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1. Development and Implementation of Secure Statistical Analyses on Distributed Databases | Effective Health Care Program
   effectivehealthcare.ahrq.gov/products/dsitributed-database-analyses
   July 28, 2010 - Development and Implementation of Secure Statistical Analyses on Distributed Databases … 2010 Abstract Archived Development and Implementation of Secure Statistical Analyses

2. Development and Implementation of Secure Statistical Analyses on Distributed Databases | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/dsitributed-database-analyses/abstract
   July 28, 2010 - Development and Implementation of Secure Statistical Analyses on Distributed Databases Abstract Archived … hurdles in fully developing such a model, namely, the current need to combine data for multivariate analyses … Objectives: To develop methods and electronic tools (e.g., SAS macros) to enable multivariate analyses

3. Empirical and Simulation-Based Comparison of Univariate and Multivariate Meta-Analysis for Binary Outcomes | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/methods-binary-outcomes-evaluation/research
   March 20, 2013 - They can be approached with separate, independent meta-analyses, or they can be analyzed jointly, in … Eligible were pairs or triplets of meta-analyses comparing the same interventions; having at least seven … Most likely, systematic review conclusions from the meta-analyses in the empirical sample would remain … The simulation analyses were congruent with the aforementioned observations from the empirical analyses … An empirical comparison of univariate and multivariate meta-analyses for categorical outcomes.

4. Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/diagnostic-tests-reviews/research
   March 27, 2012 - Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy Research Report March … diagnostic tests, validate newly proposed methods, develop new statistical methods to perform meta-analyses … Meta-analyses used multiple electronic databases (62 percent used at least one electronic database in … of meta-analyses. … Conclusions Meta-analyses of diagnostic or predictive tests are increasingly performed.

5. Simulation-Based Comparison of Methods for Meta-Analysis of Proportions and Rates | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/metanalysis-proportion-rate-comparison/research
   November 04, 2013 - For example, researchers commonly perform meta-analyses of sensitivity and specificity to summarize medical … Methods We simulated a large number of scenarios for meta-analyses of proportions and incidence rates … For each scenario we generated 1000 random meta-analyses, on which we applied fixed and random effects … analyses for two families of methods: (1) methods that approximate within-study variability with a normal … Conclusions Discrete likelihood methods are preferable for the meta-analyses of proportions and rates

6. Empirical Assessment of Within-Arm Correlation Imputation in Trials of Continuous Outcomes | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/continuous-outcomes-correlation/research
   November 19, 2012 - Structured Abstract Objectives To better understand how to impute within-arm correlation for meta-analyses … We simulated meta-analyses, assessing the bias, coverage, and accuracy of the summary estimates derived … values higher than the true correlation resulted in coverage probabilities that were lower than those in analyses … Imputing values in meta-analyses where some or all within-group correlation estimates are not reported … In such cases, sensitivity analyses using alternative imputation values, possibly informed by studies

7. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/bivariate-methods-utility/research
   November 19, 2012 - diagnostic tests, validate newly proposed methods, develop new statistical methods to perform meta-analyses … Methods We constructed a database of PubMed-indexed meta-analyses (1987–2003) from which 2×2 tables … using inverse variance methods; univariate random effects meta-analyses with maximum likelihood (ML; … Results We reanalyzed 308 meta-analyses of test performance. … Point estimates from univariate and bivariate random effects meta-analyses were similar when performing

8. Disposition of Comments for CER 225: Substance Abuse Disorders in Adolescents (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-comments.pdf
   May 21, 2020 - • The draft results section was reported extensive detailed results of all analyses done. … only and removing complementary sensitivity analyses. 4) reduced the number of tables reporting … We 1) performed additional pairwise analyses (using restricted maximum likelihood estimation and Bayesian … TAU and report these analyses along with with network meta-analyses. 2) reported results of network … meta-analyses of non-brief interventions with the added the proviso that these networks were very sparse

9. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
   January 01, 2013 - Separate Meta-Analyses Versus Joint Analyses Accounting for Within-Study Correlations .............. … Separate Meta-Analyses Versus Joint Analyses Not Accounting for Within-Study Correlations .......... … meta-analyses is at best modest. … Separate Meta-Analyses Versus Joint Analyses Not Accounting for Within-Study Correlations As shown … SDDiff or SEDiff Analyses in the 11 paired studies Separate meta-analyses of the two tests

10. Defining an Optimal Format for Presenting Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
    January 01, 2019 - and VOI analyses). … (meta- analyses). … = cost-utility analyses. … being more common among meta- analyses and VOI analyses and less common among cost-effectiveness analyses … , cost-effectiveness/utility analyses, and value of information analyses.

11. Detection of Associations Between Trial Quality and Effect Sizes | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/trial-quality-effect-association/research
    January 05, 2012 - Data sources The analyses are based on four meta-epidemiological datasets. … These datasets consist of a number of meta-analyses; each contained between 100 and 216 controlled trials … Review methods We identified treatment effect meta-analyses and included trials and extracted treatment … Results for evidence of bias varied between datasets, clinical fields, and individual meta-analyses. … Detecting quality moderator effects requires more statistically powerful analyses than are employed in

12. Horizon Scanning_Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
    January 01, 2015 - Horizon Scanning_Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports AHRQ … Healthcare Horizon Scanning System Report of a Pilot Project: Rapid Cost Analyses of Selected Potential … Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High Impact Intervention Reports … We welcome comments on this report on the rapid cost analyses. … In 2014, AHRQ requested exploratory, rapid, cost analyses to elucidate the potential 1-year spend of

13. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/bivariate-methods-utility_research.pdf
    November 01, 2012 - We reanalyzed 308 meta-analyses of test performance. … Statistical Analyses Meta-analyses of sensitivity and specificity aim to provide helpful summaries of … Slope of ROC line in the logit-space Method Meta-Analyses With Positive Slope N (%) Meta-Analyses … SROC (unweighted) SAS Estimates from ML analyses agree with Bayesian analyses; CIs from ML analysis … those of separate univariate analyses (also observed elsewhere37).

14. Change Score or Followup Score? An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/choice-of-mean/white-paper
    April 20, 2015 - Data were abstracted from a total of 63 meta-analyses (156 trials) to evaluate differences in baseline … Using the Knapp-Hartung modification of random effect estimate led to most (10) meta-analyses showing … Finally, among the 10 meta-analyses that compared active intervention versus control or usual care, using … Among the other 53 meta-analyses comparing different interventions, there were 4 discrepancies using … Sensitivity analyses using both change scores and final values should be conducted to check the robustness

15. Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/diagnostic-tests-reviews
    March 27, 2012 - Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy Timeline … 2012 Research Report Comprehensive Overview of Methods and Reporting of Meta-Analyses

16. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/methodological-recommendations-framework-communications
    September 09, 2013 - Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses … Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses

17. Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World Trial Data and Simulation | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/bayesian-mixed-treatment
    January 31, 2013 - Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World … 2013 Research Report Findings of Bayesian Mixed Treatment Comparison Meta-Analyses

18. Use of Mixed Treatment Comparisons in Systematic Reviews | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/mixed-treatment-comparisons/research
    August 23, 2012 - use of, meta-analytic methods for mixed treatment comparison (MTC) evidence synthesis; to identify analyses … Bayesian analyses either used noninformative priors or did not report detail about priors used. … Published meta-analyses using these methods varied in how they conducted and reported results.

19. A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/primary-research-design
    January 03, 2012 - A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research … Research Report A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses

20. Final_multivariate_v22_CLEAN_03-11-2013 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-binary-outcomes-evaluation_research.pdf
    March 11, 2013 - The simulation analyses were congruent with the aforementioned observations from the empirical analyses … Between-study variance estimates in univariate versus multivariate analyses (frequentist analyses) . … Between-study variance estimates in univariate versus multivariate analyses in Bayesian analyses ... … analyses) and analyses using the discrete likelihood (Bayesian analyses, noninformative priors) generally … analyses used here.