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261. Self-Measured Blood Pressure: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure-future_research.pdf
     August 01, 2012 - In addition, sensitivity analyses may be used to explore the robustness of findings for nonrandomized … Post hoc analyses of existing observational studies can be done quickly and with modest resources. … Overall, subgroup analyses did not exhibit clear signals as to what populations might differentially … Ethical Issues There should be no ethical issues in conducting subgroup analyses. … Value of Study Design In addition to the expected merit of a simple CEA, sensitivity analyses may be

262. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a search of their … We will conduct meta-analyses of summary data when there are sufficient data (at least three studies … All analyses will be intention to treat. … For studies amenable to pooling with meta-analyses, we will calculate a weighted mean difference using … Recommendations for examining and interpreting funnel  plot asymmetry in meta-­‐analyses of randomised

263. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - Peer Reviewer #1 Methods Subgroup analyses: From the included data extraction form, it is not clear … If an individual trial did not conduct any subgroup analyses upon the relevant variables, it would … also be useful to know, so that we can inform future researchers to conduct such subgroup analyses. … Peer Reviewer #1 Results 5.When subgroup analyses were not possible because there was only a single … analyses, based on drug regimen.

264. Cancer-Anemia-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_executive.pdf
     April 01, 2013 - This resulted in multiple pooled analyses of ESA trial data over several years, as well as regulatory … Sensitivity analyses performed for each outcome with data from studies excluded because of size showed … Moreover, we did not find those trial results influential in these analyses.

265. Disposition of comments_Comparative Effectiveness Review No. 242: Radiation Therapy for Brain Metastases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-disposition-comments.pdf
     June 09, 2021 - Finally, what is the role of patient registries to obtain data for analyses like this in the future … With respect to subgroup analyses of studies, patient level data was not available. … As you noted, the use of the term 'chemotherapy' when referring to analyses that include cytotoxic … However, the vast majority of studies included a mixed population of tumor types, and the analyses … Re 4) Meta-analyses for randomized trials use means and SDs per group at the latest follow up.

266. Evidence Summary: Comparative Effectiveness Review No. 245_Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-evidence-summary-updated-1.pdf
     October 01, 2021 - there was sufficient evidence with an acceptable amount of heterogeneity, we conducted pairwise meta-analyses … of this Evidence Summary, we provide numeric estimates of summary treatment effects only where meta-analyses … When subgroup data were reported, statistical analyses evaluating heterogeneity of treatment effects

267. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
     December 01, 2010 - Subsequent meta-analyses have generally confirmed these results16 and have helped to provide a clearer … The disconnect between the research findings of CutLASS 1 and the CATIE study and meta-analyses (favoring … will be performed if the number of studies is sufficient to warrant these analyses.24 The following … variables will be considered in subgroup analyses if data are available: disorder subtypes, gender, … Sensitivity analyses will be conducted to assess the robustness of the findings.

268. Minimal Modeling Approaches to Value of Information Analysis for Health Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
     June 01, 2011 - For example, VOI analyses performed by the National Institute for Health and Clinical Excellence (NICE … Perhaps the most important drawback is that VOI studies based on decision analyses can be very time … Cost-effectiveness analyses done alongside clinical trials6 in which comprehensive outcomes measures … In addition, we performed two new minimal modeling VOI analyses. … Enhancing value of information analyses. Value Health 2009;12(6):935–941. 11. Detsky AS.

269. Disposition of Comments for Interventions To Improve Cardiovascular Risk Factors in People With Serious Mental Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_disposition-comments.pdf
     April 22, 2013 - In quantitative analyses, however, this is frowned upon because small studies have little weight in … meta-analyses models. … For meta-analyses one would expect sensitivity analyses with/without poor studies. … Studies with high risk of bias were included in both qualitative and quantitative analyses. … For meta-analyses, we conducted sensitivity analyses (by quality rating) on a limited basis since

270. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
     December 09, 2009 - If appropriate, meta-analyses will be conducted using the random effects model. … Subgroup analyses or meta-regression will be conducted, if possible, to investigate sources of heterogeneity … Sensitivity analyses will be conducted to assess the robustness of the findings across study quality … , and random effects vs. fixed effects analyses. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

271. MEDICAL MANAGEMENT OF CONGESTIVE HEART FAILURE AND THE EFFECTIVENESS OF ISOSORBIDE DINITRATE AND HYDRALAZINE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
     March 01, 2010 - factors on 76,828 veterans with heart failure were analyzed using propensity-adjusted Cox regression analyses … Index.12 Effective Health Care Research Report Number 19 2 The dependent variables for our analyses … The findings are similar when these analyses are limited to African-American patients. … Comparable analyses with HF hospitalization as the dependent variable consistently showed hazard ratios … the ability of this approach to reduce confounding beyond that provided by traditional regression analyses

272. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
     September 01, 2021 - Meta- analyses were conducted for vertebroplasty versus no vertebroplasty (sham or usual care) and effects … on pain, function, quality of life, and harms; analyses were conducted to assess how the control type … Otherwise, meta-analyses were not conducted due to small number of studies, 3 methodological … • Three trials that conducted within-study subgroup analyses found no interaction between duration

273. S66 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s66.pdf
     October 01, 2007 - We evaluated persistence through survival analyses, and adherence within episodes through the medication … A risk score was included in the analyses to account for measured confounders. … Analyses were performed in Stata version 9.0 (StataCorp., College Station, TX). … We performed a number of secondary analyses to evaluate the robustness of our findings. … All analyses were repeated excluding nursing home residents (0.63% of records).

274. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_disposition-comments.pdf
     March 10, 2010 - Methods 2-3 of the large studies that were included in the meta-analyses were categorized as 'Fair' … I think it would be helpful to present sensitivity analyses where poorer quality studies are separated … Several other analyses (and the trials included) have distinguished between women > vs < 50 and found … What further analyses could be done that would address the key questions, and have the trial groups … been asked to undertake such analyses?

275. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
     February 07, 2025 - domain and specific measurement), and relevant study results (including subgroup and interaction analyses … use random-effects models, anticipating that even with efforts made to reduce heterogeneity in the analyses … distribution of social determinants among included studies as well as report any subgroup or other analyses … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in … randomized controlled trials and meta-analyses.

276. Chicago-Area DEcIDE Center (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
     May 01, 2009 - weighting of these factors in the priority list modeling, and the specifications of the sensitivity analyses … input from our technical expert panel, we identified four drug characteristics to include in the analyses … First, the base analyses dropped indications that could not be found in DRUGDEX, where a match was not … Only well structured analyses following good scientific techniques can help build useful evidence for … Such research would initially take the form of meta-analyses to accumulate and assess past clinical

277. Appendix F 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix%20F_0.xlsx
     May 29, 2025 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other

278. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0030_06-19-2008.pdf
     January 01, 2008 - the use of these devices, because of identified studies that have not been included in previous meta-analyses

279. Binge-Eating Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
     December 01, 2015 - ) was control for critical potential confounding through design or statistical analyses. … However, we did consider studies with high risk of bias in sensitivity analyses of our meta-analyses … Evidence based on meta- analyses pertains to second-generation antidepressants and lisdexamfetamine; … Evidence of the benefits of therapist-led CBT was particularly compelling; meta-analyses estimated … Two later meta-analyses reached a similar conclusion.

280. Title (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
     March 31, 2010 - We will conduct meta-analyses when there is sufficient data (at least 5 studies of the same design) … For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk … We will identify statistical heterogeneity between the intervention studies in all the meta-analyses … All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp, College Station … Subgroup analysis: We will conduct subgroup meta-analyses when there are sufficient data (at least