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321. Atrial-Fibrillation-Ablation Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
     May 16, 2013 - Univariable analyses within 31 studies that reported recurrence rates for PAF vs. other types of AF … However, only a minority of multivariable analyses bear this out. … In both univariable and multivariable analyses reported, no study or population factors were found … In multivariable analyses, 5 of 17 studies found an association between lower EF and AF recurrence, … However,  only  a  minority  of  multivariable   analyses  bear  this  out.  

322. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
     November 20, 2013 - We found the diversity between studies to be too large to perform any meta-analyses. … Four articles were secondary analyses of data initially collected in RCTs; however, the secondary analyses … It is quite worrying when CART analyses are applied how clinically poor even NT-proBNP really is. … There should be more requests for NRI, IDI and CART analyses. … Rev 7 General It is unclear why meta-analyses were only limited to KQ1 and 2.

323. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Preferred reporting items for systematic reviews and meta- analyses: the PRISMA statement. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. 49. … Adjustment of meta-analyses on the basis of quality scores should be abandoned. … Did the author(s) specify the type of analyses undertaken for harms data?

324. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - Design 1D1: Incomplete reporting and inadequate analyses were common. 1D2: Few high quality studies … Outcomes 2O: No analyses of clinical outcomes were done. … Systematic Review Cost-effectiveness analyses were not addressed by the CER. … Outcomes 2O: No analyses of clinical outcomes were done. … Multivariable analyses would need larger sample sizes than univariable analyses to reach the same statistical

325. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-protocol-update-2023.pdf
     January 01, 2023 - made publicly available, they may be presented in a format that does not readily lend itself to re-analyses … The PTSD-Repository could (1) serve as a data source for future systematic reviews, meta-analyses, or … Hand Searching: Reference lists of relevant, recent, high-quality systematic reviews or meta- analyses … result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

326. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - health disorders associated with suicide, such as major depressive disorder (MDD).19, 20 However, meta-analyses … • Comparative observational studies • Before—after studies • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct preplanned subgroup analyses (listed in Table 1 … We will lower SOE grading when sensitivity analyses (1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

327. Ced-Topic-Refinement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-topic-refinement.pdf
     November 01, 2022 - process unrelated to study design and conduct, and if they were evaluations of costs of therapies, analyses … We also added a sentence to encourage exploratory analyses as appropriate. N. … The investigators demonstrate robustness of results by conducting alternative analyses, and/or using … The investigators demonstrate robustness of results by conducting alternative analyses and/or using other … The investigators demonstrate robustness of results by conducting alternative analyses and/or using other

328. Rapid Evidence Product_Nonemergent Percutaneous Coronary Intervention Versus Optimal Medical Treatment for Stable Ischemic Heart Disease: A Rapid Response Literature Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-evidence-heart-disease.pdf
     October 01, 2022 - • Another factor that complicates comparison is that the meta-analyses often included data from CABG … However, three other good-quality meta-analyses have been performed in the CTO population that have … Older trials included in the reviewed meta-analyses 6. … PubMed search history (guidelines, systematic reviews, meta-analyses) Search Number Query Filters … Embase search history (guidelines, systematic reviews, meta-analyses) Search Number Query Results

329. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - that combined studies of both therapies, as well as separate analyses. … However, we conducted numerous meta-analyses in order to identify effects that may not be evident … that combined studies of both therapies, as well as separate analyses. … However, we conducted numerous meta-analyses in order to identify effects that may not be evident … that combined studies of both therapies, as well as separate analyses.

330. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
     January 01, 2006 - • In fair-quality meta-analyses of arthritis trials, most of which evaluated short-term use, celecoxib … Indirect evidence from various meta- analyses of either rofecoxib or celecoxib vs. nonselective NSAIDs … • Meta-analyses of the risks associated with selective COX-2 inhibitors need to continue to assess … Addendum As this report was going to press, two relevant meta- analyses on risks associated with NSAIDs … Assessments of increased risk were modest (relative risks all <2.0), and all of the main analyses were

331. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-centered-medical-home_research-protocol.pdf
     February 23, 2012 - For KQ 1, we will conduct quantitative meta-analyses if there are sufficient studies with similar designs … If possible, we will conduct separate meta-analyses for each outcome category (e.g., patient experiences … If meta- analyses are not indicated, we will use cross-case analyses to evaluate the association between … comprehensive PCMH) and study effect, using methods based on Miles and Huberman.31 These exploratory analyses … To carry out these analyses, we will rank studies by impact level, based on an overall impact measure

332. Clopidogrel after Drug-Eluting Stent Implantation: Is current practice sufficient (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
     March 01, 2009 - Landmark analyses were performed among patients who were event-free (no death, myocardial infarction … Landmark Analyses Based on Clopidogrel Use Landmark analysis is a form of survival analysis that classifies … In our analyses, we define landmark time and study outcomes in terms of their elapsed time from a patient … Data Analyses Baseline characteristics and event rates were summarized for patient groups as numbers … Thus, these results reinforce those observed in our overall analyses.

333. Gastric-Cancers-Supplementary-App-D (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
     January 01, 2023 - Reported Results Some Concerns (Unclear if SAP was finalized before unblinding, potential exploratory analyses … Primary analyses are intention-to-treat. … Multiple analyses (ITT and PP) were used.

334. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - For all analyses, we will use random-effects models to estimate pooled or comparative effects. … In order to determine whether quantitative analyses are appropriate, we will assess the clinical … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

335. Single-arm studies in comparative effectiveness reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
     January 01, 2013 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Time-series analyses represent another example of a before-after single group study design, frequently … Time-series analyses follow a given group or region over time, typically without covariate data on … Subgroup analyses may be applied to single group studies to identify subsets of patients who may … In these designs, analyses may identify whether a variable is a significant independent predictor of

336. Cannabis-2023-Surv-Rep-4-Tables-F1-F-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-F1-F-2.xlsx
     January 01, 2023 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

337. Cannabis-2022-Surv-Rep-4-Tables-G1-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-G1-2.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

338. Cannabis-2023-Surv-Rep-1-App-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-G.xlsx
     January 01, 2023 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

339. Treatments for Adults with Schizophrenia: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
     September 23, 2016 - For key outcomes, we will update meta- analyses. … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for … Network meta-analyses will be conducted using a Bayesian hierarchical model34-36 and in all models we … Given that such analyses are exploratory, they will be limited to key effectiveness outcomes. … Sensitivity analyses will be conducted to explore heterogeneity.

340. Nonsurgical Treatments for Urinary Incontinence in Adult Women: (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
     June 06, 2017 - We expect to conduct random effects model meta-analyses of comparative studies, if they are sufficiently … If time and resources allow, we plan to explore the possibility of conducting network meta-analyses … The exact methodology to conduct the network meta-analyses will be determined based on the available … Full methodology for conducting the network meta-analyses will be reported, as will all results and … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses