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181. Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
     February 01, 2014 - We based our main analyses for these two approaches on the treatment effects from a meta-analysis of … Finally, when we based the analyses on baseline incidence rates of the placebo groups in the trials … most sensitivity analyses. … The sensitivity analyses that used baseline risks obtained from trials showed that the incidence of … Finally, the sensitivity analyses for the Gail/NCI approach showed that the relative weights used to

182. Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-meta-analysis.ppt
     June 01, 2012 - When are summary ROC curves appropriate for diagnostic meta-analyses? … subgroup analyses in the context of the primary methodology used to summarize the studies. … Finally, meta-regression-based analyses or subgroup analyses should be used to look at the impact of … This is a joint analysis of both quantities instead of a separate univariate meta-analyses. … When are summary ROC curves appropriate for diagnostic meta-analyses?

183. Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
     June 01, 2012 - When are summary ROC curves appropriate for diagnostic meta-analyses? … subgroup analyses in the context of the primary methodology used to summarize the studies. … Finally, meta-regression-based analyses or subgroup analyses should be used to look at the impact of … This is a joint analysis of both quantities instead of a separate univariate meta-analyses. … When are summary ROC curves appropriate for diagnostic meta-analyses?

184. CER 221 Disposition of Comments: Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-comments_0.pdf
     October 11, 2019 - Heterogeneity is always a concern for meta-analyses. … As a result, despite of 95 studies included in the analyses, no meta-analyses included more than 4 … : No Additional analyses Are the methods appropriate? … : No Additional analyses Are the methods reported clearly and accurately? … Summarizing systematic review/meta-analyses is not in the KQs and the protocol.

185. Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
     November 01, 2023 - When possible, we conducted quantitative analyses using random-effects models to estimate pooled effects … We included all studies in the main analyses and conducted sensitivity analyses without studies rated … (e.g., alcohol dependence and depression) and those that did not have a dual diagnosis in the meta-analyses

186. S103 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
     October 01, 2007 - ORIGINAL ARTICLE Using Inverse Probability-Weighted Estimators in Comparative Effectiveness Analyses … Finally, we offer detailed guidance about how to implement the estimators in comparative effectiveness analyses … Next, we discuss how to use inverse probability-weighted esti- mators for comparative effectiveness analyses … Although these characteristics can then be used to define strata for subsequent analyses, analysts should … Researchers should also use sensitivity analyses to explore the robustness of the model to the inclusion

187. Ptsd-Adults-Trauma-Interventions Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
     April 01, 2013 - We conducted quantitative syntheses using meta-analyses of outcomes reported by multiple studies that … Heterogeneity was also explored through sensitivity analyses. … Quantitative pairwise meta-analyses were conducted using Stata® version 11.1. … Overall, we included 19 trials in our main analyses. … Another 37 studies otherwise meeting inclusion criteria were omitted from our main analyses because

188. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
     December 01, 2011 - For quantitative analyses, we included all eligible studies without sample size limitations. … If we concluded that we could not conduct any quantitative analyses, then we included studies only if … We conducted meta-analyses of 6 direct comparisons; the remaining 72 analyses employed mixed treatment … comparison meta-analyses to derive indirect comparisons. … These results are based on meta-analyses of head-to-head trials.

189. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
     July 13, 2011 - be able to be abstracted from data presented in the papers (including Systematic Reviews and Meta-analyses … Hospitalization Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … recurrent depression Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … effects Adherence Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … Because we do not have access to individual patient data, we will not conduct any subgroup analyses.

190. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/case-management_research-protocol.pdf
     June 06, 2011 - We will include systematic reviews and meta-analyses that included unpublished data inaccessible to … the public; but because the results of such analyses are not verifiable, we will consider this a … ascertaining exposures, potential confounders, and outcomes; and whether appropriate statistical analyses … Few of the studies include sub-group analyses. … Thus, comparisons among intervention characteristics are usually indirect, and these analyses also

191. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - A subsequent publication presents exploratory analyses in which a subset of ICH patients was described … We present both risk difference analyses (main body of report) and analyses using the arc sine method … The pooling of dose-escalation studies with Phase 2 or Phase 3 studies in the efficacy analyses is a … Results Page 39, when sensitivity analyses were done, mention them in the methods section, too. … used to define indications within the Premier analyses (page 42).

192. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - Relevant systematic review articles, meta-analyses, and methods articles were flagged for hand-searching … For each SROC calculation, we ran separate analyses of the accuracy of each NIT modality compared with … In our primary analyses, we evaluated these performance characteristics in the population of women … In secondary analyses, we explored a broader patient population by including those studies that had … We also assessed the impact on our findings if, in each population, we restricted our analyses to those

193. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
     January 31, 2023 - We will conduct sensitivity analyses to determine if the treatment effect is meaningfully different … studies in children with and without a formal diagnosis of a DBD are analyzed together versus when analyses … When conducting meta-analyses, we will test for publication bias and for small study effects when there … For all pooled analyses, we will estimate the magnitude of treatment effects as small, moderate, or … Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised

194. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
     January 01, 2020 - Treatment Guidelines and Meta-analyses on Maintenance of Weight No treatment guidelines for maintenance … We will conduct meta-analyses when there is sufficient data (at least 3 studies of the same design) … • For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences … We will conduct sensitivity analyses by omitting one study http://www.effectivehealthcare.ahrq.gov/ … All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp, College Station

195. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
     March 13, 2012 - Pre-1990 studies are likely to be included in meta-analyses that meet our inclusion criteria so that … Included meta-analyses will be appraised according to criteria adapted from the PRISMA Statement.21 … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … , or systematic reviews and study-level meta- analyses. … Explicit clarification of the use of systematic reviews and meta- analyses in the review.

196. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
     September 08, 2011 - Although the utility of procalcitonin has been reviewed in meta-analyses, these reviews have been limited … We will use results from previously conducted meta-analyses and systematic reviews when appropriate … Prespecified subgroup analyses guard against the problems of data dredging. E. … If meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment of … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment

197. Quantitative Synthesis: Chapter 5. Network Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
     February 01, 2018 - Reporting of results from network meta-analyses: methodological systematic review. … The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … Reporting of results from network meta-analyses: methodological systematic review. … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

198. Tonsillectomy for Obstructive Sleep-Disordered Breathing or Recurrent Throat Infection in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
     January 01, 2017 - We carried out hand searches of the reference lists of recent systematic reviews or meta-analyses of … We also conducted analyses to estimate the effects of including high risk of bias studies in the analyses … These analyses suggested no systematic effects of these studies; thus, we retained them. … after sensitivity analyses showed that they had no systematic effects on outcomes. … final analyses (Table B).

199. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
     September 01, 2009 - Anticipating a dearth of available evidence in answering the key questions, analyses were broadened to … the following categories: Dose and statin-specific analyses comparing lower dose of a specific statin … The DerSimonian and Laird approach was used for all meta-analyses, except for rare events (less than … Conclusions pertaining to the key questions, as well as additional analyses in mixed populations, are … Even across all combinations, no differences were detected when analyses were restricted to the few

200. Breast-Abnormalities-Tests-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
     July 01, 2010 - Small studies are unable to detect sufficient numbers of events for meaningful analyses to be performed … The clinical relevance of the findings of the analyses will be explored by using likelihood ratios and … What contributions do languages other than English make on the results of meta-analyses? … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … Measuring inconsistency in meta- analyses. BMJ 2003;327:557-60.