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181. Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
     June 01, 2012 - When are summary ROC curves appropriate for diagnostic meta-analyses? … subgroup analyses in the context of the primary methodology used to summarize the studies. … Finally, meta-regression-based analyses or subgroup analyses should be used to look at the impact of … This is a joint analysis of both quantities instead of a separate univariate meta-analyses. … When are summary ROC curves appropriate for diagnostic meta-analyses?

182. Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
     February 01, 2014 - We based our main analyses for these two approaches on the treatment effects from a meta-analysis of … Finally, when we based the analyses on baseline incidence rates of the placebo groups in the trials … most sensitivity analyses. … The sensitivity analyses that used baseline risks obtained from trials showed that the incidence of … Finally, the sensitivity analyses for the Gail/NCI approach showed that the relative weights used to

183. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methodological-recommendations-framework-communications/research

184. S103 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
     October 01, 2007 - ORIGINAL ARTICLE Using Inverse Probability-Weighted Estimators in Comparative Effectiveness Analyses … Finally, we offer detailed guidance about how to implement the estimators in comparative effectiveness analyses … Next, we discuss how to use inverse probability-weighted esti- mators for comparative effectiveness analyses … Although these characteristics can then be used to define strata for subsequent analyses, analysts should … Researchers should also use sensitivity analyses to explore the robustness of the model to the inclusion

185. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - However, follow-up duration will be considered as a covariate in the analyses. … Separate meta-analyses will be conducted on each category. … We will conduct sensitivity analyses to evaluate robustness of our findings by excluding studies with … We will lower SOE grading when sensitivity analyses 1) show substantial difference in estimates derived … Improving the interpretation of quality of life evidence in meta-analyses: the application of minimal

186. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
     December 11, 2015 - These searches will include RCTs, CCTs, and systematic reviews/meta-analyses. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses, including studies with a high risk … Two sets of additional analyses will be used to synthesize and contextualize the data. … Our proposed analyses will acknowledge several limitations of QCA.

187. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
     July 13, 2011 - be able to be abstracted from data presented in the papers (including Systematic Reviews and Meta-analyses … Hospitalization Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … recurrent depression Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … effects Adherence Study design Head-to-head, double-blind, RCTs Good or fair quality meta-analyses … Because we do not have access to individual patient data, we will not conduct any subgroup analyses.

188. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/case-management_research-protocol.pdf
     June 06, 2011 - We will include systematic reviews and meta-analyses that included unpublished data inaccessible to … the public; but because the results of such analyses are not verifiable, we will consider this a … ascertaining exposures, potential confounders, and outcomes; and whether appropriate statistical analyses … Few of the studies include sub-group analyses. … Thus, comparisons among intervention characteristics are usually indirect, and these analyses also

189. Ptsd-Adults-Trauma-Interventions Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
     April 01, 2013 - We conducted quantitative syntheses using meta-analyses of outcomes reported by multiple studies that … Heterogeneity was also explored through sensitivity analyses. … Quantitative pairwise meta-analyses were conducted using Stata® version 11.1. … Overall, we included 19 trials in our main analyses. … Another 37 studies otherwise meeting inclusion criteria were omitted from our main analyses because

190. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
     December 01, 2011 - For quantitative analyses, we included all eligible studies without sample size limitations. … If we concluded that we could not conduct any quantitative analyses, then we included studies only if … We conducted meta-analyses of 6 direct comparisons; the remaining 72 analyses employed mixed treatment … comparison meta-analyses to derive indirect comparisons. … These results are based on meta-analyses of head-to-head trials.

191. Heart-Failure-Transition-Care Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_executive.pdf
     May 01, 2014 - them in sensitivity analyses for KQ 1 and KQ 2. … We conducted meta-analyses stratified by intensity, delivery personnel, and method of communication … Subgroup analyses were not possible for other categories of interventions because of either lack of … Only STS interventions varied in the method of communication; our subgroup analyses for reduction in … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. Epub: 2003/09/06.

192. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - Relevant systematic review articles, meta-analyses, and methods articles were flagged for hand-searching … For each SROC calculation, we ran separate analyses of the accuracy of each NIT modality compared with … In our primary analyses, we evaluated these performance characteristics in the population of women … In secondary analyses, we explored a broader patient population by including those studies that had … We also assessed the impact on our findings if, in each population, we restricted our analyses to those

193. Quantitative Synthesis: Chapter 5. Network Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
     February 01, 2018 - Reporting of results from network meta-analyses: methodological systematic review. … The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … Reporting of results from network meta-analyses: methodological systematic review. … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

194. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
     March 13, 2012 - Pre-1990 studies are likely to be included in meta-analyses that meet our inclusion criteria so that … Included meta-analyses will be appraised according to criteria adapted from the PRISMA Statement.21 … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … , or systematic reviews and study-level meta- analyses. … Explicit clarification of the use of systematic reviews and meta- analyses in the review.

195. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - A subsequent publication presents exploratory analyses in which a subset of ICH patients was described … We present both risk difference analyses (main body of report) and analyses using the arc sine method … The pooling of dose-escalation studies with Phase 2 or Phase 3 studies in the efficacy analyses is a … Results Page 39, when sensitivity analyses were done, mention them in the methods section, too. … used to define indications within the Premier analyses (page 42).

196. Systematic Review of Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
     January 01, 2020 - For both KQs, we will capitalize on the availability of existing systematic reviews and meta-analyses … We will consider performing meta-analyses where we have at least three unique studies of low or medium … We plan to exclude studies deemed high risk of bias from our main data synthesis and main analyses; … we will include them only in sensitivity analyses. … We will show forest plots for all meta-analyses performed, either in the main report or in appendices

197. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
     September 08, 2011 - Although the utility of procalcitonin has been reviewed in meta-analyses, these reviews have been limited … We will use results from previously conducted meta-analyses and systematic reviews when appropriate … Prespecified subgroup analyses guard against the problems of data dredging. E. … If meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment of … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment

198. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
     September 01, 2009 - Anticipating a dearth of available evidence in answering the key questions, analyses were broadened to … the following categories: Dose and statin-specific analyses comparing lower dose of a specific statin … The DerSimonian and Laird approach was used for all meta-analyses, except for rare events (less than … Conclusions pertaining to the key questions, as well as additional analyses in mixed populations, are … Even across all combinations, no differences were detected when analyses were restricted to the few

199. Breast-Abnormalities-Tests-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
     July 01, 2010 - Small studies are unable to detect sufficient numbers of events for meaningful analyses to be performed … The clinical relevance of the findings of the analyses will be explored by using likelihood ratios and … What contributions do languages other than English make on the results of meta-analyses? … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … Measuring inconsistency in meta- analyses. BMJ 2003;327:557-60.

200. S158 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
     October 01, 2007 - OF INDIVIDUAL CONFOUNDERS Simple sensitivity analyses can be performed without use of additional data … No addi- tional data need be collected, and these analyses provide bounds for possible confounding by … To address confounding by multiple confounders, an extension of these simple sensitivity analyses has … Although this approach is a significant improvement over analyses based on a single confounder, it does … This resulted in 5108 MCBS subjects used for all subsequent analyses. TABLE 2.