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41. Cer-242-Radiation-Therapy-Brain-Metastases-Evidence-Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
    June 01, 2021 - comparators, and outcome measures and reporting, the number of studies that could be combined for analyses … Random effects meta-analyses computed hazard ratios (HRs), relative risks (RRs), and standardized mean … studies used mixed samples in terms of primary tumor type and prognosis, only WBRT studies allowed analyses … at all, and analyses were only possible for selected outcomes. … Despite the large number of identified research studies, analyses were limited as studies evaluated

42. Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment–An Update to the 2006 Report | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/cancer-anemia-update/research-protocol
    June 16, 2010 - Rather, new analyses are needed. … Study-level and individual patient data meta-analyses. … Accordingly, the tool will be applied to all meta-analyses. … A random effects model will be assumed for all meta-analyses. … Meta-analyses of safety data: a comparison of exact versus asymptotic methods.

43. Menopausal Symptoms: Comparative Effectiveness Review of Therapies | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/menopause/research-protocol
    April 03, 2012 - Other meta-analyses and systematic reviews will not be included. … a Meta-analyses/systematic reviews Include Observational studies Include if meta-analyses/systematic … A proposed method of bias adjustment for meta-analyses of published observational studies. … Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses. … appropriate (e.g. missing data, covariate adjustment, sensitivity analyses)

44. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
    June 16, 2010 - Rather, new analyses are needed. … Study-level and individual patient data meta-analyses. … Ongoing studies and interim analyses. Sources of Full text publications. … Accordingly, the tool will be applied to all meta-analyses. … A random effects model will be assumed for all meta-analyses.

45. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - Sensitivity Analyses Completing a CER is a structured process. … Studies with zero events in one arm should be included in the analyses. 3.2. … Sensitivity analyses 1. … This article does not address every major issue relevant to meta-analyses. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560. 18 48.

46. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - Sensitivity Analyses Completing a CER is a structured process. … Studies with zero events in one arm should be included in the analyses. 3.2. … Sensitivity analyses 1. … This article does not address every major issue relevant to meta-analyses. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560. 18 48.

47. Colorectal-Surgery-Preparation Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
    April 01, 2014 - We also performed sensitivity analyses, such as leave-one-out analyses, analyses assuming a fixed-effects … model, analyses including a retracted study, and analyses evaluating alternative network topologies … Fifty-eight studies were included in main analyses. … Forty-two of the 44 RCTs were included in main analyses. … Results were robust in all sensitivity analyses: use of informative priors, leave-one-out analyses,

48. Comparative Effectiveness of Antihypertensive Therapies on Cardiovascular Disease Outcomes In End-Stage Renal Disease | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/renal-disease-therapies/abstract
    March 31, 2011 - Within each data source, we will perform several longitudinal analyses to assess the comparative effectiveness … Analyses will adjust for potential confounders of the relation between antihypertensive medication and … We will conduct sensitivity analyses to assess the robustness of our findings using alternative techniques

49. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
    March 16, 2017 - We have clarified our approach to subgroup analyses, and mentioned that we conducted sensitivity analyses … for outcomes with at least three studies and network meta-analyses for two outcomes. … All analyses were conducted in a Bayesian framework. No response required. … Peer Reviewer 9 Methods It is fine to use Bayesian method to conduct pairwise meta-analyses. … All meta-analyses were random effects. TEP 10 Methods Yes to all.

50. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children-update-disposition-170621.pdf
    March 16, 2017 - We have clarified our approach to subgroup analyses, and mentioned that we conducted sensitivity analyses … for outcomes with at least three studies and network meta-analyses for two outcomes. … All analyses were conducted in a Bayesian framework. No response required. … Peer Reviewer 9 Methods It is fine to use Bayesian method to conduct pairwise meta-analyses. … All meta-analyses were random effects. TEP 10 Methods Yes to all.

51. Identification of Future Research Needs in the Comparative Management of Uterine Fibroid Disease | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/uterine-fibroids-2010/research
    March 10, 2011 - The team also reviewed the findings from the preliminary data analyses conducted for this project. … The data analyses produced descriptive profiles of patient populations with a uterine fibroid diagnosis … While the data analyses provided valuable insights into variation in treatment patterns, they also highlighted … the limitations of retrospective claims-based data analyses, including an inability to adjust data to … The two primary goals of these data analyses are: (1) to provide information on treatment patterns and

52. Disposition of Comments Report for Comparative Effectiveness Review 128 Oral Mechanical Bowel Preparation for Colorectal Surgery (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
    April 30, 2014 - , but not necessarily for the network analyses). … , including analyses not stratified by the use of enema. … We have added results from these analyses for all outcomes. … statistical analyses. … There is just too much information and too many analyses. Thank you.

53. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - The Appendix also contains analyses based on last follow-up. … For meta-analyses looking at post-RT up to 4 weeks, if studies reported earlier time frames, we used … The report analyses, tables and plots are consistent with the protocol for answering the key questions … arms (i.e., non-comparative analyses). … These additional analyses would be beyond the scope of the protocol and raise methodological concerns

54. Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/signals/research
    June 15, 2011 - effects of omega-3 fatty acids on cancer, cognition and aging, and cardiovascular diseases (with separate analyses … quantitative signal for the need to update was based on statistical differences with the original meta-analyses … and caveats about the previously reported findings, were sought for outcomes without existing meta-analyses

55. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
    March 10, 2010 - We really wanted to conduct these analyses but as we discuss in KQ7, we cannot fully provide this data … We acknowledge We now specify which ACE inhibitors and ARBs were included in the different analyses … analyses, there is a complicated matrix of different analyses partitioned according to population, … We strongly suggest that the EPC eliminate those analyses in which studies of ACE inhibitors and ARBs … In our revised CER we now provide more insight into our rationale for conducting the analyses in this

56. Menopause-Protocol-130612 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
    June 12, 2013 - Other meta-analyses and systematic reviews will not be included. … insufficienta Meta-analyses/systematic reviews Include Observational studies Include if meta-analyses … Conducting Meta-Analyses in R with the metafor Package. … How should meta-regression analyses be undertaken and interpreted? … Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

57. A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/primary-research-design/research
    January 03, 2012 - A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research … Data sources Published frameworks or models designed to use results of systematic reviews or meta-analyses

58. Practice-Based Interventions Addressing Concomitant Depression and Chronic Medical Conditions in the Primary Care Setting | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/depression-chronic-conditions-interventions/research
    August 13, 2012 - We conducted quantitative analyses for outcomes when feasible and reported all results by medical condition … published articles reporting data from 12 studies (9 randomized controlled trials and 3 preplanned subgroup analyses … Our meta-analyses found that intervention recipients achieved greater improvement than controls in depression

59. Ch 11-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
    January 03, 2012 - Analyses are available that can be used to estimate a study result in the presence of an hypothesized … The chapter concludes with a checklist of key considerations for including sensitivity analyses in a … It is not intended to be a comprehensive guide to implementing sensitivity analyses. … Spreadsheets that facilitate the conduct of these sensitivity analyses are available. … Guidance Key Considerations Check Propose and describe planned sensitivity analyses

60. Choice-Of-Mean White-Paper (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/choice-of-mean_white-paper.pdf
    April 01, 2015 - These meta-analyses included 5 to 13 studies and 218 to 4,100 patients (Table 2). … The other three meta-analyses compared sleepiness16 and depression18 variables. … These meta-analyses included 3 to 17 studies and 215 to 3,252 patients (Table 3). … These meta-analyses revealed no clear common characteristics. 8 Table 2. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.