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1. Development and Implementation of Secure Statistical Analyses on Distributed Databases | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/dsitributed-database-analyses/abstract
   December 01, 2019 - Evidence Reports Development and Implementation of Secure Statistical Analyses … SHARE: Development and Implementation of Secure Statistical Analyses … Objectives: To develop methods and electronic tools (e.g., SAS macros) to enable multivariate analyses … Project Timeline Development and Implementation of Secure Statistical Analyses on Distributed Databases … https://effectivehealthcare.ahrq.gov/products/dsitributed-database-analyses/abstract  

2. The Magnitude of Small-Study Effects in the Cochrane Database of Systematic Reviews: an Empirical Study of Nearly 30 000 Meta-analyses | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/cochrane-database-abstract
   June 01, 2024 - Small-Study Effects in the Cochrane Database of Systematic Reviews: an Empirical Study of Nearly 30 000 Meta-analyses … Small-Study Effects in the Cochrane Database of Systematic Reviews: an Empirical Study of Nearly 30 000 Meta-analyses … Publication bias, more generally termed as small-study effect, is a major threat to the validity of meta-analyses … We use six measures to evaluate small-study effects in 29 932 meta-analyses from the Cochrane Database … small-study effects in the Cochrane Database of Systematic Reviews: an empirical study of nearly 30 000 meta-analyses

3. Borrowing of Strength From Indirect Evidence in 40 Network Meta-analyses | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/borrowing-strength-abstract
   June 01, 2024 - Evidence Reports Borrowing of Strength From Indirect Evidence in 40 Network Meta-analyses … Borrowing of Strength From Indirect Evidence in 40 Network Meta-analyses … Study design and setting: We performed both network and pairwise meta-analyses on 40 published data … Researchers should routinely report and compare the results from both network and pairwise meta-analyses … Borrowing of strength from indirect evidence in 40 network meta-analyses.

4. OpenMetaAnalyst: Powerful Open-Source Software for Meta-Analysis | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/open-meta-analyst/abstract
   August 01, 2019 - diagnostic tests, validate newly proposed methods, develop new statistical methods to perform meta-analyses … by quantitatively summarizing the available evidence pertaining to precise clinical questions, meta-analyses … Given the vital role of meta-analyses, it is therefore imperative that they are performed correctly, … i.e., that appropriate statistical techniques are used to guide meta-analyses so that the conclusions … meta-analysts are familiar with only basic meta-analytic methods, limiting the accuracy and power of analyses

5. Empirical and Simulation-Based Comparison of Univariate and Multivariate Meta-Analysis for Binary Outcomes | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/methods-binary-outcomes-evaluation/research
   November 01, 2017 - They can be approached with separate, independent meta-analyses, or they can be analyzed jointly, in … Eligible were pairs or triplets of meta-analyses comparing the same interventions; having at least seven … Most likely, systematic review conclusions from the meta-analyses in the empirical sample would remain … The simulation analyses were congruent with the aforementioned observations from the empirical analyses … An empirical comparison of univariate and multivariate meta-analyses for categorical outcomes.

6. Disposition of Comments for CER 225: Substance Abuse Disorders in Adolescents (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-comments.pdf
   May 21, 2020 - • The draft results section was reported extensive detailed results of all analyses done. … only and removing complementary sensitivity analyses. 4) reduced the number of tables reporting … We 1) performed additional pairwise analyses (using restricted maximum likelihood estimation and Bayesian … TAU and report these analyses along with with network meta-analyses. 2) reported results of network … meta-analyses of non-brief interventions with the added the proviso that these networks were very sparse

7. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
   January 01, 2013 - Separate Meta-Analyses Versus Joint Analyses Accounting for Within-Study Correlations .............. … Separate Meta-Analyses Versus Joint Analyses Not Accounting for Within-Study Correlations .......... … meta-analyses is at best modest. … Separate Meta-Analyses Versus Joint Analyses Not Accounting for Within-Study Correlations As shown … SDDiff or SEDiff Analyses in the 11 paired studies Separate meta-analyses of the two tests

8. A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/primary-research-design/research
   January 01, 2019 - Evidence Reports A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses … A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses … Data sources Published frameworks or models designed to use results of systematic reviews or meta-analyses … Project Timeline A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design … Research Report: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses

9. Defining an Optimal Format for Presenting Research Needs (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
   January 01, 2019 - and VOI analyses). … (meta- analyses). … = cost-utility analyses. … being more common among meta- analyses and VOI analyses and less common among cost-effectiveness analyses … , cost-effectiveness/utility analyses, and value of information analyses.

10. Horizon Scanning_Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
    January 01, 2015 - Horizon Scanning_Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports AHRQ … Healthcare Horizon Scanning System Report of a Pilot Project: Rapid Cost Analyses of Selected Potential … Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High Impact Intervention Reports … We welcome comments on this report on the rapid cost analyses. … In 2014, AHRQ requested exploratory, rapid, cost analyses to elucidate the potential 1-year spend of

11. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/diagnostic-tests-accuracy/research
    November 01, 2017 - Secondary analyses included an additional 19 studies on shortened femur only. … Findings In the application, separate and joint meta-analyses yielded very similar estimates. … compared with separate meta-analyses for each test. … is half of that with separate meta-analyses. … Simulation and empirical analyses are needed to better define the role of the proposed methodology.

12. Simulation-Based Comparison of Methods for Meta-Analysis of Proportions and Rates | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/metanalysis-proportion-rate-comparison/research
    November 01, 2017 - For example, researchers commonly perform meta-analyses of sensitivity and specificity to summarize medical … Methods We simulated a large number of scenarios for meta-analyses of proportions and incidence rates … For each scenario we generated 1000 random meta-analyses, on which we applied fixed and random effects … analyses for two families of methods: (1) methods that approximate within-study variability with a normal … Conclusions Discrete likelihood methods are preferable for the meta-analyses of proportions and rates

13. Final_multivariate_v22_CLEAN_03-11-2013 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-binary-outcomes-evaluation_research.pdf
    March 11, 2013 - The simulation analyses were congruent with the aforementioned observations from the empirical analyses … Between-study variance estimates in univariate versus multivariate analyses (frequentist analyses) . … Between-study variance estimates in univariate versus multivariate analyses in Bayesian analyses ... … analyses) and analyses using the discrete likelihood (Bayesian analyses, noninformative priors) generally … analyses used here.

14. Comparing the Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/glaucoma/abstract
    December 01, 2019 - for race/ethnicity groups, and sensitivity analyses. … will be submitted after patient enrollment is complete and will summarize the findings of the interim analyses … Report 3: Primary Analysis Report will be submitted after final study analyses are complete and will … Report 4: Secondary Analyses Report will be submitted after final study analyses are complete and will … summarize the findings of the secondary analyses.

15. Machine-Learning-Tools-Appendix-D (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/machine-learning-tools-appendix-d.xlsx
    January 01, 2024 - Mistral are promising for extracting numerical findings from trial reports to produce automated meta-analyses … Mistral are promising for extracting numerical findings from trial reports to produce automated meta-analyses … Automatic extraction of quantitative data from ClinicalTrials.gov to conduct meta-analyses 2019 ExaCT … Artificial Intelligence to Automate Network Meta‑Analyses: Four Case Studies to Evaluate the Potential … Automatic extraction of quantitative data from ClinicalTrials.gov to conduct meta-analyses 2019 ExaCT

16. Quantitative Synthesis: Learning Objectives and Recommendations (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-learning-objectives-recommendations.pdf
    July 01, 2019 - Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … How should meta‐ regression analyses be undertaken and interpreted?

17. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methodological-recommendations-framework-communications_research.pdf
    September 01, 2013 - , and decision or economic analyses. … The same resource levels apply to meta-analyses of mixed treatment comparisons (network meta-analyses … Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy. … Arcsine test for publication bias in meta- analyses with binary outcomes. … Does blinding of readers affect the results of meta-analyses?

18. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses. … Outcome reporting bias: a pervasive problem in published meta-analyses. … Chapter 10: Analysing data and undertaking meta-analyses.

19. Quantitative Synthesis: Chapter 4. Quantifying, Testing, and Exploring Statistical Heterogeneity (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
    July 01, 2019 - Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60. … Chapter 10: Analysing data and undertaking meta-analyses. … How should meta‐ regression analyses be undertaken and interpreted?

20. Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/pilot-projects/white-paper
    January 01, 2025 - Key Findings While analyses of electronic health record (EHR) data may fill clinical evidence gaps and … Conducting supplemental data analyses is feasible but required substantial additional total hours across … Single health system datasets may be too small for subgroup analyses, and use of larger, national health … EPCs also tracked additional resources needed to conduct supplemental analyses. … Supplementing existing systematic reviews with analyses of EHR data is feasible, but resource intensive