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421. Glaucoma-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
     November 16, 2010 - statistic suggests considerable heterogeneity (a threshold will be established before undertaking any analyses … Subgroup analysis If there are sufficient data, we will conduct subgroup analyses by stage or severity … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses … The TEP does not perform analyses of any kind nor does it contribute to the writing of the report.

422. Pharma-Nonpharma-Ptsd-2022-Update-App-G1 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
     January 01, 2022 - result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

423. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/child-growth-development-outcomes-protocol-amended.pdf
     November 18, 2024 - will adhere to the international PRISMA51 (Preferred Reporting Items for Systematic reviews and Meta-Analyses … Studies rated high risk of bias may be analyzed separately when appropriate (e.g., sensitivity analyses … studies if there are at least two clinically and methodologically comparable studies.50,55,56 Meta-analyses … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by … Findings table will be constructed for each comparison in each Key Question, with quantitative (meta-analyses

424. Rapid Evidence Product_Assisted Home Dialysis in the United States: New Interest in an Old Idea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/home-dialysis-ESKD-rapid-research.pdf
     April 01, 2025 - In multivariate analyses, APD patients receiving nurse assistance were less likely to remain peritonitis … However, that difference disappeared when analyses were restricted to patients who received home visits … with a cohort of patients who were PD-assist eligible but chose not to participate.25 In adjusted analyses … and 47 percent, respectively, less likely to be on PD compared with White populations in adjusted analyses … excluded for wrong study design because they were systematic reviews, literature reviews, or meta- analyses

425. Stroke-Atrial-Fibrillation Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
     August 01, 2013 - Relevant review articles, meta-analyses, and methods articles were flagged for manual searching of … Where there were sufficient studies, we performed subgroup analyses and/or meta- regression analyses … (HR 0.94; 95% CI 0.75 to 1.17) Hemorrhagic stroke 2 (15,544) SOE = Low In on-treatment analyses … 0.09 to 0.61) Major bleeding 2 (15,544) SOE = Moderate No difference in 2 studies in on-treatment analyses … Research Gaps In our analyses, we identified research gaps for all the KQs examined, as described below

426. head-neck-cancer-update-140204 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
     February 04, 2014 - In this CER, our analyses will account for multimodal treatment strategies by organizing evidence according … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment of … The standard variables for subgroup/sensitivity analyses are study size, study quality, and treatment … Network meta-analyses require strong assumptions of exchangeability such that studies are similar in … for a given outcome while not reporting other, less favorable analyses.

427. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
     September 13, 2012 - Data Synthesis We will conduct meta-analyses when there are sufficient data (at least three studies … We plan to conduct analyses by treatment or drug class where possible. … formula for calculating between-study variance.9 Heterogeneity among the trials in all the meta-analyses … of the asymmetry of funnel plots for each comparison of interest for the outcomes for which meta-analyses … Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60. PMID: 12958120. 11.

428. Disposition of Comments for Migraine in Adults: Preventive Pharmacologic Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
     April 18, 2013 - We added the results from the statistical tests for heterogeneity in the tables with pooled analyses … We provide heterogeneity statistics for all pooled analyses. … meta-analyses. … The original RCTs justified reported subgroup analyses. … Our pooled analyses did not show differences in the outcomes among botulinum formulations.

429. Ptsd-Adults-Trauma-Interventions Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adults-trauma-interventions_research-protocol.pdf
     November 08, 2012 - For all analyses, we will use random-effects models to estimate pooled or comparative effects. … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

430. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
     August 19, 2024 - will adhere to the international PRISMA50 (Preferred Reporting Items for Systematic reviews and Meta-Analyses … Studies rated high risk of bias may be analyzed separately when appropriate (e.g., sensitivity analyses … studies if there are at least two clinically and methodologically comparable studies.51,59,60 Meta-analyses … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by … Findings table will be constructed for each comparison in each Key Question, with quantitative (meta-analyses

431. Disposition of Comments Report for Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
     October 23, 2014 - To address heterogeneity we performed many stratified/sensitivity analyses and also focused on direct … Where decisions were made to conduct specific analyses, the rationale for doing so was duly provided … Perhaps a section summarizing cost-effectiveness analyses comparing ultrasound, CT and MRI would be … Stratified analyses were performed on studies that used and didn’t use confidence rating scales (there … Peer Reviewer #8 General As with all meta analyses, the quality of the ultimate observations and

432. DEcIDE 34 - Developing a Registry of Patient Registries: Options for the Agency for Healthcare Research and Quality (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries-development_research_0.pdf
     February 01, 2012 - Third, summaries of registry analyses could be available in standard table formats. … Analyses  How frequently are data transferred to the central database? …  Can ad hoc analyses be performed for the health care providers? … The projects include analyses of existing databases, analyses of linked data sources, and prospective … Third, summaries of registry analyses could be stored and searchable in standard table formats.

433. Executive Summary_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-263-postpartum-hypertensive-pregnancy-executive-summary.pdf
     May 01, 2023 - effectivehealthcare.ahrq.gov/topics/cer-methods-guide/overview 4 heterogeneity, we conducted pairwise meta-analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses … Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

434. Liver-Cancer-Therapy Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
     May 01, 2013 - • Three RCTs reported subgroup analyses of interest for the comparison of RFA with PEI/PAI. … • No studies presented subgroup analyses on age, sex, disease etiology, or HCC stage. … Although RCTs may not be possible for all comparisons in all centers, well-done multivariate analyses … These analyses can enhance the design of future RCTs or observational studies. … Subgroup analyses on patients with larger size lesions found low strength of evidence that patients

435. Peripheral-Artery-Disease-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
     May 01, 2013 - Meta-analyses were based on the nature of the outcome variable, but random-effects models were used … Literature flow diagram 9 of and variation in subgroup analyses precluded the calculation of any … Types of studies to consider include: (a) RCTs and potentially patient-level meta-analyses of existing … Types of studies to consider include: (a) RCTs and potentially patient-level meta- analyses of existing … Types of studies to consider include: (a) RCTs and potentially patient-level meta-analyses of existing

436. Implementation of Recommended Screening and Counseling Interventions to Prevent Mental Health Disorders in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol.pdf
     October 01, 2023 - Reviews.18 Our reporting will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … For all meta-analyses, we will use random effects models to estimate pooled effects. … To determine whether quantitative analyses are appropriate, we will assess the contextual, clinical, … heterogeneity of the studies under consideration following established guidance.26 If we conduct meta-analyses

437. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
     October 30, 2019 - Although “as treated” analyses can be useful, most often they are considered secondary to the ITT … There are two key analyses: 1. … Conducting such analyses have major limitations because of the differences in study design, patient … heterogeneity is present) with respect to the pooled analyses. … We have now inserted information on the heterogeneity for all of the pooled analyses 130.

438. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - This application is discussed in the analyses. … We performed sensitivity analyses for the GPI analyses in KQ 2 because of the heterogeneity of the … Not at all clear where the CURE data were pulled from for these analyses. … Specifically, the forest plots are nice visual representations of the meta-analyses. … This doesn’t come out in the analyses.

439. Effectiveness of Treatments for Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetic-neuropathy_research-protocol.pdf
     May 09, 2016 - Two comprehensive systematic reviews and meta-analyses focusing solely on pharmacologic interventions … Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a references list … We will conduct meta-analyses when there are sufficient data (at least three studies) and studies are … Dichotomous data with zero values in both arms will not be included in meta-analyses. … All meta-analyses will be conducted using STATA (College Station, TX).

440. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - We reviewed primary studies, as defined by our inclusion criteria, and we performed de novo meta-analyses … Our results are similar to results of three published meta-analyses, which reported no statistically … LOCM.42-44 Even though our review included six RCTs that have been published since those three meta-analyses … important limitations and included different sets of studies than our review.45-49 In one of these meta-analyses