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321. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
     October 20, 2011 - Identification of Relevant Studies To Answer the Key Questions Results from previously conducted meta-analyses … We will include systematic reviews and meta-analyses that included unpublished data inaccessible to … the public, but because the results of such analyses are not verifiable, we will consider this a methodological … exposures, potential confounders, and outcomes; and whether they performed appropriate statistical analyses

322. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - Design 1D1: Incomplete reporting and inadequate analyses were common. 1D2: Few high quality studies … Outcomes 2O: No analyses of clinical outcomes were done. … Systematic Review Cost-effectiveness analyses were not addressed by the CER. … Outcomes 2O: No analyses of clinical outcomes were done. … Multivariable analyses would need larger sample sizes than univariable analyses to reach the same statistical

323. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Preferred reporting items for systematic reviews and meta- analyses: the PRISMA statement. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. 49. … Adjustment of meta-analyses on the basis of quality scores should be abandoned. … Did the author(s) specify the type of analyses undertaken for harms data?

324. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
     November 20, 2013 - We found the diversity between studies to be too large to perform any meta-analyses. … Four articles were secondary analyses of data initially collected in RCTs; however, the secondary analyses … It is quite worrying when CART analyses are applied how clinically poor even NT-proBNP really is. … There should be more requests for NRI, IDI and CART analyses. … Rev 7 General It is unclear why meta-analyses were only limited to KQ1 and 2.

325. Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/maternal-child-outcomes-wic-disposition-comments.pdf
     April 19, 2022 - systematic review addresses the shortcomings of current research, such as the need for more subgroup analyses … We did not conduct analyses that required sensitivity analyses.

326. Ced-Topic-Refinement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-topic-refinement.pdf
     November 01, 2022 - process unrelated to study design and conduct, and if they were evaluations of costs of therapies, analyses … We also added a sentence to encourage exploratory analyses as appropriate. N. … The investigators demonstrate robustness of results by conducting alternative analyses, and/or using … The investigators demonstrate robustness of results by conducting alternative analyses and/or using other … The investigators demonstrate robustness of results by conducting alternative analyses and/or using other

327. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - health disorders associated with suicide, such as major depressive disorder (MDD).19, 20 However, meta-analyses … • Comparative observational studies • Before—after studies • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct preplanned subgroup analyses (listed in Table 1 … We will lower SOE grading when sensitivity analyses (1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

328. Healthcare Industry Waste and Lifecycle Assessment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lifecycle-assessment-protocol.pdf
     August 23, 2023 - Increasingly, commercial companies present their own life cycle analyses to market and promote adoption … The frameworks and analyses appear comparable, and restricting searches further will miss foundational … It is critical to understand the context for the analyses, as circumstances are different in developed … We will highlight any identified cradle to grave analyses and document the relative frequency of the … different start and endpoints of the analyses employed in the studies.

329. Cer-250-Cannabis-Tables-F1-F2-2022-Update 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-tables-f1-f2-2022-update_0.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

330. Cannabis-2022-Update-Surv-Rep-1-Apps-G1-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-apps-G1-2.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

331. Cannabis-2022-Surv-Rep-3-App-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-app-G.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

332. Rapid Evidence Product_Nonemergent Percutaneous Coronary Intervention Versus Optimal Medical Treatment for Stable Ischemic Heart Disease: A Rapid Response Literature Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-evidence-heart-disease.pdf
     October 01, 2022 - • Another factor that complicates comparison is that the meta-analyses often included data from CABG … However, three other good-quality meta-analyses have been performed in the CTO population that have … Older trials included in the reviewed meta-analyses 6. … PubMed search history (guidelines, systematic reviews, meta-analyses) Search Number Query Filters … Embase search history (guidelines, systematic reviews, meta-analyses) Search Number Query Results

333. Cer-238-Cervical-Ripening-Appendix-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-g.xlsx
     October 08, 2025 - Did the study perform appropriate statistical analyses on potential confounders (e.g., age, other medications

334. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - that combined studies of both therapies, as well as separate analyses. … However, we conducted numerous meta-analyses in order to identify effects that may not be evident … that combined studies of both therapies, as well as separate analyses. … However, we conducted numerous meta-analyses in order to identify effects that may not be evident … that combined studies of both therapies, as well as separate analyses.

335. Gastric-Cancers-Supplementary-App-D (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
     January 01, 2023 - Reported Results Some Concerns (Unclear if SAP was finalized before unblinding, potential exploratory analyses … Primary analyses are intention-to-treat. … Multiple analyses (ITT and PP) were used.

336. Single-arm studies in comparative effectiveness reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
     January 01, 2013 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Time-series analyses represent another example of a before-after single group study design, frequently … Time-series analyses follow a given group or region over time, typically without covariate data on … Subgroup analyses may be applied to single group studies to identify subsets of patients who may … In these designs, analyses may identify whether a variable is a significant independent predictor of

337. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - For all analyses, we will use random-effects models to estimate pooled or comparative effects. … In order to determine whether quantitative analyses are appropriate, we will assess the clinical … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., due to heterogeneity, insufficient numbers of

338. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0129_07-13-2009.pdf
     January 01, 2009 - Numerous meta-analyses and systematic reviews exist on specific maternal characteristics, intrapartum

339. EHC Research Protocol (Amended): Treatments for Acute Episodic Migraine (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
     January 09, 2020 - RCTs o Comparative observational studies • Any sample size • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct subgroup analyses based on length of followup ( … We will conduct sensitivity analyses to evaluate robustness of our findings by excluding studies with … We will lower SOE grading when sensitivity analyses 1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

340. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
     February 05, 2025 - health disorders associated with suicide, such as major depressive disorder (MDD).19, 20 However, meta-analyses … • Comparative observational studies • Before—after studies • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct preplanned subgroup analyses (listed in Table 1 … We will lower SOE grading when sensitivity analyses (1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses