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  1. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary19/high-blood-pressure-in-adults-screening-monitoring-october-2015
    December 22, 2014 - For prediction of cardiovascular events, we combined fatal and nonfatal events within outcome categories … Results were inconsistently significant for cardiac events, CHF, and all-cause mortality. … persons had a consistently higher incidence of hypertension at rescreening than white persons. 5 (adverse … Which methods and associated protocols best predict cardiovascular events?      b. … What are the adverse effects of screening for high blood pressure in adults?
  2. www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/unhealthy-alcohol-use-adolescents-adults-behavioral-counseling-interventions
    August 05, 2025 - Alcohol consumption during pregnancy can result in fetal alcohol spectrum disorders and additional adverse … reviewed epidemiologic evidence on the association between excessive alcohol consumption and a range of adverse … reviewed 7 studies (n= 3991) on the harms of interventions to reduce UAU in adults and none reported any adverseevents in the intervention or control groups. 1 Return to Table of Contents
  3. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
    August 20, 2024 - Harms of iron supplementation included transient gastrointestinal adverse effects. … Adverse effects included clinical harms, harms leading to discontinuation, and accidental overdose. … No trial reported any serious adverse events from iron supplementation, and infant harms were not reported … 1.28-1.97]). 32 In contrast, no statistically significant differences in rates of gastrointestinal adverse … consistent Some imprecision Some reporting bias detected Outcomes mostly reported as ad hoc events
  4. www.uspreventiveservicestaskforce.org/home/getfilebytoken/vxPM4Bo9RXZGUDH6MWnDht
    May 01, 2013 - events or a (statistically nonsignificant) paradoxical increase in suicide attempts, which is discussed … None identified serious adverse effects of screening (29, 34, 35). … Specific adverse effects were not reported. Figure 3. Depression in psychotherapy trials. … 2/188 44/293 80/378 7/52 31/1043 39/153 385/3136 3/52 3/52 5/60 5/60 Treatment Control Events … The trial with the largest increase was small (n � 31 with follow-up) and had few events but reported
  5. www.uspreventiveservicestaskforce.org/home/getfilebytoken/827CwGYMVawpVoVg_syJpF
    October 01, 2015 - balance of benefits and harms of screening for iron deficiency anemia in pregnant women to prevent adverse … balance of benefits and harms of screening for iron deficiency anemia in pregnant women to prevent adverse … Many observational studies have explored the as- sociation between adverse maternal and infant health … Reported adverse events of iron sup- plementation or treatment with iron include limited gastrointestinal … The major concern about iron deficiency anemia in pregnant women is whether it has adverse effects on
  6. www.uspreventiveservicestaskforce.org/home/getfilebytoken/mTPBWPMDqfuWvodfd5R5Ms
    November 01, 2012 - What are the adverse effects (including false- positive tests and anxiety) of rapid versus standard HIV … What are the adverse effects (including false-positive results and anxiety) of rapid versus standard … No study compared psychological or other harms as- sociated with rapid versus standard tests or adverse … USPSTF review in- cluded 1 study of 226 U.S. women that found no differ- ence in risk for AIDS-defining events … Receipt of antiretroviral therapy during pregnancy is associated with the nonobstetric adverse events
  7. www.uspreventiveservicestaskforce.org/uspstf/document/screening-for-hiv-in-pregnant-women-evidence-summary/human-immunodeficiency-virus-hiv-infection-screening-2013
    November 15, 2012 - What are the adverse effects (including false-positive tests and anxiety) of rapid versus standard HIV … pregnancy outcomes; adverse congenital, neurodevelopmental, cardiovascular, metabolic, or hematologic … No study compared psychological or other harms associated with rapid versus standard tests or adverse … USPSTF review included 1 study of 226 U.S. women that found no difference in risk for AIDS-defining events … Antiretroviral therapy during pregnancy is associated with the nonobstetric adverse events typically
  8. www.uspreventiveservicestaskforce.org/home/getfilebytoken/hhrqMCEgbsBMJ_Ppbcp4yJ
    January 14, 2025 - A pooled analysis of 21 RCTs found no significant differ- ence in serious adverse events. … One trial reported a statistically sig- nificant increase in gastrointestinal adverse events in the treatment … events in participants tak- ing bisphosphonates compared with those taking placebo. … ing from 0.01% to 0.06%.64 For denosumab, pooled analyses found no significant increase in serious adverseevents (5 RCTs) or upper gastrointestinal tract ad- verse events (4 trials), although the CIs were wide
  9. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breastfeeding-primary-care-interventions
    April 11, 2025 - health outcome (eg, maternal mental health symptoms, infant or child gastrointestinal symptoms), or adverse … Seven of the 90 included trials (n = 1404) commented on the occurrence of adverse events or lack of adverseevents; 41 , 42 , 56 , 75 , 77 , 82 , 94 5 of these studies reported that no adverse events were reported … precise Unclear applicability, given proportion of trials reporting harms Six trials reported “no adverseevents” related to the intervention One trial reported greater feelings of anxiety, decreased confidence
  10. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-primary-care-screening-for-and-treatment-of/depression-in-adults-screening
    January 26, 2016 - serotonin withdrawal syndrome, neonatal respiratory distress, cardiopulmonary effects, and other serious eventsevents, and diagnostic accuracy statistics. … The absolute increase in risk for most infant outcomes was very small, given the rarity of the events … The analytic framework also depicts the possible adverse events occurring after screening (KQ3) or treatment … events or other specific harms.
  11. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-adults-preventive-medication
    April 17, 2018 - Main Outcomes and Measures: Incident fracture, mortality, kidney stones, cardiovascular events, and … 11 Statistical heterogeneity was assessed using the I 2 statistic. 12 Because fracture and harm events … Cardiovascular disease events in the third RCT were rare; 1 woman experienced a myocardial infarction … and 1 underwent coronary artery bypass graft surgery in the vitamin D group, and no cardiovascular events … of harm outcome ascertainment, some relying on self-report to identify cases and others relying on adverse
  12. www.uspreventiveservicestaskforce.org/uspstf/recommendation/syphilis-infection-in-pregnancy-screening
    May 13, 2025 - or improve maternal health outcomes. 1 , 30 Evidence from previous reviews 31 demonstrates fewer adverse … During the same time, the incidence of adverse pregnancy outcomes decreased from 42.7% to 19.2%, and … https://www.fda.gov/news-events/press-announcements/fda-marketing-authorization-enables-increased-access-first-step-syphilis-diagnosis … Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic … for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse
  13. www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/perinatal-depression-interventions-to-prevent
    April 22, 2025 - history of physical or sexual abuse, having an unplanned or unintended pregnancy, current stressful life events … health–related factors such as elevated anxiety symptoms or a history of significant negative life events … achieved by addressing and managing negative thoughts, beliefs, and attitudes and by increasing positive events … Depression during pregnancy: a risk factor for adverse neonatal outcomes?
  14. www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/drug-use-illicit-screening
    October 20, 2016 - Key Question 4a) and health outcomes (Key Question 4b) and whether these interventions result in any adverseevents (Key Question 5).
  15. www.uspreventiveservicestaskforce.org/home/getfilebytoken/DTRggkjEPQ5-ALArTjrhKT
    July 11, 2017 - There was no evidence of greater incidence of serious adverse events, injuries, or falls in intervention … events related to the intervention. … The data on health outcomes (KQ1) and adverse events (KQ4) did not allow for pooled analyses and so were … 1 What adverse events are associated with primary care behavioral counseling interventions to improve … What adverse events are associated with primary care behavioral counseling interventions to improve diet
  16. www.uspreventiveservicestaskforce.org/home/getfilebytoken/Y5p8ZXy2ydg_VZMUfxbJ-6
    April 25, 2017 - Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth … Adverse peri- natal outcomes for the fetus and newborn include intrauterine growth restriction, low birth … include a history of eclampsia or preeclampsia (particularly early-onset preeclampsia), a previous adverseevents. … studies of timing of delivery, trial evidence supports delivery of the fetus to reduce the risk of adverse
  17. www.uspreventiveservicestaskforce.org/uspstf/recommendation/depression-in-adults-screening
    January 26, 2016 - previously and using clinical judgment in consideration of risk factors, comorbid conditions, and life events … an individual may include emotional suffering, reduced quality of personal relationships, possible adverse … and Treatment General Adult Population and Older Adults One trial in general adults reported no adverseevents attributable to screening in a subset of participants with newly-identified depression; 24 none … trial, which focused on the effects of screening alone in postpartum women, specifically reported on adverse
  18. www.uspreventiveservicestaskforce.org/uspstf/document/treatment-evidence-summary/gestational-diabetes-mellitus-screening-january-2014
    May 28, 2013 - The more immediate risk for adverse outcomes of GDM in the mother and child is less well-established. … Evidence was insufficient for birth injury due to imprecision (low number of events and participants … There were no differences in perinatal death, although the number of events was extremely low (<0.5%) … This is probably due to the infrequent occurrence of these events and a resulting lack of power across … Hyperglycemia and adverse pregnancy outcomes. N Engl J Med . 2008;358:1991-2002.
  19. www.uspreventiveservicestaskforce.org/home/getfilebytoken/kAg43FLUnTjCU5ZNaaHQtW
    March 01, 2016 - For rare events, meta-analyses are needed that include only children and adolescents with MDD and focus … reported on harms and found no ap- parent differences in harms-related, suicide-related, or psychiatric adverseevents between the CBT and pla- cebo groups (10). … the data are limited, the USPSTF concludes that the evidence on the frequency of medication-related adverseevents in adolescents is adequate to estimate that the magnitude of harms of pharmacotherapy is small
  20. www.uspreventiveservicestaskforce.org/uspstf/recommendation/vitamin-d-and-calcium-to-prevent-fractures-preventive-medication-2013
    February 15, 2013 - community-dwelling adults, the association of vitamin D and calcium levels with bone health outcomes, and the adverse … Potential Harms of Preventive Medication Reporting of adverse outcomes in clinical trials and observational … It is uncertain if this adverse effect occurs in vitamin D–deficient populations. … None of the studies reviewed by the USPSTF reported this adverse effect. … Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis

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