Results

Total Results: 1,912 records

Showing results for "analyses".
Users also searched for: heart failure

41. Cer-242-Radiation-Therapy-Brain-Metastases-Evidence-Summary (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
    June 01, 2021 - comparators, and outcome measures and reporting, the number of studies that could be combined for analyses … Random effects meta-analyses computed hazard ratios (HRs), relative risks (RRs), and standardized mean … studies used mixed samples in terms of primary tumor type and prognosis, only WBRT studies allowed analyses … at all, and analyses were only possible for selected outcomes. … Despite the large number of identified research studies, analyses were limited as studies evaluated

42. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
    June 16, 2010 - Rather, new analyses are needed. … Study-level and individual patient data meta-analyses. … Ongoing studies and interim analyses. Sources of Full text publications. … Accordingly, the tool will be applied to all meta-analyses. … A random effects model will be assumed for all meta-analyses.

43. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - Sensitivity Analyses Completing a CER is a structured process. … Studies with zero events in one arm should be included in the analyses. 3.2. … Sensitivity analyses 1. … This article does not address every major issue relevant to meta-analyses. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560. 18 48.

44. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - Sensitivity Analyses Completing a CER is a structured process. … Studies with zero events in one arm should be included in the analyses. 3.2. … Sensitivity analyses 1. … This article does not address every major issue relevant to meta-analyses. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560. 18 48.

45. Colorectal-Surgery-Preparation Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
    April 01, 2014 - We also performed sensitivity analyses, such as leave-one-out analyses, analyses assuming a fixed-effects … model, analyses including a retracted study, and analyses evaluating alternative network topologies … Fifty-eight studies were included in main analyses. … Forty-two of the 44 RCTs were included in main analyses. … Results were robust in all sensitivity analyses: use of informative priors, leave-one-out analyses,

46. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children-update-disposition-170621.pdf
    March 16, 2017 - We have clarified our approach to subgroup analyses, and mentioned that we conducted sensitivity analyses … for outcomes with at least three studies and network meta-analyses for two outcomes. … All analyses were conducted in a Bayesian framework. No response required. … Peer Reviewer 9 Methods It is fine to use Bayesian method to conduct pairwise meta-analyses. … All meta-analyses were random effects. TEP 10 Methods Yes to all.

47. First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/antipsychotics-children-update-disposition-170621.pdf
    March 16, 2017 - We have clarified our approach to subgroup analyses, and mentioned that we conducted sensitivity analyses … for outcomes with at least three studies and network meta-analyses for two outcomes. … All analyses were conducted in a Bayesian framework. No response required. … Peer Reviewer 9 Methods It is fine to use Bayesian method to conduct pairwise meta-analyses. … All meta-analyses were random effects. TEP 10 Methods Yes to all.

48. Comparative Effectiveness of Pharmacologic Therapies for the Management of Crohn’s Disease | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/crohns-disease/research-protocol
    December 01, 2019 - Follow-up duration will be considered in the analyses. … These sensitivity analyses will be compared to our analyses of moderate-to-severe Crohn’s disease. … We will then use these meta-analyses to conduct a network (also called mixed effects) meta-analysis ( … If we identify such variables explaining inconsistency we will stratify the analyses accordingly. … Sensitivity analyses for all Key Questions will include all levels of disease severity.

49. Testing the Predictive Validity of Strength of Evidence Grades | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/grades-predictive-values/abstract
    December 01, 2019 - Evolves From Single Trials to High-Quality Bodies of Evidence We assembled a pool of published meta-analyses … Using cumulative meta-analyses, we graded the SOE of subsets of this evidence at different points in … Using a large sample of meta-analyses, the outcome of interest is the proportion of stable results over … Cochrane Branch (expected stability) and the proportion of stable summary effects from the sample of meta-analyses

50. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse-drug-therapy/research
    January 01, 2021 - We conducted meta-analyses using random-effects models. … Our meta-analyses of four head-to-head trials found no statistically significant difference between the … For injectable naltrexone, meta-analyses found no significant benefit for return to any or heavy drinking … Our meta-analyses for variation in naltrexone response related to OPRM1 polymorphisms found no statistically

51. Disposition of Comments Report for Comparative Effectiveness Review 128 Oral Mechanical Bowel Preparation for Colorectal Surgery (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
    April 30, 2014 - , but not necessarily for the network analyses). … , including analyses not stratified by the use of enema. … We have added results from these analyses for all outcomes. … statistical analyses. … There is just too much information and too many analyses. Thank you.

52. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - The Appendix also contains analyses based on last follow-up. … For meta-analyses looking at post-RT up to 4 weeks, if studies reported earlier time frames, we used … The report analyses, tables and plots are consistent with the protocol for answering the key questions … arms (i.e., non-comparative analyses). … These additional analyses would be beyond the scope of the protocol and raise methodological concerns

53. Identification of Future Research Needs in the Comparative Management of Uterine Fibroid Disease | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/uterine-fibroids-2010/research
    September 01, 2019 - The team also reviewed the findings from the preliminary data analyses conducted for this project. … The data analyses produced descriptive profiles of patient populations with a uterine fibroid diagnosis … While the data analyses provided valuable insights into variation in treatment patterns, they also highlighted … the limitations of retrospective claims-based data analyses, including an inability to adjust data to … The two primary goals of these data analyses are: (1) to provide information on treatment patterns and

54. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
    March 10, 2010 - We really wanted to conduct these analyses but as we discuss in KQ7, we cannot fully provide this data … We acknowledge We now specify which ACE inhibitors and ARBs were included in the different analyses … analyses, there is a complicated matrix of different analyses partitioned according to population, … We strongly suggest that the EPC eliminate those analyses in which studies of ACE inhibitors and ARBs … In our revised CER we now provide more insight into our rationale for conducting the analyses in this

55. Menopause-Protocol-130612 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
    June 12, 2013 - Other meta-analyses and systematic reviews will not be included. … insufficienta Meta-analyses/systematic reviews Include Observational studies Include if meta-analyses … Conducting Meta-Analyses in R with the metafor Package. … How should meta-regression analyses be undertaken and interpreted? … Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

56. Drug Therapy for Early Rheumatoid Arthritis in Adults – An Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine-update/research-protocol
    September 01, 2019 - We will adapt the Cochrane ROB tool 26 for RCT trials by adding items about the statistical analyses … Unlike the prior update, this review will not synthesize relevant SRs or meta-analyses with findings … We will interpret results of such analyses cautiously. … will include them only in sensitivity analyses. … Measuring inconsistency in meta-analyses.

57. Comparative Effectiveness of Terbutaline Pump for the Prevention of Preterm Birth | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/preterm-birth-terbutaline-pump/research-protocol
    December 01, 2019 - Exploring heterogeneity The primary analyses for KQ1 and KQ2 are inherently subgroup analyses to assess … Sensitivity analyses Sensitivity analyses are planned to explore the robustness of combined estimates … at high risk of bias; limiting meta-analyses to randomized trials only; and including studies in meta-analyses … Sensitivity analyses will take the form of subgroup analyses as described above. … Sensitivity analyses In addition to the sensitivity analyses outlined above, we will conduct sensitivity

58. Choice-Of-Mean White-Paper (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/choice-of-mean_white-paper.pdf
    April 01, 2015 - These meta-analyses included 5 to 13 studies and 218 to 4,100 patients (Table 2). … The other three meta-analyses compared sleepiness16 and depression18 variables. … These meta-analyses included 3 to 17 studies and 215 to 3,252 patients (Table 3). … These meta-analyses revealed no clear common characteristics. 8 Table 2. … Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60.

59. Executive summary_Comparative Effectiveness Review No. 276: Diagnosis and Management of Obsessive Compulsive Disorders in Children (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-276-ocd-executive-summary.pdf
    December 01, 2024 - Where there was sufficient evidence, we conducted random effects network and pairwise meta-analyses. … Network meta-analyses indicated that remote ERP is equivalent to in-person ERP for OCD symptoms and … We found 15 studies (2 RCTs and 13 single-arm studies) that reported multivariable analyses of predictors … Given the relatively sparse evidence within comparator-outcome categories, we did not perform subgroup analyses … , including non-white, low socioeconomic status children, and of sufficient size to allow subgroup analyses

60. The Empirical Evidence of Bias in Trials Measuring Treatment Differences | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/treatment-effects-bias/research
    November 01, 2017 - We included meta-epidemiological studies (studies drawing from multiple meta-analyses), meta-analyses … Within many epidemiological studies, the included meta-analyses or trials varied along these dimensions … evaluating precision in meta-epidemiological studies developed from potentially heterogeneous meta-analyses … We suggest that systematic reviewers consider subgroup analyses, with and without studies with flaws