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41. App-E-Opioid-Chronic-Pain-Surveill-Report-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveill-report-1.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

42. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
    June 22, 2017 - - analyses). … Therefore, network meta- analyses are improper analytic tools for this systematic review. … Pooled analyses are highly flawed analyses that do not meet any current standards of appropriate systematic … All network meta-analyses use random effects model. … Additional analyses and assessments regarding LMWH vs.

43. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
    May 01, 2005 - When reviews include meta-analyses, we recommend that systematic reviewers consider sensitivity analyses … or other independent analyses. … Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Updating criteria to evaluate the credibility of subgroup analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

44. S5 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
    October 01, 2007 - events of pharmaceutical use; and (3) inventing or refining ways to decrease the threats to validity of analyses … comprise a wide range of nonexperimental designs but also, in this context, various types of database analyses … is decreasing the threats to validity that bedevil analyses of administrative or other observational … Improving depiction of benefits and harms: analyses of studies of well-known therapeutics and review … Using inverse probability- weighted estimators in comparative effectiveness analyses with obser- vational

45. Rheumatoid-Arthritis-Medicine Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
    April 01, 2012 - We generally synthesized the literature qualitatively, but we did conduct meta-analyses comparing the … Subpopulation analyses are described after Table A because the evidence is very limited. 4 Table … Our MTC meta-analyses, suggest some differences, such as etanercept having a higher probability of … The results of the MTC meta-analyses suggested some differences. … Analyses involving subpopulations, specifically those defined by age and coexisting conditions, will

46. Disposition of Comments Report for Decision Aids for Cancer Screening and Treatment (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-decision-support-tools_disposition-comments.pdf
    December 23, 2014 - We now clarify in the report that “Our main analyses used hierarchical (random effects) regression … , we repeated all analyses for subset of trials included in the Cochrane review.” … quantitative analyses for outcomes with enough information. … In sensitivity analyses we pooled across all instruments using SMDs. … The analyses here seem to downplay or not confirm that result for cancer trials.

47. App-E-Opioid-Chronic-Pain-Surveillance-Report-2 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-2.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

48. Research Protocol: Radiation Therapy for Brain Metastases (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiation-therapy-brain-metases-protocol.pdf
    October 10, 2019 - , main analysis, 9 or subgroup analyses. … Chemotherapy, immunotherapy, and radiosensitizer agents will be grouped for the analyses. … subgroup analyses. … Finally, we will present analyses according to how the evidence will be used. … Chapter 11: Undertaking network meta- analyses.

49. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
    February 01, 2009 - Secondary confirmatory analyses employed methods based on propensity scores and instrumental variables … The findings were also observed in the alternative analyses employing propensity score adjustments and … We also restricted analyses to just new users to guard against selection bias among prevalent users … multivariable Cox analyses. … Atypical APMs Other Covariates Analyses Results Discussion References Condition

50. Disposition of Comments for Evidence Report 224 Omega-3 Fatty Acids (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
    October 12, 2016 - We have now added pooled analyses that combine all sources of omega-3 FAs. … We have now added overall pooled analyses to the existing analyses, and show the meta-analyses by type … : Therefore we redid those pooled analyses. … , and consideration of sub-analyses. … we did include in favor of conducting our own de novo analyses.

51. M (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-de-novo-processes_methods.pdf
    September 01, 2009 - • May provide analyses that are not readily available from other sources (e.g., subgroup analyses … • Build on existing SRs by updating meta-analyses or qualitative syntheses. … Quality of Reporting of Meta-analyses. Lancet 1999;354:1896- 900. 8. … Data extraction errors in meta-analyses that use standardized mean differences. … What contributions do languages other than English make on the results of meta- analyses?

52. M (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/systematicreviewsreplacedenovo.pdf
    September 01, 2009 - • May provide analyses that are not readily available from other sources (e.g., subgroup analyses … • Build on existing SRs by updating meta-analyses or qualitative syntheses. … Quality of Reporting of Meta-analyses. Lancet 1999;354:1896- 900. 8. … Data extraction errors in meta-analyses that use standardized mean differences. … What contributions do languages other than English make on the results of meta- analyses?

53. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-executive-170622.pdf
    June 01, 2017 - Pairwise meta-analyses were conducted in R using the metafor package. … Network meta-analyses were conducted in R using the gemtc package. … ) analyses. … Ideally, these analyses should be adequately powered. … Almost no studies reported subgroup analyses.

54. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/thromboembolism-update-executive-170622.pdf
    June 01, 2017 - Pairwise meta-analyses were conducted in R using the metafor package. … Network meta-analyses were conducted in R using the gemtc package. … ) analyses. … Ideally, these analyses should be adequately powered. … Almost no studies reported subgroup analyses.

55. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
    September 01, 2010 - , and biologics to placebo (there are 43 meta-analyses for Crohn’s disease medications; 18 from the … Follow-up duration will be considered in the analyses. … These sensitivity analyses will be compared to our analyses of moderate-to-severe Crohn’s disease. … If we identify such variables explaining inconsistency we will stratify the analyses accordingly. … □ Sensitivity analyses for all Key Questions will include all levels of disease severity.

56. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
    May 01, 2005 - When reviews include meta-analyses, we recommend that systematic reviewers consider sensitivity analyses … or other independent analyses. … Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Updating criteria to evaluate the credibility of subgroup analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

57. S166 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s166.pdf
    October 01, 2007 - and Bayesian methods of analysis of indirect comparisons should be considered when performing meta-analyses … We recalculated the direct com- parison frequentist meta-analyses described above using these Bayesian … Prior Sensitivity for Bayesian Analyses All our Bayesian analyses were completely insensitive to the … Direct Comparison—Bayesian The model used for the Bayesian meta-analyses was as follows. … The chosen prior distributions were examined in sen- sitivity analyses.

58. Methods Guide for Comparative Effectiveness Reviews - Avoiding Bias in Selecting Studies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
    February 01, 2013 - One might expect that all the trials included in earlier meta-analyses would be included in later meta-analyses … Meta- analyses of therapies for postmenopausal osteoporosis. II. … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … What contributions do languages other than English make on the results of meta- analyses? … Does blinding of readers affect the results of meta-analyses?

59. App-E-Opioid-Chronic-Pain-Surveillance-Report-3 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-3.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

60. Partial Breast Irradiation for Breast Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/partial-breast-irradiation-disposition-comments.pdf
    January 31, 2023 - We added p value for the interaction between all subgroup analyses in Appendix J. … The findings were generated from subgroup analyses and suffer higher risk of bias. … We intended to include “sexual health” in the analyses without restrictions. … In the methods, we stated that “we were unable to conduct other prespecified subgroup analyses … to rate and their rating may be misleading because they are derived from subgroup analyses.