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341. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update - Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
     April 01, 2020 - We performed stratified analyses to evaluate specific techniques within broader intervention categories … Data Analysis and Synthesis Meta-analyses from the 2018 report were updated and new analyses conducted … We performed additional sensitivity and subgroup analyses based on specific interventions (e.g., type … when poolable data were available, and conducting stratified and sensitivity analyses to evaluate … Some meta-analyses were based on two or three trials; findings based on such meta- analyses must be

342. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - To maximize the similarities amongst studies that could potentially be combined for meta-analyses, we … There are several patient characteristics that we may further explore with sensitivity analyses (if … meta-analyses can be undertaken) including the following: 1) disease severity (within MDD only); 2) … If a particular outcome is shown to have a high risk of publication bias, then the analyses will be … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

343. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
     September 01, 2011 - We searched for systematic reviews, clinical controlled trials, meta-analyses, and nonexperimental studies … quality of individual studies as good, fair, or poor; only good or fair studies are included in these analyses … If data were sufficient, we conducted meta-analyses of data for comparisons involving trials that were … The use of inconsistent definitions of TRD in the trials and the absence of analyses considering the … investigators in designing TRD trials and may be important to consider as a potential covariate in analyses

344. Nonsurgical Treatments for Urinary Incontinence in Adult Women: (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
     June 06, 2017 - We expect to conduct random effects model meta-analyses of comparative studies, if they are sufficiently … If time and resources allow, we plan to explore the possibility of conducting network meta-analyses … The exact methodology to conduct the network meta-analyses will be determined based on the available … Full methodology for conducting the network meta-analyses will be reported, as will all results and … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

345. Treatments for Adults with Schizophrenia: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
     September 23, 2016 - For key outcomes, we will update meta- analyses. … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for … Network meta-analyses will be conducted using a Bayesian hierarchical model34-36 and in all models we … Given that such analyses are exploratory, they will be limited to key effectiveness outcomes. … Sensitivity analyses will be conducted to explore heterogeneity.

346. Disposition of Comments_Comparative Effectiveness Review No. 257_Schedule of Visits and Televisits for Routine Antenatal Care: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-257-antenatal-care-disposition-comments.pdf
     June 28, 2022 - evaluating the impact of replacing routine antenatal visits with televisits provided demographic subgroup analyses … summarized the applicability in the Discussion and more explicitly highlighted the lack of subgroup analyses

347. Cervical Degenerative Disease Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cervical-degenerative-protocol.pdf
     January 12, 2022 - Data Synthesis We will conduct meta-analyses of randomized trials and nonrandomized studies separately … pooling studies if there are at least two clinically and methodologically comparable studies.42,43 Meta-analyses … Sensitivity and subgroup analyses will be performed to explore statistical heterogeneity using the I2 … We will summarize within-study analyses of subgroup differences and perform study-level analyses on … Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised

348. Methods-Balancing-Harms-Benefits Research-2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
     January 01, 2012 - The fifth step consists of sensitivity analyses to explore the effects of changing the estimates or … In such cases, sensitivity analyses should take different weights into consideration. … (2) The type of analyses: Analyses for benefit harm assessment could include any type of statistical … Since none of the approaches are perfect and all require some assumptions, sensitivity analyses are … Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

349. Disposition of Comments for Imaging Tests for the Staging of Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
     November 20, 2014 - Most of the analyses were odds ratios of errors in staging—not bivariate models—which readily produces … We have redone the analyses using odds ratios for matched data since the same patients underwent both … We have provided the data on which the under and over staging analyses were based. … Statistical heterogeneity was discussed in the text for analyses where it was detected. … As a general rule, the authors of the studies did not perform any statistical analyses.

350. hemangioma-protocol-141223 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_research-protocol.pdf
     December 23, 2014 - Existing Systematic Reviews and Meta-Analyses We identified 13 treatment-focused systematic reviews … or meta-analyses published in the last 10 years addressing IH (Appendix A). … We will carry out hand searches of the reference lists of recent systematic reviews or meta-analyses … We will report findings of poor quality studies in evidence tables but will focus our analyses on those … It is likely that analyses will be combined using a hierarchical mixed effects model.

351. Evidence Summary-Comparative-Effectiveness-Review-213-Lower-Limb-Prostheses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
     September 01, 2018 - Half of studies used nonvalidated instruments and analyses were inadequate. … , regression analyses, or individual patient data which would allow subgroup analyses. … Another study (Hahn 2015) conducted correlation and regression analyses but did not fully report the … results of these analyses. … Subgroup analyses in single studies tended to be underpowered to detect differences, mostly leading

352. Treatment of Depression in Children and Adolescents: A Systematic Review - Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
     April 01, 2020 - We synthesized the data qualitatively when quantitative analyses were not appropriate (e.g., due to … For bodies of evidence for which we could conduct sensitivity analyses, we based the final SOE grade … We appended a footnote to SOE tables to indicate when sensitivity analyses changed the SOE grade. … The full report appendices list all moderator analyses. … These subgroup analyses, when available, were generally hypothesis generating because studies were

353. Cannabis-2023-Surv-Rep-1-App-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-G.xlsx
     January 01, 2023 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

354. Cannabis-2023-Surv-Rep-4-Tables-F1-F-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-F1-F-2.xlsx
     January 01, 2023 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

355. Cannabis-2022-Surv-Rep-4-Tables-G1-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-G1-2.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

356. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
     October 01, 2010 - A p-value of <0.05 was considered statistically significant for all analyses. … , subgroup and sensitivity analyses were conducted. … Only four studies employed multivariate analyses (each using different questionnaires to rate HRQoL). … Only five studies employed multivariate analyses (each using different questionnaires to rate HRQoL). … In univariate analyses, there was no relationship between FEV1, FVC, or BMI and bone fracture.

357. Disposition of Comments Report for Comparison of Characteristics of Nursing Homes and Other Residential Long-Term Care Settings for People With Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_disposition-comments.pdf
     October 23, 2012 - studies did not specify that at least 80 percent of the study population had dementia and (2) that analyses … Our review sought to include RCTs, NonRCTs, systematic reviews, meta analyses, subgroup and or post-hoc … analyses, case-control studies, and prospective cohorts. … Did not seem to guide the analyses. … As to the analyses, the report does (for example) differentiate the effect of NH SCUs compared to AL

358. Psychological and Pharmacological Treatments for Adults with Posttraumatic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
     December 31, 2017 - All new qualitative and quantitative analyses will synthesize relevant studies included in the 2013 … For all analyses, we will use random-effects models to estimate pooled or comparative effects. … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

359. Digestible Carbohydrate Intake and Maternal-Infant Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-protocol.pdf
     April 08, 2024 - and mode of nutritional assessment including supplement use matters,13 making data collection and analyses … will adhere to the international PRISMA45 (Preferred Reporting Items for Systematic reviews and Meta-Analyses … cohort studies • Nested case-control studies • Narrative reviews • Systematic reviews • Meta-analyses … studies if there are at least two clinically and methodologically comparable studies.46,56,57 Meta-analyses … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by

360. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk … We will identify statistical heterogeneity between the trials in all the meta-analyses by using: 1) … We will conduct sensitivity analyses by omitting one study at a time to assess the influence of any … For all meta-analyses, we will conduct formal tests for publication bias by using Begg’s and Egger’s … What contributions do languages other than English make on the results of meta-analyses?