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21. Comparing the Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/glaucoma/abstract
    November 09, 2011 - for race/ethnicity groups, and sensitivity analyses. … will be submitted after patient enrollment is complete and will summarize the findings of the interim analyses … Report 3: Primary Analysis Report will be submitted after final study analyses are complete and will … Report 4: Secondary Analyses Report will be submitted after final study analyses are complete and will … summarize the findings of the secondary analyses.

22. Quantitative Synthesis: Learning Objectives and Recommendations (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-learning-objectives-recommendations.pdf
    July 01, 2019 - Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … How should meta‐ regression analyses be undertaken and interpreted?

23. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methodological-recommendations-framework-communications_research.pdf
    September 01, 2013 - , and decision or economic analyses. … The same resource levels apply to meta-analyses of mixed treatment comparisons (network meta-analyses … Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy. … Arcsine test for publication bias in meta- analyses with binary outcomes. … Does blinding of readers affect the results of meta-analyses?

24. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses.

25. Quantitative Synthesis: Chapter 4. Quantifying, Testing, and Exploring Statistical Heterogeneity (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
    July 01, 2019 - Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … How should meta‐ regression analyses be undertaken and interpreted?

26. Muscle Disorders | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/muscle-disorders
    January 26, 2015 - Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses

27. Ch 3-User-Guide-To-Ocer 130129 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
    September 21, 2012 - Numerous subgroup analyses were conducted, most of which indicated relatively consistent effects of … Findings from such unfocused, exploratory subgroup analyses should be interpreted with caution even … Compared to confirmatory and descriptive HTE analyses, exploratory analyses enjoy more flexibility … - If confirmatory analyses, do power calculations. … Statistics in medicine – reporting of subgroup analyses in clinical trials.

28. Methods Guide for Comparative Effectiveness Reviews - Expanded Guidance on Selected Quantitative Synthesis Topics (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - and binary analyses of relative measures (odds ratio or relative risk). … • The additional power may not be necessary for many meta-analyses. … The exploratory nature of these analyses should be clear. … Sensitivity analyses Specify what sensitivity analyses are being done and how they relate to key … analyses undertaken. 15 References 1.

29. Slide 1
    effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
    January 01, 2013 - This presentation will: Propose and describe planned sensitivity analyses Describe important subpopulations … When results of analyses are consistent or unchanged by testing variations on underlying assumptions, … When the results of analyses are consistent or unchanged by testing variations on underlying assumptions … Sensitivity analyses can allow the investigator to quantify the effect that an unmeasured confounding … Presentation of Sensitivity Analyses Tabular The classic approach to presenting sensitivity analyses

30. The Empirical Evidence of Bias in Trials Measuring Treatment Differences | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/treatment-effects-bias/research
    September 29, 2014 - We included meta-epidemiological studies (studies drawing from multiple meta-analyses), meta-analyses … Within many epidemiological studies, the included meta-analyses or trials varied along these dimensions … evaluating precision in meta-epidemiological studies developed from potentially heterogeneous meta-analyses … We suggest that systematic reviewers consider subgroup analyses, with and without studies with flaws

31. Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/horizon-scan/research-2015
    October 01, 2015 - Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports … In 2014, AHRQ requested exploratory, rapid, cost analyses to elucidate the potential 1-year spend of … Conclusions Limitations of these rapid cost analyses include the short timeframe to produce them, limited

32. Expanded Guidance on Selected Quantitative Synthesis Topics | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/quantitative-synthesis-expanded-methods/methods
    March 13, 2013 - The additional power may not be necessary for many meta-analyses. … Meta-analyses of the individual components should also be performed. … The exploratory nature of these analyses should be clear. … Sensitivity analyses   Specify what sensitivity analyses are being done and how they relate to key … analyses undertaken.

33. Comparative Effectiveness Review Disposition of Comments Report: Anxiety in Children (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
    August 31, 2017 - We understand the importance of subgroup analyses. … In this revision, we added some subgroup analyses. … The subgroup analyses examined disorder specific studies. … Some studies appear to be missing in the analyses. … Our concerns regarding these analyses are twofold.

34. Methods Guide for Medical Test Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
    July 01, 2012 - Multivariate meta-analyses require advanced hierarchical modeling. … in a large empirical exploration of 308 meta-analyses.40 Chappell et al. argued that in meta-analyses … or subgroup analyses. … Guidelines for meta-analyses evaluating diagnostic tests. … When are summary ROC curves appropriate for diagnostic meta-analyses?

35. Web Interactive Presentation of EPC Reports: A Foray Into Interactive Reports (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-web-interactive-presentation.pdf
    September 01, 2019 - In its current form, the tool does not provide or allow for additional analyses not included in the … First, there is a need to perform analyses, including sensitivity analyses, dynamically. … This can be accomplished by embedding statistical analyses in the interactive report. … We submit that, perhaps, the advantages of offering dynamic analyses outweigh their risks. … Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(3). 6.

36. Testing the Predictive Validity of Strength of Evidence Grades | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/grades-predictive-values/abstract
    September 14, 2015 - Evolves From Single Trials to High-Quality Bodies of Evidence We assembled a pool of published meta-analyses … Using cumulative meta-analyses, we graded the SOE of subsets of this evidence at different points in … Using a large sample of meta-analyses, the outcome of interest is the proportion of stable results over … Cochrane Branch (expected stability) and the proportion of stable summary effects from the sample of meta-analyses

37. Presentation of Findings: Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/reporting-quiz.ppt
    January 01, 2009 - The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) Statement is a reporting … Guidelines Reporting Guidelines The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses … Empirical evidence exists for randomized trials, diagnostic studies, meta-analyses, and acupuncture interventions … The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health … in the presentations are taken from the PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses

38. Future Research Needs for Treatment of Obstructive Sleep Apnea (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Analyses of CPAP stratified by disease severity b. … Analyses of CPAP stratified by disease severity b. … and subgroup analyses. … Analyses of CPAP stratified by disease severity b. … or post hoc analyses of existing trials.

39. AHRQ Slide Template 2009 (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/reporting.ppt
    September 01, 2009 - Describe the methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression … Example: Sensitivity analyses were pre-specified. … PMID: 20704038 Results: Additional Sensitivity Analyses Give the results of additional analyses, … Results: Additional Sensitivity Analyses Authors should report sensitivity analyses, which is usually … Results: Additional Subgroup Analyses It is important to separate subgroup analyses, which is usually

40. S58 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s58.pdf
    October 01, 2007 - For example, longitudinal analyses of antiretroviral medication use among Medicaid beneficiaries with … Supports detailed analyses of subgroups, rare conditions and comorbidities, including individuals with … Censoring and changes in diagnosis, treatment, and eligibility status complicate analyses. … Construction of eligibility timelines is used to select intervals to be included in analyses. … Descriptive analyses of the integrity of a US Medicaid claims database.