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1221. Layout 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
      October 01, 2011 - CV harms: Celecoxib High for GI harms vs. nonselective NSAIDs (multiple systematic reviews and meta-analyses … and observational studies) Moderate for CV harms vs. placebo (multiple systematic reviews and meta-analyses … HTN, CHF, and impaired renal function Moderate (randomized trials and observational studies, but analyses … Consistent evidence from clinical trials and observational studies Moderate for CV harms: Subgroup analyses … • Meta-analyses of the risks associated with selective COX-2 inhibitors need to better assess for the

1222. Mrsa-Screening-2010 Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
      January 01, 2010 - A number of analyses suggest that MRSA infections are associated with increased mortality and cost … Published Online: October 24, 2011 appropriate signage posted on the door to the room.20 Other analyses … Research and Quality in its Methods Guide about inclusion of results from previously conducted meta-analyses … Response criteria – Followup frequency and duration – Data analysis details: Statistical analyses … If a meta-analysis can be performed, subgroup and sensitivity analyses will be based on assessment

1223. RESPONSE TO REQUEST FOR WORK ASSIGNMENT (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
      December 01, 2009 - Effective Health Care Research Report Number 15 4 Analysis Analyses were done separately for … We conducted several sensitivity analyses to evaluate the impact on study results. … Analyses were conducted with Stata/MP 10.0 for Windows (StataCorp LP, College Station, TX USA) and SAS … corticosteroids plus long-acting beta- agonists while in the base case and all of the other sensitivity analyses … Importantly, we conducted sensitivity analyses in which we used controls from both periods as well as

1224. Bladder-Cancer-Non-Muscle-Invasive Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
      July 21, 2014 - remains an important health problem, with no improvement in associated mortality since 1975.3 Economic analyses … included, we will update findings with any new primary studies identified in our searches, update meta- analyses … study with very high loss to follow up (e.g., >60%), failure to perform appropriate intention-to-treat analyses … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for … among studies in design, patient population, interventions, and outcomes, and may conduct sensitivity analyses

1225. CER 173 Executive Summary: Diabetes Medications for Adults With Type 2 Diabetes: An Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
      January 01, 2015 - Ten of the new publications were either extensions or additional analyses of studies included in the … Figure C shows the data from the meta-analyses that could feasibly be conducted. … We report between-group differences in the text regarding results where meta-analyses could not be … Our results augment findings from prior meta-analyses published in 2012 and 2013, which relied more … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414): 557-60. PMID: 12958120. 15.

1226. Systematic Review of Intermittent Inhaled Corticosteroids and of Long-acting Muscarinic Antagonists for Asthma (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-pharmacologic-treatment_research-protocol.pdf
      December 27, 2016 - We will attempt to determine potential reasons by conducting relevant subgroup analyses and/or meta-regression … Technical Expert Panel (TEP) was consulted for the stratifications or categories to consider for subgroup analyses … the presence of publication bias, visual inspection of funnel plots will be considered for pooled analyses … with 10 or greater studies as well as consideration of Egger’s weighted regression tests.17 All meta-analyses … Measuring inconsistency in meta- analyses. BMJ. 2003;327:557-60. PMID: 12958120. 17.

1227. S149 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
      October 01, 2007 - We chose these dates for our baseline analyses so that we would have all data from the first 6 months … Longitudinal Outcomes For these analyses, we excluded patients who were not on any medications for diabetes … We demonstrated the use of this methodology with our analyses of the effect of a new drug for treating … Our analyses have limitations. … Very few people with laboratory data were using exenatide, so the analyses were limited to patients using

1228. home-based-care-protocol-141119 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/home-based-care_research-protocol.pdf
      November 19, 2014 - interventions have been the subject of articles in general publications,14 as well as a topic for policy analyses … Research articles often do not provide sufficient descriptions of the interventions to allow nuanced analyses … For KQ2 and KQ3 comparisons will be made across studies as well as examining any subgroup analyses within … Meta-analyses will be considered and conducted to summarize data and obtain more precise estimates on … Based on the evidence tables, and these analyses and we will develop ways to summarize and present the

1229. Medication-Adherence-Interventions Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-adherence-interventions_executive.pdf
      September 01, 2012 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … For KQ 4, we intended to stratify our analyses and perform subgroup analyses when possible and appropriate … Nevertheless, we attempted to address this limitation through analyses for KQ 3, and those findings … These analyses suggest that patients’ adherence to chronic- disease medications can be improved through … Compliance in antihypertensive therapy: analyses in scientific articles.

1230. Methods Guide for Medical Test Reviews Chapter 10 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
      July 01, 2012 - So when is it reasonable to perform decision or cost effectiveness analyses to complement a systematic … identify the major factors that contribute to the uncertainty, as is done in “value of information” analyses … recommendations on evaluating the quality of modeling studies, especially in the context of cost- effectiveness analyses … Enhancing Value of Information Analyses. Value Health 2009. 24.

1231. Observed Association Between Antidepressant Use and Pneumonia Risk Was Confounded by Comorbidity Measures (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
      May 01, 2008 - This is analogous to time-to-event analyses of cohort studies, and ensures the interpretability of the … In addition to considering exposure to any antidepressant, we also performed sub-analyses of the two … We used SAS version 9.1 for all analyses. … misclassification would have resulted in bias toward the null in both the unadjusted and adjusted analyses

1232. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
      August 19, 2011 - If all these studies are of poor methodological quality, then we will conduct sensitivity analyses with … We will consider performing meta-analyses where there are at least three nonoverlapping studies that … Further analyses will be stratified based on patient- and lesion-level characteristics (diabetes, length … We will perform random effects model meta-analyses of continuous, binary, and time-to-event outcomes

1233. Nephropathy-Contrast-Induced Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
      October 01, 2015 - We performed de novo meta-analyses of all studies on a given comparison if the studies were similar … We included in the meta-analyses 53 RCTs investigating N-acetylcysteine with intravenous saline versus … Sensitivity analyses revealed imprecise estimates of the pooled risk ratio for CIN when stratified by … All of the studies included in those meta-analyses were of patients receiving intra-arterial contrast

1234. Ebell_Presentation_REVISED_FINAL (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/use_of_handheld_ebell_presentation.pdf
      January 01, 2009 - Developing  HDST:  Classification  and  Regression  Trees   • Series  of  multivariate  analyses

1235. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - For the final comment, rather than redoing the entire meta-analysis, we chose to do focused meta- analyses … equivalent in efficacy for pain and have been treated as such in Griebeler et al. and previous meta- analyses … We assessed dropout rates due to side effects as a measure of harm, as was done in previous meta- analyses … dropout rates due to lack of efficacy, as this would have been accounted for in the intent-to-treat analyses

1236. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - For the final comment, rather than redoing the entire meta-analysis, we chose to do focused meta- analyses … equivalent in efficacy for pain and have been treated as such in Griebeler et al. and previous meta- analyses … We assessed dropout rates due to side effects as a measure of harm, as was done in previous meta- analyses … dropout rates due to lack of efficacy, as this would have been accounted for in the intent-to-treat analyses

1237. Pharmacotherapy for Adults with Alcohol-Use Disorders in Outpatient Settings (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy-surveillance.pdf
      September 01, 2017 - We included systematic reviews and meta-analyses, whether or not they were included (as a study design … or subgroup analyses from trials, prospective cohort studies, and case-control studies … or subgroup analyses from trials, prospective cohort studies, and case- control studies were eligible … Novel citation-based search method for scientific literature: application to meta-analyses. … Novel citation-based search method for scientific literature: application to meta-analyses.

1238. Mental-Illness-Heart Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
      April 01, 2013 - Relevant review articles and meta-analyses were flagged 4 K Q s 1- 4 K Q s 1- 4 K Q s … We organized our analyses by KQ. … When a single study reported outcomes relevant to multiple KQs, it was included in the analyses for … moderate, or high based on I2 values of 25 percent, 50 percent, and 75 percent respectively.37 All analyses … We had sufficient studies to perform three meta-analyses: behavioral interventions, the anticonvulsant

1239. Hemorrhage-Postpartum Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
      April 01, 2015 - searched reference lists of included studies and of recent narrative and systematic reviews and meta- analyses … We did not conduct meta-analyses, given significant heterogeneity in the study populations, interventions … classification algorithm (Appendix G of the full report), few cohort studies provided comparative analyses … The literature about systems- level interventions is limited by lack of analyses that seek to adjust … The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses.

1240. Rapid-Reviews-End-User White-Paper (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
      April 01, 2016 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … End-users spoke about needing to conduct supplemental searches and analyses themselves in order to … What contributions do languages other than English make on the results of meta- analyses? … Complete additional analyses iii. Complete additional syntheses 2. … Did you conduct additional analyses or gather additional information? d.