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241. Osteoporosis-Bone-Fracture Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
     March 01, 2012 - of trial efficacy data by a subgroup of interest; by noting whether subgroup analyses were reported … For adverse events, two main analyses were performed: analyses to assess the relationship between a … Among a number of meta-analyses, some reported a reduced risk for vitamin D relative to placebo, some … Our pooled analyses showed alendronate had a slightly increased risk of mild upper GI events. … Post hoc analyses of trials of treatment show that changes in BMD while on treatment only modestly

242. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - We abstracted information from study-specific sensitivity analyses and regression analyses when available … Population and Methodological Factors Affecting the Risk of Reinfection We conducted analyses of six … Sensitivity Analyses Figure C-1. … Measuring inconsistency in meta-analyses. … Sensitivity Analyses Appendix D. Ongoing Studies Appendix E.

243. Medication-Therapy-Management Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
     January 01, 2014 - We plan to exclude studies deemed at high risk of bias from our main data synthesis and main analyses … ; we will include them only in sensitivity analyses. … For all analyses, we will use random-effects models to estimate pooled or comparative effects. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers

244. Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-protocol-acute-pain-treatments.pdf
     August 08, 2019 - , or if there is inconsistency between the findings of the new studies and the prior meta-analyses. … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for … To determine whether meta-analyses are indicated, we will consider the quality of the studies and the … Meta-analyses will be conducted using a random effects model. … Stratified analyses will also be conducted on characteristics pertaining to study design and setting

245. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
     March 22, 2023 - We will conduct sensitivity analyses to determine if the treatment effect is meaningfully different … studies in children with and without a formal diagnosis of a DBD are analyzed together versus when analyses … When conducting meta-analyses, we will test for publication bias and for small study effects when there … For all pooled analyses, we will estimate the magnitude of treatment effects as small, moderate, or … Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised

246. Disposition of Comments for CER 147 Menopausal Symptoms: Comparative Effectiveness of Therapies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_disposition-comments.pdf
     March 05, 2015 - From a perspective of evidence synthesis, a separate set of analyses would have been required. … In pairwise analyses, the pooled SMD for SNRIs was - 0.36 (95% CI: -0.55 to -0.17) and for all SSRI/ … When scale domains were clearly distinguishable on clinical basis, analyses were reported separately … Stronger rationale for analyses for KQ3 should be provided. … We did account for dose in analyses, but to subset the vaginal administration trials further could

247. Executive Summary_Comparative Effectiveness Review No. 271: Nonpharmacologic Treatments for Maternal Mental Health Conditions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-271-mental-health-pregnant-executive-summary.pdf
     July 01, 2024 - Where sufficient comparable studies were available, we conducted meta-analyses of relative risk (RR) … full outcome data, which limited our ability to include studies with insufficient reporting in our analyses … study for specific comparisons or were reported in an insufficient number of studies to allow meta-analyses

248. Behavioral Programs for Type 2 Diabetes Mellitus: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician.pdf
     November 01, 2016 - . �� In subgroup analyses, results for reduced hemoglobin A1c (HbA1c) favored participants with suboptimal … evaluation. �� Trials including populations with diverse ethnic backgrounds should perform subgroup analyses

249. Ch 8-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
     October 01, 2013 - Selection of Data Sources for sensitivity analyses, as may be appropriate. … The results of these analyses are combined in a central location, but individual study data do not … unified guidelines can be developed for inclusion criteria, exposures, and outcomes, and analyses … A critical look at methods for handling missing covariates in epidemiologic regression analyses. … Traditional reviews, meta-analyses and pooled analyses in epidemiology.

250. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
     October 01, 2022 - evidence on infants 1 month to less than 36 months, including a laborious search for pertinent subgroup analyses … evidence prior to 1999 (which may have excluded some relevant studies), sparse data which precluded analyses

251. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
     January 01, 2010 - Only when subgroup analyses were performed on the data, was it possible to show an effect on symptoms … However, subgroup analyses are best-recognized as “exploratory” parameters that provide insight into … Indeed, these type analyses are often performed post-fact in an attempt to “mine the data” to learn … reviewing Skoner’s original paper, we did not find any evidence that Skoner performed any post-fact analyses … In fact, it should be considered “weak” based on the statistical methods (subgroup analyses) which

252. Amended Protocol: Interventions for Breathlessness in Patients with Advanced Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
     May 19, 2020 - Relevant reviews, including systematic reviews and meta-analyses, will be tagged for a references list … We will conduct meta- analyses when there are sufficient data (at least two studies) and studies are … small, medium or large.12 Dichotomous data with zero values in both arms will not be included in meta-analyses … providing information on the confidence intervals for the proportion of events in each arm.13 All meta-analyses … chronic breathlessness in people with advanced disease: An exploratory systematic review and meta-analyses

253. Disposition of Comments_CER 241: Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-241-wheelchair-users-disposition-comments.pdf
     October 18, 2022 - Further, there should be subquestions/analyses focused on the type of wheelchair. … studies reported that wheelchair users were included in the study, so we were unable to do any sub analyses … I liked the discussion of others relevant reviews and meta-analyses.

254. Evidence-based Practice Center Systematic Review Protocol: Prehospital Airway Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prehospital-airway-management-protocol.pdf
     December 20, 2019 - Meta-analyses will be conducted if possible to combine data and obtain more precise estimates on outcomes … To determine whether meta-analyses are indicated, we will consider the quality of the individual studies … Meta-analyses will be conducted using a random effects model. … If warranted, we will conduct sensitivity analyses by repeating meta-analyses with and without selected

255. labor-dystocia-protocol-amended-160728 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
     July 28, 2016 - lay midwife, doula Study design • KQ 1: o Original data, including systematic reviews and meta-analyses … For comparison, we will also perform fixed-effect meta-analyses. … If there are sufficient studies, we will perform subgroup analyses and/or meta-regression analyses to … As noted above, there is already a large body of systematic reviews, some with meta- analyses, in this … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

256. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Post-hoc and 8 subgroup analyses of included studies will be considered when they provide … will present other comparisons (non-opioids to non-opioids or opioids to opioids) as supplemental analyses … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003;327:557-60. 28. … Arcsine test for publication bias in meta- analyses with binary outcomes.

257. Adverse Effects of First-Line Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-depression-research-protocol.pdf
     February 07, 2018 - Post-hoc and subgroup analyses of included studies will be considered when they provide data on the … All analyses were performed using the ‘meta’ or ‘metafor’ packages in R (version 3.1.3; the R Project … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003;327:557-60. 21. … Arcsine test for publication bias in meta- analyses with binary outcomes.

258. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
     December 01, 2009 - studies that used a combination of followup and open surgical biopsy as the reference standard in our analyses … The model is based on the point estimates of accuracy from our analyses and do not incorporate estimates … We have performed sensitivity analyses (Table D) of the impact of this possibility on our conclusions … Sensitivity analyses using overestimation of the sensitivity by 5 percent and 10 percent suggest that … Our analyses found the highest sensitivity for methods utilizing stereotactic guidance, particularly

259. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
     January 01, 2024 - domain and specific measurement), and relevant study results (including subgroup and interaction analyses … use random-effects models, anticipating that even with efforts made to reduce heterogeneity in the analyses … distribution of social determinants among included studies as well as report any subgroup or other analyses … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in … randomized controlled trials and meta-analyses.

260. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/presentation.ppt
     August 01, 2009 - ” could be used to help appreciate the scope of the evidence and to identify opportunities for meta-analyses … Look at the emptiness of the table and how “selected” the meta-analyses that we can conduct in this field … Statistical significance status in the primary studies could be based on different analyses (e.g., haplotype-based … analyses or adjusted analyses) than the ones we performed in this technology assessment.