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281. Treatments for Schizophrenia in Adults: A Systematic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
     January 01, 2017 - We conducted pairwise meta-analyses, using the DerSimonian and Laird random- effects model. … Network meta- analyses were conducted using a Bayesian hierarchical model. … These findings are based on two published network meta-analyses (low SOE). … Our review, and two other reviews, conducted sensitivity analyses (two analyses, one including the … Efficacy of psychological therapy in schizophrenia: conclusions from meta- analyses.

282. Appendicitis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
     December 01, 2015 - We explored heterogeneity using subgroup and meta-regression analyses. … When studies reported results at multiple cutpoints, we performed analyses at low-risk and high- risk … The full report presents the results of sensitivity analyses for the test performance of imaging … For some important modalities that have been investigated to some extent in previous meta-analyses … Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement.

283. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
     January 01, 2005 - The above conclusion was based on three recent meta-analyses of randomized controlled trials comparing … These analyses had minimal bias and their results are considered valid (Grade A). … From 2 meta-analyses, PPIs reported more adverse events compared with H2RA or placebo; headache, diarrhea

284. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-nursing-home-characteristics_research-protocol.pdf
     November 03, 2011 - c If we do conduct meta-analyses, we will include studies of any size. … We will not include poor-quality studies in our analyses. E. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate. … These analyses will take place in the context of KQs 1 to 4. F. … If the data allow, we will perform subgroup analyses to explore the influence of specific factors (

285. Transparency of Reporting Requirements: Omega-3 Fatty Acids and Cardiovascular Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-omega-3_research-protocol.pdf
     September 02, 2016 - Empirical analyses of prospective registry data can inform on the time between study completion and … Analyses of studies included in the original review that also have a registry record For these studies … If meta-analyses are not conducted, we will assess whether the new studies fall within the range of … A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. … Also LOW risk of bias if any baseline differences were adjusted for in all relevant analyses.

286. Disposition of comments_Comparative Effectiveness Review No. 242: Radiation Therapy for Brain Metastases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
     June 09, 2021 - Finally, what is the role of patient registries to obtain data for analyses like this in the future … With respect to subgroup analyses of studies, patient level data was not available. … As you noted, the use of the term 'chemotherapy' when referring to analyses that include cytotoxic … However, the vast majority of studies included a mixed population of tumor types, and the analyses … Re 4) Meta-analyses for randomized trials use means and SDs per group at the latest follow up.

287. Medical Care Journal Supplement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/toc.pdf
     January 01, 2007 - Improving Depiction of Benefits and Harms: Analyses of Studies of Well-known Therapeutics and Review … Analyses With Observational Databases. Med Care. 2007;45(Suppl 2): S103–S107. S108 Matthew H.

288. Research Protocol for Interventions for Substance Use Disorders in Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/suda-final-protocol.pdf
     October 02, 2018 - Data Extraction Each study with multiple publications or secondary analyses will be extracted together … We may conduct random effects model meta-analyses of comparative studies if at least three studies are … We will also explore the use of hierarchical (random intercept/random slope) meta-regression analyses … Sensitivity analyses will examine robustness of results to alternative prior distributions; attribute … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

289. Comparative Effectiveness of Medications in Patients with Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
     March 01, 2012 - Peer Reviewer #2 Methods “Subgroup and Sensitivity Analyses” I would like to know why there were … no subgroup / sensitivity analyses done base upon study quality? … Given the large number of outcomes and the large number of subgroup and sensitivity analyses to be … Peer Reviewer #2 Methods “We also considered measures of heterogeneity from our meta- analyses in … The authors note that these subgroup analyses were not very informative.

290. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0030_06-19-2008.pdf
     January 01, 2008 - the use of these devices, because of identified studies that have not been included in previous meta-analyses

291. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
     January 01, 2021 - made publicly available, they may be presented in a format that does not readily lend itself to re-analyses … Repository.”9 The PTSD-Repository could (1) serve as a data source for future systematic reviews, meta-analyses … Indicate if subgroup analyses are reported (Y/N) n. … result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

292. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
     October 01, 2022 - made publicly available, they may be presented in a format that does not readily lend itself to re-analyses … The PTSD-Repository could (1) serve as a data source for future systematic reviews, meta- analyses, or … Indicate if subgroup analyses are reported (Y/N) n. … result being assessed likely to have been selected, on the basis of the results, from multiple eligible analyses

293. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - Because recent reviews and meta-analyses have assessed the impact of interventions to improve medication … Recent meta-analyses and reviews of HIV medication adherence interventions have been conducted. … To determine whether quantitative analyses are appropriate, we will assess the heterogeneity of the … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers … We plan to stratify analyses and perform subgroup analyses when possible and appropriate.

294. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - We will conduct meta-analyses when there are sufficient data (at least three trials) and studies are … We will then stratify studies by medication and repeat the pooled analyses and measures of heterogeneity … For the outcome of hypoglycemia, we will conduct separate analyses for: (a) severe hypoglycemia and … We will conduct sensitivity analyses by omitting one study at a time to assess the influence of any … Measuring inconsistency in meta- analyses. BMJ. 2003 Sep 6;327(7414):557-60. 30.

295. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
     February 01, 2008 - A p-value of <0.05 will be considered statistically significant for all analyses. … We will conduct subgroup and sensitivity analysis to assess the heterogeneity of our meta- analyses … Source: www.effectivehealthcare.ahrq.gov Published Online: July 01, 2010 In subgroup analyses … In both the older versus newer and innovator versus generic evaluations, we will perform subgroup analyses … We will also consider measures of heterogeneity from our meta-analyses in evaluating consistency.

296. Antipsychotics-Children Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children_research-protocol.pdf
     June 04, 2010 - In cases of substantial heterogeneity, subgroup and meta-regression analyses will be performed if the … number of studies is sufficient to warrant these analyses.13 A priori subgroups have been identified … Sensitivity analyses will be conducted to assess the robustness of the findings across study quality … , parallel vs. crossover trial designs, and random effects vs. fixed effects analyses. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

297. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
     February 07, 2025 - domain and specific measurement), and relevant study results (including subgroup and interaction analyses … use random-effects models, anticipating that even with efforts made to reduce heterogeneity in the analyses … distribution of social determinants among included studies as well as report any subgroup or other analyses … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in … randomized controlled trials and meta-analyses.

298. Binge-Eating Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
     July 21, 2014 - For all analyses, we will use random- effects models to estimate pooled or comparative effects. … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses, including high-risk- of-bias studies … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers

299. Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World Trial Data and Simulation | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/bayesian-mixed-treatment/research

300. Cad-Women-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-treatment_executive.pdf
     August 01, 2012 - Relevant review articles, meta-analyses, and methods articles were flagged for manual searching and … Systematic reviews and meta-analyses were excluded from abstraction but hand-searched as potential … In contrast, previous meta-analyses that combined results for men and women found similar outcomes for … In contrast, previous meta-analyses that combined results for men and women found similar outcomes … Subgroup analyses across trials can be done similarly to a previous AHRQ report on the comparative