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261. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - Peer Reviewer #1 Methods Subgroup analyses: From the included data extraction form, it is not clear … If an individual trial did not conduct any subgroup analyses upon the relevant variables, it would … also be useful to know, so that we can inform future researchers to conduct such subgroup analyses. … Peer Reviewer #1 Results 5.When subgroup analyses were not possible because there was only a single … analyses, based on drug regimen.

262. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a search of their … We will conduct meta-analyses of summary data when there are sufficient data (at least three studies … All analyses will be intention to treat. … For studies amenable to pooling with meta-analyses, we will calculate a weighted mean difference using … Recommendations for examining and interpreting funnel  plot asymmetry in meta-­‐analyses of randomised

263. Evidence Summary: Comparative Effectiveness Review No. 245_Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-245-breast-reconstruction-after-mastectomy-evidence-summary-updated-1.pdf
     October 01, 2021 - there was sufficient evidence with an acceptable amount of heterogeneity, we conducted pairwise meta-analyses … of this Evidence Summary, we provide numeric estimates of summary treatment effects only where meta-analyses … When subgroup data were reported, statistical analyses evaluating heterogeneity of treatment effects

264. Minimal Modeling Approaches to Value of Information Analysis for Health Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
     June 01, 2011 - For example, VOI analyses performed by the National Institute for Health and Clinical Excellence (NICE … Perhaps the most important drawback is that VOI studies based on decision analyses can be very time … Cost-effectiveness analyses done alongside clinical trials6 in which comprehensive outcomes measures … In addition, we performed two new minimal modeling VOI analyses. … Enhancing value of information analyses. Value Health 2009;12(6):935–941. 11. Detsky AS.

265. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
     December 01, 2010 - Subsequent meta-analyses have generally confirmed these results16 and have helped to provide a clearer … The disconnect between the research findings of CutLASS 1 and the CATIE study and meta-analyses (favoring … will be performed if the number of studies is sufficient to warrant these analyses.24 The following … variables will be considered in subgroup analyses if data are available: disorder subtypes, gender, … Sensitivity analyses will be conducted to assess the robustness of the findings.

266. Disposition of Comments for Interventions To Improve Cardiovascular Risk Factors in People With Serious Mental Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_disposition-comments.pdf
     April 22, 2013 - In quantitative analyses, however, this is frowned upon because small studies have little weight in … meta-analyses models. … For meta-analyses one would expect sensitivity analyses with/without poor studies. … Studies with high risk of bias were included in both qualitative and quantitative analyses. … For meta-analyses, we conducted sensitivity analyses (by quality rating) on a limited basis since

267. Cancer-Anemia-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_executive.pdf
     April 01, 2013 - This resulted in multiple pooled analyses of ESA trial data over several years, as well as regulatory … Sensitivity analyses performed for each outcome with data from studies excluded because of size showed … Moreover, we did not find those trial results influential in these analyses.

268. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
     December 09, 2009 - If appropriate, meta-analyses will be conducted using the random effects model. … Subgroup analyses or meta-regression will be conducted, if possible, to investigate sources of heterogeneity … Sensitivity analyses will be conducted to assess the robustness of the findings across study quality … , and random effects vs. fixed effects analyses. … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

269. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
     September 01, 2021 - Meta- analyses were conducted for vertebroplasty versus no vertebroplasty (sham or usual care) and effects … on pain, function, quality of life, and harms; analyses were conducted to assess how the control type … Otherwise, meta-analyses were not conducted due to small number of studies, 3 methodological … • Three trials that conducted within-study subgroup analyses found no interaction between duration

270. MEDICAL MANAGEMENT OF CONGESTIVE HEART FAILURE AND THE EFFECTIVENESS OF ISOSORBIDE DINITRATE AND HYDRALAZINE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
     March 01, 2010 - factors on 76,828 veterans with heart failure were analyzed using propensity-adjusted Cox regression analyses … Index.12 Effective Health Care Research Report Number 19 2 The dependent variables for our analyses … The findings are similar when these analyses are limited to African-American patients. … Comparable analyses with HF hospitalization as the dependent variable consistently showed hazard ratios … the ability of this approach to reduce confounding beyond that provided by traditional regression analyses

271. S66 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s66.pdf
     October 01, 2007 - We evaluated persistence through survival analyses, and adherence within episodes through the medication … A risk score was included in the analyses to account for measured confounders. … Analyses were performed in Stata version 9.0 (StataCorp., College Station, TX). … We performed a number of secondary analyses to evaluate the robustness of our findings. … All analyses were repeated excluding nursing home residents (0.63% of records).

272. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_disposition-comments.pdf
     March 10, 2010 - Methods 2-3 of the large studies that were included in the meta-analyses were categorized as 'Fair' … I think it would be helpful to present sensitivity analyses where poorer quality studies are separated … Several other analyses (and the trials included) have distinguished between women > vs < 50 and found … What further analyses could be done that would address the key questions, and have the trial groups … been asked to undertake such analyses?

273. Chicago-Area DEcIDE Center (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
     May 01, 2009 - weighting of these factors in the priority list modeling, and the specifications of the sensitivity analyses … input from our technical expert panel, we identified four drug characteristics to include in the analyses … First, the base analyses dropped indications that could not be found in DRUGDEX, where a match was not … Only well structured analyses following good scientific techniques can help build useful evidence for … Such research would initially take the form of meta-analyses to accumulate and assess past clinical

274. Binge-Eating Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
     December 01, 2015 - ) was control for critical potential confounding through design or statistical analyses. … However, we did consider studies with high risk of bias in sensitivity analyses of our meta-analyses … Evidence based on meta- analyses pertains to second-generation antidepressants and lisdexamfetamine; … Evidence of the benefits of therapist-led CBT was particularly compelling; meta-analyses estimated … Two later meta-analyses reached a similar conclusion.

275. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
     January 01, 2024 - domain and specific measurement), and relevant study results (including subgroup and interaction analyses … use random-effects models, anticipating that even with efforts made to reduce heterogeneity in the analyses … distribution of social determinants among included studies as well as report any subgroup or other analyses … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in … randomized controlled trials and meta-analyses.

276. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - We performed sensitivity analyses assuming a recessive or additive model. … We used hazard or incidence rate ratios in our meta- analyses whenever available or extractable from … Generally, these analyses were congruent with analyses using a dominant model because they also indicated … to reconstruct such analyses from the reported data. … (All analyses assumed a dominant model for loss-of-function alleles; analyses under an alternative

277. Title (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
     March 31, 2010 - We will conduct meta-analyses when there is sufficient data (at least 5 studies of the same design) … For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk … We will identify statistical heterogeneity between the intervention studies in all the meta-analyses … All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp, College Station … Subgroup analysis: We will conduct subgroup meta-analyses when there are sufficient data (at least

278. Evidence-based Practice Center Systematic Review Protocol: Prehospital Airway Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prehospital-airway-management-protocol.pdf
     December 20, 2019 - Meta-analyses will be conducted if possible to combine data and obtain more precise estimates on outcomes … To determine whether meta-analyses are indicated, we will consider the quality of the individual studies … Meta-analyses will be conducted using a random effects model. … If warranted, we will conduct sensitivity analyses by repeating meta-analyses with and without selected

279. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-off-label-update_research-protocol.pdf
     May 19, 2010 - We will define loss to follow-up as the number of patients excluded from efficacy analyses, expressed … (Across a broad array of meta-analyses, an evaluation found that trials scoring 0-2 report exaggerated … For the efficacy and comparative effectiveness analyses, we will focus on controlled trials that report … Since most of the scales used as outcome measures in the pooled analyses are scored so that more severely … All meta-analyses will be conducted with Stata statistical software, version 8.2 (Stata Corp., College

280. Transparency of Reporting Requirements: Management of Infertility (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research-protocol.pdf
     September 02, 2016 - studies identified there to published studies (to detect publication bias) and to compare planned analyses … arms • Intervention description • Study design • Outcomes measures • Analysis approach • Subgroup analyses … Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised … Evidence for the selective reporting of analyses and discrepancies in clinical trials: a systematic … meta-analysis"[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tiab] OR "meta-analyses