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221. Disposition of Comments CER 185 Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
     May 05, 2017 - The network meta-analyses are particularly novel and useful. … For KQ1, we included RCTs only in the network meta-analyses. … Meta-analyses were performed for specific outcomes when studies reported sufficient data. … Meta-analyses were performed for specific outcomes when studies reported sufficient data. … Meta-analyses were performed for specific outcomes when studies reported sufficient data.

222. Asthma-Immunotherapy-2011 Research (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
     January 01, 2011 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Analytical framework 1.Systematic reviews and meta-analyses of observational nontherapeutic studies … quality of evaluated systematic reviews compared with the best published systematic reviews or meta-analyses … We did not score missing responses and did not include them in the analyses. … C Other (please specify) D Sponsoring organization did not participate in data analyses and

223. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
     December 04, 2015 - analyses!of!individual!patient6level!data!from!one!or!a! combination!of!similar!trials).! … The original review focused on these pairwise meta-analyses. … Heterogeneity will also be examined during our planned subgroup analyses. … What contributions do languages other than English make on the results of meta-analyses? … The Newcastle-Ottawa Scale for assessing the quality of nonrandomized studies in meta-analyses.

224. Antidepressant Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
     July 01, 2014 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … ) checklist.21 All methods and analyses were determined a priori. … Timing of exposure was primarily in the first trimester, although our sensitivity analyses removing … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414): 557-60. PMID: 12958120. 27.

225. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-provider-adherence_research-protocol.pdf
     March 02, 2012 - The interventions used in the studies that the report authors included in their analyses had been tested … Furthermore, although pediatric studies were included in the report analyses, the interventions used … All analyses will be intention to treat. … are conducted.37 All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

226. Allergy-Seasonal Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
     July 01, 2013 - Three was an arbitrary number used as an operational criterion for meta- analyses. … In this review, we formed conclusions about treatment classes based on meta-analyses of studies that … The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)53 diagram shown in … No RCTs, observational studies, systematic reviews, or meta- analyses met the inclusion criteria. … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

227. Coronary-Artery-Stenting Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
     February 01, 2013 - However, a large number of studies did not report full statistical analyses of the net change. … We performed sensitivity meta-analyses by excluding studies that were rated as being at a high risk … Meta-analyses of QCA outcomes in the short term, including procedural MLD, reference vessel diameter … Meta-analyses of QCA outcomes in the medium term—including MLD, diameter stenosis, 10 reference … Meta-analyses of clinically-driven repeat revascularization favored IVUS.

228. A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/primary-research-design/research

229. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - However, we will not search for cost effectiveness studies or conduct cost-effectiveness analyses of … All meta-analyses will use a random effects model. … In cases of substantial heterogeneity, we will perform subgroup and meta-regression analyses if the … analyses include glucose thresholds for tests, type of treatment, maternal age, race or ethnicity, … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses

230. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-mortality-elderly_research.pdf
     March 01, 2009 - The analyses were restricted to new users of APMs to guard against potential selection bias caused … In confirmatory analyses, Propensity score adjustments was used to balance measured risk factors … In analyses restricted by dementia status or nursing home residency, with the exception of patients … to the traditional multivariable Cox regression analyses, adding further support to the findings … In the instrumental variable analyses, use of conventional antipsychotic medications continued to

231. Prognostic Tests (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
     June 01, 2012 - Perform appropriate statistical analyses based on outcome probabilities. … Conduct meta-analyses of estimates of outcome probabilities. … Example: Hazard ratios from Cox regression analyses or odds ratios from logistic regression analyses … For example, investigators commonly report estimated hazard ratios (HRs) from Cox regression analyses … Reviewer access to patient-level data would allow uniform analyses to overcome these difficulties.

232. Prognostic Tests (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
     June 01, 2012 - Perform appropriate statistical analyses based on outcome probabilities. … Conduct meta-analyses of estimates of outcome probabilities. … Example: Hazard ratios from Cox regression analyses or odds ratios from logistic regression analyses … For example, investigators commonly report estimated hazard ratios (HRs) from Cox regression analyses … Reviewer access to patient-level data would allow uniform analyses to overcome these difficulties.

233. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
     January 01, 2020 - Treatment Guidelines and Meta-analyses on Maintenance of Weight No treatment guidelines for maintenance … We will conduct meta-analyses when there is sufficient data (at least 3 studies of the same design) … • For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences … We will conduct sensitivity analyses by omitting one study http://www.effectivehealthcare.ahrq.gov/ … All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp, College Station

234. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
     January 31, 2023 - We will conduct sensitivity analyses to determine if the treatment effect is meaningfully different … studies in children with and without a formal diagnosis of a DBD are analyzed together versus when analyses … When conducting meta-analyses, we will test for publication bias and for small study effects when there … For all pooled analyses, we will estimate the magnitude of treatment effects as small, moderate, or … Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised

235. Grades-Predictive-Values White-Paper-2015 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
     January 01, 2015 - Results of stratified analyses based on sample size, risk of bias, and magnitude of effect estimates … For all meta-analyses we used DerSimonian-Laird random effects models. … We used DerSimonian-Laird random- effects meta-analyses to calculate summary differences in magnitudes … Stratified Analyses In stratified analyses and meta-regression we explored the effects of sample sizes … Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time.

236. Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/horizon-scan/research-2015

237. Disposition of Comments Report for Comparative Effectiveness Review #68 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
     July 01, 2012 - In addition, we conducted analyses— including mixed treatment effects analyses and analyses by effectiveness … The analyses have been revised to analyze these groups separately. … As an example, cumulative meta-analyses of thrombolysis for MI have shown a consistent benefit over … In KQ4, we present subgroup analyses by efficacy-effectiveness score and setting. … The analyses in this section have been stratified by specific NPPV application and in some instances

238. Systematic Review of Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
     January 01, 2020 - For both KQs, we will capitalize on the availability of existing systematic reviews and meta-analyses … We will consider performing meta-analyses where we have at least three unique studies of low or medium … We plan to exclude studies deemed high risk of bias from our main data synthesis and main analyses; … we will include them only in sensitivity analyses. … We will show forest plots for all meta-analyses performed, either in the main report or in appendices

239. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
     September 01, 2011 - Peer Reviewer #1 Introduction The introduction provides a cogent rationale for the detailed analyses … Our analyses, though limited to a small number of studies, did not suggest a substantial difference … The detailed analyses of Tiers 2 and 3 are still in the Results section, but they are not addressed … Therefore, it should be added to the report’s analyses as it describes results from one of the largest … The study performs cost-effective analyses.

240. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
     May 02, 2025 - domain and specific measurement), and relevant study results (including subgroup and interaction analyses … use random-effects models, anticipating that even with efforts made to reduce heterogeneity in the analyses … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in … randomized controlled trials and meta-analyses. … Given the number of comparisons anticipated in proposed network meta-analyses (>100), this approach