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401. Executive Summary_Comparative Effectiveness Review No. 261_Postpartum Care up to 1 Year After Pregnancy: A Systematic Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-261-postpartum-care-executive-summary.pdf
     June 01, 2023 - was sufficient evidence without an unacceptable amount of heterogeneity, we conducted pairwise meta-analyses … of key informants and technical experts and other outcomes for which we were able to conduct meta-analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses

402. Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents - Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
     November 01, 2021 - in the prior report for cumulative meta-analyses • KQ 3: Monitoring strategies and long-term effects … In addition, we will update the meta-analyses included in the prior report and incorporate prior and … new studies into pooled analyses in order to provide a full picture of the existing evidence.5, 47 … included in the 2018 report to summarize data and obtain more precise estimates in cumulative analyses … If there are sufficient studies, we will perform meta-regression analyses to examine these hypotheses

403. Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
     May 01, 2016 - . �� Meta-analyses provided strong evidence that lisdexamfetamine increased binge-eating abstinence … b Waitlist refers to patients who received no treatment at all. c For quantitative synthesis, meta-analyses … meta-analysis; RCT = randomized controlled trial; RR = risk ratio a For quantitative synthesis, meta-analyses

404. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/quality-gap-palliative-hospice_research-protocol.pdf
     June 27, 2011 - We will also conduct focused searches and separate analyses for QI studies in hospice care and nursing … the information we abstract in a systematic manner, but it is not our intention to conduct any meta-analyses … address common outcomes and in similar populations and settings, we will consider conducting meta-analyses … We plan to conduct subgroup analyses for hospice care and for nursing home settings. F. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

405. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
     January 01, 2013 - Utility and Preference-Based Measures Patient-reported outcomes and cost analyses intersect around the … In health economic analyses, utilities are used to justify devoting resources to a treatment. … Sensitivity Analysis One of the key factors to address in planned sensitivity analyses for an observational … Sensitivity analyses should be performed when questions arise around the study outcomes. … Sensitivity analyses should be proposed that address different relevant definitions of the study outcome

406. skin-cancer-protocol-160810 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-cancer_research-protocol.pdf
     August 10, 2016 - nonrandomized comparative studies (e.g., see references11-16) and over 30 systematic reviews and meta-analyses … We expect to conduct random effects model meta-analyses of comparative studies, if they are sufficiently … explored qualitatively and, if appropriate data are available, we may also conduct metaregression analyses … Full methodology for conducting the network meta-analyses will be reported, as will all results and … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

407. Cer-254-Rural-Telehealth-App-E (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-app-e.xlsx
     January 01, 2021 - Groups Similar or Design and Analyses Account for Important Potential Confounding and Modifying Variables … Design and Analyses Account for Important Potential Confounding and Modifying Variables Appropriately

408. Reduction in Medication Use after Bariatric Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bariatric-surgery_research.pdf
     June 01, 2010 - was included in the models as a covariate to test for differences by diabetes diagnosis where the analyses … The analyses for each class of medication were stratified by diagnosis of diabetes when the diagnosis … Analyses were done using SAS version 9.13 (SAS Institute, Cary, NC). … In the analyses stratified by diagnosis of diabetes, for the classes of antihypertensive and lipid-lowering … We then conducted multivariate logistic regression analyses in several phases using: (1) all variables

409. Disposition of Comments_Comparative Effectiveness Review No. 248: Prehabilitation and Rehabilitation for Major Joint Replacement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-disposition-comments.pdf
     November 03, 2021 - Some reviewers questioned why we did not conduct meta-analyses, especially given that some past reviews

410. Automated-Entry Patient Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-generated-health-data-protocol-chronic-conditions.pdf
     March 17, 2020 - Partial economic evaluations and other cost analyses or descriptions are out of scope as costs are … We will note whether cost analyses were reported. … Partial economic evaluations and other cost analyses or descriptions are out of scope as costs … The sentence on partial economic evaluations and other cost analyses was deleted based on the earlier

411. Covariate Selection for Observational Comparative Effectiveness Research
     effectivehealthcare.ahrq.gov/sites/default/files/covariate-selection-chapter-7.pptx
     January 01, 2013 - Pharmacoepidemiological studies that do not restrict analyses to incident episodes of treatments are … Both the “as treated” and “per protocol’’ analyses can be used to evaluate time-varying treatment. … Investigators routinely adjust analyses by using proxy confounders and mismeasured confounders. … (See chapter 11 for further discussion of sensitivity analyses.) … Sensitivity analyses can address residual confounding.

412. Evidence Summary Comparative Effectiveness Review 216 Telehealth for Acute and Chronic Care Consultations (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-216-telehealth-evidence-summary.pdf
     April 01, 2019 - Both systematic reviews and decision analyses have accepted methodologies, but they are not frequently … We were able to conduct meta- analyses for some but not all topics and outcomes due to the heterogeneity … , the model was built to allow inclusion of patient outcomes following treatment for cost benefit analyses … more direct comparisons across clinical topics and both facilitate and inform additional decision analyses … For example, the work on the decision analyses highlighted the importance of clearly specifying the

413. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - would get meta analyses? … At times, the use of meta analyses seem arbitrary. … The forest plots are labeled as meta analyses, technically they are forest plots. … We have added to the Methods, “We also conducted sensitivity analyses by omitting one study at time … It looks as if Wang 2012 was excluded as having an uncertain risk of bias, but in other meta-analyses

414. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
     May 01, 2010 - Analyses by dosing, rather than cases of use, could have different findings. … supplied by the manufacturer of rFVIIa (Novo Nordisk), searched the bibliographies of identified meta-analyses … Studies When there were sufficient studies to warrant meta- analytic evaluation, we performed these analyses … In all cases where meta-analyses were performed, the results of the risk difference and arcsine metrics … In all cases where meta-analyses were performed, the results of the risk difference and arcsine metrics

415. Glasgow Coma Scale for Field Triage of Trauma: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow_executive.pdf
     January 01, 2017 - We did not exclude studies rated high risk of bias a priori, but performed sensitivity analyses to … We also performed analyses using the Profile Likelihood method. … Stratified and sensitivity analyses were performed on the potential modifiers of effects. … Findings for discrimination were robust in sensitivity and subgroup analyses based on the age group … We also found no clear differences in estimates of predictive utility when we restricted analyses to

416. Disposition of Comments for CER 178 Newer Medications for Lower Urinary Tract Symptoms (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/prostatic-hyperplasia-medications_disposition-comments.pdf
     May 26, 2016 - methods described and used in this report are typical for systematic reviews and quantitative meta-analyses … carefully managed data extraction and outstanding application of modern statistical methods for meta-analyses … Because sub-scale score analyses were never suggested by team or TEP members, we did not explore the … the key questions (KQ#3) -for key points under anticholinergics, would again note that secondary analyses … shown no differences in efficacy when evaluating demographic/clinical analyses (with ___ SOE).

417. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - particularly as pertain to reviews of comparative effectiveness, diagnostic tests, and complex meta-analyses … , the appropriateness of their eligibility criteria, the statistical appropriateness of their meta-analyses … and other analyses, and their evaluation of the study-level risk of bias. … We do not expect to be able to conduct statistical analyses on these evaluations. … Meta-analyses of Current Strategies to Treat Uncomplicated Diverticulitis.

418. Systematic Review Update: Noninvasive Nonpharmacologic Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
     December 11, 2018 - As appropriate, sensitivity analyses may be performed to elucidate differences between studies that … Meta-analyses from the 2018 report will be updated and new analyses conducted to summarize data and … studies to account for uncertainty across them and provide more conservative estimates.20-22 Primary analyses … We will perform sensitivity and subgroup analyses based on specific interventions (e.g., type of acupuncture … Measuring inconsistency in meta-analyses.

419. Alcohol-Misuse Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
     April 28, 2010 - that leads to a very high risk of bias) in one or more categories and will exclude them from our analyses … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate. … Planned stratifications or categories for subgroup analyses include geographic location of studies

420. Dementia-Nursing-Home-Characteristics Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
     October 01, 2012 - must have explicitly stated that at least 80 percent of the population had dementia or that some analyses … We excluded poor- quality studies from our analyses, which could in turn affect the strength of the … Data Synthesis To determine whether quantitative analyses were appropriate, we assessed the clinical … Because we determined that quantitative analyses were not appropriate (owing to clinical heterogeneity … insufficient regarding the effects of lighting interventions on these outcomes and for subgroup analyses