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241. Coronary-Artery-Stenting Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
     February 01, 2013 - However, a large number of studies did not report full statistical analyses of the net change. … We performed sensitivity meta-analyses by excluding studies that were rated as being at a high risk … Meta-analyses of QCA outcomes in the short term, including procedural MLD, reference vessel diameter … Meta-analyses of QCA outcomes in the medium term—including MLD, diameter stenosis, 10 reference … Meta-analyses of clinically-driven repeat revascularization favored IVUS.

242. Disposition of Comments for CER 147 Menopausal Symptoms: Comparative Effectiveness of Therapies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_disposition-comments.pdf
     March 05, 2015 - From a perspective of evidence synthesis, a separate set of analyses would have been required. … In pairwise analyses, the pooled SMD for SNRIs was - 0.36 (95% CI: -0.55 to -0.17) and for all SSRI/ … When scale domains were clearly distinguishable on clinical basis, analyses were reported separately … Stronger rationale for analyses for KQ3 should be provided. … We did account for dose in analyses, but to subset the vaginal administration trials further could

243. Prognostic Tests (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
     June 01, 2012 - Perform appropriate statistical analyses based on outcome probabilities. … Conduct meta-analyses of estimates of outcome probabilities. … Example: Hazard ratios from Cox regression analyses or odds ratios from logistic regression analyses … For example, investigators commonly report estimated hazard ratios (HRs) from Cox regression analyses … Reviewer access to patient-level data would allow uniform analyses to overcome these difficulties.

244. Prognostic Tests (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
     June 01, 2012 - Perform appropriate statistical analyses based on outcome probabilities. … Conduct meta-analyses of estimates of outcome probabilities. … Example: Hazard ratios from Cox regression analyses or odds ratios from logistic regression analyses … For example, investigators commonly report estimated hazard ratios (HRs) from Cox regression analyses … Reviewer access to patient-level data would allow uniform analyses to overcome these difficulties.

245. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - However, we will not search for cost effectiveness studies or conduct cost-effectiveness analyses of … All meta-analyses will use a random effects model. … In cases of substantial heterogeneity, we will perform subgroup and meta-regression analyses if the … analyses include glucose thresholds for tests, type of treatment, maternal age, race or ethnicity, … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

246. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-mortality-elderly_research.pdf
     March 01, 2009 - The analyses were restricted to new users of APMs to guard against potential selection bias caused … In confirmatory analyses, Propensity score adjustments was used to balance measured risk factors … In analyses restricted by dementia status or nursing home residency, with the exception of patients … to the traditional multivariable Cox regression analyses, adding further support to the findings … In the instrumental variable analyses, use of conventional antipsychotic medications continued to

247. Amended Protocol: Interventions for Breathlessness in Patients with Advanced Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
     May 19, 2020 - Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a references list … We will conduct meta- analyses when there are sufficient data (at least two studies) and studies are … small, medium or large.12 Dichotomous data with zero values in both arms will not be included in meta-analyses … providing information on the confidence intervals for the proportion of events in each arm.13 All meta-analyses … chronic breathlessness in people with advanced disease: An exploratory systematic review and meta-analyses

248. Ch 8-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
     October 01, 2013 - Selection of Data Sources for sensitivity analyses, as may be appropriate. … The results of these analyses are combined in a central location, but individual study data do not … unified guidelines can be developed for inclusion criteria, exposures, and outcomes, and analyses … A critical look at methods for handling missing covariates in epidemiologic regression analyses. … Traditional reviews, meta-analyses and pooled analyses in epidemiology.

249. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
     January 01, 2010 - Only when subgroup analyses were performed on the data, was it possible to show an effect on symptoms … However, subgroup analyses are best-recognized as “exploratory” parameters that provide insight into … Indeed, these type analyses are often performed post-fact in an attempt to “mine the data” to learn … reviewing Skoner’s original paper, we did not find any evidence that Skoner performed any post-fact analyses … In fact, it should be considered “weak” based on the statistical methods (subgroup analyses) which

250. Disposition of Comments_CER 241: Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-241-wheelchair-users-disposition-comments.pdf
     October 18, 2022 - Further, there should be subquestions/analyses focused on the type of wheelchair. … studies reported that wheelchair users were included in the study, so we were unable to do any sub analyses … I liked the discussion of others relevant reviews and meta-analyses.

251. Grades-Predictive-Values White-Paper-2015 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
     January 01, 2015 - Results of stratified analyses based on sample size, risk of bias, and magnitude of effect estimates … For all meta-analyses we used DerSimonian-Laird random effects models. … We used DerSimonian-Laird random- effects meta-analyses to calculate summary differences in magnitudes … Stratified Analyses In stratified analyses and meta-regression we explored the effects of sample sizes … Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time.

252. Executive Summary_Comparative Effectiveness Review No. 271: Nonpharmacologic Treatments for Maternal Mental Health Conditions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-271-mental-health-pregnant-executive-summary.pdf
     July 01, 2024 - Where sufficient comparable studies were available, we conducted meta-analyses of relative risk (RR) … full outcome data, which limited our ability to include studies with insufficient reporting in our analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses

253. labor-dystocia-protocol-amended-160728 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
     July 28, 2016 - lay midwife, doula Study design • KQ 1: o Original data, including systematic reviews and meta-analyses … For comparison, we will also perform fixed-effect meta-analyses. … If there are sufficient studies, we will perform subgroup analyses and/or meta-regression analyses to … As noted above, there is already a large body of systematic reviews, some with meta- analyses, in this … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

254. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
     October 01, 2022 - evidence on infants 1 month to less than 36 months, including a laborious search for pertinent subgroup analyses … evidence prior to 1999 (which may have excluded some relevant studies), sparse data which precluded analyses

255. Self-Measured Blood Pressure: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure-future_research.pdf
     August 01, 2012 - In addition, sensitivity analyses may be used to explore the robustness of findings for nonrandomized … Post hoc analyses of existing observational studies can be done quickly and with modest resources. … Overall, subgroup analyses did not exhibit clear signals as to what populations might differentially … Ethical Issues There should be no ethical issues in conducting subgroup analyses. … Value of Study Design In addition to the expected merit of a simple CEA, sensitivity analyses may be

256. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
     December 01, 2009 - studies that used a combination of followup and open surgical biopsy as the reference standard in our analyses … The model is based on the point estimates of accuracy from our analyses and do not incorporate estimates … We have performed sensitivity analyses (Table D) of the impact of this possibility on our conclusions … Sensitivity analyses using overestimation of the sensitivity by 5 percent and 10 percent suggest that … Our analyses found the highest sensitivity for methods utilizing stereotactic guidance, particularly

257. Adverse Effects of First-Line Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-depression-research-protocol.pdf
     February 07, 2018 - Post-hoc and subgroup analyses of included studies will be considered when they provide data on the … All analyses were performed using the ‘meta’ or ‘metafor’ packages in R (version 3.1.3; the R Project … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003;327:557-60. 21. … Arcsine test for publication bias in meta- analyses with binary outcomes.

258. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Post-hoc and 8 subgroup analyses of included studies will be considered when they provide … will present other comparisons (non-opioids to non-opioids or opioids to opioids) as supplemental analyses … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003;327:557-60. 28. … Arcsine test for publication bias in meta- analyses with binary outcomes.

259. Behavioral Programs for Type 2 Diabetes Mellitus: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician.pdf
     November 01, 2016 - . �� In subgroup analyses, results for reduced hemoglobin A1c (HbA1c) favored participants with suboptimal … evaluation. �� Trials including populations with diverse ethnic backgrounds should perform subgroup analyses

260. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/presentation.ppt
     August 01, 2009 - ” could be used to help appreciate the scope of the evidence and to identify opportunities for meta-analyses … Look at the emptiness of the table and how “selected” the meta-analyses that we can conduct in this field … Statistical significance status in the primary studies could be based on different analyses (e.g., haplotype-based … analyses or adjusted analyses) than the ones we performed in this technology assessment.