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401. Evidence Summary for Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
     December 01, 2020 - Meta- analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain and likelihood … Otherwise, meta- analyses were not conducted due to small number of studies, methodological limitations

402. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
     September 18, 2012 - Partners Inc., Ottawa, Ontario, Canada),21 which is designed specifically for systematic reviews and meta-analyses … Analyses will be conducted with Stat Xact Procs for SAS.23 Unless statistical power is adequate, … subgroup analyses will be narrative in order to be able to make comparisons between study designs and … assessed for quality, and analyzed) as one study to ensure that the same participants do not enter the analyses … control/comparison group such as population surveillance, retrospective and prospective cohorts, and analyses

403. Executive Summary_Comparative Effectiveness Review No. 261_Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-261-postpartum-care-executive-summary.pdf
     June 01, 2023 - was sufficient evidence without an unacceptable amount of heterogeneity, we conducted pairwise meta-analyses … of key informants and technical experts and other outcomes for which we were able to conduct meta-analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses

404. skin-cancer-protocol-160810 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-cancer_research-protocol.pdf
     August 10, 2016 - nonrandomized comparative studies (e.g., see references11-16) and over 30 systematic reviews and meta-analyses … We expect to conduct random effects model meta-analyses of comparative studies, if they are sufficiently … explored qualitatively and, if appropriate data are available, we may also conduct metaregression analyses … Full methodology for conducting the network meta-analyses will be reported, as will all results and … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

405. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
     January 01, 2013 - Utility and Preference-Based Measures Patient-reported outcomes and cost analyses intersect around the … In health economic analyses, utilities are used to justify devoting resources to a treatment. … Sensitivity Analysis One of the key factors to address in planned sensitivity analyses for an observational … Sensitivity analyses should be performed when questions arise around the study outcomes. … Sensitivity analyses should be proposed that address different relevant definitions of the study outcome

406. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/quality-gap-palliative-hospice_research-protocol.pdf
     June 27, 2011 - We will also conduct focused searches and separate analyses for QI studies in hospice care and nursing … the information we abstract in a systematic manner, but it is not our intention to conduct any meta-analyses … address common outcomes and in similar populations and settings, we will consider conducting meta-analyses … We plan to conduct subgroup analyses for hospice care and for nursing home settings. F. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

407. Standardized Library of Asthma Outcome Measures (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-asthma.pdf
     April 01, 2019 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … ‘uncontrolled’ only) on the selected measurement instrument should be recorded to permit future analyses … ‘uncontrolled’ only) on the selected measurement instrument should be recorded to permit future analyses

408. Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
     May 01, 2016 - . �� Meta-analyses provided strong evidence that lisdexamfetamine increased binge-eating abstinence … b Waitlist refers to patients who received no treatment at all. c For quantitative synthesis, meta-analyses … meta-analysis; RCT = randomized controlled trial; RR = risk ratio a For quantitative synthesis, meta-analyses

409. Cer-254-Rural-Telehealth-App-E (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-app-e.xlsx
     January 01, 2021 - Groups Similar or Design and Analyses Account for Important Potential Confounding and Modifying Variables … Design and Analyses Account for Important Potential Confounding and Modifying Variables Appropriately

410. Reduction in Medication Use after Bariatric Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bariatric-surgery_research.pdf
     June 01, 2010 - was included in the models as a covariate to test for differences by diabetes diagnosis where the analyses … The analyses for each class of medication were stratified by diagnosis of diabetes when the diagnosis … Analyses were done using SAS version 9.13 (SAS Institute, Cary, NC). … In the analyses stratified by diagnosis of diabetes, for the classes of antihypertensive and lipid-lowering … We then conducted multivariate logistic regression analyses in several phases using: (1) all variables

411. Automated-Entry Patient Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-generated-health-data-protocol-chronic-conditions.pdf
     March 17, 2020 - Partial economic evaluations and other cost analyses or descriptions are out of scope as costs are … We will note whether cost analyses were reported. … Partial economic evaluations and other cost analyses or descriptions are out of scope as costs … The sentence on partial economic evaluations and other cost analyses was deleted based on the earlier

412. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - would get meta analyses? … At times, the use of meta analyses seem arbitrary. … The forest plots are labeled as meta analyses, technically they are forest plots. … We have added to the Methods, “We also conducted sensitivity analyses by omitting one study at time … It looks as if Wang 2012 was excluded as having an uncertain risk of bias, but in other meta-analyses

413. Covariate Selection for Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/covariate-selection-chapter-7.pptx
     January 01, 2013 - Pharmacoepidemiological studies that do not restrict analyses to incident episodes of treatments are … Both the “as treated” and “per protocol’’ analyses can be used to evaluate time-varying treatment. … Investigators routinely adjust analyses by using proxy confounders and mismeasured confounders. … (See chapter 11 for further discussion of sensitivity analyses.) … Sensitivity analyses can address residual confounding.

414. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
     May 01, 2010 - Analyses by dosing, rather than cases of use, could have different findings. … supplied by the manufacturer of rFVIIa (Novo Nordisk), searched the bibliographies of identified meta-analyses … Studies When there were sufficient studies to warrant meta- analytic evaluation, we performed these analyses … In all cases where meta-analyses were performed, the results of the risk difference and arcsine metrics … In all cases where meta-analyses were performed, the results of the risk difference and arcsine metrics

415. Rapid Evidence Product_Assisted Home Dialysis in the United States: New Interest in an Old Idea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/home-dialysis-ESKD-rapid-research.pdf
     April 01, 2025 - In multivariate analyses, APD patients receiving nurse assistance were less likely to remain peritonitis … However, that difference disappeared when analyses were restricted to patients who received home visits … with a cohort of patients who were PD-assist eligible but chose not to participate.25 In adjusted analyses … and 47 percent, respectively, less likely to be on PD compared with White populations in adjusted analyses … excluded for wrong study design because they were systematic reviews, literature reviews, or meta- analyses

416. Dietary Total Fat Intake and Dietary Polyunsaturated Fatty Acid Intake and Child Growth and Development Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/child-growth-development-outcomes-protocol-amended.pdf
     November 18, 2024 - will adhere to the international PRISMA51 (Preferred Reporting Items for Systematic reviews and Meta-Analyses … Studies rated high risk of bias may be analyzed separately when appropriate (e.g., sensitivity analyses … studies if there are at least two clinically and methodologically comparable studies.50,55,56 Meta-analyses … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by … Findings table will be constructed for each comparison in each Key Question, with quantitative (meta-analyses

417. Alcohol-Misuse Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
     April 28, 2010 - that leads to a very high risk of bias) in one or more categories and will exclude them from our analyses … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate. … Planned stratifications or categories for subgroup analyses include geographic location of studies

418. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - particularly as pertain to reviews of comparative effectiveness, diagnostic tests, and complex meta-analyses … , the appropriateness of their eligibility criteria, the statistical appropriateness of their meta-analyses … and other analyses, and their evaluation of the study-level risk of bias. … We do not expect to be able to conduct statistical analyses on these evaluations. … Meta-analyses of Current Strategies to Treat Uncomplicated Diverticulitis.

419. Systematic Review Update: Noninvasive Nonpharmacologic Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
     December 11, 2018 - As appropriate, sensitivity analyses may be performed to elucidate differences between studies that … Meta-analyses from the 2018 report will be updated and new analyses conducted to summarize data and … studies to account for uncertainty across them and provide more conservative estimates.20-22 Primary analyses … We will perform sensitivity and subgroup analyses based on specific interventions (e.g., type of acupuncture … Measuring inconsistency in meta-analyses.

420. Dementia-Nursing-Home-Characteristics Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
     October 01, 2012 - must have explicitly stated that at least 80 percent of the population had dementia or that some analyses … We excluded poor- quality studies from our analyses, which could in turn affect the strength of the … Data Synthesis To determine whether quantitative analyses were appropriate, we assessed the clinical … Because we determined that quantitative analyses were not appropriate (owing to clinical heterogeneity … insufficient regarding the effects of lighting interventions on these outcomes and for subgroup analyses