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101. Comparative Effectiveness of Strategies to De-escalate Aggressive Behavior in Psychiatric Patients in Acute Care Settings | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/aggression/research-protocol
     January 01, 2020 - (PRISMA) checklist. 63 All methods and analyses are determined a priori. … analyses. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses including high risk-of-bias studies … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

102. Behavioral Programs for Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/diabetes-behavior-programs/research
     December 01, 2019 - For T1DM, we conducted pairwise meta-analysis to assess program effectiveness; subgroup analyses to examine … direct and indirect comparisons) to assess potential moderation of program effectiveness, and subgroup analyses … In subgroup analyses, results for reduced HbA 1c favored participants with suboptimal baseline glycemic … For T2DM, our analyses showed limited benefit in glycemic control from DSME programs offering ≤10 hours

103. 04-E029-1 Summary (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
     December 01, 2011 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … Furthermore, many analyses or databases combine AS, WW, and noncurative interventions like primary ADT … in their analyses, making it impossible to ferret out issues specifically related to AS. … We required multivariable analyses adjusting for a minimum of age and tumor stage (if the analysis was … We included multivariable database analyses of predictors for the offer or acceptance of or adherence

104. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
     October 18, 2010 - Surrogate endpoints (such as delay in delivery) are therefore common and meta-analyses are used to assess … Additional subgroup analyses may be considered posthoc as deemed appropriate. … at high risk of bias; limiting meta-analyses to randomized trials only; and including studies in meta-analyses … Sensitivity analyses will take the form of subgroup analyses as described above. … In addition to the sensitivity analyses outlined above, we will conduct sensitivity analyses to explore

105. Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
     February 01, 2018 - Meta-analyses of safety data: a comparison of exact versus asymptotic methods. … ► Conduct sensitivity analyses acknowledging data adequacy. … ► Conduct sensitivity analyses with acknowledgement of the inadequacy of data. … Low-event-rate meta-analyses of clinical trials: implementing good practices. … Meta-analyses of safety data: a comparison of exact versus asymptotic methods.

106. Practice-Based Interventions Addressing Concomitant Depression and Chronic Medical Conditions in the Primary Care Setting | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-chronic-conditions-interventions/research
     December 01, 2019 - We conducted quantitative analyses for outcomes when feasible and reported all results by medical condition … published articles reporting data from 12 studies (9 randomized controlled trials and 3 preplanned subgroup analyses … Our meta-analyses found that intervention recipients achieved greater improvement than controls in depression

107. Drug Therapy for Rheumatoid Arthritis in Adults: An Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine/research
     December 01, 2019 - prospective cohort studies with at least 100 participants, and relevant good- or fair-quality meta-analyses … Network meta-analyses found higher odds of reaching ACR 50 response for etanercept compared with most … Network meta-analyses from placebo-controlled trials of biologics suggest some differences, including

108. S50 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/s50.pdf
     October 01, 2007 - Its comprehensive measurement frame- work provides a basis for analyses of significant bivariate and … Conclusions: Outcomes improved when practices associated with better outcomes in PBE-CPI analyses were … Create a study database suitable for statistical analyses. 5. … Subsequently, the clinical teams helped with data analyses. … PSROP regression analyses produced 2 surprising con- sistent findings.

109. Appendicitis Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
     December 09, 2013 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Main analyses will include all relevant studies. … All meta-analyses will be based on random effects models.59 Sensitivity analyses (including leave-one-out … analyses, analyses assuming a fixed effects model, and reanalyses after excluding a group of studies … How should meta-regression analyses be undertaken and interpreted?

110. Acs-Pci-Adjunctive-Devices Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
     April 01, 2013 - the risk of mortality, stroke, MACE, coronary dissection, and coronary perforation in the overall analyses … and analyses limited to good- quality trials. … on final health outcomes (effect of distal filter on target revascularization) was seen in overall analyses … and analyses limited to good-quality trials. … Conclusion #4 Given the inadequate power in overall analyses and lack of data, we could not definitively

111. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
     August 01, 2016 - Observational studies must have reported multivariate analyses. … All observational studies reported multivariate analyses (this was an eligibility criterion). … ) analyses. … Twenty subgroup analyses by statin use were reported (1 with ALA, 19 with marine oil). … • Other n-3 FA analyses: o There is insufficient evidence comparing n-3 FA to each other.

112. Living Systematic Reviews: Practical Considerations for the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/practical-considerations.pdf
     March 01, 2022 - review the relevant scientific literature on topics assigned to them by AHRQ and conduct additional analyses … We were able to rapidly identify important new studies, especially those that might add to meta-analyses … Continuous updating meta-analyses as new studies are incorporated into the report presents advantages … As the evidence base matures, we will need to consider how often to update the meta- analyses. … The decision to update the meta-analyses depends on the relative sample sizes and risk of bias of the

113. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_executive.pdf
     July 01, 2009 - However, only a minority of multivariable analyses bear this out. … Among 11 comparisons that reported both univariable and multivariable analyses, 6 found statistically … In both univariable and multivariable analyses reported, no study or population factors were found to … However, the reported data suggest that only a small proportion of patients included in the analyses … However, the reported data suggest that only a small proportion of patients included in the analyses

114. Breast-Biopsy-Update Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
     September 01, 2014 - For this reason we refrained from performing meta-analyses for these outcomes. … Meta-regression analyses were possible for the following factors: needle gauge, choice of reference … Overall, within-study analyses and meta-regression analyses were insufficient to confirm (or exclude … Contextualizing the Results of Test Performance Meta-Analyses To contextualize the results of the … Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

115. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … Pairwise meta-analyses Direct pairwise meta-analyses will be undertaken when there are more than three … All meta-analyses will be based on random effects models.29 Sensitivity analyses (including leave- one-out … analyses, analyses assuming a fixed effects model, and reanalyses after excluding a group of studies … How should meta-regression analyses be undertaken and interpreted?

116. Template for Draft Reports (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_appendixes.pdf
     October 06, 2006 - Not RCT Appendix C: Additional Analyses and Evidence Tables Appendix C: Additional Analyses … C-2 Appendix C: Additional Analyses and Evidence Tables (continued) Appendix Table 2. … C-4 Appendix C: Additional Analyses and Evidence Tables (continued) Appendix Table 3. … Appendix C: Additional Analyses and Evidence Tables (continued) Appendix Table 10. … C-27 Appendix C: Additional Analyses and Evidence Tables (continued) Appendix Table 14.

117. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
     January 01, 2024 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses if at least three studies … We will then conduct multivariate meta- analyses of the spline models (at each knot) and tabulate and … We may also conduct network meta-analyses, if such analyses are appropriate, feasible, and would provide

118. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
     January 01, 2024 - All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … In addition, we will assess the adequacy of analyses. … Where appropriate and feasible, we will conduct random-effects meta-analyses if at least three studies … We will then conduct multivariate meta- analyses of the spline models (at each knot) and tabulate and … We may also conduct network meta-analyses, if such analyses are appropriate, feasible, and would provide

119. Executive summary_Comparative Effectiveness Review No. 270: Behavioral Interventions for Migraine Prevention (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-270-bimp-executive-summary.pdf
     May 01, 2024 - systematically screened trials, extracted 3 data, assessed the risk of bias, conducted meta-analyses … Most evidence was inconclusive, and this section describes only our analyses that resulted in strength … variations in the labeling and implementation of treatment components, introduced subjectivity to our analyses … underpowered studies resulted in wide confidence intervals, undermining the precision of our meta-analyses

120. Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/major-depressive-disorder/research-protocol
     December 01, 2019 - We will include pooled estimates of effect or other relevant results from SRs with meta-analyses that … For all analyses, we will use random-effects models to estimate pooled or comparative effects. … We plan to stratify analyses and/or perform subgroup analyses when possible and appropriate to examine … For any quantitative analyses, we will conduct sensitivity analyses including high risk-of-bias studies … When quantitative analyses are not appropriate (e.g., because of heterogeneity, insufficient numbers