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101. Disposition of Comments Report for Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
     June 07, 2013 - , pooled analyses of individual data collected across multiple studies offers an opportunity to address … Additionally, you do conduct analyses in the body of the manuscript, but then do not discuss them in … It is reassuring to see that the authors redid the meta-analyses excluding poor quality studies, and … Introduction/ Methods/ Literature Search Results Can the meta analyses of cervical cancer risk be … We do, however, perform sensitivity analyses in these analyses that explore the impact of relaxing

102. Disposition of Comments for Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_disposition-comments.pdf
     April 25, 2013 - However, the sensitivity analyses provide relevant results with varying relative risk. … Moreover, we did not find those trial results influential in these analyses.” … Amgen requests AHRQ review and carefully consider the alternative analyses provided before any final … In addition, Amgen did the same type of influence analyses of the on-study mortality data in Figure … We have applied to corrections noted and revised analyses.

103. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - However, in inferential analyses (e.g., meta-analyses), we excluded studies reporting results on the … We no longer use this variable in descriptive or inferential analyses. … We generally prefer to include all relevant studies and then perform appropriate subgroup analyses. … We provide a comprehensive review of single test performance and extensive comparative analyses of … (e.g., meta-analyses).

104. Comparative Effectiveness of Coronary Bypass Surgery and Percutaneous Coronary Interventions for Multivessel Disease: A Pooled Analysis of Individual Patient Data from Ten Randomized Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_addendum.pdf
     February 01, 2010 - All analyses were by intention to treat. Findings. … of large clinical registries,13-17 and in meta-analyses of the published trial results.18-20 However … Statistical Analysis All analyses followed the intention-to-treat principle. … Statistical analyses were performed using SAS Version 9.1 and R Version 2.4.0. … Practical methodology of meta-analyses (overviews) using updated individual patient data.

105. Major-Depressive-Disorder Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
     November 24, 2014 - We will include pooled estimates of effect or other relevant results from SRs with meta- analyses that … For all analyses, we will use random-effects models to estimate pooled or comparative effects. … If we include any meta-analyses with considerable statistical heterogeneity in this report, we will … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses including high risk-of- bias studies

106. Prostate-Cancer-Test Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
     April 01, 2013 - Analyses included clinical sensitivity, clinical specificity (or the false positive rate equal to 1- … When data were available, the following analyses were performed for PCA3 and one or more comparators … Results Detailed description of analyses with tables and figures are included in the full report. … This bias cannot be avoided by statistical analysis, but was addressed by stratifying analyses and … No similar analyses can be made for any other comparator for diagnostic accuracy.

107. Research White Paper Managing Missing Data in Patient Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - Once analyses are complete, reports of the registry findings should include information on the amount … Information that is being collected for secondary objectives or to support subgroup analyses may be … Complete case analyses, which are based on only observations for which all relevant data are present … For analyses that account for missing data, authors should describe the nature of the analysis (e.g. … Conducting sensitivity analyses (see 12 Managing Missing Data in Patient Registries sections

108. A Systematic Review of Postpartum Home Blood Pressure Monitoring, Postpartum Treatment of Hypertensive Disorders of Pregnancy, and Peripartum Magnesium Sulfate Regimens for Preeclampsia With Severe Features (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/hypertensive-disorders-pregnancy-protocol-amendment.pdf
     April 20, 2022 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … In extraction and summary of NRCSs, we will preferentially include adjusted over crude analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses of comparative studies … For both KQ 2 and 3, we will explore the possibility of conducting network meta-analyses of RCTs of

109. Nppv-Respiratory-Failure Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_executive.pdf
     July 01, 2012 - A total of 12 RCTs were included in our analyses for KQ 2. … Table G summarizes the findings and strength of evidence for each of these analyses. … These analyses were limited by the paucity of effectiveness trials. … These analyses were limited by the paucity of effectiveness trials. … if analyses use all patients randomized.

110. DST_Draft_Protocol_Nov_4_2013_clean (2) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
     November 12, 2013 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Meta-regression analyses or network meta- analyses are more complex, but provide an opportunity to address … Main analyses will include all relevant studies; subgroup analyses by clinical diversity (e.g., at high … All meta-analyses will be based on random effects models.33 Sensitivity analyses (including leave-one-out … analyses, analyses assuming a fixed effects model, and reanalyses after excluding a group of studies

111. Acs-Pci-Adjunctive-Devices Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
     July 01, 2010 - participant selection method, exposure measurement method, potential design biases, and appropriate analyses … For each outcome, we will conduct separate analyses of studies and compare each individual adjunctive … We will conduct meta- analyses when two or more RCTs that are adequate for data pooling are available … For all analyses, a p-value of <0.05 will be considered statistically significant. … the conclusions of our meta-analysis, we will conduct subgroup, meta-regression, and sensitivity analyses

112. Continuous-Outcomes-Quantitative-Synthesis Methods (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/continuous-outcomes-quantitative-synthesis_methods.pdf
     March 01, 2011 - Subgroup analyses can also be done by grouping studies according to inclusion criteria. … to compare results from ANCOVA versus non-ANCOVA estimates as sensitivity analyses. … Imputing missing standard deviations in meta-analyses can provide accurate results. … Multiplicity of data in trial reports and the reliability of meta-analyses: empirical study. … Expressing findings from meta-analyses of continuous outcomes in terms of risks.

113. Fiber Intake and Laxation Outcomes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-protocol.pdf
     August 15, 2023 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses if at least three studies … The goal of the meta-analyses will be to determine fiber intake thresholds above which laxation outcomes … We may also conduct network meta-analyses, if such analyses are appropriate, feasible, and would provide

114. Supplemental Project To Assess the Transparency of Reporting for Trials Evaluating Treatment for Infertility (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
     June 01, 2017 - A secondary goal was to estimate the person-hours required to complete these analyses. … • The analytic approach and any plans for subgroup analyses were not addressed in CT.gov for any … However, subgroup analyses were not reported in the published manuscripts for any of these trials. … Recommendations for examining and interpreting funnel plot asymmetry in meta- analyses of randomised … Evidence for the selective reporting of analyses and discrepancies in clinical trials: a systematic

115. Disposition of Comments for Treatments for Fibromyalgia in Adult Subgroups (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_disposition-comments.pdf
     January 26, 2015 - I think including higher functioning/less impaired patients impacts applicability (e.g. in analyses … on pooled within-study analyses), and which outcomes are reported. … The pooled IPD analyses were pooled within- study comparisons. … patients randomized in the input RCTs were reported in the pooled analyses. … the literature, including limited credibility of reported subgroup analyses.

116. breast-biopsy-update-130920 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
     September 20, 2013 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Main analyses will include all relevant studies. … We will also perform subgroup analyses by individual risk-of-bias items to assess the impact of each … We will evaluate the robustness of our findings in sensitivity analyses that exclude studies at high … Diagnostic  statistical  procedures  in  medical  meta-­‐analyses.  

117. CER 229 Evidence Summary: Opioid Treatments for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
     April 01, 2020 - For meta-analyses of opioids versus placebo, the main analysis was stratified by opioid type. … For meta-analyses involving nonopioids (opioids versus nonopioids, opioids plus nonopioids vs. … All meta- analyses were conducted using Stata/SE 14.0 (StataCorp, College Station, TX). … Analyses of placebo-controlled trials also found an interaction (p=0.005) between higher opioid dose … Measuring inconsistency in meta-analyses.

118. Borrowing of Strength From Indirect Evidence in 40 Network Meta-analyses | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/grant-manuscripts/borrowing-strength-abstract

119. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0002_03-04-2008.pdf
     January 01, 2008 -  Blood glucose control was found to be addressed by several recent systematic reviews and meta- analyses … Furthermore, recent systematic reviews and meta-analyses agree in their overall conclusions that widespread

120. Gastric-Cancers-Supplementary-App-I (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-i.xlsx
     January 01, 2019 - Pathological stage Yes Overall survival Hazard ratio Definitely no Protocol available, but subgroup analyses … 80101 [Alliance] Age Yes Overall survival Hazard ratio Definitely no No protocol available and subgroup analyses … ST03 Age Yes Overall survival Hazard ratio Probably no or unclear Protocol available, but subgroup analyses … Publication does state subgroup analyses were "pre-specified," but also does not discuss a prior hypotheses … within stomach Yes Overall survival Hazard ratio Probably no or unclear Protocol available, but subgroup analyses