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121. Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
     October 01, 2016 - Sensitivity analyses (to assess the influence of model inputs) and stability analyses (to evaluate the … analyses using ordered bar charts). … the need to perform sensitivity and stability analyses. … In statistical analyses, account for heterogeneity. … Random-effects meta-analyses are not always conservative.

122. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
     September 01, 2011 - A clinical rationale for these decisions should be provided or separate analyses should be presented … We have revised our depression analyses, conducting separate analyses for augmention studies of tx … Patient heterogenity is an issue in most of our analyses. … Yet the computation of the overall effects in several of the meta-analyses, which may be one of the … Actually, we refrained from doing pooled analyses across, drugs in response to reviewers comments

123. Assessing the Risk of Bias in Systematic Reviews of Health Care Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
     December 01, 2017 - Previous Reviews • When using an existing systematic review in a new systematic review or subgroup analyses … Previous Reviews If you are using an existing systematic review in a new systematic review or subgroup analyses … Use Risk of Bias Assessments in Synthesizing Evidence (I) At stage 4, you conduct preplanned analyses … Consider and conduct, as appropriate, additional quantitative or qualitative sensitivity analyses or … When summarizing evidence, consider conducting sensitivity analyses to evaluate whether including studies

124. Executive Summary_Systematic Review: Association of Digestible Carbohydrate Intake With Cardiovascular Disease, Type 2 Diabetes, Obesity, and Body Composition (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-executive-summary.pdf
     March 01, 2025 - Reviews.17 The reporting complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses … Nonlinear dose-response meta-analyses suggested that the risk of incident stroke was generally flat … levels and populations that can be partially explained in dose-response meta-analysis and subgroup analyses … The nonlinear dose-response analyses reflected a U-shaped association. … Implications and Conclusions Dose-response meta-analyses suggest a nonlinear relationship between the

125. Treatment of Osteoarthritis of the Knee: An Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/osteoarthritis-knee-update/research-protocol
     July 01, 2021 - Alternatively, we will include smaller studies and conduct sensitivity analyses to assess the effect … the results of the earlier meta-analyses narratively. … If new meta-analyses are done, these findings will be reported quantitatively with forest plots. … Sensitivity analyses will be conducted for significant findings, using outliers, sample size, type of … Prior meta-analyses will be treated as one study.

126. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - As such, we have refrained from these analyses. … It had already been included in our analyses. … – e.g. modified ROC analyses – are generally rarely reported). … We used fixed effects analyses as sensitivity analyses. … In such cases we actually performed meta-analyses.

127. Disposition of Comments Report for CER 207 on PTSD (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-207-ptsd-disposition-comments.pdf
     May 17, 2018 - We did not include any high risk of bias studies in our meta analyses or SOE gradings. … Peer Reviewer 1 Methods Why did this SR not include sensitivity analyses like the 2013 SR? … We have now indicated that STATA was used for all meta analyses. … This study did not report findings from such an analyses. … Peer Reviewer 1 General 3) not doing quantitative sensitivity analyses.

128. Methods Guide for Medical Test Reviews Chapter 9 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
     July 01, 2012 - Summarizing results from major axis regressions or Bland-Altman analyses is probably informative. … Again, it is advisable to seek expert statistical help when considering such quantitative analyses, … An important piece of information gained from such analyses is the range of 9-11 values defined … The difference versus average analyses from each study are represented by three horizontal lines: a … Applying the right statistics: analyses of measurement studies.

129. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
     December 01, 2019 - participant selection method, exposure measurement method, potential design biases, and appropriate analyses … For each outcome, we will conduct separate analyses of studies and compare each individual adjunctive … We will conduct separate analyses for studies that enrolled patients experiencing only STEMI and studies … We will conduct meta-analyses when two or more RCTs that are adequate for data pooling are available … For all analyses, a p-value of <0.05 will be considered statistically significant.

130. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/polyunsaturated-fatty/protocol
     November 01, 2024 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses if at least three studies … We will then conduct multivariate meta-analyses of the spline models (at each knot) and tabulate and … We may also conduct network meta-analyses, if such analyses are appropriate, feasible, and would provide

131. Blood-Clots-Hip-Knee-Surgery Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
     March 01, 2012 - as to compare results of our meta- analyses with previously published similar analyses. … Our results are similar to that of previous pooled analyses of patients with total hip and total knee … The results of previous meta- analyses are in general agreement with the findings of our comparative … In base case analyses, prolonged prophylaxis increases the occurrence of minor bleeding and surgical … Sensitivity Analyses: A “what if” analysis that helps determine the robustness of a study.

132. Finding Grey Literature Evidence and Assessing for Outcome and Analysis Reporting Biases When Comparing Medical Interventions: AHRQ and the Effective Health Care Program | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-reporting-bias/methods
     December 01, 2019 - Part 3 provides guidance on the process of assessing for selective reporting of outcomes and analyses … only for the whole study population when analyses were also done for subpopulations. … Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses. … Direction and impact of language bias in meta-analyses of controlled trials: empirical study. … What contributions do languages other than English make on the results of meta-analyses?

133. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/saturated-fat-replacement/protocol
     November 01, 2024 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses if at least three studies … We will then conduct multivariate meta-analyses of the spline models (at each knot) and tabulate and … We may also conduct network meta-analyses, if such analyses are appropriate, feasible, and would provide

134. Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions — An Update to the 2009 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-biopsy-update/research-protocol
     December 01, 2019 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Main analyses will include all relevant studies. … We will also perform subgroup analyses by individual risk-of-bias items to assess the impact of each … We will evaluate the robustness of our findings in sensitivity analyses that exclude studies at high … Diagnostic statistical procedures in medical meta-analyses.

135. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
     March 01, 2012 - The quality of these meta-analyses could vary greatly. … Also what is the real value to include all these prior-meta-analyses while some earlier meta-analyses … We performed all the meta- analyses that we judged were appropriate based on the analyses conducted … additional trials not included in the prior analyses. … It did not do de novo meta-analyses when meta-analyses already existed.

136. Microsoft Word - ehcrr#2toCSI.doc (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
     August 01, 2007 - Results were confirmed in propensity score analyses and instrumental variables estimation adjusting for … yielded no substantive changes relative to traditional multivariable Cox regression analyses. … In instrumental variable analyses, conventional APMs continued to be associated with greater risks of … Sensitivity analyses revealed that very large relative risks of 5 or greater would be needed linking … This is evidence that our analyses did not differentially adjust important confounding variables with

137. Menopause Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
     March 01, 2015 - 1 that reported subgroup analyses were included. … For vasomotor symptoms and quality-of-life outcomes, network meta-analyses formed the primary analyses … Finally, interpreting network and pairwise meta-analyses deserves comment. … In the pairwise meta-analyses, only direct randomized comparisons are included; the network analyses … Data extraction errors in meta-analyses that use standardized mean differences.

138. Since their introduction in 20xx, DES have been shown in clinical trials to decrease TLR (… (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
     January 01, 2010 - The resulting analyses will better inform national practice patterns overall and in important patient … We refer to these latter analyses as 6 and 12 month landmark analyses. … S ens itivity Analys es We conducted two sensitivity analyses. … P res pec ified Outc omes Death Prior analyses comparing survival in DES and BMS treated patients … Unadjusted and adjusted results from time-to-event analyses for prespecified endpoints.

139. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/plant-based-chronic-pain-treatment/living-review
     March 01, 2025 - We conducted random effects meta-analyses and categorized magnitude of benefit (large, moderate, small … should stratify and conduct subgroup analyses based on product specifics, pain conditions, and population … For almost all analyses, there were too few trials to apply graphical or statistical methods to detect … Meta-analyses were based on relatively small numbers of trials (less than 20), which can result in overly … Meta-analyses based on fewer than five studies should be interpreted with caution, as CIs based on the

140. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antiplatelet-treatment/research-protocol
     December 01, 2019 - (meta-analyses, published in 2010–2011) have assessed the utility of CYP2C19 variants for predicting … In meta-analyses of both phenotypic and genetic tests, the summary effect sizes were low or moderate … If quantitative analyses are undertaken, we will consider performing subgroup analyses to assess the … Sensitivity analyses (including leave-one-out analyses, analyses assuming a fixed effects model, and … Meta-analyses involving cross-over trials: methodological issues.