … heterogeneity of the studies under consideration following established guidance.26 If we conduct meta-analyses

445. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol-amendment.pdf
     February 05, 2025 - Reviews.18 Our reporting will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … For all meta-analyses, we will use random effects models to estimate pooled effects. … To determine whether quantitative analyses are appropriate, we will assess the contextual, clinical, … heterogeneity of the studies under consideration following established guidance.26 If we conduct meta-analyses

446. Research Protocol: Safety of Vaccines Used for Routine Immunization in the United States (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
     January 30, 2020 - , main analysis, or subgroup analyses. … We refer to these as multivariate risk factor analyses. … Where possible, we will combine study results in meta-analyses, aggregating data across studies. … The analyses will explore whether patient or vaccine characteristics are systematically associated … Systematic Review of Health Economic Analyses of Measles and Rubella Immunization Interventions.

447. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - Study Design KQ1-2: Screening and diagnosis impact analyses and diagnostic accuracy studies KQ3- … For screening and diagnostic studies, we will include screening and diagnostic analyses that assess … conference abstracts) will be excluded because these will provide insufficient detail for detailed analyses … primary research studies, but relevant scoping reviews, systematic reviews, evidence maps, and meta-analyses … We will explore potential sources of heterogeneity through subgroup analyses while recognizing that

448. Diagnosis and Management of Obsessive Compulsive Disorders in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ocd-protocol.pdf
     August 15, 2023 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … In extraction and summary of RCTs and NRCSs, we will preferentially include adjusted over crude analyses … Where appropriate and feasible, we will conduct random-effects meta-analyses of comparative studies … For KQ 2, we will explore the possibility of conducting network meta-analyses of a widely reported

449. Arthritis-Psoriatric Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
     April 01, 2012 - shortcoming that leads to a very high risk of bias) in one or more categories and excluded them from our analyses … controlled trials, 0 head- to-head nonrandomized controlled trials, 10 placebo- controlled trials, 3 meta-analyses … The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT): results of radiographic analyses

450. Protocol Amendment - Safety of Vaccines 030413 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
     September 18, 2012 - Partners Inc., Ottawa, Ontario, Canada),21 which is designed specifically for systematic reviews and meta-analyses … Analyses will be conducted with Stat Xact® Procs for SAS.23 Unless statistical power is adequate, … subgroup analyses will be narrative in order to be able to make comparisons between study designs and … assessed for quality, and analyzed) as one study to ensure that the same participants do not enter the analyses … control/comparison group such as population surveillance, retrospective and prospective cohorts, and analyses

451. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - This approach is recommended for analyses in which neither test can be considered a reference (gold) … Analyses of sensitivity and specificity can be inappropriate. … the effect of an intervention on intermediate and clinical outcomes—we will consider performing meta-analyses … We will perform only random effects model meta-analyses. … If data are available, we will consider sub-group meta-analyses based on the findings of these studies

452. Evidence Summary for CER 239: Acute Treatments for Episodic Migraine (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
     December 01, 2020 - Reviews.7 The reporting complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

453. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - Moher et al.20 have demonstrated that exclusion of non–English language studies from meta-analyses has … inconsistent will be examined for possible causes of the inconsistency; if any are found, subgroup analyses … What contributions do languages other than English make on the results of meta-analyses? … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

454. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
     September 13, 2011 - followup times will be included, with attention paid to validity issues when pooling or conducting other analyses … comparable groups, reliable and valid measurements, clear definition of interventions, and appropriate analyses … Quantitative Analyses Key Questions 1, 3, and 4 We will assess whether the included studies are … We will undertake meta-analyses of studies where appropriate for the outcomes listed below. … We will undertake subgroup analyses to explore heterogeneity among studies irrespective of the magnitude

455. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
     February 25, 2016 - We will not exclude studies rated high risk of bias a priori, but will perform sensitivity analyses … based on similarities in the populations, interventions, comparisons, and settings evaluated.35 Meta-analyses … on clinical outcomes using the DerSimonian-Laird model; if statistical heterogeneity is present in analyses … of clinical outcomes we will also perform analyses using the Profile Likelihood method. … Stratified and sensitivity analyses will be performed on the potential modifiers of effects described

456. Evidence Summary Comparative Effectiveness Review 216 Telehealth for Acute and Chronic Care Consultations (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-216-telehealth-evidence-summary.pdf
     April 01, 2019 - Both systematic reviews and decision analyses have accepted methodologies, but they are not frequently … We were able to conduct meta- analyses for some but not all topics and outcomes due to the heterogeneity … , the model was built to allow inclusion of patient outcomes following treatment for cost benefit analyses … more direct comparisons across clinical topics and both facilitate and inform additional decision analyses … For example, the work on the decision analyses highlighted the importance of clearly specifying the

457. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
     October 05, 2012 - When meta- analysis could be performed, subgroup and sensitivity analyses would be based on assessment … flaws are listed, but in this report, the most common fatal flaw was a lack of intention-to-treat analyses … Meta-analyses have been added for antibiotic duration, antibiotic prescription rate, short-term mortality … We have added meta-analyses on antibiotic duration for both critically ill/ventilator-associated pneumonia … PR #1 General Comments Authors should note that older studies, and thus meta- analyses, are limited

458. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - Discussions with the TEP also informed pre-planned subgroup analyses described in the data synthesis … resource countries or conflict zones Study Design KQ1: Diagnostic accuracy and diagnostic impact analyses … abstracts) Note: KQ key question, TEP technical expert panel Relevant systematic reviews and meta-analyses … termination of studies, inadequate reporting of intervention details, and lack of intention-to-treat analyses … tethered cord syndrome) versus confirmed tethered spinal cord syndrome We will perform meta-regression analyses

459. Disposition of comments_Comparative Effectiveness Review No. 244: Safety of Vaccines Used for Routine Immunization in the United States: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-of-vaccines.pdf
     May 25, 2021 - We believe that our approach is more suitable to the 400+ meta-analyses undertaken for this report. … We considered including forest plots, however because of the number of analyses (400+) and the length … There is an important discussion of the limitations of self-controlled case series analyses (Page 132 … Does the fact that results from self- controlled case series analyses cannot be combined with results … The content and analyses of multiple studies are provided in an organized and easy-to- follow manner

460. Finding Evidence for Comparing Medical Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-finding-evidence_methods.pdf
     January 01, 2011 - Grey literature in meta-analyses. Nurs Res [Review] 2003 Jul-Aug;52(4):256-261. 11. … Grey literature in meta-analyses of randomized trials of health care interventions. … What should be included in meta-analyses? … An exploration of methodological issues using the ISPOT meta-analyses. … English-language restriction when conducting systematic review-based meta- analyses: systematic review