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381. Disposition of Comments: CER 224, Treatment of Depression in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-224-depression-children-comments.pdf
     April 10, 2020 - Wagner et al present pooled analyses of RCTs (ineligible design) and did not present individual estimates … These subgroup analyses, when available, were generally hypothesis generating because studies were … and require confirmation from larger preplanned analyses.” … and require confirmation from larger preplanned analyses.” … Point applies to many of the outcomes examined, I wonder whether better to leave these analyses out

382. Methods Guide for Medical Test Reviews Chapter 6 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-applicability_methods.pdf
     July 01, 2012 - Conducting subgroup analyses after appraising the included studies may introduce type 1 error (i.e., … − Include presence/absence as parameter in meta-regression or sensitivity analyses. … − Model cut-offs and conduct sensitivity analyses. Comparator Use of gold standard vs. … identify these factors ahead of time and justify when to “split” questions or to conduct subgroup analyses … should prompt consideration of using timeframes as criteria for inclusion or careful descriptions and analyses

383. Disposition of Comments Report for Otitis Media With Effusion (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_disposition-comments.pdf
     May 04, 2013 - Analyses by Paradise et al. suggest that mild hearing loss in preschool children for periods of up … This phrase was written in relation to meta- analyses that were described by the authors as combining … but we include a number of pooled analyses that were conducted by the earlier Cochrane studies. … were not appropriate, we did all analyses qualitatively. … Evidence used in the synthesis included the results from the earlier meta-analyses, additional data

384. Treatment Strategies for Women With Coronary Artery Disease: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment-future_research.pdf
     February 01, 2013 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … ; also possible would be meta- analyses of all existing clinical trials with patient-level data to more … Analyses suggested a benefit of CABG (OR, 0.62; 95% CI, 0.31 to 1.24) or either PCI or CABG (OR, 0.71 … A search of PubMed for relevant systematic reviews and meta-analyses included in our original search … Many of the same issues inherent in meta-analyses of RCTs (both study-level and patient-level data)

385. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
     March 08, 2012 - with activities of daily living and/or sleeping) Results of existing systematic reviews and meta-analyses … Years of Age or Older Comparative adverse effects reported in the RCTs, systematic reviews, meta-analyses … Additionally, systematic reviews and meta-analyses that specifically assess adverse events associated … Inclusion criteria for RCTs, observational studies, systematic reviews, and meta- analyses are as outlined … appropriate (e.g. missing data, sensitivity analyses) Appendix C Deeks criteria for nonrandomized

386. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
     July 01, 2011 - We performed subgroup meta-analyses based on study design (parallel or crossover), minimum AHI threshold … Analysis of difference versus average analyses plots suggest that substantial differences in the measured … Very few trials reported subgroup analyses based on baseline characteristics, and for most comparisons … Such analyses were feasible for the comparison between CPAP and control, where subgroup meta-analyses … Other frequent methodological problems with studies included incomplete reporting and/or inadequate analyses

387. Disposition of Comments for CER 183 Tonsillectomy for OSDB (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
     January 17, 2017 - Stating the post-tonsillectomy bleeding (PTH) was "low (<4% in meta-analyses)" does not make sense, … We have revised this text to note that bleeding rates were less than 4% in meta-analyses and have added … We agree that additional data are needed to inform analyses and have added a statement to the research … We did not identify studies or analyses explicitly focused on this population, though some studies … after sensitivity analyses showed no significant effects.

388. pneumonia-antibiotic-treatment-protocol-130718 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
     July 19, 2013 - We plan to omit studies deemed to have high risk of bias from our main data synthesis and main analyses … ; we will include them only in sensitivity analyses. … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … If sufficient data are available, meta-analyses and results will be stratified by (1) method of PK/PD … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. PMID: 12958120. 33.

389. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - Meta-analyses that used methods to indirectly compare interventions of interest, including adjusted … indirect comparisons or network meta-analyses, were included and summarized qualitatively for all … Identified network meta-analyses from the second literature search were qualitatively described in … There were no previously conducted traditional meta-analyses identified by our literature search that … Future analyses using indirect comparisons may also help supplement lack of direct comparative data.

390. Omega-3 Fatty Acids and Maternal and Child Health: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_executive.pdf
     October 01, 2016 - were performed in R 3.2.0.16 New trial results were added to original meta-analyses, when appropriate … Pooled analyses of four RCTs also found no significant effects of fish oil supplementation (DHA+EPA) … None of the analyses showed evidence for publication bias. … Across RCTs, the most common risk-of- bias limitation was a lack of intention-to-treat analyses (54 … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. PMID: 12958120. 16.

391. Disposition of Comments Report for Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/obesity-child_disposition-comments.pdf
     June 10, 2013 - It is true that the pooled analyses were not significant for either BMI or BMI z-score. … State # of studies for which pooled analyses were possible. … Do these studies note up front which analyses were primary? … We describe in the methods section our rationale for including studies in the meta-analyses. … We analyzed the last reported time point for studies that were eligible for the meta analyses.

392. Liver-Cancer Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
     October 01, 2014 - Data Synthesis We performed meta-analyses on measures of test performance in order to help summarize … data and obtain more precise estimates.15 All quantitative analyses were conducted using SAS® 9.3 … We conducted separate analyses for each imaging modality, stratified according to the unit of analysis … We performed analyses stratified according to the reference standard used and on domains related to … Conclusions were generally robust on sensitivity and stratified analyses based on study factors such

393. Medication-Therapy-Management Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
     November 01, 2014 - We excluded studies that we deemed at high risk of bias from our main data synthesis and main analyses … For all analyses, we used random-effects models to estimate pooled or comparative effects. … When quantitative analyses were not appropriate (e.g., because of heterogeneity, insufficient numbers … No meta- analyses included more than five studies; as a result, we did not examine included studies … US pharmacists’ effect as team members on patient care: systematic review and meta-analyses.

394. Asthma-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-treatment_executive.pdf
     May 01, 2011 - We used Stata 11.2® for all effect size calculations and meta-analyses (Stata Corp., College Station … characteristics.22,30,41 Subgroup analyses were not described as being planned a priori, but were … • Exploratory analyses suggest that comprehensive approaches, especially those including additional … These analyses were purely exploratory and did not account for effect size, so should be considered … Subgroup analyses of teens and/or emerging adults were not reported.

395. Disparities-Quality-Improvement Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disparities-quality-improvement_executive.pdf
     August 01, 2012 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … When possible to identify, analyses resulting from the same study were grouped together. … Studies by Clinical Condition Cancer Five RCTs with subgroup analyses explored the effects of various … Racial disparities were of interest in all three, but interim analyses were also performed based on … The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses

396. Tools to (Semi) Automate Evidence Synthesis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/AI-tools-protocol.pdf
     August 15, 2023 - ”) • Exclude: Usability analyses Study Designs • Primary studies • Systematic reviews, to be … source of citations • Exclude: narrative (non-quantitative) summaries, usability studies • Exclude: Analyses

397. Evidence Summary for Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
     December 01, 2020 - Meta- analyses were conducted on pharmacologic therapy for dental pain and kidney stone pain and likelihood … Otherwise, meta- analyses were not conducted due to small number of studies, methodological limitations

398. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline-disposition-170707pdf.pdf
     March 24, 2017 - Systematic reviews and subsequent meta-analyses are meant to facilitate an evaluation of the totality … Individual differences analyses need to be run (for example K-means cluster). … We could not perform meta-analyses because the cognitive measures were too diverse; they did not even … Which and how many of these studies are actually included in the analyses? … Modern methods of handling missing data, in particular propensity score weighted analyses (in which

399. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cognitive-decline-disposition-170707pdf.pdf
     March 24, 2017 - Systematic reviews and subsequent meta-analyses are meant to facilitate an evaluation of the totality … Individual differences analyses need to be run (for example K-means cluster). … We could not perform meta-analyses because the cognitive measures were too diverse; they did not even … Which and how many of these studies are actually included in the analyses? … Modern methods of handling missing data, in particular propensity score weighted analyses (in which

400. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
     September 18, 2012 - Partners Inc., Ottawa, Ontario, Canada),21 which is designed specifically for systematic reviews and meta-analyses … Analyses will be conducted with Stat Xact Procs for SAS.23 Unless statistical power is adequate, … subgroup analyses will be narrative in order to be able to make comparisons between study designs and … assessed for quality, and analyzed) as one study to ensure that the same participants do not enter the analyses … control/comparison group such as population surveillance, retrospective and prospective cohorts, and analyses