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121. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
     November 22, 2011 - (meta-analyses, published in 2010– 2011) have assessed the utility of CYP2C19 variants for predicting … Four additional meta-analyses have assessed the predictive utility of phenotypic tests for platelet … In meta-analyses of both phenotypic and genetic tests, the summary effect sizes were low or moderate … If quantitative analyses are undertaken, we will consider performing subgroup analyses to assess the … Sensitivity analyses (including leave- one-out analyses, analyses assuming a fixed effects model, and

122. Comparative Effectiveness of Second Generation Antidepressants in the Pharmacologic Treatment of Adult Depression—An Update to a 2007 Report. (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_disposition-comments.pdf
     December 01, 2011 - To some extent we could overcome this issue by conducting meta-analyses. … Peer Reviewer #5 Methods Pg 33, line 30 “…included meta-analyses in this CER…” Comment: delete meta-analyses … Did you use it in analyses? Qualitative synthesis - e.g. stratification? … Above mentioned results are based on meta-analyses of head to- head trials. … We use bullet points just for the listing of meta- analyses.

123. Disposition of Comments for CERs 155 156 Contast-Induced Nephropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
     January 07, 2016 - We stratified analyses according to selected characteristics of the study populations, such as age, … We also added this data to the meta-analyses. 36 Peer Reviewer #2 Methods b. … of NAC and CIN (though it seems to be included in a secondary analyses). … The ACT study appears in the analyses of the revised version of the CIN prevention report. … We included RCTs in the analyses.

124. Integrating Health System Data With Systematic Reviews_Methods Research Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-integrating-health-system-data.pdf
     April 01, 2020 - We identified an example from the VA ESP in which secondary data analyses of VA data17 were carried … Most importantly, any analyses of health system data, published or not, must be critically appraised … We recommend formal critical appraisal of the data analyses using study design-specific criteria (e.g … Value and usability of unpublished data sources for systematic reviews and network meta-analyses. … Meta- analyses using real-world data to generate clinical and epidemiological evidence: a systematic

125. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
     December 01, 2024 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Then, we conducted meta-analyses combining unpublished and published studies. … Our analysis identified important discrepancies in effect sizes, with meta-analyses of both published … After going through this process for the three drug-indication combinations, we conducted analyses only … Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses.

126. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
     November 19, 2009 - We do not explicitly discuss costs and cost-effectiveness analyses, nor do we provide guidelines and … Instead, we highlight specific examples to help readers appreciate the role of formal quantitative analyses … Decision analyses assessed tradeoffs associated with the choices to give vidarabine empirically, withhold … In an evidence report, cost-effectiveness analyses contrasted 17 technologies (tests) and 4 combinations … All readers of decision analyses should be mindful of the assumptions that are invoked when estimates

127. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_executive.pdf
     December 01, 2011 - We conducted separate analyses for studies that enrolled patients experiencing only STEMI, studies that … For all analyses, a p-value of <0.05 was considered statistically significant. … These analyses were conducted to assess the methodological study quality (analyses limited to “good” … Data from RCTs, observational studies, and individual patient data meta- analyses were utilized. … and analyses limited to good-quality trials.

128. Quantitative Synthesis: Chapter 2. Presenting Different Effects for Different Data Types (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
     February 01, 2018 - Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. … Ratio (RR) - Easily interpretable - Commonly reported in individual trials considered in meta-analyses … even with differing baseline risks - Commonly reported in individual trials considered in meta-analyses … easily interpretable - Can be misleading when interpreted like relative risks - Widespread use in meta-analyses … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

129. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
     March 10, 2010 - Revised accordingly Methods Throughout the report and appendix, statistical analyses (e.g., odds … In systematic reviews statistical analyses are conducted by systematic review methodologists. … higher dose analyses. … Please make correction for other such analyses in the report. … These separate analyses were nothing but exploration of heterogeneity of the more general analyses!

130. Renal-Function Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
     August 01, 2014 - For KQ 3 , there was insufficient data for conducting meta- analyses. … For KQ 4 , we conducted two types of meta- analyses. … Studies were too few to generate meta-analyses for subgroup type. … , whereas Khan et al. only performed relative risk analyses. … This limited our ability to pool data and perform meta-analyses.

131. Meditation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
     October 17, 2012 - For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk … We will conduct sensitivity analyses by omitting one study at a time to assess the influence of any … All meta-analyses will be conducted using STATA (Intercooled, version 11, StataCorp, College Station … We will conduct meta-analyses when there is sufficient data (at least 3 studies that sufficiently … For studies amenable to pooling with meta-analyses, we will calculate pooled mean differences, risk

132. Arthritis-Knee-Physical-Therapy Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-knee-physical-therapy_executive.pdf
     November 01, 2012 - We developed the protocol following Preferred Reporting Items for Systematic Reviews and Meta-Analyses … Only 84 RCTs met pooling criteria and were included into meta-analyses. … Different reporting formats precluded pooled analyses. … ▪ Pain did not differ between electrical stimulation and exercise in pooled analyses. … Adjustment of meta- analyses on the basis of quality scores should be abandoned.

133. Treatment of Osteoarthritis of the Knee: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-update_research-protocol.pdf
     June 15, 2016 - To the extent data are available to allow it, we will conduct subgroup analyses to assess early vs. … , or more appropriately, whether new meta-analyses can be conducted, since the Hartung Knapp method … the results of the earlier meta-analyses narratively. … If new meta- analyses are done, these findings will be reported quantitatively with forest plots. … Prior meta-analyses will be treated as one study.

134. Physical Therapy for Knee Pain Secondary to Osteoarthritis Disposition of Comment Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-knee-physical-therapy_disposition-comments.pdf
     November 06, 2012 - When the numbers of the studies were sufficient to conduct meta-analyses, we included studies with … We revised strength of evidence grading and focused on sufficient evidence from pooled analyses. … , and the reason of not including in the pooled analyses. … We revised key messages to focus on effective interventions according to pooled analyses. … We revised the report focusing on sufficient evidence from pooled analyses.

135. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/selection-of-data-sources-chapter-8.pptx
     January 01, 2013 - These are points in time where the database is discontinuous, and analyses that cross over these points … A critical look at methods for handling missing covariates in epidemiologic regression analyses. … However, pooled analyses require close coordination and can be very difficult to complete due to differences … The results of these analyses are combined in a central location, but individual study data do not leave … Traditional reviews, meta-analyses and pooled analyses in epidemiology.

136. Machine-Learning-Tools-Appendix-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/machine-learning-tools-appendix-c.xlsx
     January 01, 2024 - The small number of missed studies across reviews with pairwise meta-analyses hindered strong conclusions … The small number of missed studies across reviews with pairwise meta-analyses hindered strong conclusions … The small number of missed studies across reviews with pairwise meta-analyses hindered strong conclusions … The small number of missed studies across reviews with pairwise meta-analyses hindered strong conclusions … The small number of missed studies across reviews with pairwise meta-analyses hindered strong conclusions

137. Disposition of Comments for CER 211: Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-211-rheumatoid-arthritis-disposition-comments.pdf
     December 20, 2018 - If no such analyses exist, please remove this interpretation that your analyses showed support for … We agree, the dearth of data is a limitation of our analyses. … meta-analyses. … Therefore, we decided against pairwise meta-analyses. … We separated the analyses by timepoint.

138. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
     February 17, 2016 - , and network meta-analyses—of potentially relevant articles. … All summaries and qualitative and quantitative analyses in the update will incorporate all relevant … We expect to conduct 12 analyses. … Full methodology for conducting the network meta-analyses will be reported, as will all results and … The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

139. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
     January 01, 2013 - it) associated with comparator choice Define time 0 for all comparator groups in describing planned analyses … Defining time 0 for all comparator groups in describing planned analyses is also important. … Sensitivity analyses can be used to quantify the effects of unmeasured confounding if potential confounders … Even in analyses using calendar time as an instrumental variable, confounding by indication may still … Sensitivity analyses assessing the impact of healthy user bias are necessary.

140. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - Sensitivity analyses around study quality may be important. … When meta- analyses include studies of different designs, reviewers should present subgroup analyses … Avoidable flaws in observational analyses: an application to statins and cancer. … When and How Can Real World Data Analyses Substitute for Randomized Controlled Trials? … Analysing data and undertaking meta- analyses. .