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301. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
     January 01, 2021 - made publicly available, they may be presented in a format that does not readily lend itself to re-analyses … Repository.”9 The PTSD-Repository could (1) serve as a data source for future systematic reviews, meta-analyses … Indicate if subgroup analyses are reported (Y/N) n. … result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

302. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
     October 01, 2022 - made publicly available, they may be presented in a format that does not readily lend itself to re-analyses … The PTSD-Repository could (1) serve as a data source for future systematic reviews, meta- analyses, or … Indicate if subgroup analyses are reported (Y/N) n. … result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

303. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - We will conduct meta-analyses when there are sufficient data (at least three trials) and studies are … We will then stratify studies by medication and repeat the pooled analyses and measures of heterogeneity … For the outcome of hypoglycemia, we will conduct separate analyses for: (a) severe hypoglycemia and … We will conduct sensitivity analyses by omitting one study at a time to assess the influence of any … Measuring inconsistency in meta- analyses. BMJ. 2003 Sep 6;327(7414):557-60. 30.

304. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
     February 01, 2008 - A p-value of <0.05 will be considered statistically significant for all analyses. … We will conduct subgroup and sensitivity analysis to assess the heterogeneity of our meta- analyses … Source: www.effectivehealthcare.ahrq.gov Published Online: July 01, 2010 In subgroup analyses … In both the older versus newer and innovator versus generic evaluations, we will perform subgroup analyses … We will also consider measures of heterogeneity from our meta-analyses in evaluating consistency.

305. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - Because recent reviews and meta-analyses have assessed the impact of interventions to improve medication … Recent meta-analyses and reviews of HIV medication adherence interventions have been conducted. … To determine whether quantitative analyses are appropriate, we will assess the heterogeneity of the … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers … We plan to stratify analyses and perform subgroup analyses when possible and appropriate.

306. Bladder-Cancer-Non-Muscle-Invasive Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
     October 01, 2015 - is an important health problem, with no improvement in associated mortality since 1975.3 Economic analyses … Results were generally robust in sensitivity analyses, despite the heterogeneity. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414): 557-60. … When are summary ROC curves appropriate for diagnostic meta-analyses? … Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy.

307. Antipsychotics-Children Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children_research-protocol.pdf
     June 04, 2010 - In cases of substantial heterogeneity, subgroup and meta-regression analyses will be performed if the … number of studies is sufficient to warrant these analyses.13 A priori subgroups have been identified … Sensitivity analyses will be conducted to assess the robustness of the findings across study quality … , parallel vs. crossover trial designs, and random effects vs. fixed effects analyses. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

308. Cannabis-2022-Surv-Rep-3-App-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-app-G.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

309. Cer-250-Cannabis-Tables-F1-F2-2022-Update 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-tables-f1-f2-2022-update_0.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

310. Cannabis-2022-Update-Surv-Rep-1-Apps-G1-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-apps-G1-2.xlsx
     January 01, 2022 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

311. Binge-Eating Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
     July 21, 2014 - For all analyses, we will use random- effects models to estimate pooled or comparative effects. … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses, including high-risk- of-bias studies … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers

312. Disposition of Comments Report for Screening, Behavioral Counseling, and Referral in Primary Care To Reduce Alcohol Misuse (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
     July 10, 2012 - because we intended to conduct our own meta-analyses that would better reflect the current body of … That literature often includes large case series or secondary analyses of trials. … We have clarified the basis of the analyses for those Tables as suggested. … There is a risk of confusing the analyses and the message with the findings of KQ 4b. … There is however a body of literature that has been omitted from the analyses.

313. Study Eligibility Criteria (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/study-eligibility-criteria.ppt
     January 01, 2000 - What contribution do languages other than English make on the results of meta-analyses? … the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses … the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses … What contribution do languages other than English make on the results of meta-analyses?

314. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
     October 20, 2011 - Identification of Relevant Studies To Answer the Key Questions Results from previously conducted meta-analyses … We will include systematic reviews and meta-analyses that included unpublished data inaccessible to … the public, but because the results of such analyses are not verifiable, we will consider this a methodological … exposures, potential confounders, and outcomes; and whether they performed appropriate statistical analyses

315. Cer-238-Cervical-Ripening-Appendix-G (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-g.xlsx
     May 29, 2025 - Did the study perform appropriate statistical analyses on potential confounders (e.g., age, other medications

316. Critical Analysis of the Evidence for Patient Safety Practices in Nursing Home Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nursing-home-safety_research-protocol.pdf
     July 22, 2015 - Early and ongoing research has focused in large part on the use of secondary data analyses, rather than … drawing inferences from such data have included interrupted time series, difference-in-differences analyses … Scope and Format As noted above, methods used to assess patient safety have ranged from database analyses … brief is on understanding the state of the intervention literature, we will not include secondary data analyses … integrate information from our Key Informants; we will use systematic reviews, narrative reviews, meta-analyses

317. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0129_07-13-2009.pdf
     January 01, 2009 - Numerous meta-analyses and systematic reviews exist on specific maternal characteristics, intrapartum

318. heart-failure-readmission-protocol-130611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
     June 10, 2013 - ¶ We plan to conduct sensitivity analyses based on risk of bias, when appropriate. … ; we will include them only in sensitivity analyses. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate. … Planned stratifications or categories for subgroup analyses include those listed in KQs 3, 4, and 5. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. PMID: 12958120. 47.

319. Suicidal-Thoughts-Young-People-Amendement-May-2025 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
     January 01, 2025 - health disorders associated with suicide, such as major depressive disorder (MDD).19, 20 However, meta-analyses … • Comparative observational studies • Before—after studies • Relevant systematic reviews, or meta-analyses … To further explore heterogeneity, we plan to conduct preplanned subgroup analyses (listed in Table 1 … We will lower SOE grading when sensitivity analyses (1) show substantial difference in estimates derived … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

320. Cad-Women-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-treatment_executive.pdf
     August 01, 2012 - Relevant review articles, meta-analyses, and methods articles were flagged for manual searching and … Systematic reviews and meta-analyses were excluded from abstraction but hand-searched as potential … In contrast, previous meta-analyses that combined results for men and women found similar outcomes for … In contrast, previous meta-analyses that combined results for men and women found similar outcomes … Subgroup analyses across trials can be done similarly to a previous AHRQ report on the comparative