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421. Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow_executive.pdf
     January 01, 2017 - We did not exclude studies rated high risk of bias a priori, but performed sensitivity analyses to … We also performed analyses using the Profile Likelihood method. … Stratified and sensitivity analyses were performed on the potential modifiers of effects. … Findings for discrimination were robust in sensitivity and subgroup analyses based on the age group … We also found no clear differences in estimates of predictive utility when we restricted analyses to

422. Disposition of Comments for CER 178 Newer Medications for Lower Urinary Tract Symptoms (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/prostatic-hyperplasia-medications_disposition-comments.pdf
     May 26, 2016 - methods described and used in this report are typical for systematic reviews and quantitative meta-analyses … carefully managed data extraction and outstanding application of modern statistical methods for meta-analyses … Because sub-scale score analyses were never suggested by team or TEP members, we did not explore the … the key questions (KQ#3) -for key points under anticholinergics, would again note that secondary analyses … shown no differences in efficacy when evaluating demographic/clinical analyses (with ___ SOE).

423. Glaucoma-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
     November 16, 2010 - statistic suggests considerable heterogeneity (a threshold will be established before undertaking any analyses … Subgroup analysis If there are sufficient data, we will conduct subgroup analyses by stage or severity … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses … The TEP does not perform analyses of any kind nor does it contribute to the writing of the report.

424. Stroke-Atrial-Fibrillation Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
     August 01, 2013 - Relevant review articles, meta-analyses, and methods articles were flagged for manual searching of … Where there were sufficient studies, we performed subgroup analyses and/or meta- regression analyses … (HR 0.94; 95% CI 0.75 to 1.17) Hemorrhagic stroke 2 (15,544) SOE = Low In on-treatment analyses … 0.09 to 0.61) Major bleeding 2 (15,544) SOE = Moderate No difference in 2 studies in on-treatment analyses … Research Gaps In our analyses, we identified research gaps for all the KQs examined, as described below

425. Disposition of Comments_Comparative Effectiveness Review No. 248: Prehabilitation and Rehabilitation for Major Joint Replacement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-disposition-comments.pdf
     November 03, 2021 - Some reviewers questioned why we did not conduct meta-analyses, especially given that some past reviews

426. Pharma-Nonpharma-Ptsd-2022-Update-App-G1 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
     January 01, 2022 - result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

427. head-neck-cancer-update-140204 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
     February 04, 2014 - In this CER, our analyses will account for multimodal treatment strategies by organizing evidence according … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment of … The standard variables for subgroup/sensitivity analyses are study size, study quality, and treatment … Network meta-analyses require strong assumptions of exchangeability such that studies are similar in … for a given outcome while not reporting other, less favorable analyses.

428. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
     August 19, 2024 - will adhere to the international PRISMA50 (Preferred Reporting Items for Systematic reviews and Meta-Analyses … Studies rated high risk of bias may be analyzed separately when appropriate (e.g., sensitivity analyses … studies if there are at least two clinically and methodologically comparable studies.51,59,60 Meta-analyses … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by … Findings table will be constructed for each comparison in each Key Question, with quantitative (meta-analyses

429. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
     September 13, 2012 - Data Synthesis We will conduct meta-analyses when there are sufficient data (at least three studies … We plan to conduct analyses by treatment or drug class where possible. … formula for calculating between-study variance.9 Heterogeneity among the trials in all the meta-analyses … of the asymmetry of funnel plots for each comparison of interest for the outcomes for which meta-analyses … Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60. PMID: 12958120. 11.

430. Disposition of Comments for Migraine in Adults: Preventive Pharmacologic Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
     April 18, 2013 - We added the results from the statistical tests for heterogeneity in the tables with pooled analyses … We provide heterogeneity statistics for all pooled analyses. … meta-analyses. … The original RCTs justified reported subgroup analyses. … Our pooled analyses did not show differences in the outcomes among botulinum formulations.

431. Ptsd-Adults-Trauma-Interventions Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adults-trauma-interventions_research-protocol.pdf
     November 08, 2012 - For all analyses, we will use random-effects models to estimate pooled or comparative effects. … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

432. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
     October 30, 2019 - Although “as treated” analyses can be useful, most often they are considered secondary to the ITT … There are two key analyses: 1. … Conducting such analyses have major limitations because of the differences in study design, patient … heterogeneity is present) with respect to the pooled analyses. … We have now inserted information on the heterogeneity for all of the pooled analyses 130.

433. Disposition of Comments Report for Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
     October 23, 2014 - To address heterogeneity we performed many stratified/sensitivity analyses and also focused on direct … Where decisions were made to conduct specific analyses, the rationale for doing so was duly provided … Perhaps a section summarizing cost-effectiveness analyses comparing ultrasound, CT and MRI would be … Stratified analyses were performed on studies that used and didn’t use confidence rating scales (there … Peer Reviewer #8 General As with all meta analyses, the quality of the ultimate observations and

434. DEcIDE 34 - Developing a Registry of Patient Registries: Options for the Agency for Healthcare Research and Quality (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries-development_research_0.pdf
     February 01, 2012 - Third, summaries of registry analyses could be available in standard table formats. … Analyses  How frequently are data transferred to the central database? …  Can ad hoc analyses be performed for the health care providers? … The projects include analyses of existing databases, analyses of linked data sources, and prospective … Third, summaries of registry analyses could be stored and searchable in standard table formats.

435. Executive Summary_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-263-postpartum-hypertensive-pregnancy-executive-summary.pdf
     May 01, 2023 - effectivehealthcare.ahrq.gov/topics/cer-methods-guide/overview 4 heterogeneity, we conducted pairwise meta-analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses … Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

436. Peripheral-Artery-Disease-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
     May 01, 2013 - Meta-analyses were based on the nature of the outcome variable, but random-effects models were used … Literature flow diagram 9 of and variation in subgroup analyses precluded the calculation of any … Types of studies to consider include: (a) RCTs and potentially patient-level meta-analyses of existing … Types of studies to consider include: (a) RCTs and potentially patient-level meta- analyses of existing … Types of studies to consider include: (a) RCTs and potentially patient-level meta-analyses of existing

437. Liver-Cancer-Therapy Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
     May 01, 2013 - • Three RCTs reported subgroup analyses of interest for the comparison of RFA with PEI/PAI. … • No studies presented subgroup analyses on age, sex, disease etiology, or HCC stage. … Although RCTs may not be possible for all comparisons in all centers, well-done multivariate analyses … These analyses can enhance the design of future RCTs or observational studies. … Subgroup analyses on patients with larger size lesions found low strength of evidence that patients

438. AHRQ Slide Template-Widescreen
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
     May 22, 2025 - We did not detect differential treatment effects associated with ADHD presentation, but analyses were … Department of Health and Human Services. 28 Context Systematic review with meta-analyses Purpose: … , other factors – for prioritized outcomes Synthesize evidence narratively and quantitatively (meta-analyses … cohorts) with multivariable analysis of potential effect modifiers/subgroups of interest 2 secondary analyses … Multiphase Optimization Strategy analyses can be used to ascertain which components are essential to

439. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - This application is discussed in the analyses. … We performed sensitivity analyses for the GPI analyses in KQ 2 because of the heterogeneity of the … Not at all clear where the CURE data were pulled from for these analyses. … Specifically, the forest plots are nice visual representations of the meta-analyses. … This doesn’t come out in the analyses.

440. Effectiveness of Treatments for Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetic-neuropathy_research-protocol.pdf
     May 09, 2016 - Two comprehensive systematic reviews and meta-analyses focusing solely on pharmacologic interventions … Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a references list … We will conduct meta-analyses when there are sufficient data (at least three studies) and studies are … Dichotomous data with zero values in both arms will not be included in meta-analyses. … All meta-analyses will be conducted using STATA (College Station, TX).