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  1. effectivehealthcare-admin.ahrq.gov/products/quantitative-synthesis-expanded-methods/methods
    December 01, 2019 - and binary analyses of relative measures (odds ratio or relative risk). … The additional power may not be necessary for many meta-analyses. … The exploratory nature of these analyses should be clear. … Sensitivity analyses   Specify what sensitivity analyses are being done and how they relate to key … analyses undertaken.
  2. effectivehealthcare-admin.ahrq.gov/products/horizon-scan/research-2015
    November 01, 2017 - Home Evidence Reports Report of a Pilot Project: Rapid Cost Analyses … SHARE: Report of a Pilot Project: Rapid Cost Analyses … In 2014, AHRQ requested exploratory, rapid, cost analyses to elucidate the potential 1-year spend of … Conclusions Limitations of these rapid cost analyses include the short timeframe to produce them, limited … Citation: Research Report: Report of a Pilot Project: Rapid Cost Analyses
  3. effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-metaanalysis/methods
    December 01, 2019 - . 2,28,30 Multivariate meta-analyses require advanced hierarchical modeling. … in a large empirical exploration of 308 meta-analyses. 40 Chappell et al. argued that in meta-analyses … or subgroup analyses. … When are summary ROC curves appropriate for diagnostic meta-analyses? … Task 1: Comprehensive Overview of Methods and Reporting of Meta- Analyses of Test Accuracy.
  4. effectivehealthcare-admin.ahrq.gov/products/methods-guide-editorial/methods
    December 01, 2019 - For example, the annual number of meta-analyses (a subset of systematic reviews) indexed by MEDLINE has … Published in 1999, the QUORUM (Quality of Reporting of Meta-Analyses) guideline for reporting systematic … Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement … Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-900. … PRISMA: Transparent reporting of systematic reviews and meta-analyses.
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
    March 01, 2013 - and binary analyses of relative measures (odds ratio or relative risk). … • The additional power may not be necessary for many meta-analyses. … The exploratory nature of these analyses should be clear. … Sensitivity analyses Specify what sensitivity analyses are being done and how they relate to key … analyses undertaken. 15 References 1.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
    December 01, 2024 - Key Findings • While analyses of electronic health record (EHR) data may fill clinical evidence gaps … • Conducting supplemental data analyses is feasible but required substantial additional total hours … • Single health system datasets may be too small for subgroup analyses, and use of larger, national … EPCs also tracked additional resources needed to conduct supplemental analyses. … • What resources (time and expertise) are needed to conduct such supplemental data analyses?
  7. effectivehealthcare-admin.ahrq.gov/products/bayesian-mixed-treatment/research
    November 01, 2017 - Evidence Reports Findings of Bayesian Mixed Treatment Comparison Meta-Analyses … SHARE: Findings of Bayesian Mixed Treatment Comparison Meta-Analyses … with Bayesian MTC meta-analysis to explore heterogeneity; and (3) how findings of Bayesian MTC meta-analyses … Project Timeline Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration … Research Report: Findings of Bayesian Mixed Treatment Comparison Meta-Analyses
  8. effectivehealthcare-admin.ahrq.gov/products/choice-of-mean/white-paper
    November 01, 2017 - Data were abstracted from a total of 63 meta-analyses (156 trials) to evaluate differences in baseline … Using the Knapp-Hartung modification of random effect estimate led to most (10) meta-analyses showing … Finally, among the 10 meta-analyses that compared active intervention versus control or usual care, using … Among the other 53 meta-analyses comparing different interventions, there were 4 discrepancies using … Sensitivity analyses using both change scores and final values should be conducted to check the robustness
  9. effectivehealthcare-admin.ahrq.gov/products/cancer-anemia-update/research-protocol
    December 01, 2019 - Rather, new analyses are needed. … Study-level and individual patient data meta-analyses. … Accordingly, the tool will be applied to all meta-analyses. … A random effects model will be assumed for all meta-analyses. … Meta-analyses of safety data: a comparison of exact versus asymptotic methods.
  10. effectivehealthcare-admin.ahrq.gov/products/methodological-recommendations-framework-communications/research
    November 01, 2017 - Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses … Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses … Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses … Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses
  11. effectivehealthcare-admin.ahrq.gov/products/health-careassociated-infections/research
    December 01, 2019 - Results Sixty-one articles yielded 71 analyses at the infection level, including 9 articles (10 analyses … Twenty-six analyses were performed on CLABSI, 19 on VAP, 15 on SSI, and 11 on CAUTI. … There were 34 analyses on adherence, of which 31 (91%) showed significant improvement. … There were 63 analyses of infection rates, of which 42 (67%) showed significant improvement.
  12. effectivehealthcare-admin.ahrq.gov/products/methods-guidance-quantitative-synthesis/methods
    December 01, 2019 - Sensitivity Analyses Completing a CER is a structured process. … Studies with zero events in one arm should be included in the analyses. 3.2. … Sensitivity analyses A CER with a meta-analysis should always include sensitivity analyses … This article does not address every major issue relevant to meta-analyses. … Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560.
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
    August 31, 2017 - We understand the importance of subgroup analyses. … In this revision, we added some subgroup analyses. … The subgroup analyses examined disorder specific studies. … Some studies appear to be missing in the analyses. … Our concerns regarding these analyses are twofold.
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
    July 01, 2012 - Multivariate meta-analyses require advanced hierarchical modeling. … in a large empirical exploration of 308 meta-analyses.40 Chappell et al. argued that in meta-analyses … or subgroup analyses. … Guidelines for meta-analyses evaluating diagnostic tests. … When are summary ROC curves appropriate for diagnostic meta-analyses?
  15. effectivehealthcare-admin.ahrq.gov/products/menopause/research-protocol
    December 01, 2019 - Other meta-analyses and systematic reviews will not be included. … A proposed method of bias adjustment for meta-analyses of published observational studies. … Conducting meta-analyses in R with the metafor Package. J Stat Software 2010;36(3):1-48. … How should meta-regression analyses be undertaken and interpreted? Stat Med2002;21(11):1559-73. … Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-report-web-interactive-presentation.pdf
    September 01, 2019 - In its current form, the tool does not provide or allow for additional analyses not included in the … First, there is a need to perform analyses, including sensitivity analyses, dynamically. … This can be accomplished by embedding statistical analyses in the interactive report. … We submit that, perhaps, the advantages of offering dynamic analyses outweigh their risks. … Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(3). 6.
  17. effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/rapid-reviews-abstract
    June 01, 2024 - Study design and setting: We recalculated meta-analyses for binary primary outcomes in Cochrane systematic … Rapid methods resulted in the loss of all data in 3.7-44.7% of meta-analyses. … Changes in statistical significance occurred in 6.5-38.6% of meta-analyses. … Changes from significant to nonsignificant were most common (2.1-13.7% meta-analyses).
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Analyses of CPAP stratified by disease severity b. … Analyses of CPAP stratified by disease severity b. … and subgroup analyses. … Analyses of CPAP stratified by disease severity b. … or post hoc analyses of existing trials.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/reporting.ppt
    September 01, 2009 - Describe the methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression … Example: Sensitivity analyses were pre-specified. … PMID: 20704038 Results: Additional Sensitivity Analyses Give the results of additional analyses, … Results: Additional Sensitivity Analyses Authors should report sensitivity analyses, which is usually … Results: Additional Subgroup Analyses It is important to separate subgroup analyses, which is usually
  20. S58 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/s58.pdf
    October 01, 2007 - For example, longitudinal analyses of antiretroviral medication use among Medicaid beneficiaries with … Supports detailed analyses of subgroups, rare conditions and comorbidities, including individuals with … Censoring and changes in diagnosis, treatment, and eligibility status complicate analyses. … Construction of eligibility timelines is used to select intervals to be included in analyses. … Descriptive analyses of the integrity of a US Medicaid claims database.

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