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161. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - • For KQ 6, we will also include secondary analyses or subgroup analyses from trials and prospective … We plan to exclude studies deemed high risk of bias from our main data synthesis and main analyses; … we will include them only in sensitivity analyses. … and/or perform subgroup analyses when possible and appropriate. … Measuring inconsistency in meta- analyses. BMJ. 2003 Sep 6;327(7414):557-60. PMID: 12958120. 45.

162. Supplemental Project To Assess the Transparency of Reporting Requirements: Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
     June 01, 2017 - The results of these trials would not have changed our initial meta-analyses, risk of bias, or strength … Empirical analyses of prospective registry data can inform on the time between study completion and … Again, the paper gave much more detail and included statistical analyses not reported in the record, … It was also difficult to draw any conclusions about publication bias based on our analyses. … A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints

163. Migraine-Adults-Executive-130408 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
     April 01, 2013 - We focused on treatment discontinuation due to any and specific adverse effects from pooled analyses … Among off-label drugs, pooled analyses demonstrated that the off-label antidepressant amitriptyline … Exploratory Bayesian network meta-analyses demonstrated that topiramate and off-label antiepileptics … Exploratory Bayesian network meta-analyses demonstrated that topiramate, off-label antiepileptics, … Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

164. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
     December 01, 2024 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Then, we conducted meta-analyses combining unpublished and published studies. … Our analysis identified important discrepancies in effect sizes, with meta-analyses of both published … After going through this process for the three drug-indication combinations, we conducted analyses only … Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses.

165. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
     March 01, 2012 - sensitivity analyses, for the impact of including studies with high or unclear risk of bias. … Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … Adjustment of meta-analyses on the basis of quality scores should be abandoned. … Did the author(s) specify the type of analyses undertaken for harms data?

166. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
     November 01, 2008 - Observational studies based on analyses of large databases. … However, for indirect analyses to be reliable, all studies should be comparable in terms of quality … In the meantime, CER authors considering indirect analyses to assess harms should carefully consider … Did the author(s) specify the type of analyses undertaken for harms data? 19 Table 4. … Sensitivity analyses, subgroup analyses, metaregression, etc.

167. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
     November 01, 2008 - Observational studies based on analyses of large databases. … However, for indirect analyses to be reliable, all studies should be comparable in terms of quality … In the meantime, CER authors considering indirect analyses to assess harms should carefully consider … Did the author(s) specify the type of analyses undertaken for harms data? 19 Table 4. … Sensitivity analyses, subgroup analyses, metaregression, etc.

168. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update--Executive Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
     January 01, 2018 - with other more direct findings from the pairwise meta-analyses. … The section ends with findings from subgroup analyses. … All Comparisons: Network Meta-Analyses for Body Composition Outcomes We conducted network meta-analyses … Findings from our analyses are presented in Figures C and D. … Twenty-six studies reported on subgroup analyses.

169. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - subgroup analyses with similar results to the base case analysis. … Data on adverse events was very limited for carbamazepine SR/CR and ethosuximide analyses. … The results of these a priori subgroup analyses are not very informative. … subgroup analyses with similar results to the base case analysis. … The results of these a priori subgroup analyses are not very informative.

170. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - subgroup analyses with similar results to the base case analysis. … Data on adverse events was very limited for carbamazepine SR/CR and ethosuximide analyses. … The results of these a priori subgroup analyses are not very informative. … subgroup analyses with similar results to the base case analysis. … The results of these a priori subgroup analyses are not very informative.

171. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
     December 11, 2015 - These searches will include RCTs, CCTs, and systematic reviews/meta-analyses. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses, including studies with a high risk … Two sets of additional analyses will be used to synthesize and contextualize the data. … Our proposed analyses will acknowledge several limitations of QCA.

172. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - However, follow-up duration will be considered as a covariate in the analyses. … Separate meta-analyses will be conducted on each category. … We will conduct sensitivity analyses to evaluate robustness of our findings by excluding studies with … We will lower SOE grading when sensitivity analyses 1) show substantial difference in estimates derived … Improving the interpretation of quality of life evidence in meta-analyses: the application of minimal

173. Heart-Failure-Transition-Care Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_executive.pdf
     May 01, 2014 - them in sensitivity analyses for KQ 1 and KQ 2. … We conducted meta-analyses stratified by intensity, delivery personnel, and method of communication … Subgroup analyses were not possible for other categories of interventions because of either lack of … Only STS interventions varied in the method of communication; our subgroup analyses for reduction in … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. Epub: 2003/09/06.

174. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methodological-recommendations-framework-communications/research

175. Ch 5-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_5-user-guide-to-ocer_130129.pdf
     January 01, 2012 - Sensitivity analyses should then be used to quantify the effects of such unmeasured confounding under … Time-to-event analyses including Cox proportional hazard regression may be appropriate when comparing … Conversely, as-treated analyses could cause bias due to informative censoring (when stopping is associated … must be taken into account when determining the followup periods that should be included in study analyses … Sensitivity analyses assessing the impact of healthy user bias is necessary and more research is needed

176. Searching for Relevant Studies (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/searching.ppt
     January 01, 2011 - The investigators were interested in the ability to retrieve economic analyses from January to March … Grey literature in meta-analyses of randomized trials of health care interventions. … Grey literature in meta-analyses of randomized trials of health care interventions. … and Meta-analyses Reference: Relevo R, Balshem H. … Grey literature in meta-analyses of randomized trials of health care interventions.

177. The Magnitude of Small-Study Effects in the Cochrane Database of Systematic Reviews: an Empirical Study of Nearly 30 000 Meta-analyses | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/grant-manuscripts/cochrane-database-abstract

178. Evidence Summary_Comparative Effectiveness Review No. 248: Prehabilitation and Rehabilitation for Major Joint Replacement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-evidence%20-summary.pdf
     November 01, 2021 - To improve interpretation and allow for future meta- analyses, researchers (and funders of research) … data on the direct and indirect costs of (p)rehabilitation programs and conduct cost-effectiveness analyses … alongside effectiveness analyses to contribute a more complete evidentiary picture to inform evidence-based

179. Disposition of Comments Report for Stroke Prevention in Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_disposition-comments.pdf
     August 23, 2013 - analyses first when available. … However, we note that numerous indirect comparison analyses of NOACs have been published in 2012. … Prior meta-analyses done through 2007 do focus on warfarin and aspirin. … We agree that the heterogeneity in the KQ2 meta analyses was high and those analyses are no longer performed … TEP #3 Results KQ3 - very confusing, mixing up trials, cohorts and retrospective analyses.

180. GRADING THE STRENGTH OF A BODY OF EVIDENCE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
     November 01, 2013 - outcome while not reporting other, less favorable analyses. … undertaken; other analyses are suppressed. … This phenomenon includes presenting selective post hoc subgroup analyses, dichotomizing continuous … Arcsine test for publication bias in meta- analyses with binary outcomes. … from among all planned analyses).