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61. Disposition of Comments for CER 212 Nonsurgical Treatments for Urinary Incontinence in Women (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-212-urinary-incontinence-disposition-comments.pdf
    August 08, 2018 - We added in the text of the methods section of the report that "Analyses were performed separately … However, we have added better sections of subgroup analyses regarding urge vs. stress, which in part … However, we have added better sections of subgroup analyses regarding urge vs. stress, which in part … urge) or by participant mean age; and in sensitivity analyses (split-node analyses to compare the direct … Our primary analyses are intead based on categories of interventions.

62. Using Existing Systematic Reviews to Replace de Novo Processes in CERs | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-de-novo-processes/methods
    December 01, 2019 - May provide analyses that are not readily available from other sources (e.g., subgroup analyses from … Build on existing SRs by updating meta-analyses or qualitative syntheses. … Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-900. 8. … Data extraction errors in meta-analyses that use standardized mean differences. … What contributions do languages other than English make on the results of meta-analyses?

63. Avoiding Bias in Selecting Studies | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-bias/methods
    August 01, 2019 - One might expect that all the trials included in earlier meta-analyses would be included in later meta-analyses … Meta-analyses of therapies for postmenopausal osteoporosis. II. … Resolving discordant meta-analyses. JAMA. 1996 Jan 24-31;275(4):308-14. PMID: 8544272. … What contributions do languages other than English make on the results of meta-analyses? … Does blinding of readers affect the results of meta-analyses?

64. Clinical Effectiveness of Coronary Stents in the Elderly: Results From 262,700 Patients in the American College of Cardiology-National Cardiovascular Data Registry | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/coronary-stents-outcomes/research
    January 01, 2020 - The resulting analyses will better inform national practice patterns overall and in important patient … We refer to these latter analyses as 6 and 12 month landmark analyses. … Sensitivity Analyses We conducted two sensitivity analyses. … Registry Versus RCT Results: Sensitivity Analyses The differences in outcomes between registry and … Unadjusted and adjusted results from time-to-event analyses for prespecified endpoints.

65. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/appendicitis/research-protocol
    December 01, 2019 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Main analyses will include all relevant studies. … All meta-analyses will be based on random effects models. 59 Sensitivity analyses (including leave-one-out … analyses, analyses assuming a fixed effects model, and reanalyses after excluding a group of studies … How should meta-regression analyses be undertaken and interpreted?

66. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
    January 01, 2012 - Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the … White Paper A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses …   Research White Paper A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses … Published frameworks or models designed to use results of systematic reviews or meta-analyses in new … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

67. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research
    December 01, 2019 - We synthesized results qualitatively, and performed Bayesian pairwise and network meta-analyses. … publications) were included: 44 RCTs, 10 NRCSs, and 6 single-group cohorts; 58 studies were included in main analyses … Of those, 18 RCTs were included in meta-analyses comparing OMBP versus enema or no preparation for the … Results were robust to extensive sensitivity analyses.

68. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
    December 01, 2019 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Pairwise meta-analyses Direct pairwise meta-analyses will be undertaken when there are more than three … All meta-analyses will be based on random effects models. 29 Sensitivity analyses (including leave-one-out … analyses, analyses assuming a fixed effects model, and reanalyses after excluding a group of studies … How should meta-regression analyses be undertaken and interpreted?

69. App-E-Opioid-Chronic-Pain-Surveillance-Report-2 (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-2.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

70. App-E-Opioid-Chronic-Pain-Surveill-Report-1 (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveill-report-1.xlsx
    January 01, 2021 - Did the Study Perform Appropriate Statistical Analyses on Potential Confounders (i.e., Age, Sex, Other … Did the Study Perform Appropriate Statistical Analyses on Potential Confounders?

71. Methods Guide for Medical Test Reviews - Editorial (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - For example, the annual number of meta-analyses (a subset of systematic reviews) indexed by MEDLINE … Published in 1999, the QUORUM (Quality of Reporting of Meta-Analyses) guideline for reporting systematic … Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement … Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-900. 3. … PRISMA: Transparent reporting of systematic reviews and meta-analyses.

72. Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/decision-models-guidance/methods
    April 01, 2021 - Sensitivity analyses (to assess the influence of model inputs) and stability analyses (to evaluate the … analyses using ordered bar charts). … the need to perform sensitivity and stability analyses. … In statistical analyses, account for heterogeneity. … Subject these assumptions to stability and sensitivity analyses.

73. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-270-bimp-disposition-comments.pdf
    September 18, 2024 - analyzed data based on the presence of a given component, regardless of other components (e.g., the CBT analyses … Given education’s special status, we did not conduct targeted meta-analyses of all studies that utilized … American Psychological Association General We commend the comprehensive reporting of subgroup analyses … categorizing behavioral interventions and the attempt to classify these in order to conduct the analyses

74. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
    June 22, 2017 - - analyses). … Therefore, network meta- analyses are improper analytic tools for this systematic review. … Pooled analyses are highly flawed analyses that do not meet any current standards of appropriate systematic … All network meta-analyses use random effects model. … Additional analyses and assessments regarding LMWH vs.

75. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
    May 01, 2005 - When reviews include meta-analyses, we recommend that systematic reviewers consider sensitivity analyses … or other independent analyses. … Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences … Updating criteria to evaluate the credibility of subgroup analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

76. S5 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/s5.pdf
    October 01, 2007 - events of pharmaceutical use; and (3) inventing or refining ways to decrease the threats to validity of analyses … comprise a wide range of nonexperimental designs but also, in this context, various types of database analyses … is decreasing the threats to validity that bedevil analyses of administrative or other observational … Improving depiction of benefits and harms: analyses of studies of well-known therapeutics and review … Using inverse probability- weighted estimators in comparative effectiveness analyses with obser- vational

77. Rheumatoid-Arthritis-Medicine Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
    April 01, 2012 - We generally synthesized the literature qualitatively, but we did conduct meta-analyses comparing the … Subpopulation analyses are described after Table A because the evidence is very limited. 4 Table … Our MTC meta-analyses, suggest some differences, such as etanercept having a higher probability of … The results of the MTC meta-analyses suggested some differences. … Analyses involving subpopulations, specifically those defined by age and coexisting conditions, will

78. Disposition of Comments Report for Decision Aids for Cancer Screening and Treatment (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-decision-support-tools_disposition-comments.pdf
    December 23, 2014 - We now clarify in the report that “Our main analyses used hierarchical (random effects) regression … , we repeated all analyses for subset of trials included in the Cochrane review.” … quantitative analyses for outcomes with enough information. … In sensitivity analyses we pooled across all instruments using SMDs. … The analyses here seem to downplay or not confirm that result for cancer trials.

79. Evaluating the Potential Use of Modeling and Value-of-Information Analysis for Future Research Prioritization Within the Evidence-based Practice Center Program | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/value-of-information-modeling/research
    December 01, 2019 - The United Kingdom (UK) Health Technology Assessment (HTA) program conducted 19 of the 52 VOI analyses … Cost-effectiveness and VOI analyses were the most commonly used modeling-based methods, but, outside … through research, identifying the appropriate resources (including technical expertise) to conduct the analyses … , defining the appropriate timing of the modeling and analyses, and identifying the appropriate level

80. PHARMACO-EPIDEMIOLOGIC METHODS FOR A STUDY OF (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
    February 01, 2009 - Secondary confirmatory analyses employed methods based on propensity scores and instrumental variables … The findings were also observed in the alternative analyses employing propensity score adjustments and … We also restricted analyses to just new users to guard against selection bias among prevalent users … multivariable Cox analyses. … Atypical APMs Other Covariates Analyses Results Discussion References Condition