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www.uspreventiveservicestaskforce.org/home/getfilebytoken/9AtjNaSwTXonz49w_DEbNz
November 07, 2023 - Four trials46,54,56,58
(n = 1704) reported no adverse events, and 1 trial55 (n = 2967) re-
ported 12 … of 1473 children assigned to varnish reported adverse
events (the most common adverse event was nausea … All adverse events were described as self-limited, al-
though 4 children were withdrawn due to mild adverse … One
subsequent trial of varnish (n = 5397) reported no adverse events.83
Only 354,61,67 of 16 trials … All (n = 775)
evaluated a resin-based sealant and reported no adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/lipid-disorders-in-children-screening
July 18, 2023 - Limited longer-term evidence shows few withdrawals due to adverse events, slightly higher rates of liver … events. … y with FH
Ezetimibe
1 (n = 138) New: 0
Similar rates of total adverse events in intervention … (simvastatin + ezetimibe)
1 (n = 248) New: 0
Similar rates of total adverse events in intervention … and control groups
Consistency NA, imprecise
High total adverse events in both the intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/breast-cancer-medication-use-reduce-risk
December 28, 2023 - status) and DCIS; breast cancer mortality; all-cause mortality; and quality of life
KQ 2 (Harms): Adverse … health outcomes
Fractures
Ophthalmologic disorders
Genitourinary outcomes
Thromboembolic events … Cardiovascular events
Risk of other cancers
Adverse outcomes related to quality of life
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/bF_Y9vcT3eNPdHjTxPZsUZ
April 17, 2023 - This trial
was among postpartum patients, and no adverse events were re-
ported in the intervention … Harm
outcomes included any adverse events, dropout due to adverse
events, serious adverse events, suicide … events. … There was also an increased risk of
serious adverse events with SSRI use compared with placebo (OR, … The
absolute risk of serious adverse events was low, and evidence for
specific serious adverse events
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June 04, 2024 - Multifactorial Interventions
Adverse events were sparsely reported for multifactorial interven-
tions … Seventeen trials18, 43, 44, 48, 50, 51, 53, 56-58, 61-64, 70, 72, 74 reported
any adverse events occurring … during the exercise intervention ses-
sions, ranging from 0%18,51,53,63,64 to 58%.56 These adverse events … and 1
trial62 reporting less than 1% serious adverse events related to the
exercise intervention (2/ … events as
18% in the intervention group and 12% in the control group; how-
ever only 1 adverse event
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-cancer-medications-for-risk-reduction-2002
May 06, 2002 - The number of adverse events, for example, would likely be higher in women with hypertension or other … Adverse events would be lower in subgroups with no predisposition to thromboembolic events and in women … Return to Table of Contents
Table 3: Adverse events in 4 randomized controlled trials of breast … Do chemopreventive agents increase the risk of adverse effects? … The adverse effects of treatment are also well documented.
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March 01, 2011 - Adverse events were not well reported in trials of behavioral in-
terventions, but no serious adverse … events in these trials were uncom-
mon; study withdrawals due to adverse events were not reported
or … In the NRT trial, no serious adverse events were reported.46
NRT was associated with increased risk … of headache, cough,
abnormal dreams, muscle pain, and patch-related adverse events
vs placebo (P < .05 … adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/breast-cancer-medication-use-reduce-risk
March 21, 2024 - breast cancer mortality; all-cause mortality; and global measures of quality of life
KQ 2 (Harms): Adverse … not limited to:
Fractures
Ophthalmologic disorders
Genitourinary outcomes
Thromboembolic events … Cardiovascular events
Risk of other cancers
Adverse outcomes related to quality of life
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/DxeDM5ywg2J7SwKmETXfbX
May 01, 2021 - 13% for men and 6% for
women.1 Severe OSA is associated with increased all-cause
mortality.2,3 Other adverse … Other adverse health outcomes associated with untreated OSA include cardiovascular
disease and cerebrovascular … In general,
mild OSA is defined as 5 to 15 events per hour, moderate OSA as 16
to 30 events per hour, … or for those with adverse effects associated with positive airway
pressure.15,16 Surgical interventions … Adverse health outcomes associated with untreated OSA include cardiovascular disease and cerebrovascular
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September 03, 2019 - Medications to reduce risk of breast cancer are effective for women at
increased risk but also cause adverse … However, these medications are also associ-
ated with adverse effects,3 and candidates for risk-reducing … All adverse outcomes at all reported
follow-up times were considered in an effort to capture potential … short- and long-term adverse effects. … For outcomes of major adverse
events, analyses were stratified by active vs posttreatment peri-
ods,
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/2wL_PmXmBxZQXX29D7nma5
September 01, 2021 - Asymptomatic pregnant persons who are at high risk for preeclampsia and have no prior adverse events … years or
older, personal history factors (eg, low birth weight or small for gestational age, previous adverse
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/rQBBkz9CrHh4vp7ZnEkF-t
July 18, 2023 - FH
Ezetimibe 1 (n = 138)
New: 0
Similar rates of total adverse events in
intervention and control groups … 6-11 y
with FH
PCSK9 inhibitor 1 (n = 158)
New: 1
Similar rates of total adverse events in
intervention … events in
intervention and control groups
Consistency NA, imprecise High total adverse events
in both … Limited longer-term evidence shows few withdraw-
als due to adverse events, slightly higher rates of … events.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/_2-KL_eHkuBhbGrzcAHsB-
June 01, 2022 - or stress, bullying, maltreatment, adverse life events, and a difficult relationship with parents. … Adverse childhood experiences in-
fluence the likelihood of experiencing mental health conditions such … events and serious adverse events compared with placebo; the dif-
ferences were not statistically significant … , likely because of a small
number of events due to poor reporting. … There
were no significant differences in adverse events reported.1,2
Response to Public Comment
A draft
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/6jFgJYJSbMc48mj2uKsAhB
October 01, 2014 - None of the dietary intervention studies explicitly reported
adverse events. … Studies of physical activity interventions
reported mostly minor adverse events, and intense physical … events during the trial and 6 spe-
cifically reported no adverse events (6). … Few trials reported
details about the adverse events, but most were minor,
including musculoskeletal … Serious adverse events were
rare.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/drug-use-illicit-screening-january-2008
January 15, 2008 - Several clinical trials of pharmacotherapy for drug misuse have reported mild to serious adverse events … , although some of these events were likely related to underlying drug use. … The specific adverse events noted to occur more frequently in the treatment arm of trials (compared to … Adverse events ranging from mild (e.g., elevated liver function tests) to serious (e.g., seizures) have … The adverse events reported more frequently in the treatment arm of trials (compared to placebo) have
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Qh7NQD6ZEynjyRso7L5-gS
January 15, 2008 - Several clinical trials of pharmacotherapy for drug misuse
have reported mild to serious adverse events … , although some of these events
were likely related to underlying drug use. … The specific adverse events noted to
occur more frequently in the treatment arm of trials (compared … Adverse events ranging from mild (e.g., elevated liver function tests) to
serious (e.g., seizures) have … The adverse events reported more frequently in the treatment arm of trials
(compared to placebo) have
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/behavioral-counseling-interventions-promote-healthy-diet-physical-activity-weight-loss-prevent-cardiovascular-disease-adults
May 18, 2023 - KQ 1: Health outcomes:
All-cause and cardiovascular disease mortality
Cardiovascular disease events … mellitus
Hypertension
Dyslipidemia
Cardiorespiratory fitness measures
KQ 3: Harms:
Any adverse … treatment-related harm after initiation of the intervention, including:
Any adverse event or serious … adverse event
Withdrawals or discontinuation of medication due to adverse effects
Unhealthy weight
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening-june-2016
June 15, 2016 - For KQ3, all trials and observational studies that reported serious adverse events requiring unexpected … Adverse events of computed tomography colonography: an Italian National Survey. … Adverse events after screening and follow-up colonoscopy. … Adverse events after outpatient colonoscopy in the Medicare population. … No studies reported serious adverse events in persons without CTC.
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www.uspreventiveservicestaskforce.org/uspstf/reconsidering-approach-prevention-recommendations-older-adults-figure-2
December 01, 2010 - interventions to reduce falls and fall-related outcomes
Figure 2 is an analytic framework that depicts the events … Risk Evaluation, Intervention, Intermediate Outcomes, Health Outcomes, Other Positive Outcomes, and Adverse … Minor adverse outcomes associated with specific interventions include: increased fall-related outpatient … KQ3: What are the adverse effects associated with interventions to reduce falls?
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4GH3or2_-oQ7ChXfjCB2ux
March 02, 2020 - and withdrawal due to adverse effects … event was 73.3%.1
Rates of serious adverse events (1.9%) and withdrawal due to ad-
verse events (0.4% … reported for older interferon-
containing therapies.1 The most common adverse events were fa-
tigue, … Five trials reported no withdraw-
als due to adverse events; 1 trial reported a serious adverse event … fa-
tigue (7 trials), and 3% to 28% for gastrointestinal adverse events
(nausea, vomiting, or diarrhea