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341. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - To maximize the similarities amongst studies that could potentially be combined for meta-analyses, we … There are several patient characteristics that we may further explore with sensitivity analyses (if … meta-analyses can be undertaken) including the following: 1) disease severity (within MDD only); 2) … If a particular outcome is shown to have a high risk of publication bias, then the analyses will be … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

342. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
     September 01, 2011 - We searched for systematic reviews, clinical controlled trials, meta-analyses, and nonexperimental studies … quality of individual studies as good, fair, or poor; only good or fair studies are included in these analyses … If data were sufficient, we conducted meta-analyses of data for comparisons involving trials that were … The use of inconsistent definitions of TRD in the trials and the absence of analyses considering the … investigators in designing TRD trials and may be important to consider as a potential covariate in analyses

343. EHC Research Protocol (Amended): Treatments for Acute Episodic Migraine (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
     January 09, 2020 - RCTs o Comparative observational studies • Any sample size • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct subgroup analyses based on length of followup ( … We will conduct sensitivity analyses to evaluate robustness of our findings by excluding studies with … We will lower SOE grading when sensitivity analyses 1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

344. hemangioma-protocol-141223 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_research-protocol.pdf
     December 23, 2014 - Existing Systematic Reviews and Meta-Analyses We identified 13 treatment-focused systematic reviews … or meta-analyses published in the last 10 years addressing IH (Appendix A). … We will carry out hand searches of the reference lists of recent systematic reviews or meta-analyses … We will report findings of poor quality studies in evidence tables but will focus our analyses on those … It is likely that analyses will be combined using a hierarchical mixed effects model.

345. Evidence Summary-Comparative-Effectiveness-Review-213-Lower-Limb-Prostheses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
     September 01, 2018 - Half of studies used nonvalidated instruments and analyses were inadequate. … , regression analyses, or individual patient data which would allow subgroup analyses. … Another study (Hahn 2015) conducted correlation and regression analyses but did not fully report the … results of these analyses. … Subgroup analyses in single studies tended to be underpowered to detect differences, mostly leading

346. Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/maternal-child-outcomes-wic-disposition-comments.pdf
     April 19, 2022 - systematic review addresses the shortcomings of current research, such as the need for more subgroup analyses … We did not conduct analyses that required sensitivity analyses.

347. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
     October 01, 2010 - A p-value of <0.05 was considered statistically significant for all analyses. … , subgroup and sensitivity analyses were conducted. … Only four studies employed multivariate analyses (each using different questionnaires to rate HRQoL). … Only five studies employed multivariate analyses (each using different questionnaires to rate HRQoL). … In univariate analyses, there was no relationship between FEV1, FVC, or BMI and bone fracture.

348. Psychological and Pharmacological Treatments for Adults with Posttraumatic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
     December 31, 2017 - All new qualitative and quantitative analyses will synthesize relevant studies included in the 2013 … For all analyses, we will use random-effects models to estimate pooled or comparative effects. … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

349. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk … We will identify statistical heterogeneity between the trials in all the meta-analyses by using: 1) … We will conduct sensitivity analyses by omitting one study at a time to assess the influence of any … For all meta-analyses, we will conduct formal tests for publication bias by using Begg’s and Egger’s … What contributions do languages other than English make on the results of meta-analyses?

350. S131 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
     October 01, 2007 - Noninformative drop-out causes bias towards the null in intention-to-treat (ITT) analyses. … For RCTs all restrictions and most subgroup analyses need to be predetermined because RCTs are by design … In database studies, several keystrokes will suffice to perform subgroup analyses to identify modifications … A meta-analyses of 3 RCTs of pravastatin showed a moderate overall mortality effect for patients 65 years … The obvious solution to this problem is to stratify analyses ac- cording to relevant clinical subgroups

351. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - Three were active-controlled clinical trials, six were systematic reviews with meta-analyses, and nine … Mixed  treatment   comparisons):  No significant differences in disease activity (ACR 50) in MTC analyses … disease activity (ACR 50) for anakinra compared with etanercept and compared with adalimumab in MTC analyses … therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta- analyses … disease activity (ACR 50) for anakinra compared with etanercept and compared with adalimumab in MTC analyses

352. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - Three were active-controlled clinical trials, six were systematic reviews with meta-analyses, and nine … Mixed  treatment   comparisons):  No significant differences in disease activity (ACR 50) in MTC analyses … disease activity (ACR 50) for anakinra compared with etanercept and compared with adalimumab in MTC analyses … therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta- analyses … disease activity (ACR 50) for anakinra compared with etanercept and compared with adalimumab in MTC analyses

353. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - Increasingly, commercial companies present their own life cycle analyses to market and promote adoption … The frameworks and analyses appear comparable, and restricting searches further will miss foundational … It is critical to understand the context for the analyses, as circumstances are different in developed … We will highlight any identified cradle to grave analyses and document the relative frequency of the … different start and endpoints of the analyses employed in the studies.

354. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Study design • Original data • Any sample size • RCTs • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct subgroup 11 analyses based on factors … We will conduct sensitivity analyses to evaluate robustness of our findings by excluding studies with … We will lower SOE grading when sensitivity analyses 1) show substantial difference in estimates derived … " or "Cox multivariate analysis" or "Cox regression" or "Cox survival analyses" or "Cox survival analysis

355. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
     December 05, 2018 - If feasible, qualitative or quantitative sensitivity analyses may be conducted to gauge the difference … For all analyses, we will use random effects models to estimate pooled or comparative effects; unlike … To determine whether quantitative analyses are appropriate, we will assess the clinical and methodological … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

356. Renal-Function Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-function_research-protocol.pdf
     June 13, 2013 - Previous reviews and meta-analyses have investigated the prognostic performance of troponin testing … We will conduct meta-analyses when there are sufficient data and studies are sufficiently homogenous … the topic, we anticipate the studies to be predominantly observational in nature, including post-hoc analyses … formula for calculating between-study variance.30 Heterogeneity among the trials in all the meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003 Sep 6;327(7414):557-60. PMID: 12958120. 32.

357. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
     January 01, 2010 - To date, no systematic reviews or meta-analyses comparing the effects of rt-CGM to SMBG have been published … Data Synthesis We will conduct meta-analyses when there are sufficient data (at least three studies … heterogeneity, we will attempt to determine potential reasons for this by conducting metaregression analyses … of the asymmetry of funnel plots for each comparison of interest for the outcomes for which meta-analyses … Measuring inconsistency in meta-analyses. BMJ 2003;327:557- 60. 31. Begg CB, Mazumdar M.

358. Kidney-Stone-Prevention Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
     June 15, 2011 - /or outcome assessor); 3) data completeness (inclusion of all randomized participants in outcomes analyses … 34 ). 13 Source: www.effectivehealthcare.ahrq.gov Published Online: June 15, 2011 For analyses … For all treatments, subgroup analyses that will be performed if feasible include evaluation of treatment … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … Measuring inconsistency in meta-analyses. BMJ 2003 Sep 6;327(7414):557-60. 35.

359. Er r or Rate Reduction Regarding Lower Limb Prosthesis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
     March 16, 2017 - congenital amputations, or pediatrics) and they report subgroup data based on these factors, include analyses … subgroup (thus, N≥20 total) [this number may change depending on available data] § If no subgroup analyses … However, if there are sufficient similar studies, we will conduct random effects model meta-analyses … explored qualitatively and, if appropriate data are available, we may also conduct metaregression analyses … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

360. Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients Wtih Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
     August 11, 2014 - criteria for the outcomes measures and the statistical methods used were sound and appropriate for the analyses … Peer reviewer #2 Results Page 21 ES—For conducted meta-analyses, did the authors request and/or have … Other published meta- analyses have been conducted that have used even more heterogeneous criteria, … We believe it is inappropriate to conduct meta-analyses for the diagnostic criteria because there were … To determine if there are any temporal trends, we sorted the studies included in the meta- analyses